Forms of internal cross-cultural context and psychological protection in the process of adaptation of first graders

The article presents the definition of the internal cross-cultural context of first-graders in the period of adaptation to school from the standpoint of the contextual approach.В статье представлено определение внутреннего кросс-культурного контекста первоклассников в период адаптации к школе с позиций контекстного подхода

Cutaneous sinus histiocytosis of face of the non-Langerhans cell histiocytoses type (cutaneous Rosai — Dorfman disease)

An extremely rare case of sinus histiocytosis of the non-Langerhans cell histiocytoses type is described in 55-year-old patient with isolated localization of cutanious lesion on the right cheek without involvement of nodular structures. Main skin lesion was an erythematous-cyanotic node with multiple milia-like lesions on the top of it. Histologically revealed feature was a large number of plasma cells, besides phenomenon of emperipolesis was described, which was first falsely perceived by pathologists as phagocytosis. In immu-nohistochemistry assay the changes were characterized by proliferation of large polygonal histiocytes with accumulation of pentalamellar markers in its cytoplasm (protein S-100, CD68)

Improved method for the obtaining DTTA-appended 2,2’-bipyridine ligands for lanthanide cations

The composition of the reaction mixture after DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines was studied. In addition to the target product, DTTA-appended 2,2’-bipyridine, the corresponding 6'-hydroxymethyl-substituted 2,2’-bipyridine and (5'-phenyl-[2,2'-bipyridin]-6-yl)methyl formate were isolated as by-products in some cases. Finally, an improved procedure for the DTTA tert-butyl ester alkylation with 6'-halomethyl-5-phenyl-2,2'-bipyridines by using Finkelstein reaction was developed

The frequency of multiple pregnancies in the maternity hospital of the Ryazan region

The aim of the study - to study the number of twin births and to analyze the frequency of cesarean sectionЦель исследования - изучить количество родов с рождением двоен и проанализировать частоту проведения кесарева сечения

New 2,5-bis(2-ethylhexyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione-2,2’-bipyridine-based co-polymer, synthesis, photophysical properties and response to metal cations

A new co-polymer based on fragments of 2-(2-pyridyl)monoazatriphenylene and 2,5-bis (2-ethylhexyl)-3,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione was prepared by using the Sonogashira reaction. The photophysical properties of the polymer were studied. The presence of a strong bathochromic shift of the absorption and emission maxima in comparison with the previously described monomer units is shown. The polymer exhibits an intense “turn-off” response toward Cu2+ cations

New trends in the economic systems management in the context of modern global challenges

New trends in the economic systems management in the context of modern global challenges: collective monograph / scientific edited by M. Bezpartochnyi, in 2 Vol. // VUZF University of Finance, Business and Entrepreneurship. – Sofia: VUZF Publishing House “St. Grigorii Bogoslov”, 2020. – Vol. 1. – 309 p

Влияние органических удобрений на основе птичьего помёта на продуктивность кормовых культур и микробиологические показатели почвы

The creation of optimum plant nutrition plays a significant role in increasing farming efficiency. Fertilisers are one of the fastest ways to intensify the cultivation technology of all crops. The application of organic fertilisers derived from chicken manure changes the soil’s nutrient regime and nitrification capacity, its biological activity and improves physical properties. The study aims to identify the comparative evaluation of organic fertilisers based on chicken manure and establish their effect on the productivity of fodder crops (soybean and oats) and soil biological activity. The authors also determined the effectiveness of using poultry manure as an organic fertiliser to preserve soil bioresources. New organic fertilisers based on chicken manure were tested in work, obtained using a cavitation-vortex heat generator by processing semi-dry manure. Their influence on growth, development and biometric indicators of oat and soybean plants, phytosanitary state of crops, yield and grain quality has been revealed. The effect of organic fertilisers from chicken manure on microbiological indicators of soil has been determined. The increase of the oat grain yield was from 0.4 to 0.63 tons/ hectare, or 17% of the control. The output of soybean grain increased significantly by 0.18 to 0.22 t/ha. There was a slight increase in the protein content of seeds (by 1.2-2.6%). It was found that the fertilisers improved the structural indicators of oat and soybean plants. Thus, the weight of grains in oats increased by 18-23%; the number of grains in the panicle also increased by 13%. As for soybean, the number of beans on a plant grown by 14-23%; the weight of grains per plant increased by 16-19%; safety of plants for harvesting increased by 5-7%. Fertilisers based on chicken manure help improve the soil’s microbiological characteristics, which grows the availability of nutrients to plants.Ведущая роль в повышении эффективности земледелия принадлежит созданию оптимального уровня питания растений. Удобрения являются одним из быстродействующих средств интенсификации технологии возделывания всех культур. Внесение органических удобрений, полученных на основе куриного помета, изменяет пищевой режим и нитрификационную способность почвы, ее биологическую активность, улучшает физические свойства. Цель исследований – дать сравнительную оценку органических удобрений на основе куриного помёта и установить их влияние на продуктивность кормовых культур (соя и овес) и биологическую активность почвы; определить эффективность использования птичьего помета в качестве органического удобрения для сохранения биоресурсов почвы. В процессе выполнения работы были испытаны новые органические удобрения на основе куриного помета, полученные при использовании кавитационно-вихревого теплогенератора методом переработки полусухого помета. Выявлено их влияние на рост, развитие и биометрические показатели растений овса и сои, фитосанитарное состояние посевов, урожайность и качество зерна. Определено влияние органических удобрений из куриного помета на микробиологические показатели почвы. Прибавка урожайности зерна овса составила 0,4–0,63 т/га, или 17% к контролю. Достоверно увеличилась – на 0,18–0,22 т/га урожайность зерна сои, отмечено небольшое (на 1,2–2,6%) повышение содержания белка в семенах. Установлено, что удобрения улучшают структурные показатели растений овса и сои: у овса на 18– 23% увеличивается масса зерна и на 13% количество зерен в метелке, у сои на 14–23% возрастает количество бобов на растении и на 16–19% – масса зерен с одного растения, на 5–7% повышается сохранность растений к уборке. Удобрения, полученные на основе куриного помета, способствуют улучшению микробиологических характеристик почвы, что повышает доступность элементов питания для растений

ОЦЕНКА МОРФОЛОГИЧЕСКИХ ПОКАЗАТЕЛЕЙ У БОЛЬНЫХ, ПРООПЕРИРОВАННЫХ ПО ПОВОДУ ДИФФУЗНОГО ТОКСИЧЕСКОГО ЗОБА

Currently, in a case if the remission of Graves' disease is not achieved during the long-term antithyroid medication, thyroidectomy should be considered as the treatment of choice. However, the predictive criteria of the surgical treatment outcome are not defined. In this regard, it is important to search criteria contributing to prediction of the results of surgical treatment. According to the findings of the study revealed morphological indicators showing a significantly greater functional activity of the thyroid tissue in patients with postoperative thyrotoxicosis. This requires further study, which may have a significant contribution to the prognosis of postoperative outcomes among patients with Graves' disease.В настоящее время при отсутствии ремиссии диффузного токсического зоба (ДТЗ) после проведения антитиреоидной терапии ставится вопрос о выполнении экстирпации щитовидной железы. Однако критериев, определяющих объем операции и прогнозирующих исход оперативного вмешательства больных ДТЗ, в настоящее время нет. В связи с этим важной задачей тиреоидологии является поиск критериев, позволяющих прогнозировать результаты оперативного лечения. По данным проведенного исследования были выявлены морфологические показатели, свидетельствующие о значительно большей функциональной активности ткани щитовидной железы у пациентов с послеоперационным тиреотоксикозом. Это требует дальнейшего изучения, и, возможно, полученные результаты внесут существенный вклад в прогнозирование послеоперационных исходов больных ДТЗ

Computational Study of the Human Dystrophin Repeats: Interaction Properties and Molecular Dynamics

Dystrophin is a large protein involved in the rare genetic disease Duchenne muscular dystrophy (DMD). It functions as a mechanical linker between the cytoskeleton and the sarcolemma, and is able to resist shear stresses during muscle activity. In all, 75% of the dystrophin molecule consists of a large central rod domain made up of 24 repeat units that share high structural homology with spectrin-like repeats. However, in the absence of any high-resolution structure of these repeats, the molecular basis of dystrophin central domain's functions has not yet been deciphered. In this context, we have performed a computational study of the whole dystrophin central rod domain based on the rational homology modeling of successive and overlapping tandem repeats and the analysis of their surface properties. Each tandem repeat has very specific surface properties that make it unique. However, the repeats share enough electrostatic-surface similarities to be grouped into four separate clusters. Molecular dynamics simulations of four representative tandem repeats reveal specific flexibility or bending properties depending on the repeat sequence. We thus suggest that the dystrophin central rod domain is constituted of seven biologically relevant sub-domains. Our results provide evidence for the role of the dystrophin central rod domain as a scaffold platform with a wide range of surface features and biophysical properties allowing it to interact with its various known partners such as proteins and membrane lipids. This new integrative view is strongly supported by the previous experimental works that investigated the isolated domains and the observed heterogeneity of the severity of dystrophin related pathologies, especially Becker muscular dystrophy