Isotope shifts of the 2p3/2p_{3/2}-2p1/2p_{1/2} transition in B-like ions

Isotope shifts of the 2$p_{3/2}$-2$p_{1/2}$ transition in B-like ions are evaluated for a wide range of the nuclear charge number: Z=8-92. The calculations of the relativistic nuclear recoil and nuclear size effects are performed using a large scale configuration-interaction Dirac-Fock-Sturm method. The corresponding QED corrections are also taken into account. The results of the calculations are compared with the theoretical values obtained with other methods. The accuracy of the isotope shifts of the 2$p_{3/2}$-2$p_{1/2}$ transition in B-like ions is significantly improved.Comment: arXiv admin note: text overlap with arXiv:1410.707

Relativistic calculations of the isotope shifts in highly charged Li-like ions

Relativistic calculations of the isotope shifts of energy levels in highly charged Li-like ions are performed. The nuclear recoil (mass shift) contributions are calculated by merging the perturbative and large-scale configuration-interaction Dirac-Fock-Sturm (CI-DFS) methods. The nuclear size (field shift) contributions are evaluated by the CI-DFS method including the electron-correlation, Breit, and QED corrections. The nuclear deformation and nuclear polarization corrections to the isotope shifts in Li-like neodymium, thorium, and uranium are also considered. The results of the calculations are compared with the theoretical values obtained with other methods.Comment: 28 page

СРАВНИТЕЛЬНЫЙ АНАЛИЗ ОЩУЩЕНИЯ СУБЪЕКТИВНОГО БЛАГОПОЛУЧИЯ И ЖИЗНЕСТОЙКОСТИ РЕПАТРИАНТОВ

The authors emphasize the relevance of the study by psychologists of the problem experiences of well-being and distress of individuals, in the need to adapt to an ever-changing world, oversaturated with information. At the same time, many people are forced to change the place of residence and living conditions. In addition, in this regard it is important to investigate factors of feeling of subjective well-being of these people, and well as their overall satisfaction with life. The authors presented a brief transactional analysis of the state of scientific problem feeling subjective well-being. The problem field of empirical research is outlined research in establishing links with satisfaction with life and the vitality of the personality of repatriates from different countries. Correctly, a sample of the study was formed, reliable and valid ones were selected psychodiagnostic methods, logically presented stages of the study. Qualitative analysis of empirical data is based on evidence-based methods of statistical thesaurus. Key findings of the study on seniority residence of immigrants in the new country, the level of resilience and psychological well-being, will allow formulating a step-by-step the program of psychological support for immigrants experiencing dissatisfaction with living conditions.Los autores enfatizan la relevancia del estudio realizado por psicólogos sobre las experiencias problemáticas de bienestar y angustia de los individuos, en la necesidad de adaptarse a un mundo en constante cambio, saturado de información. Al mismo tiempo, muchas personas se ven obligadas a cambiar el lugar de residencia y las condiciones de vida. Además, a este respecto, es importante investigar los factores del sentimiento de bienestar subjetivo de estas personas y su satisfacción general con la vida. Los autores presentaron un breve análisis transaccional del estado del problema científico sintiendo un bienestar subjetivo. El campo problemático de la investigación empírica se resume en la investigación para establecer vínculos con la satisfacción con la vida y la vitalidad de la personalidad de los repatriados de diferentes países. Correctamente, se formó una muestra del estudio, se seleccionaron métodos confiables y válidos de psicodiagnóstico, etapas lógicamente presentadas del estudio. El análisis cualitativo de los datos empíricos se basa en métodos de tesauro estadístico basados en la evidencia. Los hallazgos clave del estudio sobre la residencia de ancianos de los inmigrantes en el nuevo país, el nivel de resiliencia y el bienestar psicológico, permitirán formular paso a paso el programa de apoyo psicológico para los inmigrantes que experimentan insatisfacción con las condiciones de vida.Авторы подчеркивают актуальность изучение психологами проблемы переживания благополучия и неблагополучия отдельными индивидами, в связи с необходимостью адаптироваться в постоянно меняющемся мире, перенасыщенном информацией. При этом множество людей вынуждены сменять место проживания и условия жизни. И в связи с этим важно исследовать факторы ощущения субъективного благополучия этих людей, а также их общую удовлетворенность жизнью. Авторами представлен краткий транспективный анализ состояния научной проблемы ощущения субъективного благополучия. Намечено проблемное поле эмпирического исследования в установление связей удовлетворенностью жизни и жизнестойкости личности репатриантов из разных стран. Корректно сформирована выборка исследования, подобраны надежные и валидные психодиагностические методики, логично представлены этапы исследования. Качественный анализ эмпирических данных основан на доказательных методах статистического тезауруса. Основные выводы исследования о стаже проживания репатриантов в новой стране, уровне жизнестойкости и психологического благополучия, позволят сформулировать пошаговую программу психологического сопровождения репатриантов, испытывающих неудовлетворенность жизненными условиями

The activity of matrix metalloproteinases and the concentration of their tissue inhibitors in the blood serum of patients with type 2 diabetes mellitus, depending on the stage of compensation of the disease

The aim of the study was to test the hypothesis on the possible reason for the decrease in the activity of matrix metalloproteinases (MMPs) as a consequence of the high concentration of their tissue inhibitors (TIMPs) in the blood serum of patients with type 2 diabetes mellitus (T2DM). Material and methods. In the experimental part of the article, we used the blood serum of patients under observation in the clinic of the Federal Research Center of Fundamental and Translational Medicine. According to the content of glycated hemoglobin (HbA1С) in blood serum, the patients were divided into 3 groups: at the stage of compensation (6.0–6.5 % HbA1С), at the stage of subcompensation (6.6–7.0 % HbA 1С) and decompensation (> 7.0 % HbA1С). The activity of MMPs 2 and 7 in blood serum samples was measured by a fluorimetric method using a fluorescent substrate specific for these MMPs. The concentration of TIMP-1 (inhibitor of all non-membrane-bound MMPs) and TIMP-2 (active against MMP-2 and -7) in blood serum were determined by enzyme immunoassay. Results and discussion. In patients with T2DM, the MMP-2 and -7 activities decreased, more pronouncedly at the stage of decompensation. An increase in the concentration of TIMP-1 was observed in the serum of all patients, while no significant changes in the content of TIMP-2 were found. At the stage of decompensation, a decrease in MMP activity was accompanied by a decrease in the content of insulin, C-peptide and a corresponding increase in the level of proinsulin. An inverse correlation was found between the concentrations of TIMP-1 and insulin in patients at the stage of decompensation of T2DM. It is assumed that the activity of MMP-2 and -7, in comparison with their inhibitors, forms stronger correlations with the parameters of carbohydrate metabolism

PULMONARY TUBERCULOSIS PATIENTS DETECTED DURING MASS SCREENING AND BY REFERRAL TO MEDICAL UNITS

In Russia tuberculosis patients are detected during preventive mass screening and by self referral to medical units with clinical signs of the disease.Goal of the study: to compare pulmonary tuberculosis patients detected during mass screening and by self referral to medical units with clinical signs of the disease.Materials and methods: Data about 446 pulmonary tuberculosis patients treated in Republican TB Dispensary of Saransk in 2012-2014 were retrieved from Rosttsat Forms no. 8 and 33 and Russian Ministry of Health Reporting Forms (Edict 50). Statistica software was used for data processing.Results. Among 446 pulmonary tuberculosis patients detected in 2012-2014, the part of those detected during mass screening made ¾ out of total number, and those detected by self-referral made ¼, however the latter group of patients was significantly more dangerous from epidemiological point of view, since among them the part of those with long period of the disease before treatment start was higher, the positive sputum tests were more often observed as well as pulmonary cavities and primary MDR compared to the patients detected during mass screening.The obtained results point out at the need to focus on mass screening in the targeted groups of population concentrated around sources of infection

Integral estimation of systemic inflammatory response under sepsis

Currently, the most significant mediators of the systemic inflammatory response (SIR), specific to the development of critical states in sepsis, have the chaotic changes of concentrations in the blood. The solution to the problem is using integral indicators. A scoring scale of the SIR (0–16 points) is proposed based on the determination in the blood plasma of CRP, TNF-α, IL-6, IL-8 and IL-10. The scale was used in the survey of 167 patients with a diagnosis of sepsis (43 patients with sepsis according to definitions of “Sepsis-1 or 2” and 124 patients with sepsis according to the criteria of “Sepsis-3”); septic shock was verified in 31 cases and in 48 cases lethal outcomes were recorded. The association of SIR with critical complications of sepsis was revealed, especially under acute septic shock and in cases of a “second wave” (days 5–7) of critical complications. In contrast, prolonged/ subacute sepsis (more than 14 days) under tertiary peritonitis is characterised by a lesser dependence of the criticality of the state on the severity of SIR. The proposed scale is an open system and allows you to modify the range of used particular indicators that are compatible by pathogenetic and diagnostic significance. © 2020, Slovak Academy of Sciences. All rights reserved.The work was carried out within the framework of the IIP UrB RAS theme No АААА-А18-118020590108-7