Growth, blood metabolites and hormones in calves fed diets with different amounts of energy and protein during the pre- or post-weaning periods

We investigated the effects of diets differing in energy and protein concentrations given during pre- and post-weaning on hormone and metabolite levels in association to parameters of growth. Sixteen Aberdeen Angus calves four-day-old were allocated in individual pens during 105 days in a randomized complete design. Animals consumed ad libitum various diets differing in proportion of energy and protein (A: 80% of concentrate, 20% alfalfa hay; B: 60% concentrate, 40% of alfalfa hay; C: 40% concentrate, 60% alfalfa hay, and D: 20% concentrate, 80% alfalfa hay). Also, calves consumed milk substitute up to 60-day-old day. Serum growth hormone and cortisol levels were not altered with diet changes (P > 0.05) neither during the pre- nor the post-weaning periods. Plasma insulin concentration average daily intake, glucose and thyroid hormone levels, and concentrations of ammonia nitrogen and propionic acid were greater (P < 0.01) for diets having higher than lower energy and protein levels during the post-weaning but not during the pre-weaning period. These results suggest inclusion of higher amounts of concentrate in the diet of weaned calves.Fil: Fernández, H. T.. Universidad Nacional del Sur. Departamento de Agronomía; ArgentinaFil: Busso, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; ArgentinaFil: Laborde, Hugo Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Centro de Recursos Naturales Renovables de la Zona Semiarida. Universidad Nacional del Sur. Centro de Recursos Naturales Renovables de la Zona Semiarida; ArgentinaFil: Torrea, M. B.. Universidad Nacional del Sur. Departamento de Agronomía; ArgentinaFil: Fernández, L. M.. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: López, G. H.. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Delucchi, F.. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: García, B. N.. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentin

The spatially resolved star formation history of CALIFA galaxies: Cosmic time scales

This paper presents the mass assembly time scales of nearby galaxies observed by CALIFA at the 3.5m telescope in Calar Alto. We apply the fossil record method of the stellar populations to the complete sample of the 3rd CALIFA data release, with a total of 661 galaxies, covering stellar masses from 10$^{8.4}$ to 10$^{12}$ M$_{\odot}$ and a wide range of Hubble types. We apply spectral synthesis techniques to the datacubes and process the results to produce the mass growth time scales and mass weighted ages, from which we obtain temporal and spatially resolved information in seven bins of galaxy morphology and six bins of stellar mass (M$_{\star}$) and stellar mass surface density ($\Sigma_{\star}$). We use three different tracers of the spatially resolved star formation history (mass assembly curves, ratio of half mass to half light radii, and mass-weighted age gradients) to test if galaxies grow inside-out, and its dependence with galaxy stellar mass, $\Sigma_{\star}$, and morphology. Our main results are as follows: (a) The innermost regions of galaxies assemble their mass at an earlier time than regions located in the outer parts; this happens at any given M$_{\star}$, $\Sigma_{\star}$, or Hubble type, including the lowest mass systems. (b) Galaxies present a significant diversity in their characteristic formation epochs for lower-mass systems. This diversity shows a strong dependence of the mass assembly time scales on $\Sigma_{\star}$ and Hubble type in the lower-mass range (10$^{8.4}$ to 10$^{10.4}$), but a very mild dependence in higher-mass bins. (c) All galaxies show negative $\langle$log age$\rangle_{M}$ gradients in the inner 1 HLR. The profile flattens with increasing values of $\Sigma_{\star}$. There is no significant dependence on M$_{\star}$ within a particular $\Sigma_{\star}$ bin, except for the lowest bin, where the gradients becomes steeper.Comment: 15 pages, 13 figures, 3 tables, accepted for publication in Astronomy & Astrophysics. *Abridged abstract

Beyond conventional factorization: Non-Hermitian Hamiltonians with radial oscillator spectrum

The eigenvalue problem of the spherically symmetric oscillator Hamiltonian is revisited in the context of canonical raising and lowering operators. The Hamiltonian is then factorized in terms of two not mutually adjoint factorizing operators which, in turn, give rise to a non-Hermitian radial Hamiltonian. The set of eigenvalues of this new Hamiltonian is exactly the same as the energy spectrum of the radial oscillator and the new square-integrable eigenfunctions are complex Darboux-deformations of the associated Laguerre polynomials.Comment: 13 pages, 7 figure

Magnetotactic bacteria for cancer therapy

Magnetotactic bacteria (MTB) are aquatic microorganisms that are able to biomineralize membrane-enclosed magnetic nanoparticles called magnetosomes. Inside the MTB, magnetosomes are arranged in a chain that allows MTB to align and navigate along the Earth's magnetic field. When isolated from the MTB, magnetosomes display a number of potential applications for targeted cancer therapies, such as magnetic hyperthermia, localized drug delivery, or tumor monitoring. The characteristics and properties of magnetosomes for these applications exceed in several aspects those of synthetic magnetic nanoparticles. Likewise, the whole MTB can also be considered as promising agents for cancer treatment, taking advantage of their self-propulsion capability provided by their flagella and the guidance capabilities ensured by their magnetosome chain. Indeed, MTB are envisaged as nanobiots that can be guided and manipulated by external magnetic fields and are naturally attracted toward hypoxic areas, such as the tumor regions, while retaining the therapeutic and imaging capacities of the isolated magnetosomes. Moreover, unlike most of the bacteria currently tested in clinical trials for cancer therapy, MTB are not pathogenic but could be engineered to deliver and/or express specific cytotoxic molecules. In this article, we will review the progress and perspectives of this emerging research field and will discuss the main challenges to overcome before the use of MTB can be successfully applied in the clinic.The Spanish and Basque Governments are acknowledged for funding under Project Nos. MAT2017-83631-C3-R and IT-1245-19, respectively

A cost utility analysis alongside a cluster-randomised trial evaluating a minor ailment service compared to usual care in community pharmacy.

BACKGROUND: Minor ailments are "self-limiting conditions which may be diagnosed and managed without a medical intervention". A cluster randomised controlled trial (cRCT) was designed to evaluate the clinical, humanistic and economic outcomes of a Minor Ailment Service (MAS) in community pharmacy (CP) compared with usual care (UC). METHODS: The cRCT was conducted for 6 months from December 2017. The pharmacist-patient intervention consisted of a standardised face-to-face consultation on a web-based program using co-developed protocols, pharmacists' training, practice change facilitators and patients' educational material. Patients requesting a non-prescription medication (direct product request) or presenting minor ailments received MAS or UC and were followed-up by telephone 10-days after the consultation. The primary economic outcomes were incremental cost-utility ratio (ICUR) of the service and health related quality of life (HRQoL). Total costs included health system, CPs and patient direct costs: health professionals' consultation time, medication costs, pharmacists' training costs, investment of the pharmacy and consultation costs within the 10 days following the initial consultation. The HRQoL was obtained using the EuroQoL 5D-5L at the time of the consultation and at 10-days follow up. A sensitivity analysis was carried out using bootstrapping. There were two sub-group analyses undertaken, for symptom presentation and direct product requests, to evaluate possible differences. RESULTS: A total of 808 patients (323 MAS and 485 UC) were recruited in 27 CPs with 42 pharmacists (20 MAS and 22 UC). 64.7% (n = 523) of patients responded to follow-up after their consultation in CP. MAS patients gained an additional 0.0003 QALYs (p = 0.053). When considering only MAS patients presenting with symptoms, the ICUR was 24,733€/QALY with a 47.4% probability of cost-effectiveness (willingness to pay of 25,000€/QALY). Although when considering patients presenting for a direct product request, MAS was the dominant strategy with a 93.69% probability of cost-effectiveness. CONCLUSIONS: Expanding community pharmacists' scope through MAS may benefit health systems. To be fully cost effective, MAS should not only include consultations arising from symptom presentation but also include an oversight of self-selected products by patients. MAS increase patient safety through the appropriate use of non-prescription medication and through the direct referral of patients to GP. TRIAL REGISTRATION: ISRCTN, ISRCTN17235323 . Registered 07/05/2021 - Retrospectively registered

The spatially-resolved star formation histories of CALIFA galaxies: Implications for galaxy formation

This paper presents the spatially resolved star formation history (SFH) of nearby galaxies with the aim of furthering our understanding of the different processes involved in the formation and evolution of galaxies. To this end, we apply the fossil record method of stellar population synthesis to a rich and diverse data set of 436 galaxies observed with integral field spectroscopy in the CALIFA survey. The sample covers a wide range of Hubble types, with stellar masses ranging from $M_\star \sim 10^9$ to $7 \times 10^{11} M_\odot$. Spectral synthesis techniques are applied to the datacubes to retrieve the spatially resolved time evolution of the star formation rate (SFR), its intensity ($\Sigma_{\rm SFR}$), and other descriptors of the 2D-SFH in seven bins of galaxy morphology (E, S0, Sa, Sb, Sbc, Sc, and Sd), and five bins of stellar mass. Our main results are: a) Galaxies form very fast independently of their current stellar mass, with the peak of star formation at high redshift ($z > 2$). Subsequent star formation is driven by $M_\star$ and morphology, with less massive and later type spirals showing more prolonged periods of star formation. b) At any epoch in the past the SFR is proportional to $M_\star$, with most massive galaxies having the highest absolute (but lowest specific) SFRs. c) While nowadays $\Sigma_{\rm SFR}$ is similar for all spirals, and significantly lower in early type galaxies (ETG), in the past $\Sigma_{\rm SFR}$ scales well with morphology. The central regions of today's ETGs are where $\Sigma_{\rm SFR}$ reached the highest values ($> 10^3 \,M_\odot\,$Gyr$^{-1}\,$pc$^{-2}$), similar to those measured in high redshift star forming galaxies. d) The evolution of $\Sigma_{\rm SFR}$ in Sbc systems matches that of models for Milky-Way-like galaxies, suggesting that the formation of a thick disk may be a common phase in spirals at early epochs.Comment: 21 pages, 11 figures, 1 table, accepted for publication in Astronomy & Astrophysics, abstract abridged for arXiv submissio