Remotely Operated Train for Inspection and Measurement in CERN's LHC Tunnel

Personnel access to the LHC tunnel will be restricted to varying extents during the life of the machine due to radiation and cryogenic hazards. For this reason a remotely operated modular inspection train, (TIM) running on the LHC tunnel’s overhead monorail has been developed. In order to be compatible with the LHC personnel access system, a small section train that can pass through small openings at the top of sector doors has now been produced. The basic train can be used for remote visual inspection; additional modules give the capability of carrying out remote measurement of radiation levels, environmental conditions around the tunnel, and even remote measurement of the precise position of machine elements such as collimators. The paper outlines the design, development and operation of the equipment including preparation of the infrastructure. Key features of the trains are described along with future developments and intervention scenarios

Sweetened Drink and Snacking Cues in Adolescents. A Study Using Ecological Momentary Assessment

The objective of this study was to identify physical, social, and intrapersonal cues that were associated with the consumption of sweetened beverages and sweet and salty snacks among adolescents from lower SES neighborhoods. Students were recruited from high schools with a minimum level of 25% free or reduced cost lunches. Using ecological momentary assessment, participants (N=158) were trained to answer brief questionnaires on handheld PDA devices: (a) each time they ate or drank, (b) when prompted randomly, and (c) once each evening. Data were collected over 7days for each participant. Participants reported their location (e.g., school grounds, home), mood, social environment, activities (e.g., watching TV, texting), cravings, food cues (e.g., saw a snack), and food choices. Results showed that having unhealthy snacks or sweet drinks among adolescents was associated with being at school, being with friends, feeling lonely or bored, craving a drink or snack, and being exposed to food cues. Surprisingly, sweet drink consumption was associated with exercising. Watching TV was associated with consuming sweet snacks but not with salty snacks or sweet drinks. These findings identify important environmental and intrapersonal cues to poor snacking choices that may be applied to interventions designed to disrupt these food-related, cue-behavior linked habits

Susceptibility divergence, phase transition and multistability of a highly turbulent closed flow

Using time-series of stereoscopic particle image velocimetry data, we study the response of a turbulent von K\'{a}rm\'{a}n swirling flow to a continuous breaking of its forcing symmetry. Experiments are carried over a wide Reynolds number range, from laminar regime at $Re = 10^{2}$ to highly turbulent regime near $Re = 10^{6}$. We show that the flow symmetry can be quantitatively characterized by two scalars, the global angular momentum $I$ and the mixing layer altitude $z_s$, which are shown to be statistically equivalent. Furthermore, we report that the flow response to small forcing dissymetry is linear, with a slope depending on the Reynolds number: this response coefficient increases non monotonically from small to large Reynolds number and presents a divergence at a critical Reynolds number $Re_c = 40\,000 \pm 5\,000$. This divergence coincides with a change in the statistical properties of the instantaneous flow symmetry $I(t)$: its pdf changes from Gaussian to non-Gaussian with multiple maxima, revealing metastable non-symmetrical states. For symmetric forcing, a peak of fluctuations of $I(t)$ is also observed at $Re_c$: these fluctuations correspond to time-intermittencies between metastable states of the flow which, contrary to the very-long-time-averaged mean flow, spontaneously and dynamically break the system symmetry. We show that these observations can be interpreted in terms of divergence of the susceptibility to symmetry breaking, revealing the existence of a phase transition. An analogy with the ferromagnetic-paramagnetic transition in solid-state physics is presented and discussed.Comment: to appear in Journal of Statistical Mechanic

A facility to Search for Hidden Particles (SHiP) at the CERN SPS

A new general purpose fixed target facility is proposed at the CERN SPS accelerator which is aimed at exploring the domain of hidden particles and make measurements with tau neutrinos. Hidden particles are predicted by a large number of models beyond the Standard Model. The high intensity of the SPS 400~GeV beam allows probing a wide variety of models containing light long-lived exotic particles with masses below ${\cal O}$(10)~GeV/c$^2$, including very weakly interacting low-energy SUSY states. The experimental programme of the proposed facility is capable of being extended in the future, e.g. to include direct searches for Dark Matter and Lepton Flavour Violation.Comment: Technical Proposa

FIRST YEAR OF OPERATIONS IN THE HIRADMAT IRRADIATION FACILITY AT CERN

HiRadMat (High Irradiation to Materials) is a new facility at CERN constructed in 2011, designed to provide high-intensity pulsed beams to an irradiation area where material samples as well as accelerator component assemblies can be tested. The facility uses a 440 GeV proton beam extracted from the CERN SPS with a pulse length of up to 7.2 s, to a maximum pulse energy of 3.4 MJ. For 2012, the first year of operations of the facility, nine experiments were scheduled and completed data-taking successfully. The experience gained in operating this unique facility, along with highlights of the experiments and the instrumentation developed for online measurements are reported

A primary electron beam facility at CERN -- eSPS Conceptual design report

The design of a primary electron beam facility at CERN is described. The study has been carried out within the framework of the wider Physics Beyond Colliders study. It re-enables the Super Proton Synchrotron (SPS) as an electron accelerator, and leverages the development invested in Compact Linear Collider (CLIC) technology for its injector and as an accelerator research and development infrastructure. The facility would be relevant for several of the key priorities in the 2020 update of the European Strategy for Particle Physics, such as an electron-positron Higgs factory, accelerator R\&D, dark sector physics, and neutrino physics. In addition, it could serve experiments in nuclear physics. The electron beam delivered by this facility would provide access to light dark matter production significantly beyond the targets predicted by a thermal dark matter origin, and for natures of dark matter particles that are not accessible by direct detection experiments. It would also enable electro-nuclear measurements crucial for precise modelling the energy dependence of neutrino-nucleus interactions, which is needed to precisely measure neutrino oscillations as a function of energy. The implementation of the facility is the natural next step in the development of X-band high-gradient acceleration technology, a key technology for compact and cost-effective electron/positron linacs. It would also become the only facility with multi-GeV drive bunches and truly independent electron witness bunches for plasma wakefield acceleration. A second phase capable to deliver positron witness bunches would make it a complete facility for plasma wakefield collider studies. [...

Epidermal Transglutaminase (TGase 3) Is Required for Proper Hair Development, but Not the Formation of the Epidermal Barrier

Transglutaminases (TGase), a family of cross-linking enzymes present in most cell types, are important in events as diverse as cell-signaling and matrix stabilization. Transglutaminase 1 is crucial in developing the epidermal barrier, however the skin also contains other family members, in particular TGase 3. This isoform is highly expressed in the cornified layer, where it is believed to stabilize the epidermis and its reduction is implicated in psoriasis. To understand the importance of TGase 3 in vivo we have generated and analyzed mice lacking this protein. Surprisingly, these animals display no obvious defect in skin development, no overt changes in barrier function or ability to heal wounds. In contrast, hair lacking TGase 3 is thinner, has major alterations in the cuticle cells and hair protein cross-linking is markedly decreased. Apparently, while TGase 3 is of unique functional importance in hair, in the epidermis loss of TGase 3 can be compensated for by other family members

Transglutaminase 6: a protein associated with central nervous system development and motor function.

Transglutaminases (TG) form a family of enzymes that catalyse various post-translational modifications of glutamine residues in proteins and peptides including intra- and intermolecular isopeptide bond formation, esterification and deamidation. We have characterized a novel member of the mammalian TG family, TG6, which is expressed in a human carcinoma cell line with neuronal characteristics and in mouse brain. Besides full-length protein, alternative splicing results in a short variant lacking the second β-barrel domain in man and a variant with truncated β-sandwich domain in mouse. Biochemical data show that TG6 is allosterically regulated by Ca(2+) and guanine nucleotides. Molecular modelling indicates that TG6 could have Ca(2+) and GDP-binding sites related to those of TG3 and TG2, respectively. Localization of mRNA and protein in the mouse identified abundant expression of TG6 in the central nervous system. Analysis of its temporal and spatial pattern of induction in mouse development indicates an association with neurogenesis. Neuronal expression of TG6 was confirmed by double-labelling of mouse forebrain cells with cell type-specific markers. Induction of differentiation in mouse Neuro 2a cells with NGF or dibutyryl cAMP is associated with an upregulation of TG6 expression. Familial ataxia has recently been linked to mutations in the TGM6 gene. Autoantibodies to TG6 were identified in immune-mediated ataxia in patients with gluten sensitivity. These findings suggest a critical role for TG6 in cortical and cerebellar neurons