Water Sustainability: Current and Future Challenges at SRM Institute of Science and Technology, Chennai, India

SRMIST has healthy approach to sustainability, incorporating social economic and environmental principles that have been in place for nearly a decade implementing short and long-term sustainable objectives. SRMIST developed, maintained the estate, and the surrounding landscape, with due environmental impact and social values and implemented effective, efficient utility management measures, policies and procedures. The 2018/2019 UI Green Metric ranked SRMIST as 9 th in India and 392nd in Global Ranking overall and 264th rank globally and 9th rank in India for water parameter and 3rd in the Nation and 243rd globally and 2nd rank nationally and 42nd rank globally for water. SRM IST improved implementation of the water conservation and recycling program from 75% in 2018 to 95 % in 2019. Water efficient appliances increased > 70% and has a long-term commitment for conservation of water by regularly monitoring the use of water with regular meters. SRMIST has 20 RO plants running 24x7 collecting 31,000L per day for all and installing Ultra Filtration unit. SRMIST’s goal is to reduce per capita water consumption varies from 3.7m3 to 3.3m. Among the 4600 M3 waste water generated an average 4140 M3 wastewater is treated and recycled. Rainwater harvesting pits have been constructed in 65% college buildings and hostels is used for the water recharge in the campus and the rainwater stored in the roof tanks are used for toilet flushing

Development of a liposomal nanodelivery system for nevirapine

<p>Abstract</p> <p>Background</p> <p>The treatment of AIDS remains a serious challenge owing to high genetic variation of Human Immunodeficiency Virus type 1 (HIV-1). The use of different antiretroviral drugs (ARV) is significantly limited by severe side-effects that further compromise the quality of life of the AIDS patient. In the present study, we have evaluated a liposome system for the delivery of nevirapine, a hydrophobic non-nucleoside reverse transcriptase inhibitor. Liposomes were prepared from egg phospholipids using thin film hydration. The parameters of the process were optimized to obtain spherical liposomes below 200 nm with a narrow polydispersity. The encapsulation efficiency of the liposomes was optimized at different ratios of egg phospholipid to cholesterol as well as drug to total lipid. The data demonstrate that encapsulation efficiency of 78.14% and 76.25% were obtained at egg phospholipid to cholesterol ratio of 9:1 and drug to lipid ratio of 1:5, respectively. We further observed that the size of the liposomes and the encapsulation efficiency of the drug increased concomitantly with the increasing ratio of drug and lipid and that maximum stability was observed at the physiological pH. Thermal analysis of the drug encapsulated liposomes indicated the formation of a homogenous drug-lipid system. The magnitude of drug release from the liposomes was examined under different experimental conditions including in phosphate buffered saline (PBS), Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum or in the presence of an external stimulus such as low frequency ultrasound. Within the first 20 minutes 40, 60 and 100% of the drug was released when placed in PBS, DMEM or when ultrasound was applied, respectively. We propose that nevirapine-loaded liposomal formulations reported here could improve targeted delivery of the anti-retroviral drugs to select compartments and cells and alleviate systemic toxic side effects as a consequence.</p

Lift-and-Round to Improve Weighted Completion Time on Unrelated Machines

We consider the problem of scheduling jobs on unrelated machines so as to minimize the sum of weighted completion times. Our main result is a $(3/2-c)$-approximation algorithm for some fixed $c>0$, improving upon the long-standing bound of 3/2 (independently due to Skutella, Journal of the ACM, 2001, and Sethuraman & Squillante, SODA, 1999). To do this, we first introduce a new lift-and-project based SDP relaxation for the problem. This is necessary as the previous convex programming relaxations have an integrality gap of $3/2$. Second, we give a new general bipartite-rounding procedure that produces an assignment with certain strong negative correlation properties.Comment: 21 pages, 4 figure

Fishing methods in coral reef areas of the Gulf of Mannar

Fishing methods being practised in the reef areas of the Gulf of Mannar for finfishes are trawling, gillnetting, fishing by hooks and lines and traps. Out of these, the most important device is trawling by which the most diverse and the highest quantity of finfishes are being landed from coral reef areas in this region

On the stranding of sei whale, Balaenoptera borealis Lesson at Mandapam along the Palk Bay coast

On 20th January, 1992, an adult female sei whale, measuring 14.0 m in total length and weighing about 10 tonnes stranded at Theedai near the marine fish farm of Central Marine Fisheries Research Institute, Mandapam Camp

Current standards and ethical landscape of engineered tissues—3D bioprinting perspective

Tissue engineering is an evolving multi-disciplinary field with cutting-edge technologies and innovative scientific perceptions that promise functional regeneration of damaged tissues/organs. Tissue engineered medical products (TEMPs) are biomaterial-cell products or a cell-drug combination which is injected, implanted or topically applied in the course of a therapeutic or diagnostic procedure. Current tissue engineering strategies aim at 3D printing/bioprinting that uses cells and polymers to construct living tissues/organs in a layer-by-layer fashion with high 3D precision. However, unlike conventional drugs or therapeutics, TEMPs and 3D bioprinted tissues are novel therapeutics and need different regulatory protocols for clinical trials and commercialization processes. Therefore, it is essential to understand the complexity of raw materials, cellular components, and manufacturing procedures to establish standards that can help to translate these products from bench to bedside. These complexities are reflected in the regulations and standards that are globally in practice to prevent any compromise or undue risks to patients. This review comprehensively describes the current legislations, standards for TEMPs with a special emphasis on 3D bioprinted tissues. Based on these overviews, challenges in the clinical translation of TEMPs & 3D bioprinted tissues/organs along with their ethical concerns and future perspectives are discussed

Gender‐specific Issues in Traumatic Injury and Resuscitation: Consensus‐based Recommendations for Future Research

Traumatic injury remains an unacceptably high contributor to morbidity and mortality rates across the United States. Gender‐specific research in trauma and emergency resuscitation has become a rising priority. In concert with the 2014 Academic Emergency Medicine consensus conference “Gender‐specific Research in Emergency Care: Investigate, Understand, and Translate How Gender Affects Patient Outcomes,” a consensus‐building group consisting of experts in emergency medicine, critical care, traumatology, anesthesiology, and public health convened to generate research recommendations and priority questions to be answered and thus move the field forward. Nominal group technique was used for the consensus‐building process and a combination of face‐to‐face meetings, monthly conference calls, e‐mail discussions, and preconference surveys were used to refine the research questions. The resulting research agenda focuses on opportunities to improve patient outcomes by expanding research in sex‐ and gender‐specific emergency care in the field of traumatic injury and resuscitation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110065/1/acem12536.pd

Sea cow Dugong dugon (Muller) washed ashore dead at Rameswaram

Sea cow Dugong dugon (Muller), is a highly endangered marine mammal, listed under Schedule-I, Part I of the Wildlife (Protection) Act, 1972. On 6th April 2010 a sea cow washed ashore dead at Rameswaram fish landing center