Estimating Dynamic Traffic Matrices by using Viable Routing Changes

Abstract: In this paper we propose a new approach for dealing with the ill-posed nature of traffic matrix estimation. We present three solution enhancers: an algorithm for deliberately changing link weights to obtain additional information that can make the underlying linear system full rank; a cyclo-stationary model to capture both long-term and short-term traffic variability, and a method for estimating the variance of origin-destination (OD) flows. We show how these three elements can be combined into a comprehensive traffic matrix estimation procedure that dramatically reduces the errors compared to existing methods. We demonstrate that our variance estimates can be used to identify the elephant OD flows, and we thus propose a variant of our algorithm that addresses the problem of estimating only the heavy flows in a traffic matrix. One of our key findings is that by focusing only on heavy flows, we can simplify the measurement and estimation procedure so as to render it more practical. Although there is a tradeoff between practicality and accuracy, we find that increasing the rank is so helpful that we can nevertheless keep the average errors consistently below the 10% carrier target error rate. We validate the effectiveness of our methodology and the intuition behind it using commercial traffic matrix data from Sprint's Tier-1 backbon

A Programmable Framework for Validating Data Planes

Due to the emerging trend of programmable network hardware, developers have begun to explore ways to accelerate various applications and services. As a result, there is a pressing need for new tools and techniques for debugging network devices. This paper presents NetDebug, a fully programmable hardware-software framework for validating and real-time debugging of programmable data planes. We describe validation use cases, compare our design to alternative solutions, and present a preliminary evaluation using a prototype implementation.Leverhulme Trust, Isaac Newton Trust, Swiss National Science Foundation (SNSF

Some aspects of the stalling of modern low-lying monoplanes

The factors affecting the stalling characteristics of modern airplanes are briefly discussed. The effect of present-day design trends is shown and means for improving the stalling characteristics of future airplanes are indicated

A Flight Investigation of the Lateral Control Characteristics of Short Wide Ailerons and Various Spoilers with Different Amounts of Wing Dihedral

This report presents the results of flight tests made to determine the lateral control characteristics of short wide ailerons and spoilers, as a consequence of the promise shown in wind-tunnel tests by these devices as means of obtaining lateral control, particularly at angles of attack above the stall. Several forms of spoilers, front-hinge, rear-hinge, plain retractable, and saw-tooth retractable were tested alone and in combination with the ailerons. The tests were made with several different amounts of wing dihedral so that the effect of the yawing moments of the different lateral control combinations, which varied from large negative to large positive values, could be evaluated. In conjunction with the tests, observations were made to throw some light on the feasibility of operating the airplane with two controls instead of the present three

Early phases of different types of isolated neutron star

Two Galactic isolated strong X-ray pulsars seem to be in the densest environments compared to other types of Galactic pulsar. X-ray pulsar J1846-0258 can be in an early phase of anomalous X-ray pulsars and soft gamma repeaters if its average braking index is ~1.8-2.0. X-ray pulsar J1811-1925 must have a very large average braking index (n~11) if this pulsar was formed by SN 386AD. This X-ray pulsar can be in an early phase of evolution of the radio pulsars located in the region P~50-150 ms and \.{P}~10$^{-14}-10^{-16}$ s/s of the P-\.{P} diagram. X-ray/radio pulsar J0540-69 seems to be evolving in the direction to the dim isolated thermal neutron star region on the P-\.{P} diagram. Possible progenitors of different types of neutron star are also discussed.Comment: to appear in the International Journal of Modern Physics

Alterations of EGFR, p53 and PTEN that mimic changes found in basal-like breast cancer promote transformation of human mammary epithelial cells

Breast cancer can be classified into different molecular subtypes with varying clinical and pathological characteristics. The basal-like breast cancer subtype represents one of the most aggressive and lethal types of breast cancer, and due to poor mechanistic understanding, it lacks targeted therapy. Many basal-like breast cancer patient samples display alterations of established drivers of cancer development, including elevated expression of EGFR, p53 inactivating mutations and loss of expression of the tumor suppressor PTEN; however, their contribution to human basal-like breast cancer pathogenesis remains ill-defined. Using non-transformed human mammary epithelial cells, we set out to determine whether altering EGFR, p53 and PTEN in different combinations could contribute to basal-like breast cancer progression through transformation of cells. Altering PTEN in combination with either p53 or EGFR in contrast to any of the single alterations caused increased growth of transformed colonies in soft agar. Concomitantly modifying all three genes led to the highest rate of cellular proliferation and the greatest degree of anchorage-independent colony formation. Results from our effort to engineer a model of BBC expressing alterations of EGFR, p53 and PTEN suggest that these changes are cooperative and likely play a causal role in basal-like breast cancer pathogenesis. Consideration should be given to targeting EGFR and restoring p53 and PTEN signaling simultaneously as a strategy for treatment of this subtype of breast cancer

Prostate Cancer Foundation Hormone-Sensitive Prostate Cancer Biomarker Working Group Meeting Summary.

Androgen deprivation therapy remains the backbone therapy for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). In recent years, several treatments, including docetaxel, abiraterone + prednisone, enzalutamide, and apalutamide, have each been shown to demonstrate survival benefit when used upfront along with androgen deprivation therapy. However, treatment selection for an individual patient remains a challenge. There is no high level clinical evidence for treatment selection among these choices based on biological drivers of clinical disease. In August 2020, the Prostate Cancer Foundation convened a working group to meet and discuss biomarkers for hormone-sensitive prostate cancer, the proceedings of which are summarized here. This meeting covered the state of clinical and biological evidence for systemic therapies in the mHSPC space, with emphasis on charting a course for the generation, interrogation, and clinical implementation of biomarkers for treatment selection

Macroevolutionary patterns in overexpression of tyrosine:An anti‐herbivore defence in a speciose tropical tree genus, Inga (Fabaceae)

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this record.1.Plant secondary metabolites are a key defence against herbivores, and their evolutionary origin is likely from primary metabolites. Yet for this to occur, an intermediate step of overexpression of primary metabolites would need to confer some advantage to the plant. Here, we examine the evolution of overexpression of the essential amino acid, L‐tyrosine and its role as a defence against herbivores. 2.We examined overexpression of tyrosine in 97 species of Inga (Fabaceae), a genus of tropical trees, at five sites throughout the Neotropics. We predicted that tyrosine could act as an anti‐herbivore defence because concentrations of 4% tyrosine in artificial diets halved larval growth rates. We also collected insect herbivores to determine if tyrosine and its derivatives influenced host associations. 3.Overexpression of tyrosine was only present in a single lineage comprising 21 species, with concentrations ranging from 5% to 20% of the leaf dry weight. Overexpression was pronounced in expanding but not in mature leaves. Despite laboratory studies showing toxicity of L‐tyrosine, Inga species with tyrosine suffered higher levels of herbivory. We therefore hypothesize that overexpression is only favoured in species with less effective secondary metabolites. Some tyrosine‐producing species also contained secondary metabolites that are derived from tyrosine: tyrosine‐gallates, tyramine‐gallates and DOPA‐gallates. Elevated levels of transcripts of prephenate dehydrogenase, an enzyme in the tyrosine biosynthetic pathway that is insensitive to negative feedback from tyrosine, were found only in species that overexpress tyrosine or related gallates. Different lineages of herbivores showed contrasting responses to the overexpression of tyrosine and its derived secondary metabolites in their host plants. 4.Synthesis. We propose that overexpression of some primary metabolites can serve as a chemical defence against herbivores, and are most likely to be selected for in species suffering high herbivory due to less effective secondary metabolites. Overexpression may be the first evolutionary step in the transition to the production of more derived secondary metabolites. Presumably, derived compounds would be more effective and less costly than free tyrosine as anti‐herbivore defences.National Science Foundatio