Superconducting On-chip Fourier Transform Spectrometer

The kinetic inductance effect is strongly nonlinear with applied current in NbTiN, TiN and NbN thin films. This can be utilized to realize novel devices. We present results from transmission lines made with these materials, where DC (current) control is used to modulate the phase velocity thereby enabling on-chip spectrometers. Utility of such compact spectrometers is discussed, along with their natural connection with parametric amplifiers

Eliciting views of Australian Pharmaceutical industry employees on collaboration and the concept of Quality Use of Medicines

Background: Pharmaceutical industry involvement in biomedicine has produced major benefits but has also caused concern. At present, there is no consensus as to how medical and government organizations should relate to the pharmaceutical industry and this is partly due to the absence of systematic study of the various alternatives. In Australia industry cooperation has been elicited via the “Quality Use of Medicines” framework within the “National Medicines Policy”. Little is known about the way employees of pharmaceutical companies respond to the QUM policy and strategies. Aims: We aimed to examine the engagement of the Australian pharmaceutical industry with QUM with a view to assisting medical, government and consumer organisations who may wish to collaborate with industry. Methods: We carried out a qualitative study using in-depth, semi-structured interviews with industry employees, primarily from medical and regulatory affairs departments. Results: Employees of pharmaceutical companies claim that collaboration is important, and that they are altruistic and committed to QUM. At the same time, there is little evidence from this study to support the notion that QUM has brought about structural changes to industry or is positioned as the central goal or framework in designing a company’s operational strategies. Moreover, there is a significant degree of ambivalence towards governments and medical organisations. Conclusions: Employees within the pharmaceutical industry claim a commitment to collaboration and QUM. While these claims cannot be taken entirely at face value, there is potential for meaningful collaboration with industry. Keywords Pharmaceutical industry Pharmaceutical ethics Quality of healthcare Health policy Pharmacolog

Simbol-Simbol dalam Komunikasi Keluarga Beda Agama

This article is one of the research having the plurality of cultural ethnic andreligion background. The religion identity is an important dimension for all societies.The goal of the article is to analyze the role of interpersonal communication in a familywith different religion, analyze the meaning of symbols in an interaction within thefamily with different religion, analyze the supporting and restricting communicationfactors in a family with different religion. Several perspectives were used as theoreticalframewaork, i.e Phenomenology, and Cross Cultural Communication. This reseachemployed in-depth interview and observation as data collecting technique.The role ofinterpersonal communication in a family with different religion cannot be separated frominitiation, experiment, intensification, integrity, bond and the role of communicationeffectiveness such as supportiveness, empathy, objectiveness and equality. The meaningof communication symbols in a family with different religion is due to language, rituals,national days, food, and dress. The supporting factors are respect each other, protect,tolerance, cooperation, and mutual cooperation. Whereas the restricting factors ofinterpersonal communication in a family with different religion, are avoiding the dialogueabout faith, freedom, and religion education for children

A Versatile, Portable Intravital Microscopy Platform for Studying Beta-cell Biology In Vivo

The pancreatic islet is a complex micro-organ containing numerous cell types, including endocrine, immune, and endothelial cells. The communication of these systems is lost upon isolation of the islets, and therefore the pathogenesis of diabetes can only be fully understood by studying this organized, multicellular environment in vivo. We have developed several adaptable tools to create a versatile platform to interrogate β-cell function in vivo. Specifically, we developed β-cell-selective virally-encoded fluorescent protein biosensors that can be rapidly and easily introduced into any mouse. We then coupled the use of these biosensors with intravital microscopy, a powerful tool that can be used to collect cellular and subcellular data from living tissues. Together, these approaches allowed the observation of in vivo β-cell-specific ROS dynamics using the Grx1-roGFP2 biosensor and calcium signaling using the GcAMP6s biosensor. Next, we utilized abdominal imaging windows (AIW) to extend our in vivo observations beyond single-point terminal measurements to collect longitudinal physiological and biosensor data through repeated imaging of the same mice over time. This platform represents a significant advancement in our ability to study β-cell structure and signaling in vivo, and its portability for use in virtually any mouse model will enable meaningful studies of β-cell physiology in the endogenous islet niche

Mean winds in the MLT, the SQBO and MSAO over Ascension Island (8° S, 14° W)

Mean winds in the mesosphere and lower thermosphere (MLT) over Ascension Island (8° S, 14° W) have been measured at heights of approximately 80–100 km by a meteor radar. The results presented in this study are from the interval October 2001 to December 2011. In all years, the monthly-mean meridional winds display a clear annual oscillation. Typically, these winds are found to be southward during April–October, when they reach velocities of up to about −23 m s−1, and northward throughout the rest of the year, when they reach velocities up to about 16 m s−1. The monthly-mean zonal winds are generally westward throughout most of the year and reach velocities of up to about −46 m s−1. However, eastward winds are observed in May–August and again in December at the lower heights observed. These eastward winds reach a maximum at heights of about 86 km with velocities of up to about 36 m s−1, but decay quickly at heights above and below that level. The mesospheric semi-annual oscillation (MSAO) is clearly apparent in the observed monthly-mean zonal winds. The winds in first westward phase of the MSAO are observed to be much stronger than in the second phase. The westward phase of the MSAO is found to maximise at heights of about 84 km with typical first-phase wind velocities reaching about −35 m s−1. These meteor-radar observations have been compared to the HWM-07 empirical model. The observed meridional winds are found to be generally more southward than those of the model during May–August, when at the lower heights observed the model suggests there will be only weakly southward, or even northward, winds. The zonal monthly-mean winds are in generally good agreement, although in the model they are somewhat less westward than those observed. Throughout the observations there were eight occasions in which the first westward phase of the MSAO was observed. Strikingly, in 2002 there was an event in which the westward winds during the first phase of the MSAO were much stronger than normal and reached velocities of about −75 m s−1. This event is explained in terms of a previously proposed mechanism in which the relative phasing of the stratospheric quasi-biennial oscillation (SQBO) and the MSAO allows an unusually large flux of gravity waves of large westward phase speed to reach the mesosphere. It is the dissipation of these gravity waves that then drives the MLT winds to the large westward velocities observed. It is demonstrated that the necessary SQBO–MSAO phase relationship did indeed exist during 2002, but not during the other years observed here. This demonstration provides strong support for the suggestion that extreme zonal-wind events during the MSAO result from the modulation of gravity-wave fluxes

Prevalence and outcome of delirium among acute general medical inpatients in Cape Town, South Africa

Background. Delirium is a common, serious, underdiagnosed condition in medical and surgical inpatients with acute conditions. It is associated with increased risk of mortality and morbidity. Data of geriatric cohorts are largely limited to developed countries.Objectives. To describe prevalence, risk factors and outcomes of delirium among general medical patients admitted to two hospitals in Cape Town, South Africa.Methods. This was a prospective cohort study of patients with acute conditions admitted to a general medical inpatient service in secondary- and tertiary-level public hospitals in the Metro West area of Cape Town. Patients ≥18 years of age were recruited daily from all acute medical admissions. Patients were excluded if they were aphasic or their Glasgow coma scale was <8/15. Delirium was diagnosed using the validated confusion assessment method (CAM) tool and performed by trained neuropsychologists. Demographic data were collected by a clinical team and short- and long-term mortality data were obtained using linkage analysis of hospitalised patients and routinely collected provincial death certification records.Results. The median age of inpatients was 51 (interquartile range 36 - 65) years, 29% were HIV-infected and the overall prevalence of delirium was 12.3%. Multivariate predictors of delirium included the presence of an indwelling urinary catheter (odds ratio (OR) 4.47; confidence interval (CI) 2.43 - 8.23), admission with a central nervous system disease (OR 4.34; CI 2.79 - 7.90), pre-existing cognitive impairment (OR 3.02; CI 1.22 - 7.43) and immobility (OR 1.88; CI 1.01 - 3.51). HIV infection was not associated with increased risk of delirium. Delirium was associated with an increased risk of inhospital (delirium v. no delirium: 29% v. 12%; p<0.01) and 12-month (30% v. 20%; p<0.01) mortality, as well as increased length of hospital stay (7 days v. 5 days; p<0.01).Conclusions. In this cohort of medical inpatients (relatively young and with a high HIV prevalence) 1 of 8 (12.3%) patients was delirious. Delirium was associated with adverse outcomes. Delirium risk factors in this young cohort were similar to those in geriatric cohorts in developed countries, and neither HIV nor opportunistic infections increased risk