4,614 research outputs found
Extraction of Dynamic Inflow Models for Coaxial and Tandem Rotors from CFD Simulations
The dynamic inflow coupling with rotor/body dynamics is crucial in the analysis of stability and control law design for helicopters. Over the past several decades, finite-state inflow models for single rotor configurations in hover, forward flight, and maneuver have developed (Ref.1-3). By capturing the interference effects between rotors, the extension of pressure potential finite state inflow model has promising result for coaxial rotor configuration (Ref.4-6). Recently, the focus of the dynamic inflow modeling has shifted to tandem rotor configurations (Ref.7, 8). The development of the dynamic inflow models for tandem rotor configuration still have some limitations due to the lack of knowledge of rotor-to-rotor interference, and rotor-wake interference. Experimental methods, and computational fluid dynamics methods are commonly used to understand the rotor performance and rotor airload variations, and measure or predict inflow velocity distributions at the rotor desk. The inflow distributions are subsequently used to improve the dynamic inflow models. Tandem rotor configurations have been studied experimentally and computationally for several decades (Ref.9-12). Sweet (Ref.10) observed that a tandem rotor with 76-percent-radius overlap required 14% more induced power at hovering condition, relative to an isolated rotor of equivalent disk area. Sweet also found that, above a shaft-to-shaft distance of 1.03 diameter, the performance of the tandem rotor was nearly the same as two isolated rotors. The objective of the present study is to apply computational fluid dynamics simulations of tandem rotors for the extraction of dynamic inflow models. The extended methodology is first validated by comparing the computed induced power against test data. Subsequently inflow distributions and wake structures are analyzed
Low-Dose T-3 Replacement Restores Depressed Cardiac T-3 Levels, Preserves Coronary Microvasculature and Attenuates Cardiac Dysfunction in Experimental Diabetes Mellitus
Thyroid dysfunction is common in individuals with diabetes mellitus (DM) and may contribute to the associated cardiac dysfunction. However, little is known about the extent and pathophysiological consequences of low thyroid conditions on the heart in DM. DM was induced in adult female Sprague Dawley (SD) rats by injection of nicotinamide (N; 200 mg/kg) followed by streptozotocin (STZ; 65 mg/kg). One month after STZ/N, rats were randomized to the following groups (N = 10/group): STZ/N or STZ/N + 0.03 g/mL T-3; age-matched vehicle-treated rats served as nondiabetic controls (C). After 2 months of T-3 treatment (3 months post-DM induction), left ventricular (LV) function was assessed by echocardiography and LV pressure measurements. Despite normal serum thyroid hormone (TH) levels, STZ/N treatment resulted in reductions in myocardial tissue content of THs (T-3 and T-4 : 39% and 17% reduction versus C, respectively). Tissue hypothyroidism in the DM hearts was associated with increased DIO3 deiodinase (which converts THs to inactive metabolites) altered TH transporter expression, reexpression of the fetal gene phenotype, reduced arteriolar resistance vessel density, and diminished cardiac function. Low-dose T-3 replacement largely restored cardiac tissue TH levels (T-3 and T-4 : 43% and 10% increase versus STZ/N, respectively), improved cardiac function, reversed fetal gene expression and preserved the arteriolar resistance vessel network without causing overt symptoms of hyperthyroidism. We conclude that cardiac dysfunction in chronic DM may be associated with tissue hypothyroidism despite normal serum TH levels. Low-dose T-3 replacement appears to be a safe and effective adjunct therapy to attenuate and/or reverse cardiac remodeling and dysfunction induced by experimental DM
Experimental and Emerging Free Fatty Acid Receptor Agonists for the Treatment of Type 2 Diabetes
The current management of Type 2 Diabetes Mellitus (T2DM) includes incretin-based treatments able to enhance insulin secretion and peripheral insulin sensitivity as well as improve body mass, inflammation, plasma lipids, blood pressure, and cardiovascular outcomes. Dietary Free Fatty Acids (FFA) regulate metabolic and anti-inflammatory processes through their action on incretins. Selective synthetic ligands for FFA1-4 receptors have been developed as potential treatments for T2DM. To comprehensively review the available evidence for the potential role of FFA receptor agonists in the treatment of T2DM, we performed an electronic database search assessing the association between FFAs, T2DM, inflammation, and incretins. Evidence indicates that FFA1-4 agonism increases insulin sensitivity, induces body mass loss, reduces inflammation, and has beneficial metabolic effects. There is a strong inter-relationship between FFAs and incretins. FFA receptor agonism represents a potential target for the treatment of T2DM and may provide an avenue for the management of cardiometabolic risk in susceptible individuals. Further research promises to shed more light on this emerging topic
National strategy for exploitation and utilization of the potential marine fishery resources of India-a projection
It is more than a decade since the
country declared in 1977 its maritime Exclusive
Economic Zone covering an area of 2.02
million sq. km, thus inheriting a great wealth
of living and non-living marine resources.
The potential of marine fishery resources of
the EEZ is of considerable magnitude and
roughly estimated at 4.5 million tonnes based
on different approaches by scientists. As
against this, during the last one and a half
decades there has not been any substantial
increase in the marine fish production of the
country which currently stands at about 1.6
million tonnes. The fact that a large gap
exists between the potential resources and the
actual yield is a matter of great concern
Probing BFKL Dynamics in the Dijet Cross Section at Large Rapidity Intervals in ppbar Collisions at sqrt{s}=1800 and 630 GeV
Inclusive dijet production at large pseudorapidity intervals (delta_eta)
between the two jets has been suggested as a regime for observing BFKL
dynamics. We have measured the dijet cross section for large delta_eta in ppbar
collisions at sqrt{s}=1800 and 630 GeV using the DO detector. The partonic
cross section increases strongly with the size of delta_eta. The observed
growth is even stronger than expected on the basis of BFKL resummation in the
leading logarithmic approximation. The growth of the partonic cross section can
be accommodated with an effective BFKL intercept of
a_{BFKL}(20GeV)=1.65+/-0.07.Comment: Published in Physical Review Letter
Search for R-parity Violating Supersymmetry in Dimuon and Four-Jets Channel
We present results of a search for R-parity-violating decay of the neutralino
chi_1^0, taken to be the Lightest Supersymmetric Particle. It is assumed that
this decay proceeds through one of the lepton-number violating couplings
lambda-prime_2jk (j=1,2; k=1,2,3). This search is based on 77.5 pb-1 of data,
collected by the D0 experiment at the Fermilab Tevatron in ppbar collisions at
a center of mass energy of 1.8 TeV in 1992-1995.Comment: 10 pages, 3 figure
Search for Electroweak Production of Single Top Quarks in ppbar Collisions
We present a search for electroweak production of single top quarks in the
electron+jets and muon+jets decay channels. The measurements use ~90 pb^-1 of
data from Run 1 of the Fermilab Tevatron collider, collected at 1.8 TeV with
the DZero detector between 1992 and 1995. We use events that include a tagging
muon, implying the presence of a b jet, to set an upper limit at the 95%
confidence level on the cross section for the s-channel process ppbar->tb+X of
39 pb. The upper limit for the t-channel process ppbar->tqb+X is 58 pb.Comment: 11 pages, 2 figures. This is the published versio
A Quasi-Model-Independent Search for New Physics at Large Transverse Momentum
We apply a quasi-model-independent strategy ("Sleuth") to search for new high
p_T physics in approximately 100 pb^-1 of ppbar collisions at sqrt(s) = 1.8 TeV
collected by the DZero experiment during 1992-1996 at the Fermilab Tevatron.
Over thirty-two e mu X, W+jets-like, Z+jets-like, and 3(lepton/photon)X
exclusive final states are systematically analyzed for hints of physics beyond
the standard model. Simultaneous sensitivity to a variety of models predicting
new phenomena at the electroweak scale is demonstrated by testing the method on
a particular signature in each set of final states. No evidence of new high p_T
physics is observed in the course of this search, and we find that 89% of an
ensemble of hypothetical similar experimental runs would have produced a final
state with a candidate signal more interesting than the most interesting
observed in these data.Comment: 28 pages, 17 figures. Submitted to Physical Review
Search for bottom squarks in pbarp collisions at sqrt(s)=1.8 TeV
We report on a search for bottom squarks produced in pbarp collisions at
sqrt(s) = 1.8 TeV using the D0 detector at Fermilab. Bottom squarks are assumed
to be produced in pairs and to decay to the lightest supersymmetric particle
(LSP) and a b quark with branching fraction of 100%. The LSP is assumed to be
the lightest neutralino and stable. We set limits on the production cross
section as a function of bottom squark mass and LSP mass.Comment: 5 pages, Latex. submitted 3-12-1999 to PRD - Rapid Communicatio
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