Multi-Objective and Financial Portfolio Optimization of Carrier-Sense Multiple Access Protocols with Cooperative Diversity

8th International Workshop on Multiple Access Communications (MACOM2015), Helsinki, Finland.This paper presents a trade-off design and optimization of a class of wireless carrier-sense multiple access protocols where collision-free transmissions are assisted by the potential cooperative retransmissions of inactive terminals with a correct copy of the original transmission. Terminals are enabled with a decode-and-forward relaying protocol. The analysis is focused on asymmetrical settings, where terminals experience different channel and queuing statistics. This work is based on multi-objective and financial portfolio optimization tools. Each packet transmission is thus regarded not only as a network resource, but also as a financial asset with different values of return and risk (or variance of the return). The objective of this financial optimization is to find the transmission policy that simultaneously maximizes return and minimizes risk in the network. The work is focused on the characterization of the boundaries (envelope) of different types of trade-off performance regions: the conventional throughput region, sum-throughput vs. fairness, sum-throughput vs. power, and return vs. risk regions. Fairness is evaluated by means of the Gini-index, which is a metric commonly used in economics to measure income inequality. Transmit power is directly linked to the global transmission rate. The protocol is shown to outperform non-cooperative solutions under different network conditions that are here discussed

What is the impact of preserving the endothelium on saphenous vein graft performance? Comments on the 'NO' touch harvesting technique.

Saphenous veins used for coronary artery bypass surgery are subjected to considerable vascular trauma when harvested by conventional methods. This vascular damage is responsible, at least in part, for the inferior patency of the saphenous vein when compared with the internal thoracic artery. The performance of saphenous vein grafts is improved when this conduit is harvested atraumatically using the no-touch technique. There is growing evidence that the success of the no-touch technique is due to the preservation of a number of vascular structures including the endothelium, vasa vasorum and perivascular fat. There is conflicting evidence regarding the degree of endothelial damage to the endothelium of conventional versus no-touch saphenous vein grafts. In general, it has been shown that this single layer of cells lining the lumen exhibits considerable damage associated with a combination of vascular trauma and high pressure intraluminal distension. Increased platelet aggregation and thrombus formation at the exposed subendothelial membrane is due to a local reduction of endothelium-derived factors including nitric oxide. In addition, damage to the vasa vasorum of conventionally-harvested veins will reduce transmural blood flow, a condition shown to promote neointimal hyperplasia and atheroma formation. By stripping off the perivascular fat during conventional harvesting, mechanical support of the graft is reduced and the source of adipocyte-derived factors potentially beneficial for graft patency removed. While most agree that endothelial damage to the saphenous vein affects graft patency, the contribution of other tissue-derived factors affected by vascular damage at harvesting need to be considered

Synthesis of Nitrogenated Heterocycles by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)haloimines

Highly optically enriched, protected, nitrogenated heterocycles with different ring sizes have been synthesized by a very efficient methodology consisting of the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)haloimines followed by treatment with a base to promote an intramolecular nucleophilic substitution process. N-Protected aziridines, pyrrolidines, piperidines, and azepanes bearing aromatic, heteroaromatic, and aliphatic substituents have been obtained in very high yields and diastereomeric ratios up to >99:1. The free heterocycles can be easily obtained by a simple and mild desulfinylation procedure. Both enantiomers of the free heterocycles can be prepared with the same good results by changing the absolute configuration of the sulfur atom of the sulfinyl group.This work was generously supported by the Spanish Ministerio de Ciencia e Innovación (MICINN; grant no. CONSOLIDER INGENIO 2010, CSD2007-00006, CTQ2007-65218 and CTQ2011-24151) and the Generalitat Valenciana (PROMETEO/2009/039 and FEDER). O.P. thanks the Spanish Ministerio de Educación for a predoctoral fellowship (grant no. AP-2008-00989)

A simple technique can reduce cardiopulmonary bypass use during lung transplantation

Cardiopulmonary bypass causes an inflammatory response and consumption of coagulation factors, increasing the risk of bleeding and neurological and renal complications. Its use during lung transplantation may be due to pulmonary hypertension or associated cardiac defects or just for better exposure of the pulmonary hilum. We describe a simple technique, or open pericardium retraction, to improve hilar exposure by lifting the heart by upward retraction of the pericardial sac. This technique permits lung transplantation without cardiopulmonary bypass when bypass use is recommended only for better exposure

Seizure and Status Epilepticus

Seizures and status epilepticus (SE) occur frequently in the neurocritical care setting. Status epilepticus has been reported in 10–25% of critically ill comatose patients depending on the underlying diagnosis. Therefore, it is important to understand how to detect, evaluate, and manage patients with this disorder. Status epilepticus is defined as 5 or more minutes of continuous clinical and/or electrographic seizure activity, or recurrent seizure activity without recovering to baseline between seizures. The history and neurological exam are essential to initial detection of SE. Some patients may present with overt convulsions, while others show more subtle signs of seizures such as eye deviation or nystagmus. Care must be taken to perform a detailed clinical exam to identify subtle or subclinical seizures. Additionally, some comatose patients will have only electrographic seizures. Therefore, a high level of suspicion for nonconvulsive SE is helpful when evaluating patients with abnormal mental status. Electroencephalography is the gold standard for detection of seizures and SE. It is an essential part of any workup for known or suspected SE. The differential diagnosis of patients with known or suspected SE includes structural intracranial lesions, metabolic derangements, intoxications, and organ failure. Therefore, the initial workup includes imaging and laboratory examination to detect an underlying pathology. The rapid management of seizures and SE is of utmost importance. The longer SE continues, the more difficult it is to treat. The initial management includes benzodiazepine therapy to stop the epileptiform activity, followed by an anticonvulsant to prevent its recurrence. If seizures persist, developing into SE, then continuous infusion of anesthetic medications is necessary. The choice of specific agents used will depend on patient factors such as renal and hepatic function and hemodynamic stability