Microstructural abnormalities in deep and superficial white matter in youths with mild traumatic brain injury

BACKGROUND: Diffusion Tensor Imaging (DTI) studies of traumatic brain injury (TBI) have focused on alterations in microstructural features of deep white matter fibers (DWM), though post-mortem studies have demonstrated that injured axons are often observed at the gray-white matter interface where superficial white matter fibers (SWM) mediate local connectivity. OBJECTIVES: To examine microstructural alterations in SWM and DWM in youths with a history of mild TBI and examine the relationship between white matter alterations and attention. METHODS: Using DTIDWM fractional anisotropy (FA) and SWM FA in youths with mild TBI (TBI, n=63) were compared to typically developing and psychopathology matched control groups (n=63 each). Following tract-based spatial statistics, SWM FA was assessed by applying a probabilistic tractography derived SWM mask, and DWM FA was captured with a white matter fiber tract mask. Voxel-wise z-score calculations were used to derive a count of voxels with abnormally high and low FA for each participant. Analyses examined DWM and SWM FA differences between TBI and control groups, the relationship between attention and DWM and SWM FA and the relative susceptibility of SWM compared to DWM FA to alterations associated with mild TBI. RESULTS: Case-based comparisons revealed more voxels with low FA and fewer voxels with high FA in SWM in youths with mild TBI compared to both control groups. Equivalent comparisons in DWM revealed a similar pattern of results, however, no group differences for low FA in DWM were found between mild TBI and the control group with matched psychopathology. Slower processing speed on the attention task was correlated with the number of voxels with low FA in SWM in youths with mild TBI. CONCLUSIONS: Within a sample of youths with a history of mild TBI, this study identified abnormalities in SWM microstructure associated with processing speed. The majority of DTI studies of TBI have focused on long-range DWM fiber tracts, often overlooking the SWM fiber type

Relationship of neurite architecture to brain activity during task-based fMRI

Functional MRI (fMRI) has been widely used to examine changes in neuronal activity during cognitive tasks. Commonly used measures of gray matter macrostructure (e.g., cortical thickness, surface area, volume) do not consistently appear to serve as structural correlates of brain function. In contrast, gray matter microstructure, measured using neurite orientation dispersion and density imaging (NODDI), enables the estimation of indices of neurite density (neurite density index; NDI) and organization (orientation dispersion index; ODI) in gray matter. Our study explored the relationship among neurite architecture, BOLD (blood-oxygen-level-dependent) fMRI, and cognition, using a large sample (n = 750) of young adults of the human connectome project (HCP) and two tasks that index more cortical (working memory) and more subcortical (emotion processing) targeting of brain functions. Using NODDI, fMRI, structural MRI and task performance data, hierarchical regression analyses revealed that higher working memory- and emotion processing-evoked BOLD activity was related to lower ODI in the right DLPFC, and lower ODI and NDI values in the right and left amygdala, respectively. Common measures of brain macrostructure (i.e., DLPFC thickness/surface area and amygdala volume) did not explain any additional variance (beyond neurite architecture) in BOLD activity. A moderating effect of neurite architecture on the relationship between emotion processing task-evoked BOLD response and performance was observed. Our findings provide evidence that neuro-/social-affective cognition-related BOLD activity is partially driven by the local neurite organization and density with direct impact on emotion processing. In vivo gray matter microstructure represents a new target of investigation providing strong potential for clinical translation

Measurement Model Value Aspects of Teacher Leadership in Vocational Education

Teaching profession at present is very challenging and the teachers themselves must be prepared to deal with it. The issue of teachers and the teaching profession continue to gain attention and often widely debated whether in the media, among the general public and even discussed until the national level. Negative sentiment against teachers often receives media attention although not authentic, and it creates a feeling of prejudice and less happy society on the individual teacher. These issues need to be addressed wisely by all teachers and the parties involved so that the dignity of the profession remain respected. Teachers need to show good values of the students, school and community. This is important because there is value in teachers will influence others to stay in school or otherwise. People often look at the behavior of teachers and assess externally only. Teachers must have admirable traits that can guide and educate students to become excellent once formed their personal character. This study aimed to verify the instrument model aspects of the leadership of teachers in technical and vocational education. Specifically, the objectives of this study were to confirm the scale of the measurement model teacher leadership and to identify the reliability of the instrument model. This study used a questionnaire to collect data from respondents. The questionnaire used is divided into two parts, Part A and Part B Section A consisted of demographic data, while Part B contains 53 item questionnaire measuring aspects of the leadership of the teachers in improving teaching and student learning, teacher leadership skills in improve relations and cooperation with the community and other parties, leadership skills and attributes of teachers in skill lead. And practice leadership skills teacher professional learning for continuous improvement. The study population consisted of all students of semester 8, IPG Zone east coast of peninsular Malaysia. This study used a sample of all the population to study. However, only 153 questionnaires that can be used for analysis and the respondents for this survey. This questionnaire has been validated by a panel of experts consisting of a lecturer who specializes in the study in IPGK Zone east coast of Malaysia, to get the validity of the content. The questionnaire was constructed and tested for suitability in the context of teacher education in IPGK Zone east coast of Malaysia

Data visualization of temporal ozone pollution between urban and sub-urban locations in Selangor Malaysia

In Malaysian environment, ground level zone has been reported as one of the most important pollutants that contribute to air quality degradation. The odourless and invisible nature of the pollutant has caused problems for individuals to realize and notice the existence of Ozone pollution in the environment. Thus, this study was conducted with the aim to assess and visualize the occurrence of potential Ozone pollution severity of two chosen locations in Selangor, Malaysia: Shah Alam (urban) and Banting (sub-urban). Data visualization analytics were employed using Ozone exceedances and Principal Component Analysis (PCA). The study results have shown an increasing pattern of Ozone pollution occurrence with several modes of distinct diurnal variations at the locations. The study also provides strong insights that Banting might experience a higher potential for Ozone pollution severity compared to Shah Alam.Keywords: ozone pollution; air quality; data visualization; data analytics; principalcomponent analysis

Myelin-Associated Glycoprotein Gene and Brain Morphometry in Schizophrenia

Myelin and oligodendrocyte disruption may be a core feature of schizophrenia pathophysiology. The purpose of the present study was to localize the effects of previously identified risk variants in the myelin-associated glycoprotein (MAG) gene on brain morphometry in schizophrenia patients and healthy controls. Forty-five schizophrenia patients and 47 matched healthy controls underwent clinical, structural magnetic resonance imaging, and genetics procedures. Gray and white matter cortical lobe volumes along with hippocampal volumes were calculated from T1-weighted MRI scans. Each subject was also genotyped for the two disease-associated MAG single nucleotide polymorphisms (rs720308 and rs720309). Repeated measures general linear model (GLM) analysis found significant region by genotype and region by genotype by diagnosis interactions for the effects of MAG risk variants on lobar gray matter volumes. No significant associations were found with lobar white matter volumes or hippocampal volumes. Follow-up univariate GLMs found the AA genotype of rs720308 predisposed schizophrenia patients to left temporal and parietal gray matter volume deficits. These results suggest that the effects of the MAG gene on cortical gray matter volume in schizophrenia patients can be localized to temporal and parietal cortices. Our results support a role for MAG gene variation in brain morphometry in schizophrenia, align with other lines of evidence implicating MAG in schizophrenia, and provide genetically based insight into the heterogeneity of brain imaging findings in this disorder

Psychometric Properties of the Inventory of Statements about Self-Injury (ISAS) in Iranian Opioid and Alcohol Abusers

Background: Non-suicidal self-injury (NSSI) is one of the most dangerous behaviors linked to substance abuse. The Inventory of Statements About Self-Injury (ISAS) has been developed to better understanding the factors associated with the onset and maintenance of NSSI behaviors. Objective: The ISAS was translated into the Persian language to study its psychometric properties in Iranian population of opioid and alcohol abusers. Methods: This is a psychometric study investigating opioid and alcohol abusers in Iran, including those residing in addiction rehabilitation camps, prisons, hospitals, and addiction treatment clinics dispensing methadone in 2017. The sample size of this study was 470. The subjects completed the Inventory of Statements About Self-Injury, Barrat Impulsiveness Scale (BIS), and the Distress Tolerance Scale (DTS). Results: The test-retest results were estimated for two weeks using the Intra-class Correlation Coefficient (ICC). The absolute reliability was determined to be 2.62. There was a significant correlation between convergent and divergent instruments. The results of the exploratory factor analysis on 235 individuals in the sample showed all subscales of the inventory measure a single factor in the Iranian population. The total Cronbach�s alpha coefficient for this subscale was 0.93. Also, the results of confirmatory factor analyses on the rest of the sample (235), after applying the AMOS software suggestions to improve the model, showed this inventory was a good indicator for this population (�2 = 131.69; P < 0.001; df = 56; �2/df = 2.35; CFI = 0.97; RMSEA = 0.76; GFI = 0.92). Conclusions: The Persian version of the Inventory of Statements About Self-Injury has high validity and reliability among the opioid and alcohol-abusing population in Iran. Copyright © 2020, Author(s)

Microbial contamination of keyboards and electronic equipment of ICU (Intensive Care Units) in Kashan University of medical sciences and health service hospitals

Microbial contamination of computer keyboards and inanimate surfaces of electronic equipment in ICU (Intensive Care Units) can have a significant role for ICU-acquired colonization and a spectrum of nosocomial infections. The aim of this study was to survey the incidence of bacterial contamination and the distribution of species of computer keyboards and inanimate surfaces of bed side equipment in ICUs in Kashan University of medical sciences and health service hospitals. This descriptive, cross-sectional study was done on 75 computer keyboards and inanimate surfaces electronic equipment in 5 ICUs during 2016�2017. Samples were collected from computer keyboards and electronic equipment with normal saline rinsed swabs. Samples were Cultivated on Blood Agar (BA), and MacConkey Agar (MAC) and growing bacteria were identified based on their morphology and biochemical properties. Seventy six (76) out of 75 computer Keyboards and electronic equipment were contaminated with bacteria and fungi. The most contamination pertained to gram positive bacteria (70.7) and the most isolated bacteria were coagulase-negative staphylococci. The highest contamination rates were found on computer keyboards and electronic equipment of which were nurses. � This study demonstrates that monitoring inanimate surfaces and considering these surfaces as source of nosocomial infections is necessary. � In total, Seventy six (76) out of 75 computer keyboards and electronic equipment in ICUs had positive culture. � It can be concluded that it is necessary for ICUs of Kashan university of medical sciences and Health service hospitals to have practical and regular program to reduce nosocomial infections. © 2019 The Author(s

Microbial contamination of keyboards and electronic equipment of ICU (Intensive Care Units) in Kashan University of medical sciences and health service hospitals

Microbial contamination of computer keyboards and inanimate surfaces of electronic equipment in ICU (Intensive Care Units) can have a significant role for ICU-acquired colonization and a spectrum of nosocomial infections. The aim of this study was to survey the incidence of bacterial contamination and the distribution of species of computer keyboards and inanimate surfaces of bed side equipment in ICUs in Kashan University of medical sciences and health service hospitals. This descriptive, cross-sectional study was done on 75 computer keyboards and inanimate surfaces electronic equipment in 5 ICUs during 2016�2017. Samples were collected from computer keyboards and electronic equipment with normal saline rinsed swabs. Samples were Cultivated on Blood Agar (BA), and MacConkey Agar (MAC) and growing bacteria were identified based on their morphology and biochemical properties. Seventy six (76) out of 75 computer Keyboards and electronic equipment were contaminated with bacteria and fungi. The most contamination pertained to gram positive bacteria (70.7) and the most isolated bacteria were coagulase-negative staphylococci. The highest contamination rates were found on computer keyboards and electronic equipment of which were nurses. � This study demonstrates that monitoring inanimate surfaces and considering these surfaces as source of nosocomial infections is necessary. � In total, Seventy six (76) out of 75 computer keyboards and electronic equipment in ICUs had positive culture. � It can be concluded that it is necessary for ICUs of Kashan university of medical sciences and Health service hospitals to have practical and regular program to reduce nosocomial infections. © 2019 The Author(s