Assessing the quality of life of children with sickle cell anaemia using self-, parent-proxy and healthcare professional-proxy reports

Objectives The quality of life (QoL) of children with sickle cell anaemia (SCA) in the United Kingdom has not been examined, and a discrepancy measure based on Gap theory has rarely been used. This study investigated whether (1) child self-reports of QoL using a discrepancy measure (the Generic Children's QoL Measure; GCQ) are lower than those from healthy children, (2) proxy reports from parents and health care professionals are lower than child self-reports, and (3) demographic and disease severity indicators are related to QoL. Design and methods An interdependent groups, cross-sectional design was implemented. Seventy-four children with SCA, their parent, and members of their health care team completed the GCQ. Demographic and disease severity indicators were recorded. GCQ data from healthy children were obtained from the UK Data Archive. Results Contrary to past research, when examining generic discrepancy QoL, children with SCA did not report a lower QoL than healthy children, and parent- and health care professional-proxy reports were not lower than child self-reports. Few of the demographic and disease severity indicators were related to QoL. Conclusions Proxy reports may be used to gain a more complete picture of QoL, but should not be a substitute for self-reports. The explanation for the relatively high levels of QoL reported is not clear, but children with SCA may have realistic expectations about their ideal-self, place greater emphasis on aspects other than health in shaping their QoL, and define achievements within the limits of their illness. Future research should focus on psychological factors in explaining QoL

Dynamical screening effects in hot-electron scattering from electron-hole plasma and LO-phonon modes in quantum wires

Cataloged from PDF version of article.We present a fully dynamical and finite temperature study of the hot-electron momentum relaxation rate and the power loss in a coupled system of electron-hole plasma and bulk LO-phonons in a quantum wire structure. Interactions of the scattered electron with neutral plasma components and phonons are treated on an equal footing within the random-phase approximation. Coupled mode effects substantially change the transport properties of the system at low temperatures. Particularly, the ''plasmon-like'' and ''LO-phonon-like'' excitations yield comparable rates which, as a consequence of the singular nature of the 1D density of states, can be large at the threshold. This is in contrast to room temperature results where only the LO-phonon mode contributes significantly to the rate. The density and temperature dependence of the power loss reveals that dynamical screening effects are important, and energy-momentum conservation cannot be satisfied above a certain density for a given initial energy. Copyright (C) 1996 Elsevier Science Lt

A qualitative exploration of health-related quality of life and health behaviours in children with sickle cell disease and healthy siblings

Objectives This study explored the health-related quality of life (HRQL) and health behaviours of children with sickle cell disease (SCD) and healthy siblings, drawing on Gap theory, which suggests HRQL is the discrepancy between current and ideal selves. Design Thirty-two interviews, facilitated by children’s drawings of their current and ideal selves were thematically analysed. Results Two themes were identified. First, limitations of SCD and adjusted expectations. Children with SCD report some discrepancy in HRQL as they would like to participate in more physical activity, but overall, they appear to have normalised their condition and adjusted their expectations in the context of the limits of their condition. Healthy siblings worry about their sibling and have greater expectations about engaging in adventurous activities and for their future. Second, coping with SCD. Children have limited social support, although children with SCD seek support from their mothers. They also modify health behaviours, like reducing exercise to help prevent and cope with sickle-related pain. Conclusion Children have some discrepancies in their HRQL but adjusted expectations among children with SCD may reduce discrepancy. Adapting health behaviours may help to cope with SCD but it is important that reductions in physical activity do not impair HRQL

Suppression of electron relaxation and dephasing rates in quantum dots caused by external magnetic fields

An external magnetic field has been applied in laterally coupled dots (QDs) and we have studied the QD properties related to charge decoherence. The significance of the applied magnetic field to the suppression of electron-phonon relaxation and dephasing rates has been explored. The coupled QDs have been studied by varing the magnetic field and the interdot distance as other system parameters. Our numerical results show that the electron scattering rates are strongly dependent on the applied external magnetic field and the details of the double QD configuration.Comment: 13 pages, 6 figure

Treatment results and prognostic factors in primary thyroid lymphoma patients: a Rare Cancer Network study

Background: This study analyzed prognostic factors and treatment outcomes of primary thyroid lymphoma. Patients and Methods: Data were retrospectively collected for 87 patients (53 stage I and 34 stage II) with median age 65 years. Fifty-two patients were treated with single modality (31 with chemotherapy alone and 21 with radiotherapy alone) and 35 with combined modality treatment. Median follow-up was 51 months. Results: Sixty patients had aggressive lymphoma and 27 had indolent lymphoma. The 5- and 10-year overall survival (OS) rates were 74% and 71%, respectively, and the disease-free survival (DFS) rates were 68% and 64%. Univariate analysis revealed that age, tumor size, stage, lymph node involvement, B symptoms, and treatment modality were prognostic factors for OS, DFS, and local control (LC). Patients with thyroiditis had significantly better LC rates. In multivariate analysis, OS was influenced by age, B symptoms, lymph node involvement, and tumor size, whereas DFS and LC were influenced by B symptoms and tumor size. Compared with single modality treatment, patients treated with combined modality had better 5-year OS, DFS, and LC. Conclusions: Combined modality leads to an excellent prognosis for patients with aggressive lymphoma but does not improve OS and LC in patients with indolent lymphom

Ground-Based Transmission Spectroscopy with FORS2: A featureless optical transmission spectrum and detection of H2O for the ultra-hot Jupiter WASP-103b

We report ground-based transmission spectroscopy of the highly irradiated and ultra-short period hot-Jupiter WASP-103b covering the wavelength range ≈ 400 – 600 nm using the FORS2 instrument on the Very Large Telescope. The light curves show significant time-correlated noise which is mainly invariant in wavelength and which we model using a Gaussian process. The precision of our transmission spectrum is improved by applying a common-mode correction derived from the white light curve, reaching typical uncertainties in transit depth of ≈ 2 × 10−4 in wavelength bins of 15 nm. After correction for flux contamination from a blended companion star, our observations reveal a featureless spectrum across the full range of the FORS2 observations and we are unable to confirm the Na absorption previously inferred using Gemini/GMOS or the strong Rayleigh scattering observed using broad-band light curves. We performed a Bayesian atmospheric retrieval on the full optical-infrared transmission spectrum using the additional data from Gemini/GMOS, HST/WFC3 and Spitzer observations and recover evidence for H2O absorption at the 4.0 σ level. However, our observations are not able to completely rule out the presence of Na, which is found at 2.0 σ in our retrievals. This may in part be explained by patchy/inhomogeneous clouds or hazes damping any absorption features in our FORS2 spectrum, but an inherently small scale height also makes this feature challenging to probe from the ground. Our results nonetheless demonstrate the continuing potential of ground-based observations for investigating exoplanet atmospheres and emphasise the need for the application of consistent and robust statistical techniques to low-resolution spectra in the presence of instrumental systematics

Lattice QCD determination of m_b, f_B and f_Bs with twisted mass Wilson fermions

We present a lattice QCD determination of the b quark mass and of the B and B_s decay constants, performed with N_f=2 twisted mass Wilson fermions, by simulating at four values of the lattice spacing. In order to study the b quark on the lattice, two methods are adopted in the present work, respectively based on suitable ratios with exactly known static limit and on the interpolation between relativistic data, evaluated in the charm mass region, and the static point, obtained by simulating the HQET on the lattice. The two methods provide results in good agreement. For the b quark mass in the MSbar scheme and for the decay constants we obtain m_b(m_b)=4.29(14) GeV, f_B=195(12) MeV, f_Bs=232(10) MeV and f_Bs/f_B=1.19(5). As a byproduct of the analysis we also obtain the results for the f_D and f_Ds decay constants: f_D=212(8) MeV, f_Ds=248(6) MeV and f_Ds/f_D=1.17(5).Comment: 23 pages, 10 figures, 2 tables. Added appendix showing the agreement of the data for the ratios with the HQE prediction. Matching JHEP published versio

Multi-phonon Raman scattering in semiconductor nanocrystals: importance of non-adiabatic transitions

Multi-phonon Raman scattering in semiconductor nanocrystals is treated taking into account both adiabatic and non-adiabatic phonon-assisted optical transitions. Because phonons of various symmetries are involved in scattering processes, there is a considerable enhancement of intensities of multi-phonon peaks in nanocrystal Raman spectra. Cases of strong and weak band mixing are considered in detail. In the first case, fundamental scattering takes place via internal electron-hole states and is participated by s- and d-phonons, while in the second case, when the intensity of the one-phonon Raman peak is strongly influenced by the interaction of an electron and of a hole with interface imperfections (e. g., with trapped charge), p-phonons are most active. Calculations of Raman scattering spectra for CdSe and PbS nanocrystals give a good quantitative agreement with recent experimental results.Comment: 16 pages, 2 figures, E-mail addresses: [email protected], [email protected], [email protected], accepted for publication in Physical Review

On The Unusual Variability of 2MASS J06195260-2903592: A Long-Lived Disk around a Young Ultracool Dwarf

We present the characterization of the low-gravity M6 dwarf 2MASS J0619-2903 previously identified as an unusual field object based on its strong IR excess and variable near-IR spectrum. Multiple epochs of low-resolution (R~150) near-IR spectra show large-amplitude (~0.1-0.5 mag) continuum variations on timescales of days to 12 years, unlike the small-amplitude variability typical for field ultracool dwarfs. The variations between epochs are well-modeled as changes in the relative extinction ($\Delta{A_V}\approx2$ mag). Likewise, Pan-STARRS optical photometry varies on timescales as long as 11 years (and possibly as short as an hour) and implies similar amplitude $A_V$ changes. NEOWISE mid-IR light curves also suggest changes on 6-month timescales, with amplitudes consistent with the optical/near-IR extinction variations. However, near-IR spectra, near-IR photometry, and optical photometry obtained in the past year indicate the source can also be stable on hourly and monthly timescales. From comparison to objects of similar spectral type, the total extinction of 2MASS J0619-2903 seems to be $A_V\approx4-6$ mag, with perhaps epochs of lower extinction. Gaia EDR3 finds that 2MASS J0619-2903 has a wide-separation (1.2' = 10450 AU) stellar companion, with an isochronal age of $31^{+22}_{-10}$ Myr and a mass of $0.30^{+0.04}_{-0.03}$ Msun. Adopting this companion's age and EDR3 distance (145.2$\pm$0.6 pc), we estimate a mass of 0.11-0.17 Msun for 2MASS J0619-2903. Altogether, 2MASS J0619-2903 appears to possess an unusually long-lived primordial circumstellar disk, perhaps making it a more obscured analog to the "Peter Pan" disks found around a few M dwarfs in nearby young moving groups.Comment: AJ, in pres