Sensitivity Analysis and Optimization Using Energy Finite Element and Boundary Element Methods

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76597/1/AIAA-20811-196.pd

Emerging roles of ATF2 and the dynamic AP1 network in cancer

Cooperation among transcription factors is central for their ability to execute specific transcriptional programmes. The AP1 complex exemplifies a network of transcription factors that function in unison under normal circumstances and during the course of tumour development and progression. This Perspective summarizes our current understanding of the changes in members of the AP1 complex and the role of ATF2 as part of this complex in tumorigenesis.Fil: Lopez Bergami, Pablo Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina; ArgentinaFil: Lau, Eric . Burnham Institute for Medical Research; Estados UnidosFil: Ronai, Zeev . Burnham Institute for Medical Research; Estados Unido

Long-term periodontal status of patients with mandibular lingual fixed retention

The purpose of this study was to evaluate the periodontal tissues of patients with mandibular fixed retention for long or short periods of time. A total of 64 individuals were selected for this study using the following inclusion criteria: long-term lingual fixed retention; identical type of lingual fixed retainer bonded with the same materials; no cavities, restorations, or fractures of the mandibular anterior teeth; absence of habits and occlusal interferences; and canine guidance bilaterally. The resultant sample comprised 32 patients (mean age 25 years) who had been in retention for a mean period of 9.65 years (range 9-11 years) and an equal number retained for a period between 3 and 6 months. Plaque, gingival, and calculus indices, probing pocket depth, marginal recession, and bone level at the mandibular six anterior teeth were recorded for both groups. Demographic, clinical, and radiographic data were investigated with conventional descriptive statistics. Comparisons of the different variables between the two participant groups (long- and short-term retention) were carried out using a Mann-Whitney test for indices (plaque, gingival, and calculus), and a Fisher's exact test (two sided) for the remaining variables.No significant difference was found with respect to the plaque and gingival indices and bone level between the two groups. The long-term group presented higher calculus accumulation, greater marginal recession, and increased probing depth (P < 0.05). The results of this study raise the question of the appropriateness of lingual fixed retainers as a standard retention plan for all patients regardless of their attitude to dental hygiene. They also emphasize the importance of individual variability and cautious application of retention protocols after a thorough consideration of issues related to the anatomy of tissues and oral hygiene

Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer

Cytokines are pivotal mediators of the immune response, and their coordinated expression protects host tissue from excessive damage and oxidant stress. Nevertheless, the development of lung pathology, including asthma, chronic obstructive pulmonary disease, and ozone-induced lung injury, is associated with oxidant stress; as evidence, there is a significant increase in levels of the modified guanine base 7,8-dihydro-8-oxoguanine (8-oxoG) in the genome. 8-OxoG is primarily recognized by 8-oxoguanine glycosylase 1 (OGG1), which catalyzes the first step in the DNA base excision repair pathway. However, oxidant stress in the cell transiently halts enzymatic activity of substrate-bound OGG1. The stalled OGG1 facilitates DNA binding of transactivators, including NF-κB, to their cognate sites to enable expression of cytokines and chemokines, with ensuing recruitments of inflammatory cells. Hence, defective OGG1 will modulate the coordination between innate and adaptive immunity through excessive oxidant stress and cytokine dysregulation. Both oxidant stress and cytokine dysregulation constitute key elements of oncogenesis by KRAS, which is mechanistically coupled to OGG1. Thus, analysis of the mechanism by which OGG1 modulates gene expression helps discern between beneficial and detrimental effects of oxidant stress, exposes a missing functional link as a marker, and yields a novel target for lung cancer. © 2018 Elsevier Inc

Blast event simulation for a structure subjected to a landmine explosion

One of the main threats to military vehicles originates from landmine blasts. In order to improve the survivability of the occupants it is important to design a military vehicle for increased occupant safety. Simulation technology that combines modeling of the blast loads from the landmine explosion, the response of the vehicle to the blast load, and the loads developed on the members of an occupant are important factors in this effort. The ability to simulate the landmine explosion is validated first by comparing simulation results to test data collected by gages placed in the ground and above the ground. Combined simulations predicting the damage to a target structure due to a landmine explosion are also compared to test data for further validation. Principal component analysis and metamodel theory is employed for generating fast running models in order to adjust the soil parameters in the simulation models during the correlation effort. Good correlation is demonstrated between the simulation methods and the test data. A case study is also performed in order to demonstrate how this new simulation technology can access the safety of an occupant due to the blast load applied on the hull of a military vehicle. Copyright © 2006 SAE International

Simulations under uncertainty for occupant safety for a vehicle subjected to a blast load

One of the main threats to military vehicles originates from landmine blasts. In order to improve the survivability of the occupants it is important to design a military vehicle for increased occupant safety. Simulation technology that combines modeling of the blast loads from the landmine explosion, the response of the vehicle to the blast load, and the loads developed on the members of an occupant are important factors in this effort. Uncertainties from the soil properties can influence the blast loads and thus the occupants' safety. In this paper, principal component analysis along with metamodel theory are employed for developing fast running models for the response functions of interest. The response functions of interest are the time domain loads which are developed on an occupant's members due to the blast. The fast running models allow assessing the probability level associated with injury for an occupant. Copyright © 2006 SAE International

Serum irisin concentrations in lean adolescents with polycystic ovary syndrome

Objective: To explore differences in irisin concentrations between lean adolescents with PCOS and age- and body mass index (BMI)-matched controls and examine the associations of irisin with core features of the syndrome. Design: Cross-sectional study. Patients: Lean females with PCOS, aged 13-21 years. Measurements: Physical, hormonal and sonographic assessment. Irisin concentrations were measured with ELISA. Results: Participants included in total 39 sedentary females (mean ± SD; age 17.3 ± 2.1 years, BMI 20.7 ± 1.3 Kg/m2), 23 adolescents with PCOS and 16 controls. Adolescents with PCOS compared to controls had significantly elevated concentrations of fasting serum irisin (mean ± SD; PCOS, 1.7 ± 1.0 μg/mL vs controls, 1.0 ± 0.4 μg/mL; P =.007), luteinizing hormone (LH), oestradiol, testosterone, Δ4-androstenedione, 17-hydroxyprogesterone, glucose, as well as free androgen index, Ferriman-Gallwey score and mean ovarian volume (MOV). For the total sample, circulating irisin was positively correlated with MOV (r =.332, P =.041), glucose (r =.428, P =.007), insulin (rs =.369, P =.021) and HOMA-IR (rs =.422, P =.007) and negatively correlated with QUICKI (r = −.329, P =.041). Follicle-stimulating hormone (B = 0.295, Beta =.342, P =.042) and MOV (B = 0.182, Beta = 0.821, P =.001) were positive predictors, and LH (B = −0.108, Beta = −0.523, P =.010) and testosterone (B = −0.431, Beta = −0.457, P =.032) were negative predictors of irisin concentrations, whereas irisin positively predicted fasting glucose (B = 0.262, Beta = 0.428, P =.007). In the PCOS group, irisin concentrations were positively correlated with HOMA-IR (rs =.416, P =.048) but negatively correlated with LH (rs = −.499, P =.015), testosterone (r = −.585, P =.003), free androgen index (r = −.426, P =.048) and Ferriman-Gallwey score (r = −.533, P =.015). Conclusions: Irisin was associated with the adolescents' metabolic and reproductive characteristics and the hyperandrogenic phenotype of the syndrome. Much research is needed to ascertain mechanisms of elevated serum irisin in adolescent PCOS. © 2018 John Wiley & Sons Lt