The erosion of nongambling spheres by smartphone gambling: a qualitative study on workplace and domestic disordered gambling

The potential dangers of internet-based gambling as compared with more traditional land-based gambling have been increasingly investigated over the past decade. The general consensus appears to be that although internet gambling might not be a more dangerous medium for gambling per se, the 24/7 availability it generates for problem gamblers, however, is. Because smartphones have become the most used way of gambling online, internet gambling must, therefore, be further subcategorized according to the device by which it is accessed. This study examines the issue by exploring the views of smartphone gamblers undergoing treatment for gambling disorder in focus group settings (N=35). Utilizing thematic analysis, the paper shows that smartphone gambling has colonized spaces previously regarded as nongambling spheres. The workplace, especially in male-dominated contexts, emerged as an accommodator and stimulator of gambling behavior, raising issues of productivity rather than criminality. Domestic gambling was mostly characterized by an invasion of bathroom and bedtime spheres of intimacy. The study examines the implications of prevention and treatment, focusing on the minimization of exposure to gambling stimuli, the erosion of intimacy that recovering gamblers must endure, and the necessity of embracing a broader definition of gambling-related harm

Inflammatory and metabolic responses to high-fat meals with and without dairy products in men.

Postprandial inflammation is an important factor for human health since chronic low-grade inflammation is associated with chronic diseases. Dairy products have a weak but significant anti-inflammatory effect on postprandial inflammation. The objective of the present study was to compare the effect of a high-fat dairy meal (HFD meal), a high-fat non-dairy meal supplemented with milk (HFM meal) and a high-fat non-dairy control meal (HFC meal) on postprandial inflammatory and metabolic responses in healthy men. A cross-over study was conducted in nineteen male subjects. Blood samples were collected before and 1, 2, 4 and 6 h after consumption of the test meals. Plasma concentrations of insulin, glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, TAG and C-reactive protein (CRP) were measured at each time point. IL-6, TNF-α and endotoxin concentrations were assessed at baseline and endpoint (6 h). Time-dependent curves of these metabolic parameters were plotted, and the net incremental AUC were found to be significantly higher for TAG and lower for CRP after consumption of the HFM meal compared with the HFD meal; however, the HFM and HFD meals were not different from the HFC meal. Alterations in IL-6, TNF-α and endotoxin concentrations were not significantly different between the test meals. The results suggest that full-fat milk and dairy products (cheese and butter) have no significant impact on the inflammatory response to a high-fat meal

Promoting bioengineered tooth innervation using nanostructured and hybrid scaffolds

The innervation of teeth mediated by axons originating from the trigeminal ganglia is essential for their function and protection. Immunosuppressive therapy using Cyclosporine A (CsA) was found to accelerate the innervation of transplanted tissues and particularly that of bioengineered teeth. To avoid the CsA side effects, we report in this study the preparation of CsA loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles, their embedding on polycaprolactone (PCL)-based scaffolds and their possible use as templates for the innervation of bioengineered teeth. This PCL scaffold, approved by the FDA and capable of mimicking the extracellular matrix, was obtained by electrospinning and decorated with CsA-loaded PLGA nanoparticles to allow a local sustained action of this immunosuppressive drug. Dental re-associations were co-implanted with a trigeminal ganglion on functionalized scaffolds containing PLGA and PLGA/cyclosporine in adult ICR mice during 2 weeks. Histological analyses showed that the designed scaffolds did not alter the teeth development after in vivo implantation. The study of the innervation of the dental re-associations by indirect immunofluorescence and transmission electron microscopy (TEM), showed that 88.4% of the regenerated teeth were innervated when using the CsA-loaded PLGA scaffold. The development of active implants thus allows their potential use in the context of dental engineering. Statement of Significance Tooth innervation is essential for their function and protection and this can be promoted in vivo using polymeric scaffolds functionalized with immunosuppressive drug-loaded nanoparticles. Immunosuppressive therapy using biodegradable nanoparticles loaded with Cyclosporine A was found to accelerate the innervation of bioengineered teeth after two weeks of implantation

Anomalous relaxation and self-organization in non-equilibrium processes

We study thermal relaxation in ordered arrays of coupled nonlinear elements with external driving. We find, that our model exhibits dynamic self-organization manifested in a universal stretched-exponential form of relaxation. We identify two types of self-organization, cooperative and anti-cooperative, which lead to fast and slow relaxation, respectively. We give a qualitative explanation for the behavior of the stretched exponent in different parameter ranges. We emphasize that this is a system exhibiting stretched-exponential relaxation without explicit disorder or frustration.Comment: submitted to PR

Problem gambling: a suitable case for social work?

Problem gambling attracts little attention from health and social care agencies in the UK. Prevalence surveys suggest that 0.6% of the population are problem gamblers and it is suggested that for each of these individuals, 10–17 other people, including children and other family members, are affected. Problem gambling is linked to many individual and social problems including: depression, suicide, significant debt, bankruptcy, family conflict, domestic violence, neglect and maltreatment of children and offending. This makes the issue central to social work territory. Yet, the training of social workers in the UK has consistently neglected issues of addictive behaviour. Whilst some attention has been paid in recent years to substance abuse issues, there has remained a silence in relation to gambling problems. Social workers provide more help for problems relating to addictions than other helping professions. There is good evidence that treatment, and early intervention for gambling problems, including psycho-social and public health approaches, can be very effective. This paper argues that problem gambling should be moved onto the radar of the social work profession, via inclusion on qualifying and post-qualifying training programmes and via research and dissemination of good practice via institutions such as the Social Care Institute for Excellence (SCIE). Keywords: problem gambling; addictive behaviour; socia

INTEGRAL and Swift/XRT observations of the source PKS 0208-512

The active galaxy PKS 0208-512, detected at lower energies by COMPTEL, has been claimed to be a MeV blazar from EGRET. We report on the most recent INTEGRAL observations of the blazar PKS 0208-512, which are supplemented by Swift ToO observations. The high energy X-ray and gamma-ray emission of PKS 0208-512 during August - December 2008 has been studied using 682 ks of INTEGRAL guest observer time and ~ 56 ks of Swift/XRT observations. These data were collected during the decay of a gamma-ray flare observed by Fermi/LAT. At X-ray energies (0.2 - 10 keV) PKS 0208-512 is significantly detected by Swift/XRT, showing a power-law spectrum with a photon index of ~ 1.64. Its X-ray luminosity varied by roughly 30% during one month. At hard X-/soft gamma-ray energies PKS 0208-512 shows a marginally significant (~ 3.2 sigma) emission in the 0.5-1 MeV band when combining all INTEGRAL/SPI data. Non-detections at energies below and above this band by INTEGRAL/SPI may indicate intrinsic excess emission. If this possible excess is produced by the blazar, one possible explanation could be that its jet consists of an abundant electron-positron plasma, which may lead to the emission of an annihilation radiation feature. Assuming this scenario, we estimate physical parameters of the jet of PKS 0208-512.Comment: accepted for publication in A&

Fast relaxation in a fragile liquid under pressure

The incoherent dynamic structure factor of ortho-terphenyl has been measured by neutron time-of-flight and backscattering technique in the pressure range from 0.1 MPa to 240 MPa for temperatures between 301 K and 335 K. Tagged-particle correlations in the compressed liquid decay in two steps. The alpha-relaxation lineshape is independent of pressure, and the relaxation time proportional to viscosity. A kink in the amplitude f_Q(P) reveals the onset of beta relaxation. The beta-relaxation regime can be described by the mode-coupling scaling function; amplitudes and time scales allow a consistent determination of the critical pressure P_c(T). alpha and beta relaxation depend in the same way on the thermodynamic state; close to the mode-coupling cross-over, this dependence can be parametrised by an effective coupling Gamma ~ n*T**{-1/4}.Comment: 4 Pages of RevTeX, 4 figures (submitted to Physical Review Letters

Simultaneous multi-wavelength observations of the TeV Blazar Mrk 421 during February - March 2003: X-ray and NIR correlated variability

In the present paper, we have reported the result of simultaneous multi-wavelength observations of the TeV blazar Mrk 421 during February $-$ March 2003. In this period, we have observed Mrk 421 using Pachmarhi Array of \v{C}erenkov Telescopes (PACT) of Tata Institute of Fundamental Research at Pachmarhi, India. Other simultaneous data were taken from the published literature and public data archives. We have analyzed the high quality X-ray (2-20 keV) observations from the NASA Rossi X-Ray Timing Explorer (RXTE). We have seen a possible correlated variability between X-ray and J band (1.25 $\mu$) near infrared (NIR) wavelength. This is the first case of X-ray and NIR correlated variability in Mrk 421 or any high energy peaked (HBL) blazar. The correlated variability reported here is indicating a similar origin for NIR and X-ray emission. The emission is not affected much by the environment of the surrounding medium around the central engine of the Mrk 421. The observations are consistent with the shock-in-jet model for the emission of radiations.Comment: 11 pages, 5 figures, Accepted for Publication in ChJA

Kinetics of photoinduced ordering in azo-dye films: two-state and diffusion models

We study the kinetics of photoinduced ordering in the azo-dye SD1 photoaligning layers and present the results of modeling performed using two different phenomenological approaches. A phenomenological two state model is deduced from the master equation for an ensemble of two-level molecular systems. Using an alternative approach, we formulate the two-dimensional (2D) diffusion model as the free energy Fokker-Planck equation simplified for the limiting regime of purely in-plane reorientation. The models are employed to interpret the irradiation time dependence of the absorption order parameters extracted from the available experimental data by using the exact solution to the light transmission problem for a biaxially anisotropic absorbing layer. The transient photoinduced structures are found to be biaxially anisotropic whereas the photosteady and the initial states are uniaxial.Comment: revtex4, 34 pages, 9 figure

Thermal Stabilization of the HCP Phase in Titanium

We have used a tight-binding model that is fit to first-principles electronic-structure calculations for titanium to calculate quasi-harmonic phonons and the Gibbs free energy of the hexagonal close-packed (hcp) and omega crystal structures. We show that the true zero-temperature ground-state is the omega structure, although this has never been observed experimentally at normal pressure, and that it is the entropy from the thermal population of phonon states which stabilizes the hcp structure at room temperature. We present the first completely theoretical prediction of the temperature- and pressure-dependence of the hcp-omega phase transformation and show that it is in good agreement with experiment. The quasi-harmonic approximation fails to adequately treat the bcc phase because the zero-temperature phonons of this structure are not all stable