610 research outputs found
Constructive updating/downdating of oblique projectors: a generalization of the Gram-Schmidt process
A generalization of the Gram-Schmidt procedure is achieved by providing
equations for updating and downdating oblique projectors. The work is motivated
by the problem of adaptive signal representation outside the orthogonal basis
setting. The proposed techniques are shown to be relevant to the problem of
discriminating signals produced by different phenomena when the order of the
signal model needs to be adjusted.Comment: As it will appear in Journal of Physics A: Mathematical and
Theoretical (2007
On the Complexity of -Closeness Anonymization and Related Problems
An important issue in releasing individual data is to protect the sensitive
information from being leaked and maliciously utilized. Famous privacy
preserving principles that aim to ensure both data privacy and data integrity,
such as -anonymity and -diversity, have been extensively studied both
theoretically and empirically. Nonetheless, these widely-adopted principles are
still insufficient to prevent attribute disclosure if the attacker has partial
knowledge about the overall sensitive data distribution. The -closeness
principle has been proposed to fix this, which also has the benefit of
supporting numerical sensitive attributes. However, in contrast to
-anonymity and -diversity, the theoretical aspect of -closeness has
not been well investigated.
We initiate the first systematic theoretical study on the -closeness
principle under the commonly-used attribute suppression model. We prove that
for every constant such that , it is NP-hard to find an optimal
-closeness generalization of a given table. The proof consists of several
reductions each of which works for different values of , which together
cover the full range. To complement this negative result, we also provide exact
and fixed-parameter algorithms. Finally, we answer some open questions
regarding the complexity of -anonymity and -diversity left in the
literature.Comment: An extended abstract to appear in DASFAA 201
Arabidopsis ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity
Diphospho-myo-inositol polyphosphates, also termed inositol pyrophosphates, are molecular messengers containing at least one high-energy phosphoanhydride bond and regulate a wide range of cellular processes in eukaryotes. While inositol pyrophosphates InsP7 and InsP8 are present in different plant species, both the identity of enzymes responsible for InsP7 synthesis and the isomer identity of plant InsP7 remain unknown. This study demonstrates that Arabidopsis ITPK1 and ITPK2 catalyze the phosphorylation of phytic acid (InsP6) to the symmetric InsP7 isomer 5-InsP7 and that the InsP6 kinase activity of ITPK enzymes is evolutionarily conserved from humans to plants. We also show by 31P nuclear magnetic resonance that plant InsP7 is structurally identical to the in vitro InsP6 kinase products of ITPK1 and ITPK2. Our findings lay the biochemical and genetic basis for uncovering physiological processes regulated by 5-InsP7 in plants
The onset of electrospray: the universal scaling laws of the first ejection
The disintegration of liquid drops with low electrical conductivity and subject to an electric field
is investigated both theoretically and experimentally. This disintegration takes place through the
development of a conical cusp that eventually ejects an ultrathin liquid ligament. A first tiny drop is
emitted from the end of this ligament. Due to its exceptionally small size and large electric charge per
unit volume, that drop has been the object of relevant recent studies. In this paper, universal scaling
laws for the diameter and electric charge of the first issued droplet are proposed and validated both
numerically and experimentally. Our analysis shows how charge relaxation is the mechanism that
differentiates the onset of electrospray, including the first droplet ejection, from the classical steady
cone-jet mode. In this way, our study identifies when and where charge relaxation and electrokinetic
phenomena come into play in electrospray, a subject of live controversy in the field.Ministerio de Economía y Competitividad DPI2013-4648
Global stability analysis of axisymmetric liquid-liquid flow focusing
Article number A10We analyse both numerically and experimentally the stability of the steady jetting tip streaming produced by focusing a liquid stream with another liquid current when they coflow through the orifice of an axisymmetric nozzle. We calculate the global eigenmodes characterizing the response of this configuration to small-amplitude perturbations. In this way, the critical conditions leading to the instability of the steady jetting tip streaming are determined. The unstable perturbations are classified according to their oscillatory character and to the region where they originate (convective and absolute instability). We derive and explain in terms of the velocity field a simple scaling law to predict the diameter of the emitted jet. The numerical stability limits are compared with experimental results, finding reasonable agreement. The experiments confirm the existence of the two instability mechanisms predicted by the global stability analysisMinisterio de Economía, Industria y Competitividad (España) DPI2016-78887Junta de Extremadura GR18175Junta de Andalucía P18-FR-362
Emergence and spread of a new community-genotype methicillin-resistant Staphylococcus aureus clone in Colombia
© 2017 The Author(s). Background: Community-genotype methicillin-resistant Staphylococcus aureus (CG-MRSA) clones are a global concern due to their resistance and increased virulence and their ability to cause infections both hospitalized patients and healthy people in the community. Here, we characterize 32 isolates of a new CG-MRSA clone. These isolates were identified in four cities in Colombia, South America. Methods: The isolates were recovered from four different epidemiological and prospective studies that were conducted in several regions of Colombia. Molecular characterizations included multilocus sequence typing; pulsed-field gel electrophoresis; SCCmec, agr and spa typing; and whole-genome sequencing. Results: All isolates belonged to ST923 (clonal complex 8), harbouring SCCmec IVa and a spa type t1635 and lacking an arginine catabolism mobile element. The isolates were classified as COL923, were resistant to at least one non-beta-lactam antibiotic, and exhibited high frequencies (>60%) of resistance to macrolides and tetracycline. Using whole-genome sequencing, we found that this new clone harbours novel prophage 3 and beta-island structures and a slightly different pathogenicity island 5. Moreover, isolates belonging to the COL923 clone are grouped in a different clade than USA300 and USA300-LV. Conclusion: Our results show the emergence and spread of the COL923 clone in different cities in Colombia. This clone is resistant to several antibiotics and possesses new structures in its mobile genetic elements
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