Diseño de un modelo de datos de redes para el transporte multimodal

Esta comunicación tiene por objeto el análisis de las relaciones entre redes de transporte y paisaje. Se aborda el análisis de la estructura de la red y su caracterización, para dar soporte a la modelización de distintos escenarios, lo que implica un complejo modelo de datos en el que se trabaja con una red multimodal conformada por los siguientes modos: transporte por carretera, ferroviario, peatonal y náutico. Se hace hincapié en el transporte combinado que emplea los diferentes modos, como ocurre frecuentemente con el viaje turístico. El territorio en el que se construye el modelo, a partir de los mapas topográficos 1:5000 y 1.000, que se complementan con ortofotografía, es la isla de Tenerife.This paper explores the relationship between transport networks and landscape. The network structure and its characteristics are studied in order to support the modeling of different scenarios. This implies a complex data model which works with a multimodal network. It is composed by different features: roads, railroads, pedestrian paths and nautical tracks. A combined transport system (the touristic travel) employing different modalities is the focus of interest. Tenerife Island acts as a reference of this transport system. Base maps in 1:5000 and 1:1000 scales and a rectified photo are used

Psychometric properties of the mindfulness in teaching scale among Spanish teachers

Mindfulness in the educational field provides several benefits. The assessment of mindfulness is a fundamental previous step for evidence-based interventions. Therefore, the present study aimed to adapt and validate the Mindfulness in Teaching Scale (MTS) among Spanish teachers. This scale comprises 14 items on two dimensions: intrapersonal and interpersonal. The sample comprised 398 teachers (31% males, 68% females) whose ages ranged from 25 to 69 years (M = 44.14; SD = 10.16). Once the scale was adapted in Spanish, we examined its psychometric properties. To do so, we conducted a Confirmatory Factor analysis (CFA), which supported the two-factor structure. As evidence for validity, the MTS scores correlated with perceived teaching self-efficacy. The reliability values using Cronbach’s alpha were good. This scale has adequate psychometric properties and is useful for assessing mindfulness among Spanish teachers. We discuss its implications for the education field

Spherically symmetric dissipative anisotropic fluids: A general study

The full set of equations governing the evolution of self--gravitating spherically symmetric dissipative fluids with anisotropic stresses is deployed and used to carry out a general study on the behaviour of such systems, in the context of general relativity. Emphasis is given to the link between the Weyl tensor, the shear tensor, the anisotropy of the pressure and the density inhomogeneity. In particular we provide the general, necessary and sufficient, condition for the vanishing of the spatial gradients of energy density, which in turn suggests a possible definition of a gravitational arrow of time. Some solutions are also exhibited to illustrate the discussion.Comment: 28 pages Latex. To appear in Phys.Rev.

Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation

Homologous long non-coding RNAs (lncRNAs) are elusive to identify by sequence similarity due to their fast-evolutionary rate. Here we develop LincOFinder, a pipeline that finds conserved intergenic lncRNAs (lincRNAs) between distant related species by means of microsynteny analyses. Using this tool, we have identified 16 bona fide homologous lincRNAs between the amphioxus and human genomes. We characterized and compared in amphioxus and Xenopus the expression domain of one of them, Hotairm1, located in the anterior part of the Hox cluster. In addition, we analyzed the function of this lincRNA in Xenopus, showing that its disruption produces a severe headless phenotype, most probably by interfering with the regulation of the Hox cluster. Our results strongly suggest that this lincRNA has probably been regulating the Hox cluster since the early origin of chordates. Our work pioneers the use of syntenic searches to identify non-coding genes over long evolutionary distances and helps to further understand lncRNA evolution

Single-crystal-to-single-crystal transformation and catalytic properties of new hybrid perhalidometallates

Two new organic–inorganic salts of perhalidometallates with protonated organic amine cations have been synthesized and characterized by X-ray diffraction and thermal analysis. (CHBMAH2) ZnBr4·3/2H2O 1 and (CHBMAH2 )ZnCl4 4 [(CHBMAH2 )2+: 1, 3-cyclohexanebis(methylammonium)] were obtained in single-crystal form. The crystal packing in all of the obtained compounds is governed by the formation of various non-covalent intermolecular forces between tetrahalidometallate anions and organic cations, assisted by water molecules in the hydrates. Hirshfeld surface analysis denotes that the most important contributions to the crystal packing are X···H/H···X (X: Cl, Br, I) and H···H interactions. Interestingly, the compound 1, 3-cyclohexanebis(methylammonium)tetrachlorido-zincate (II) dihydrate, (CHBMAH2 )ZnCl4·2H2O 2, undergoes thermally-triggered single-crystal-to-single-crystal (SCSC) transformation upon dehydration to produce a supramolecular solid compound, 1, 3-cyclohexanebis(methylammonium) tetrachloridozincate (II), (CHBMAH2 )ZnCl4 4. The SCSC transformation causes changes in the lattice parameters and a structural rearrangement. Furthermore, the catalytic properties of (CHBMAH2 )ZnCl4·2H2O 2 and (CHBMAH2 )CdI4·2H2O 3 have been explored in the acetalization process using various uncommon alcohols, beyond methanol or ethanol, for the first time in the literature, with outstanding results, and opening the door to the formation of alternative acetals. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Clinical Relevance of Medicinal Plants and Foods of Vegetal Origin on the Activity of Cytochrome P450

Drug metabolism is a pharmacokinetic process whose main objective is to modify the chemical structure of drugs to easily excretable compounds. This process is carried out through phase I and phase II reactions. The enzymes of cytochrome P450 (CYP450) participate in phase I reactions, and their activity can be inhibited or induced by xenobiotics. The aim of this chapter is to study the clinical relevance of the induction and inhibition of CYP450, by describing the effect that some bioactive compounds present in medicinal plants or foods can modify, either increasing or decreasing the activity of CYP450 enzymes and with it modify the bioavailability and depuration of drugs. Examples will be described on the interaction of medicinal plants and foods of vegetal origin that when combined with some drugs can generate toxicity or therapeutic failure; this will allow gathering relevant information on the adequate pharmacological management in different clinical situations

Fifteen years controlling unwanted thoughts: A systematic review of the thought control ability questionnaire (TCAQ)

Thought control ability is a vulnerability factor implicated in the etiology and maintenance of emotional disorders. This manuscript aims to systematically review the use and psychometric performance of the Thought Control Ability Questionnaire (TCAQ), designed to assess people's ability to control unwanted thoughts. Three electronic databases were searched for papers administering the TCAQ published in indexed peer-reviewed journals. Data (participants characteristics, country, study design, etc.) were extracted from the results for qualitative synthesis. The TCAQ's content validity, dimensionality, internal consistency, test-retest reliability, convergent/divergent validity, floor/ceiling effects, and interpretability were summarized. Two reviewers independently screened articles and assessed quality taking COSMIN criteria into account. Finally, the review included 17 papers. The TCAQ has been administered to healthy individuals, students, and adult patients, in six languages from nine countries. We found that the TCAQ, and its shorter versions, demonstrate robust reliability and adequate content validity. Of interest is the TCAQ's capacity to predict performance in diverse experimental tasks focused on thought control. The TCAQ unidimensionality has been supported in exploratory and confirmatory factor analyses. Regarding construct validity, the TCAQ is significantly related to a wide range of psychopathological measures of anxiety, worry, depression, obsessive-compulsive symptoms, etc. However, as only a few of the included studies had a longitudinal design, we are unable to draw firm conclusions about the measure's temporal stability. Moreover, psychometric aspects such as factorial invariance across different samples have not been analyzed. Despite these limitations, based on available psychometric evidence we can recommend using the TCAQ for measuring perceived control of unwanted thoughts

Anestesia local y Sedación para Intubación con Fibrobroncoscopio de paciente con Vía Aérea Difícil

Presentamos el caso clínico de un varón de 60 años con vía aérea difícil que debía realizarse una tiroidectomía total por el diagnóstico de bocio multinodular tóxico y que, un mes antes, había tenido un intento fallido de intubación con fibrobroncoscopio

3D printed scaled setup for smoke transport analysis in a subterranean passenger platform

In this work, the study of smoke fire transportation inside of a subway passenger platform is presented. The study includes a set of numerical simulations to observe the behavior of the smoke inside the platform. Two smoke transport simulations using the FDS program are also included. Subsequently, the development of a 3D - 1:100 scale model is described and it was used to perform an experimental observation of the phenomenon. The model was built by using a 3D printer which allowed to include more architectural details of the real scenario. The inclusion of these details allowed to observe qualitative similarity between the results of the simulation and the experimental work. Although there are clear differences between what could happen in a real scenario and what was observed in the scale model, it was identified that the model is an important complement to the simulations. In addition to the simulations, the use of this type of 3D models allows the observation of the phenomenon by different specialists such as firefighters, policeman, medical personnel, etc., in the same place and its intention is to provide a more interactive tool to the observation group, increasing the time devoted to the development of contingency actions and reducing the costs associated with the logistics of a real simulacrum. The model allows to better identify the strengths, opportunities, weaknesses and threats of the contingency procedures developed by the safety and hygiene groups and to make their corresponding adjustments if necessary.Peer Reviewe