347 research outputs found
Analysis and Evaluation of PUF-based SoC Designs for Security Applications
This paper presents a critical analysis and statistical evaluation of two categories of Physically Unclonable Functions (PUFs): ring oscillator PUF and a new proposed adapted latch based PUF. The main contribution is that of measuring the properties of PUF which provide the basic information for using them in security applications. The original method involved the conceptual design of adapted latch based PUFs and ring oscillator PUFs in combination with peripheral devices in order to create an environment for experimental analysis of PUF properties. Implementation, testing and analysis of results followed. This approach has applications on high level security
A Novel PUF-Based Encryption Protocol for Embedded System On Chip
This paper presents a novel security mechanism for sensitive data stored, acquired or processed by a complex electronic circuit implemented as System-on-Chip (SoC) on an FPGA reconfigurable device. Such circuits are increasingly used in embedded or cyber systems employed in civil and military applications. Managing security in the overarching SoC presents a challenge as part of the process of securing such systems. The proposed new method is based on encrypted and authenticated communications between the microprocessor cores, FPGA fabric and peripherals inside the SoC. The encryption resides in a key generated with Physically Unclonable Function (PUF) circuits and a pseudorandom generator. The conceptual design of the security circuit was validated through hardware implementation, testing and analysis of results
Kadanoff-Baym approach to time-dependent quantum transport in AC and DC fields
We have developed a method based on the embedded Kadanoff-Baym equations to
study the time evolution of open and inhomogeneous systems. The equation of
motion for the Green's function on the Keldysh contour is solved using
different conserving many-body approximations for the self-energy. Our
formulation incorporates basic conservation laws, such as particle
conservation, and includes both initial correlations and initial embedding
effects, without restrictions on the time-dependence of the external driving
field. We present results for the time-dependent density, current and dipole
moment for a correlated tight binding chain connected to one-dimensional
non-interacting leads exposed to DC and AC biases of various forms. We find
that the self-consistent 2B and GW approximations are in extremely good
agreement with each other at all times, for the long-range interactions that we
consider. In the DC case we show that the oscillations in the transients can be
understood from interchain and lead-chain transitions in the system and find
that the dominant frequency corresponds to the HOMO-LUMO transition of the
central wire. For AC biases with odd inversion symmetry odd harmonics to high
harmonic order in the driving frequency are observed in the dipole moment,
whereas for asymmetric applied bias also even harmonics have considerable
intensity. In both cases we find that the HOMO-LUMO transition strongly mixes
with the harmonics leading to harmonic peaks with enhanced intensity at the
HOMO-LUMO transition energy.Comment: 16 pages, 9 figures. Submitted at "Progress in Nonequilibrium Green's
Functions IV" conferenc
Hofstadter butterflies of carbon nanotubes: Pseudofractality of the magnetoelectronic spectrum
The electronic spectrum of a two-dimensional square lattice in a
perpendicular magnetic field has become known as the Hofstadter butterfly
[Hofstadter, Phys. Rev. B 14, 2239 (1976).]. We have calculated
quasi-one-dimensional analogs of the Hofstadter butterfly for carbon nanotubes
(CNTs). For the case of single-wall CNTs, it is straightforward to implement
magnetic fields parallel to the tube axis by means of zone folding in the
graphene reciprocal lattice. We have also studied perpendicular magnetic fields
which, in contrast to the parallel case, lead to a much richer, pseudofractal
spectrum. Moreover, we have investigated magnetic fields piercing double-wall
CNTs and found strong signatures of interwall interaction in the resulting
Hofstadter butterfly spectrum, which can be understood with the help of a
minimal model. Ubiquitous to all perpendicular magnetic field spectra is the
presence of cusp catastrophes at specific values of energy and magnetic field.
Resolving the density of states along the tube circumference allows recognition
of the snake states already predicted for nonuniform magnetic fields in the
two-dimensional electron gas. An analytic model of the magnetic spectrum of
electrons on a cylindrical surface is used to explain some of the results.Comment: 14 pages, 12 figures update to published versio
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So you call that research? : mending methodological biases in strategy and organization departments of top business schools
We believe that all strategy and organization (SO) scholars should be able to decide for themselves whether to specialize in certain parts of the knowledge cycle or adopt a broader, multi-method view on the scientific process. In a situation of ―methodological pluralism‖, individuals might choose to contribute to the construction of new administrative theories by means of qualitative works like case studies, ethnographies, biographies, or grounded theory studies (e.g., see Denzin and Lincoln, 2000). Others could then specialize in testing these theories by means of experiments, surveys, or longitudinal econometric studies (e.g., see Lewis-Beck, 1987-2004). Again others could combine both approaches in Herculean attempts to conduct high-impact, integrative research with the potential to change the way we understand the field as a whole
P19-46. Co-delivery of mucosal chemokine plasmids in a systemically delivered DNA vaccine elicits systemic and mucosal immune responses in mice and macaques
The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells
The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody. We found that the combination of acidic pH and Env-specific IgG, including that from cervicovaginal and seminal fluids of HIV-1-infected individuals, augmented transcytosis across epithelial cells as much as 20-fold compared with Env-specific IgG at neutral pH or non-specific IgG at either pH. Enhanced transcytosis was observed with clinical HIV-1 isolates, including transmitted/founder strains, and was eliminated in Fc neonatal receptor (FcRn)-knockdown epithelial cells. Non-neutralizing antibodies allowed similar or less transcytosis than neutralizing antibodies. However, the ratio of total:infectious virus was higher for neutralizing antibodies, indicating that they allowed transcytosis while blocking infectivity of transcytosed virus. Immunocytochemistry revealed abundant FcRn expression in columnar epithelia lining the human endocervix and penile urethra. Acidity and Env-specific IgG enhance transcytosis of virus across epithelial cells via FcRn and could facilitate translocation of virus to susceptible target cells following sexual exposure
Is complexity leadership theory complex enough? A critical appraisal, some modifications and suggestions for further research
Scholars are increasingly seeking to develop theories that explain the underlying processes whereby leadership is enacted. This shifts attention away from the actions of ‘heroic’ individuals and towards the social contexts in which people with greater or lesser power influence each other. A number of researchers have embraced complexity theory, with its emphasis on non-linearity and unpredictability. However, some complexity scholars still depict the theory and practice of leadership in relatively non-complex terms. They continue to assume that leaders can exercise rational, extensive and purposeful influence on other actors to a greater extent than is possible. In effect, they offer a theory of complex organizations led by non-complex leaders who establish themselves by relatively non-complex means. This testifies to the enduring power of ‘heroic’ images of leader agency. Without greater care, the terminology offered by complexity leadership theory could become little more than a new mask for old theories that legitimize imbalanced power relationships in the workplace. This paper explores how these problems are evident in complexity leadership theory, suggests that communication and process perspectives help to overcome them, and outlines an agenda for further research on these issues
Calpain Cleavage Prediction Using Multiple Kernel Learning
Calpain, an intracellular -dependent cysteine protease, is known to play a role in a wide range of metabolic pathways through limited proteolysis of its substrates. However, only a limited number of these substrates are currently known, with the exact mechanism of substrate recognition and cleavage by calpain still largely unknown. While previous research has successfully applied standard machine-learning algorithms to accurately predict substrate cleavage by other similar types of proteases, their approach does not extend well to calpain, possibly due to its particular mode of proteolytic action and limited amount of experimental data. Through the use of Multiple Kernel Learning, a recent extension to the classic Support Vector Machine framework, we were able to train complex models based on rich, heterogeneous feature sets, leading to significantly improved prediction quality (6% over highest AUC score produced by state-of-the-art methods). In addition to producing a stronger machine-learning model for the prediction of calpain cleavage, we were able to highlight the importance and role of each feature of substrate sequences in defining specificity: primary sequence, secondary structure and solvent accessibility. Most notably, we showed there existed significant specificity differences across calpain sub-types, despite previous assumption to the contrary. Prediction accuracy was further successfully validated using, as an unbiased test set, mutated sequences of calpastatin (endogenous inhibitor of calpain) modified to no longer block calpain's proteolytic action. An online implementation of our prediction tool is available at http://calpain.org
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