Quenched lattice calculation of the B --> D l nu decay rate

We calculate, in the continuum limit of quenched lattice QCD, the form factor that enters in the decay rate of the semileptonic decay B --> D l nu. Making use of the step scaling method (SSM), previously introduced to handle two scale problems in lattice QCD, and of flavour twisted boundary conditions we extract G(w) at finite momentum transfer and at the physical values of the heavy quark masses. Our results can be used in order to extract the CKM matrix element Vcb by the experimental decay rate without model dependent extrapolations.Comment: 5 pages, 4 figures, accepted for publication on Phys. Lett. B, corrected one typ

Impact of Internet gambling on problem gambling among adolescents in Italy: Findings from a large-scale nationally representative survey

Aims: The primary aim of the present study was to understand the impact of online gambling on gambling problems in a large-scale nationally representative sample of Italian youth, and to identify and then further examine a subgroup of online gamblers who reported higher rates of gambling problems. Design: Data from the ESPAD®Italia2013 (European School Survey Project on Alcohol and Other Drugs) Study were used for analyses of adolescent Internet gambling. Setting: Self-administered questionnaires were completed by a representative sample of high school students, aged 15–19 years. Participants: A total of 14,778 adolescent students. Measurements: Respondents’ problem gambling severity; gambling behavior (participation in eight different gambling activities, the number of gambling occasions and the number of online gambling occasions, monthly gambling expenditure); Socio-demographics (e.g., family structure and financial status); and control variables were measured individually (i.e., use of the Internet for leisure activities and playing video games). Findings: Rates of problem gambling were five times higher among online gamblers than non-online gamblers. In addition, factors that increased the risk of becoming a problem online gambler included living with non-birth parents, having a higher perception of financial family status, being more involved with gambling, and the medium preferences of remote gamblers (e.g., Internet cafes, digital television, and video game console). Conclusions: The online gambling environment may pose significantly greater risk to vulnerable players. Family characteristics and contextual elements concerning youth Internet gambling (e.g., remote mediums) may play a key role in explaining problem online gambling among adolescents

Colour and stellar population gradients in galaxies

We discuss the colour, age and metallicity gradients in a wide sample of local SDSS early- and late-type galaxies. From the fitting of stellar population models we find that metallicity is the main driver of colour gradients and the age in the central regions is a dominant parameter which rules the scatter in both metallicity and age gradients. We find a consistency with independent observations and a set of simulations. From the comparison with simulations and theoretical considerations we are able to depict a general picture of a formation scenario.Comment: 4 pages, 4 figures. Proceedings of 54th Congresso Nazionale della SAIt, Napoli 4-7 May 201

Online Independent Set Beyond the Worst-Case: Secretaries, Prophets, and Periods

We investigate online algorithms for maximum (weight) independent set on graph classes with bounded inductive independence number like, e.g., interval and disk graphs with applications to, e.g., task scheduling and spectrum allocation. In the online setting, it is assumed that nodes of an unknown graph arrive one by one over time. An online algorithm has to decide whether an arriving node should be included into the independent set. Unfortunately, this natural and practically relevant online problem cannot be studied in a meaningful way within a classical competitive analysis as the competitive ratio on worst-case input sequences is lower bounded by $\Omega(n)$. As a worst-case analysis is pointless, we study online independent set in a stochastic analysis. Instead of focussing on a particular stochastic input model, we present a generic sampling approach that enables us to devise online algorithms achieving performance guarantees for a variety of input models. In particular, our analysis covers stochastic input models like the secretary model, in which an adversarial graph is presented in random order, and the prophet-inequality model, in which a randomly generated graph is presented in adversarial order. Our sampling approach bridges thus between stochastic input models of quite different nature. In addition, we show that our approach can be applied to a practically motivated admission control setting. Our sampling approach yields an online algorithm for maximum independent set with competitive ratio $O(\rho^2)$ with respect to all of the mentioned stochastic input models. for graph classes with inductive independence number $\rho$. The approach can be extended towards maximum-weight independent set by losing only a factor of $O(\log n)$ in the competitive ratio with $n$ denoting the (expected) number of nodes

The multiplicative effect of combining alcohol with energy drinks on adolescent gambling

Purpose: There has been increased concern about the negative effects of adolescents consuming a combination of alcohol mixed with energy drinks (AmED). To date, few studies have focused on AmED use and gambling. The present study analyzed the multiplicative effect of AmED consumption, compared to alcohol alone, on the likelihood of at-risk or problem gambling during adolescence. Methods: Data from the ESPAD®Italia 2015 study, a cross-sectional survey conducted in a nationally representative sample of students (ages 15 to 19 years) were used to examine the association between self-reported AmED use (≥ 6 times, ≥ 10 times, and ≥ 20 times during the last month) and self-reported gambling severity. Multivariate models were used to calculate adjusted prevalence ratios to evaluate the association between alcohol use, AmED use, and gambling among a representative sample of adolescents who reported gambling in the last year and completed a gambling severity scale (n = 4495). Results: Among the 19% students classed as at-risk and problem gamblers, 43.9% were classed as AmED consumers, while 23.6% were classed as alcohol consumers (i.e. did not mix alcohol with energy drinks). In multivariate analyses that controlled for covariates, AmED consumers were three times more likely to be at-risk and problem gamblers (OR = 3.05) compared to non-consuming adolescents, while the effect became less pronounced with considering those who consumed alcohol without the addition of energy drinks (OR = 1.37). Conclusions: The present study clearly established that consuming AmED might pose a significantly greater risk of experiencing gambling-related problems among adolescents

Colour and stellar population gradients in galaxies: correlation with mass

We analyse the colour gradients (CGs) of ∼ 50 000 nearby Sloan Digital Sky Survey galaxies estimated by their photometrical parameters (Sérsic index, total magnitude and effective radius). From synthetic spectral models based on a simplified star formation recipe, we derive the mean spectral properties and explain the observed radial trends of the colour as gradients of the stellar population age and metallicity. CGs have been correlated with colour, luminosity, size, velocity dispersion and stellar mass. Distinct behaviours are found for early- and late-type galaxies (ETGs and LTGs), pointing to slightly different physical processes at work in different morphological types and at different mass scales. In particular, the most massive ETGs (M*≳ 1011 M☉) have shallow (even flat) CGs in correspondence of shallow (negative) metallicity gradients. In the stellar mass range (1010.3− 1010.5) ≲M*≲ 1011 M☉, the metallicity gradients reach their minimum of ∼ − 0.5 dex−1. At M*∼ 1010.3− 1010.5 M☉, colour and metallicity gradient slopes suddenly change. They turn out to anticorrelate with the mass, becoming highly positive at the very low masses, the transition from negative to positive occurring at M*∼ 109−9.5 M☉. These correlations are mirrored by similar trends of CGs with the effective radius and the velocity dispersion. We have also found that age gradients anticorrelate with metallicity gradients, as predicted by hierarchical cosmological simulations for ETGs. On the other side, LTGs have colour and metallicity gradients which systematically decrease with mass (and are always more negative than in ETGs), consistently with the expectation from gas infall and supernovae feedback scenarios. Metallicity is found to be the main driver of the trend of CGs, especially for LTGs, but age gradients are not negligible and seem to play a significant role too. Owing to the large data set, we have been able to highlight that older galaxies have systematically shallower age and metallicity gradients than younger ones. The emerging picture is qualitatively consistent with the predictions from hydrodynamical and chemodynamical simulations. In particular, our results for high-mass galaxies are in perfect agreement with predictions based on the merging scenario, while the evolution of LTGs and younger and less massive ETGs seems to be mainly driven by infall and supernovae feedbac

CP violation in the lepton sector and implications for leptogenesis

We review the current status of the data on neutrino masses and lepton mixing and the prospects for measuring the CP-violating phases in the lepton sector. The possible connection between low energy CP violation encoded in the Dirac and Majorana phases of the Pontecorvo-Maki-Nakagawa-Sakata mixing matrix and successful leptogenesis is emphasized in the context of seesaw extensions of the Standard Model with a flavor symmetry Gf (and CP symmetry)

Comparative prediction of cardiac events by wall motion, wall motion plus coronary flow reserve, or myocardial perfusion analysis: a multicenter study of contrast stress echocardiography

ObjectivesThis study sought to determine whether the increasing difficulty of assessing wall motion (WM), Doppler coronary flow reserve on the left anterior descending coronary artery (CFR-LAD), and myocardial perfusion (MP) during stress echocardiography (SE) was justified by increasing prognostic information in patients with known or suspected coronary artery disease.BackgroundThe use of echocardiographic contrast agents during SE permits the assessment of both CFR-LAD and MP, but their relative incremental prognostic value is undefined.MethodsThis study followed a multicenter cohort of 718 patients for 16 months after high-dose dipyridamole contrast SE for evaluation of known or suspected coronary artery disease. The ability of WM, CFR-LAD, and MP to predict cardiac events was studied by multivariable models and risk reclassification.ResultsAbnormal SE was detected as a reversible WM abnormality in 18%, reversible MP defect in 27%, and CFR-LAD <2 in 38% of subjects. Fifty cardiac events occurred (annualized event rate 6.0%). A normal MP stress test had a 1-year hard event rate of 1.2%. The C-index of outcomes prediction based on clinical data was improved with MP (p < 0.001) and WM/CFR-LAD (p = 0.037), and MP (p = 0.003) added to clinical and WM data. Net risk reclassification was improved by adding MP (p < 0.001) or CFR-LAD (net reclassification improvement p = 0.001) in addition to clinical and WM data. The model including clinical data, WM/CFR-LAD, and MP performed better than that without MP did (p = 0.012).ConclusionsThe multiparametric assessment of WM, CFR-LAD and MP during stress testing in patients with known or suspected coronary artery disease is feasible. Contrast SE allowed better prognostication, irrespective of the use of CFR-LAD or MP. The addition of either CFR-LAD or MP assessment to standard WM analysis and clinical parameters yielded progressively higher values for the prediction of cardiac events and may be required in today's intensively treated patients undergoing SE, because their average low risk of future cardiac events requires methods with higher predictive sensitivity than that available with standalone WM assessment

Optimal tumor sampling for immunostaining of biomarkers in breast carcinoma

IntroductionBiomarkers, such as Estrogen Receptor, are used to determine therapy and prognosis in breast carcinoma. Immunostaining assays of biomarker expression have a high rate of inaccuracy; for example, estimates are as high as 20% for Estrogen Receptor. Biomarkers have been shown to be heterogeneously expressed in breast tumors and this heterogeneity may contribute to the inaccuracy of immunostaining assays. Currently, no evidence-based standards exist for the amount of tumor that must be sampled in order to correct for biomarker heterogeneity. The aim of this study was to determine the optimal number of 20X fields that are necessary to estimate a representative measurement of expression in a whole tissue section for selected biomarkers: ER, HER-2, AKT, ERK, S6K1, GAPDH, Cytokeratin, and MAP-Tau.MethodsTwo collections of whole tissue sections of breast carcinoma were immunostained for biomarkers. Expression was quantified using the Automated Quantitative Analysis (AQUA) method of quantitative immunofluorescence. Simulated sampling of various numbers of fields (ranging from one to thirty five) was performed for each marker. The optimal number was selected for each marker via resampling techniques and minimization of prediction error over an independent test set.ResultsThe optimal number of 20X fields varied by biomarker, ranging between three to fourteen fields. More heterogeneous markers, such as MAP-Tau protein, required a larger sample of 20X fields to produce representative measurement.ConclusionsThe optimal number of 20X fields that must be sampled to produce a representative measurement of biomarker expression varies by marker with more heterogeneous markers requiring a larger number. The clinical implication of these findings is that breast biopsies consisting of a small number of fields may be inadequate to represent whole tumor biomarker expression for many markers. Additionally, for biomarkers newly introduced into clinical use, especially if therapeutic response is dictated by level of expression, the optimal size of tissue sample must be determined on a marker-by-marker basis