24,966 research outputs found
Van der Waals Frictional Drag induced by Liquid Flow in Low- Dimensional Systems
We study the van der Waals frictional drag force induced by liquid flow in
low-dimensional systems (2D and 1D electron systems, and 2D and 1D channels
with liquid). We find that for both 1D and 2D systems, the frictional drag
force induced by liquid flow may be several orders of magnitude larger than the
frictional drag induced by electronic current.Comment: 10 pages, 4 figure
Electrocardiographic safety evaluation of dihydroartemisinin piperaquine in the treatment of uncomplicated falciparum malaria.
Dihydroartemisinin-piperaquine (DP) could become a leading fixed combination malaria treatment worldwide. Although there is accumulating evidence of efficacy and safety from clinical trials, data on cardiotoxicity are limited. In two randomized controlled trials in Thailand, 56 patients had ECGs performed before treatment, 4 hours after the first dose, and 4 hours after the last dose. The mean (95% CI) changes in QTc interval (Bazett's correction) were 2 (-6 to 9) ms and 14 (7 to 21) ms, respectively. These small changes on the third day of treatment are similar to those observed elsewhere in the convalescent phase following antimalarial treatment with drugs known to have no cardiac effects and are therefore likely to result from recovery from acute malaria and not the treatment given. At therapeutic doses, DP does not have clinically significant effects on the electrocardiogram
The quantized Hall conductance of a single atomic wire: A proposal based on synthetic dimensions
We propose a method by which the quantization of the Hall conductance can be
directly measured in the transport of a one-dimensional atomic gas. Our
approach builds on two main ingredients: (1) a constriction optical potential,
which generates a mesoscopic channel connected to two reservoirs, and (2) a
time-periodic modulation of the channel, specifically designed to generate
motion along an additional synthetic dimension. This fictitious dimension is
spanned by the harmonic-oscillator modes associated with the tightly-confined
channel, and hence, the corresponding "lattice sites" are intimately related to
the energy of the system. We analyze the quantum transport properties of this
hybrid two-dimensional system, highlighting the appealing features offered by
the synthetic dimension. In particular, we demonstrate how the energetic nature
of the synthetic dimension, combined with the quasi-energy spectrum of the
periodically-driven channel, allows for the direct and unambiguous observation
of the quantized Hall effect in a two-reservoir geometry. Our work illustrates
how topological properties of matter can be accessed in a minimal
one-dimensional setup, with direct and practical experimental consequences.
OpWise: Operons aid the identification of differentially expressed genes in bacterial microarray experiments
BACKGROUND: Differentially expressed genes are typically identified by analyzing the variation between replicate measurements. These procedures implicitly assume that there are no systematic errors in the data even though several sources of systematic error are known. RESULTS: OpWise estimates the amount of systematic error in bacterial microarray data by assuming that genes in the same operon have matching expression patterns. OpWise then performs a Bayesian analysis of a linear model to estimate significance. In simulations, OpWise corrects for systematic error and is robust to deviations from its assumptions. In several bacterial data sets, significant amounts of systematic error are present, and replicate-based approaches overstate the confidence of the changers dramatically, while OpWise does not. Finally, OpWise can identify additional changers by assigning genes higher confidence if they are consistent with other genes in the same operon. CONCLUSION: Although microarray data can contain large amounts of systematic error, operons provide an external standard and allow for reasonable estimates of significance. OpWise is available at
The COBE DIRBE Point Source Catalog
We present the COBE DIRBE Point Source Catalog, an all-sky catalog containing
infrared photometry in 10 bands from 1.25 microns to 240 microns for 11,788 of
the brightest near and mid-infrared point sources in the sky. Since DIRBE had
excellent temporal coverage (100 - 1900 independent measurements per object
during the 10 month cryogenic mission), the Catalog also contains information
about variability at each wavelength, including amplitudes of variation
observed during the mission. Since the DIRBE spatial resolution is relatively
poor (0.7 degrees), we have carefully investigated the question of confusion,
and have flagged sources with infrared-bright companions within the DIRBE beam.
In addition, we filtered the DIRBE light curves for data points affected by
companions outside of the main DIRBE beam but within the `sky' portion of the
scan. At high Galactic latitudes (|b| > 5 degrees), the Catalog contains
essentially all of the unconfused sources with flux densities greater than 90,
60, 60, 50, 90, and 165 Jy at 1.25, 2.2, 3.5, 4.9, 12, and 25 microns,
respectively, corresponding to magnitude limits of approximately 3.1, 2.6, 1.7,
1.3, -1.3, and -3.5. At longer wavelengths and in the Galactic Plane, the
completeness is less certain because of the large DIRBE beam and possible
contributions from extended emission. The Catalog also contains the names of
the sources in other catalogs, their spectral types, variability types, and
whether or not the sources are known OH/IR stars. We discuss a few remarkable
objects in the Catalog. [abridged]Comment: Accepted for publication in the Astrophysical Journal Supplement. The
full tables are available at http://www.etsu.edu/physics/bsmith/dirbe
The Dispersion Velocity of Galactic Dark Matter Particles
The self-consistent spatial distribution of particles of Galactic dark matter
is derived including their own gravitational potential, as also that of the
visible matter of the Galaxy. In order to reproduce the observed rotation curve
of the Galaxy the value of the dispersion velocity of the dark matter
particles, \rmsveldm, should be \sim 600\kmps or larger.Comment: RevTex, 4 pages, 1 ps figure, accepted for publication in Physical
Review Letter
A novel method for accurate operon predictions in all sequenced prokaryotes
We combine comparative genomic measures and the distance separating adjacent genes to predict operons in 124 completely sequenced prokaryotic genomes. Our method automatically tailors itself to each genome using sequence information alone, and thus can be applied to any prokaryote. For Escherichia coli K12 and Bacillus subtilis, our method is 85 and 83% accurate, respectively, which is similar to the accuracy of methods that use the same features but are trained on experimentally characterized transcripts. In Halobacterium NRC-1 and in Helicobacter pylori, our method correctly infers that genes in operons are separated by shorter distances than they are in E.coli, and its predictions using distance alone are more accurate than distance-only predictions trained on a database of E.coli transcripts. We use microarray data from six phylogenetically diverse prokaryotes to show that combining intergenic distance with comparative genomic measures further improves accuracy and that our method is broadly effective. Finally, we survey operon structure across 124 genomes, and find several surprises: H.pylori has many operons, contrary to previous reports; Bacillus anthracis has an unusual number of pseudogenes within conserved operons; and Synechocystis PCC 6803 has many operons even though it has unusually wide spacings between conserved adjacent genes
Evaluating an evidence-based care pathway for the management of anxiety and depression in cancer care
The Pan-STARRS1 Photometric System
The Pan-STARRS1 survey is collecting multi-epoch, multi-color observations of
the sky north of declination -30 deg to unprecedented depths. These data are
being photometrically and astrometrically calibrated and will serve as a
reference for many other purposes. In this paper we present our determination
of the Pan-STARRS photometric system: gp1, rp1, ip1, zp1, yp1, and wp1. The
Pan-STARRS photometric system is fundamentally based on the HST Calspec
spectrophotometric observations, which in turn are fundamentally based on
models of white dwarf atmospheres. We define the Pan-STARRS magnitude system,
and describe in detail our measurement of the system passbands, including both
the instrumental sensitivity and atmospheric transmission functions.
Byproducts, including transformations to other photometric systems, galactic
extinction, and stellar locus are also provided. We close with a discussion of
remaining systematic errors.Comment: 39 pages, 9 figures, machine readable table of bandpasses, accepted
for publication in Ap
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