Polarization-selective excitation of N-V centers in diamond

The nitrogen-vacancy (N-V) center in diamond is promising as an electron spin qubit due to its long-lived coherence and optical addressability. The ground state is a spin triplet with two levels ($m_s = \pm 1$) degenerate at zero magnetic field. Polarization-selective microwave excitation is an attractive method to address the spin transitions independently, since this allows operation down to zero magnetic field. Using a resonator designed to produce circularly polarized microwaves, we have investigated the polarization selection rules of the N-V center. We first apply this technique to N-V ensembles in [100] and [111]-oriented samples. Next, we demonstrate an imaging technique, based on optical polarization dependence, that allows rapid identification of the orientations of many single N-V centers. Finally, we test the microwave polarization selection rules of individual N-V centers of known orientation

Coupling of nitrogen-vacancy centers in diamond to a GaP waveguide

The optical coupling of guided modes in a GaP waveguide to nitrogen-vacancy (NV) centers in diamond is demonstrated. The electric field penetration into diamond and the loss of the guided mode are measured. The results indicate that the GaP-diamond system could be useful for realizing coupled microcavity-NV devices for quantum information processing in diamond.Comment: 4 pages 4 figure

Low-temperature tapered-fiber probing of diamond NV ensembles coupled to GaP microcavities

In this work we present a platform for testing the device performance of a cavity-emitter system, using an ensemble of emitters and a tapered optical fiber. This method provides high-contrast spectra of the cavity modes, selective detection of emitters coupled to the cavity, and an estimate of the device performance in the single- emitter case. Using nitrogen-vacancy (NV) centers in diamond and a GaP optical microcavity, we are able to tune the cavity onto the NV resonance at 10 K, couple the cavity-coupled emission to a tapered fiber, and measure the fiber-coupled NV spontaneous emission decay. Theoretically we show that the fiber-coupled average Purcell factor is 2-3 times greater than that of free-space collection; although due to ensemble averaging it is still a factor of 3 less than the Purcell factor of a single, ideally placed center.Comment: 15 pages, 6 figure

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

Elevated coexpression of colony-stimulating factor receptor (CSF-1R) and its ligand, CSF-1, correlates with invasiveness and poor prognosis of a variety of epithelial tumors (Kacinski, B.M. 1995. Ann. Med. 27:79–85). Apart from recruitment of macrophages to the tumor site, the mechanisms by which CSF-1 may potentiate invasion are poorly understood. We show that autocrine CSF-1R activation induces hyperproliferation and a profound, progressive disruption of junctional integrity in acinar structures formed by human mammary epithelial cells in three-dimensional culture. Acini coexpressing receptor and ligand exhibit a dramatic relocalization of E-cadherin from the plasma membrane to punctate intracellular vesicles, accompanied by its loss from the Triton-insoluble fraction. Interfering with Src kinase activity, either by pharmacological inhibition or mutation of the Y561 docking site on CSF-1R, prevents E-cadherin translocation, suggesting that CSF-1R disrupts cell adhesion by uncoupling adherens junction complexes from the cytoskeleton and promoting cadherin internalization through a Src-dependent mechanism. These findings provide a mechanistic basis whereby CSF-1R could contribute to invasive progression in epithelial cancers

Flat Dielectric Grating Reflectors with High Focusing Power

Sub-wavelength dielectric gratings (SWG) have emerged recently as a promising alternative to distributed-Bragg-reflection (DBR) dielectric stacks for broadband, high-reflectivity filtering applications. A SWG structure composed of a single dielectric layer with the appropriate patterning can sometimes perform as well as thirty or forty dielectric DBR layers, while providing new functionalities such as polarization control and near-field amplification. In this paper, we introduce a remarkable property of grating mirrors that cannot be realized by their DBR counterpart: we show that a non-periodic patterning of the grating surface can give full control over the phase front of reflected light while maintaining a high reflectivity. This new feature of dielectric gratings could have a substantial impact on a number of applications that depend on low-cost, compact optical components, from laser cavities to CD/DVD read/write heads.Comment: submitted to Nature Photonic

The 2020 Five Domains Model: Including Human-Animal Interactions in Assessments of Animal Welfare

Throughout its 25-year history, the Five Domains Model for animal welfare assessment has been regularly updated to include at each stage the latest authenticated developments in animal welfare science thinking. The domains of the most up-to-date Model described here are: 1 Nutrition, 2 Physical Environment, 3 Health, 4 Behavioural Interactions and 5 Mental State. The first four domains focus attention on factors that give rise to specific negative or positive subjective experiences (affects), which contribute to the animal’s mental state, as evaluated in Domain 5. More specifically, the first three domains focus mainly on factors that disturb or disrupt particular features of the body’s internal stability. Each disturbed or disrupted feature generates sensory inputs which are processed by the brain to form specific negative affects. These affects are associated with behaviours that act to restore the body’s internal stability. Each such behaviour is essential for the survival of the animal

Demography and disorders of the French Bulldog population under primary veterinary care in the UK in 2013

Abstract Background Despite its Gallic name, the French Bulldog is a breed of both British and French origin that was first recognised by The Kennel Club in 1906. The French Bulldog has demonstrated recent rapid rises in Kennel Club registrations and is now (2017) the second most commonly registered pedigree breed in the UK. However, the breed has been reported to be predisposed to several disorders including ocular, respiratory, neurological and dermatological problems. The VetCompass™ Programme collates de-identified clinical data from primary-care veterinary practices in the UK for epidemiological research. Using VetCompass™ clinical data, this study aimed to characterise the demography and common disorders of the general population of French Bulldogs under veterinary care in the UK. Results French Bulldogs comprised 2228 (0.49%) of 445,557 study dogs under veterinary care during 2013. Annual proportional birth rates showed that the proportional ownership of French Bulldog puppies rose steeply from 0.02% of the annual birth cohort attending VetCompass™ practices in 2003 to 1.46% in 2013. The median age of the French Bulldogs overall was 1.3 years (IQR 0.6–2.5, range 0.0–13.0). The most common colours of French Bulldogs were brindle (solid or main) (32.36%) and fawn (solid or main) (29.9%). Of the 2228 French Bulldogs under veterinary care during 2013, 1612 (72.4%) had at least one disorder recorded. The most prevalent fine-level precision disorders recorded were otitis externa (14.0%, 95% CI: 12.6–15.5), diarrhoea (7.5%, 95% CI: 6.4–8.7), conjunctivitis (3.2%, 95% CI: 2.5–4.0), nails overlong (3.1%, 95% CI% 2.4–3.9) and skin fold dermatitis (3.0%, 95% CI% 2.3–3.8). The most prevalent disorder groups were cutaneous (17.9%, 95% CI: 16.3–19.6), enteropathy (16.7%, 95% CI: 15.2–18.3), aural (16.3%, 95% CI: 14.8–17.9), upper respiratory tract (12.7%, 95% CI: 11.3–14.1) and ophthalmological (10.5%, 95% CI: 9.3–11.9). Conclusions Ownership of French Bulldogs in the UK is rising steeply. This means that the disorder profiles reported in this study reflect a current young UK population and are likely to shift as this cohort ages. Otitis externa, diarrhoea and conjunctivitis were the most common disorders in French Bulldogs. Identification of health priorities based on VetCompass™ data can support evidence–based reforms to improve health and welfare within the breed

Science results from the imaging Fourier transform spectrometer SpIOMM

SpIOMM is an imaging Fourier transform spectrometer designed to obtain the visible range (350 to 850 nm) spectrum of every light source in a circular field of view of 12 arcminutes in diameter. It is attached to the 1.6-m telescope of the Observatoire du Mont Megantic in southern Quebec. We present here some results of three successful observing runs in 2007, which highlight SpIOMMs capabilities to map emission line objects over a very wide field of view and a broad spectral range. In particular, we discuss data cubes from the planetary nebula M27, the supernova remnants NGC 6992 and M1, the barred spiral galaxy NGC7479, as well as Stephans quintet, an interacting group of galaxies.Comment: 10 pages, 7 figures, to appear in "Ground-based and Airborne Instrumentation for Astronomy II", SPIE conference, Marseille, 23-28 June 200

1S-2S Spectrum of a Hydrogen Bose-Einstein Condensate

We calculate the two-photon 1S-2S spectrum of an atomic hydrogen Bose-Einstein condensate in the regime where the cold collision frequency shift dominates the lineshape. WKB and static phase approximations are made to find the intensities for transitions from the condensate to motional eigenstates for 2S atoms. The excited state wave functions are found using a mean field potential which includes the effects of collisions with condensate atoms. Results agree well with experimental data. This formalism can be used to find condensate spectra for a wide range of excitation schemes.Comment: 13 pages, 4 figure