Limited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis

The clinical value of imaging is well established for the follow-up of many lymphoid malignancies but not for chronic lymphocytic leukemia (CLL). A meta-analysis was performed with the dataset of 3 German CLL Study Group phase 3 trials (CLL4, CLL5, and CLL8) that included 1372 patients receiving first-line therapy for CLL. Response as well as progression during follow-up was reassessed according to the National Cancer Institute Working Group1996 criteria. A total of 481 events were counted as progressive disease during treatment or follow-up. Of these, 372 progressions (77%) were detected by clinical symptoms or blood counts. Computed tomography (CT) scans or ultrasound were relevant in 44 and 29 cases (9% and 6%), respectively. The decision for relapse treatment was determined by CT scan or ultrasound results in only 2 of 176 patients (1%). CT scan results had an impact on the prognosis of patients in complete remission only after the administration of conventional chemotherapy but not after chemoimmunotherapy. In conclusion, physical examination and blood count remain the methods of choice for staging and clinical follow-up of patients with CLL as recommended by the International Workshop on Chronic Lymphocytic Leukemia 2008 guidelines. These trials are registered at http://www.isrctn.org as ISRCTN 75653261 and ISRCTN 36294212 and at http://www.clinicaltrials.gov as NCT00281918

Inclusive-Jet and Dijet Cross Sections in Deep Inelastic Scattering at HERA.

Inclusive-jet and dijet differential cross sections have been measured in neutral current deep inelastic ep scattering for exchanged boson virtualities Q2 > 125 GeV2 with the ZEUS detector at HERA using an integrated luminosity of 82 pb-1. Jets were identified in the Breit frame using the kt cluster algorithm. Jet cross sections are presented as functions of several kinematic and jet variables. The results are also presented in different regions of Q2. Next-to-leading-order QCD calculations describe the measurements well. Regions of phase space where the theoretical uncertainties are small have been identified. Measurements in these regions have the potential to constrain the gluon density in the proton when used as inputs to global fits of the proton parton distribution functions.Comment: 31 pages, 12 figures, revised version with small modifications to the text, accepted by Nuclear Physics