Passive Janus Particles Are Self-propelled in Active Nematics

While active systems possess notable potential to form the foundation of new classes of autonomous materials, designing systems that can extract functional work from active surroundings has proven challenging. In this work, we extend these efforts to the realm of designed active liquid crystal/colloidal composites. We propose suspending colloidal particles with Janus anchoring conditions in an active nematic medium. These passive Janus particles become effectively self-propelled once immersed into an active nematic bath. The self-propulsion of passive Janus particles arises from the effective $+1/2$ topological charge their surface enforces on the surrounding active fluid. We analytically study their dynamics and the orientational dependence on the position of a companion $-1/2$ defect. We predict that at sufficiently small activity, the colloid and companion defect remain bound to each other, with the defect strongly orienting the colloid to propel either parallel or perpendicular to the nematic. At sufficiently high activity, we predict an unbinding of the colloid/defect pair. This work demonstrates how suspending engineered colloids in active liquid crystals may present a path to extracting activity to drive functionality.Comment: 14 pages, 9 figure

Anisotropic run-and-tumble-turn dynamics

Run-and-tumble processes successfully model several living systems. While studies have typically focused on particles with isotropic tumbles, recent examples exhibit “tumble-turns", in which particles undergo 90° tumbles and so possess explicitly anisotropic dynamics. We study the consequences ofsuch tumble-turn anisotropicity at both short and long-time scales. We model run-and-tumble-turn particles as self-propelled particles subjected to an angular potential that favors directions of movement parallel to Cartesian axes. Using agent-based simulations, we study the effects of the interplay between rotational diffusion and an aligning potential on the particles’ trajectories, whichleads to the right-angled turns. We demonstrate that the long-time effect is to alter the tumble-turn time, which governs the long-time dynamics. In particular, when normalized by this timescale, trajectories become independent of the underlying details of the potential. As such, we develop a simplified continuum theory, which quantitatively agrees with agent-based simulations. We find that the purely diffusive hydrodynamic limit still exhibits anisotropic features at intermediate times and conclude that the transition to diffusive dynamics precedes the transition to isotropic dynamics.By considering short-range repulsive and alignment particle-particle interactions, we show how theanisotropic features of a single particle are inherited by global order of the system. We hope thiswork will shed light on how active systems can extend local anisotropic properties to macroscopicscales, which might be important in biological processes occurring in anisotropic environment

The Cardiac Pacemaker Story—Fundamental Role of the Na+/Ca2+ Exchanger in Spontaneous Automaticity

The electrophysiological mechanism of the sinus node automaticity was previously considered exclusively regulated by the so-called “funny current”. However, parallel investigations increasingly emphasized the importance of the Ca$^{2+}$-homeostasis and Na+/ Ca$^{2+}$ exchanger (NCX). Recently, increasing experimental evidence, as well as insight through mechanistic in silico modeling demonstrates the crucial role of the exchanger in sinus node pacemaking. NCX had a key role in the exciting story of discovery of sinus node pacemaking mechanisms, which recently settled with a consensus on the coupled-clock mechanism after decades of debate. This review focuses on the role of the Na$^{+}$/Ca$^{2+}$ exchanger from the early results and concepts to recent advances and attempts to give a balanced summary of the characteristics of the local, spontaneous, and rhythmic Ca$^{2+}$ releases, the molecular control of the NCX and its role in the fight-or-flight response. Transgenic animal models and pharmacological manipulation of intracellular Ca$^{2+}$ concentration and/or NCX demonstrate the pivotal function of the exchanger in sinus node automaticity. We also highlight where specific hypotheses regarding NCX function have been derived from computational modeling and require experimental validation. Nonselectivity of NCX inhibitors and the complex interplay of processes involved in Ca$^{2+}$ handling render the design and interpretation of these experiments challenging

Microclimatological, Pedological, and Geomorphological Studies in the Western Tasersiaq Area, Greenland During Summer 1964

Final Report - 30 April 1964 -29 July 1965During the summer 1964, personnel of The Ohio State University Institute of Polar Studies conducted a field program in the Sukkertoppen Ice Cap area of southwest Greenland. The program included studies of soil and mass wasting in the Tasersiaq area immediately east of the ice cap, and studies of the microclimatology across the eastern edge of the ice cap. The results of this research program are contained in four parts. Part I, by Adolph Kryger, discusses the microclimatological (excluding radiation) results of observations taken at four stations, one at the base of the slope below the eastern edge of the Sukkertoppen Ice Cap, two intermediate ones on the slope, and one at the edge of the glacier. Part II, by Fritz Loewe, discusses the radiation observations. Both have related their observations to those at other permanent stations along the western Greenland coast. Part III, by K. R. Everett, presents the results of studies of mass-wasting and patterned ground phenomena. Part IV, by N. Holowaychuk and K. R. Everett, contains most of the results of the pedological studies. The report herein includes the discussion of soil morphology,chemistry, and classification.U.S. Army Natick Laboratories, Contract No. DA-19-129-AMC-301(N

Field of homogeneous Plane in Quantum Electrodynamics

We study quantum electrodynamics coupled to the matter field on singular background, which we call defect. For defect on the infinite plane we calculated the fermion propagator and mean electromagnetic field. We show that at large distances from the defect plane, the electromagnetic field is constant what is in agreement with the classical results. The quantum corrections determining the field near the plane are calculated in the leading order of perturbation theory.Comment: 16 page

ECGdeli - An open source ECG delineation toolbox for MATLAB

The electrocardiogram (ECG) is a standard cost-efficient and non-invasive tool for the early detection of various cardiac diseases. Quantifying different timing and amplitude features of and in between the single ECG waveforms can reveal important information about the underlying (dys-)function of the heart. Determining these features requires the detection of fiducial points that mark the on- and offset as well as the peak of each ECG waveform (P wave, QRS complex, T wave). Manually setting these points is time-consuming and requires a physician’s expert knowledge. Therefore, the highly modular ECGdeli toolbox for MATLAB was developed, which is capable of filtering clinically recorded 12-lead ECG signals and detecting the fiducial points, also called delineation. It is one of the few open toolboxes offering ECG delineation for P waves, T Waves and QRS complexes. The algorithms provided were evaluated with the QT database, an ECG database comprising 105 signals with fiducial points annotated by clinicians. The median difference between the fiducial points set by the boundary detection algorithm and the clinical annotations serving as a ground truth is less than 4 samples (16 ms) for the P wave and the QRS complex markers. The T wave onset, peak and offset were detected with a median difference of 5, 2 and 7 samples, respectively. Results were compared to two free algorithms available on PhysioNet. Our results show that ECGdeli can reliably detect P waves, QRS complexes and T waves. Thus, it can contribute to diagnose specific cardiac diseases by analyzing the ECG signal. As ECGdeli is published under GNU GPLv3 and thanks to its modularity, it can be used to extend existing algorithms or as a benchmark for new algorithms

The Han documents from Chuyen.

Abstract Not Provided

Helical Flow States in Active Nematics

We show that confining extensile nematics in 3D channels leads to the emergence of two self-organized flow states with nonzero helicity. The first is a pair of braided anti-parallel streams - this double helix occurs when the activity is moderate, anchoring negligible and reduced temperature high. The second consists of axially aligned counter-rotating vortices - this grinder train arises between spontaneous axial streaming and the vortex lattice. These two unanticipated helical flow states illustrate the potential of active fluids to break symmetries and form complex but organized spatio-temporal structures in 3D fluidic devices.Comment: 4 pages, 4 figures, appendice

Optical lattice quantum simulator for QED in strong external fields: spontaneous pair creation and the Sauter-Schwinger effect

Spontaneous creation of electron-positron pairs out of the vacuum due to a strong electric field is a spectacular manifestation of the relativistic energy-momentum relation for the Dirac fermions. This fundamental prediction of Quantum Electrodynamics (QED) has not yet been confirmed experimentally as the generation of a sufficiently strong electric field extending over a large enough space-time volume still presents a challenge. Surprisingly, distant areas of physics may help us to circumvent this difficulty. In condensed matter and solid state physics (areas commonly considered as low energy physics), one usually deals with quasi-particles instead of real electrons and positrons. Since their mass gap can often be freely tuned, it is much easier to create these light quasi-particles by an analogue of the Sauter-Schwinger effect. This motivates our proposal of a quantum simulator in which excitations of ultra-cold atoms moving in a bichromatic optical lattice represent particles and antiparticles (holes) satisfying a discretized version of the Dirac equation together with fermionic anti-commutation relations. Using the language of second quantization, we are able to construct an analogue of the spontaneous pair creation which can be realized in an (almost) table-top experiment.Comment: 21 pages, 10 figure

Quantification and classification of potassium and calcium disorders with the electrocardiogram: What do clinical studies, modeling, and reconstruction tell us?

Diseases caused by alterations of ionic concentrations are frequently observed challenges and play an important role in clinical practice. The clinically established method for the diagnosis of electrolyte concentration imbalance is blood tests. A rapid and non-invasive point-of-care method is yet needed. The electrocardiogram (ECG) could meet this need and becomes an established diagnostic tool allowing home monitoring of the electrolyte concentration also by wearable devices. In this review, we present the current state of potassium and calcium concentration monitoring using the ECG and summarize results from previous work. Selected clinical studies are presented, supporting or questioning the use of the ECG for the monitoring of electrolyte concentration imbalances. Differences in the findings from automatic monitoring studies are discussed, and current studies utilizing machine learning are presented demonstrating the potential of the deep learning approach. Furthermore, we demonstrate the potential of computational modeling approaches to gain insight into the mechanisms of relevant clinical findings and as a tool to obtain synthetic data for methodical improvements in monitoring approaches