Optimizing outpatient total hip arthroplasty: perspectives of key stakeholders

Background Advances in surgical techniques combined with multimodal analgesia and early rehabilitation have potentiated early mobilization in patients undergoing total hip arthroplasty (THA). Given an increasing push from patients to accelerate recovery and health care budgetary limitations, there has been growing interest in the implementation of outpatient THA in selected patients. Understanding the patient and primary caregiver experience of outpatient THA is important to optimize care. We aimed to gain insight into patient and caregiver perspectives regarding the perceived advantages and disadvantages of same-day discharge to identify areas of care that can be improved. Method Using a qualitative descriptive approach, we conducted in-depth semistructured interviews with patient-primary caregiver dyads who experienced same-day discharge or standard care after primary THA with the direct anterior approach in 2016-2017. Two members of the research team coded the data independently, implementing a thematic and content analysis. Results Twenty-eight participants (16 same-day discharge, 12 standard care) were included. Both groups experienced high levels of satisfaction with their care pathway. Concerns and challenges identified in both groups pertained to mobility, pain, self-care and caregiver support. Challenges and concerns unique to same-day discharge were identified regarding expectations for recovery, medications and their impact on mobility, the timing of postoperative education and the availability of formal care. Conclusion Outpatient THA can be implemented with high patient and caregiver satisfaction. Preoperative education, clarification of recovery processes and expectations, and proactively addressing concerns related to caregiving are important

Species of Fungi in the Root System of Woody Plants in Urban Plantations

The features of the species composition of microscopic fungi in the root system and rhizosphere soil of woody plants in connection with the level of soil contamination have not been studied sufficiently. This article presents the results of studying the species composition of fungi in the root system and soil of three species of woodyplants (Acer negundo L., Acer platanoides L., and Betula pendula Roth.) growing in urban plantations of various ecological categories with different levels of heavy metal soil contamination. The study was carried out in a large industrial center of the Urals region, Izhevsk. When studying the species composition of fungi, microscopyand molecular genetic analysis were used. Isolates of endotrophic fungi from the root system of plants were isolated, and systematic membership was determined by molecular genetic analysis. The results showed that in soils with a high level of contamination, the DNA of endotrophic mycorrhiza-forming fungi was found in theroots of woody plants in a good living state. Keywords: fungi, heavy metals, plantations, urban environment, resistanc

Sentinel headache as a warning symptom of ischemic stroke

Background: There are no previous controlled studies of sentinel headache in ischemic stroke. The purpose of the present study was to evaluate the presence of such headache, its characteristics and possible risk factors as compared to a simultaneous control group. Methods: Eligible patients (n = 550) had first-ever acute ischemic stroke with presence of new infarction on magnetic resonance imaging with diffusion-weighted imaging (n = 469) or on computed tomography (n = 81). As a control group we studied in parallel patients (n = 192) who were admitted to the emergency room without acute neurological deficits or serious neurological or somatic disorders. Consecutive patients with stroke and a simultaneous control group were extensively interviewed soon after admission using validated neurologist conducted semi-structured interview forms. Based on our previous study of sentinel headache in transient ischemic attacks we defined sentinel headache as a new type of headache or a previous kind of headache with altered characteristics (severe intensity, increased frequency, absence of effect of drugs) within seven days before stroke. Results: Among 550 patients with stroke 94 patients (17.1%) had headache during seven days before stroke and 12 (6.2%) controls (p < 0.001; OR 3.9; 95% CI 1.7-5.8). Totally 81 patients (14.7%) had sentinel headache within the last week before stroke and one control. Attacks of arrythmia during seven days before stroke were significantly associated with sentinel headache (p = 0.04, OR 2.3; 95% CI 1.1-4.8). Conclusions: A new type of headache and a previous kind of headache with altered characteristics during one week before stroke are significantly more prevalent than in controls. These headaches represent sentinel headaches. Sudden onset of such headaches should alarm about stroke. © 2020 The Author(s)

Expression of TLR1-10 and caspase-3 alfa at women with early miscarriages

Toll-like receptors (TLR) are the first signal receptors of innate immunity, recognizing bacteria and viruses and promoting development of inflammation through the activation of proinflammatory cytokines secretion (1). In animal models it was shown, that TLRs play role in pathogenesis of miscarriages (2, 3) and can influence to trophoblast apoptosis. The aim of research was to investigate study specialty of mRNA expression of TLR1-10 and caspase-3a in endometrium at patients with early miscarriagesyesBelgorod State Universit

Is multiculturalism in Russia possible? Intercultural relations in North Ossetia-Alania

This article examines intercultural relations in the Republic of North Ossetia-Alania (RNO-A). The research is based on the theory of acculturation of J. Berry and uses the hypotheses and measures developed in the Mutual Intercultural Relations in Plural Societies project. The RNO-A is the most favorable place for Russians living in the North Caucasus because attitudes toward the Russian minority in the RNO-A are not discriminatory. Our goal was to test three hypotheses in the RNO-A: the multiculturalism hypothesis, the integration hypothesis, and the contact hypothesis. We conducted a sociopsychological survey. The sample included members of the ethnic majority, the Ossetians (N= 318), and members of the ethnic minority, the Russians (N= 327). Data processing was carried out using structural equation modeling (SEM) separately for the ethnic minority and for the ethnic majority, and the models were compared with each other. The results show that perceived security among the Russians (the ethnic minority) as well as among the Ossetians (the ethnic majority) promoted support for a multicultural ideology, tolerance, and mutual integration. The number and frequency of friendly intercultural contacts had a positive and significant impact on a preference for integration among both the Ossetians and the Russians. An integration strategy and the expectation of integration promoted life satisfaction in both groups. Because the results of the study confirmed all three hypotheses, we conclude that interethnic relations between the Russians and the Ossetians in the RNO-A are based on the principles of multiculturalism

Impact monitoring of mining enterprises of Kursk magnetic anomaly on hydro ecological river situation of the Belgorod region

The results of contrastive analysis of hydrochemical state of surface water bodies exposed to the impact of mining enterprises, by way of example of small rivers of the Belgorod region, according to the results of exploration carried out in the years 2009-201

Magnetically operated nanorelay based on two single-walled carbon nanotubes filled with endofullerenes Fe@C20

Structural and energy characteristics of the smallest magnetic endofullerene Fe@C20 have been calculated using the density functional theory approach. The ground state of Fe@C20 is found to be a septet state, and the magnetic moment of Fe@C20 is estimated to be 8 Bohr magnetons. Characteristics of an (8,8) carbon nanotube with a single Fe@C20 inside are studied in the framework of the semiempirical approach. The scheme of a magnetic nanorelay based on cantilevered nanotubes filled with magnetic endofullerenes is elaborated. The proposed nanorelay is turned on as a result of bending of nanotubes by a magnetic force. Operational characteristics of such a nanorelay based on (8,8) and (21,21) nanotubes fully filled with Fe@C20 are estimated and compared to the ones of a nanorelay made of a (21,21) nanotube fully filled with experimentally observed (Ho3N)@C80 with the magnetic moment of 21 Bohr magnetons. Room temperature operation of (21,21) nanotube based nanorelays is shown.Comment: 18 pages, 9 figure

Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR

Posttranscriptional gene regulation relies on hundreds of RNA binding proteins (RBPs) but the function of most RBPs is unknown. The human RBP HuR/ELAVL1 is a conserved mRNA stability regulator. We used PAR-CLIP, a recently developed method based on RNA-protein crosslinking, to identify transcriptome-wide ~26,000 HuR binding sites. These sites were on average highly conserved, enriched for HuR binding motifs and mainly located in 3' untranslated regions. Surprisingly, many sites were intronic, implicating HuR in mRNA processing. Upon HuR knockdown, mRNA levels and protein synthesis of thousands of target genes were downregulated, validating functionality. HuR and miRNA binding sites tended to reside nearby but generally did not overlap. Additionally, HuR knockdown triggered strong and specific upregulation of miR-7. In summary, we identified thousands of direct and functional HuR targets, found a human miRNA controlled by HuR, and propose a role for HuR in splicing

Physical culture of society within the confines of cyclic model of sociodynamics

За последние годы наблюдается устойчивая тенденция повышения роли физической культуры в обществе, что обусловлена необходимостью решения проблем девиантного поведения. В настоящее время развитие физической культуры в сочетании и взаимосвязи традиционных знаний и инновационных технологий является проявлением циклической модели социодинамики.Over the past years there has been a steady upward trend in the role of physical culture in society that caused the need to solve problems of deviant behavior. Currently, the development of physical culture and relationships in combination of traditional knowledge and innovative technologies is a manifestation of the cyclic model sociodynamics