Rindler Particles and Classical Radiation

We describe the quantum and classical radiation by a uniformly accelerating point source in terms of the elementary processes of absorption and emission of Rindler scalar photons of the Fulling-Davies-Unruh bath observed by a co-accelerating observer.To this end we compute the emission rate by a DeWitt detector of a Minkowski scalar particle with defined transverse momentum per unit of proper time of the source and we show that it corresponds to the induced absorption or spontaneous and induced emission of Rindler photons from the thermal bath. We then take what could be called the inert limit of the DeWitt detector by considering the limit of zero gap energy. As suggested by DeWitt, we identify in this limit the detector with a classical point source and verify the consistency of our computation with the classical result. Finally, we study the behavior of the emission rate in D space-time dimensions in connection with the so called apparent statistics inversion.Comment: 8 pages, 2 figure

Exportaci?n de sacha inchi al mercado de Estados Unidos

Las caracter?sticas nutritivas del sacha Inchi, debidas a la cantidad de ?cidos grasos omega 3 que posee, han motivado que agricultores y empresas inicien la explotaci?n de esta semilla con el prop?sito de exportar sus derivados en el futuro. Sin embargo, su cultivo se realiza de manera artesanal y poco tecnificada y, en el caso de las exportaciones, estas no se sustentan en el an?lisis t?cnico del mercado externo, sino en contactos directos con algunos potenciales clientes. Abona a favor de la exportaci?n el que la tendencia mundial de consumo de aceites vegetales se haya incrementado en los ?ltimos a?os. Estados Unidos es el segundo mercado m?s importante, pues ah? la poblaci?n es cada vez m?s consciente de la necesidad de una alimentaci?n sana, nutritiva y equilibrada para evitar problemas de salud, lo que incluye el menor consumo de grasas de origen animal. Por estas razones, la presente investigaci?n busca establecer si es posible desarrollar un modelo de negocio exitoso que permita viabilizar la exportaci?n de los derivados del sacha inchi con est?ndares internacionales de competitividad global. Esta propuesta est? enmarcada en la producci?n de la empresa Agropex S.A.C., que produce aceite y est? interesada en la exportaci?n de este nuevo producto

Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma

Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, a known STAT3 regulator, is robustly silenced in MF tumor-stage and CTCL cells. OBJECTIVE: We studied here whether deregulation of miR-124 contributes to STAT3 pathway activation in CTCL. METHODS: We measured the effect of ectopic mir-124 expression in active phosphorylated STAT3 (p-STAT3) levels and evaluated the transcriptional impact of miR-124-dependent STAT3 pathway regulation by expression microarray analysis. RESULTS: We found that ectopic expression of miR-124 results in massive downregulation of activated STAT3 in different CTCL lines, which resulted in a significant alteration of genetic signatures related with gene transcription and proliferation such as MYC and E2F. CONCLUSIONS: Our study highlights the importance of the miR-124/STAT3 axis in CTCL and demonstrates that the STAT3 pathway is regulated through epigenetic mechanisms in these cells. Since deregulated STAT3 signaling has a major impact on CTCL initiation and progression, a better understanding of the molecular basis of the miR-124/STAT3 axis may provide useful information for future personalized therapies

Desarrollo de la oferta de caf?s de especialidad (Honey) con alta valoraci?n en taza para tostadores de Estados Unidos : plan de negocios para la empresa Peruvian Harvest Agronegocios SAC en joint venture con la CACFEVAM Ltda. en el valle de Alto Mayo (Regi?n San Mart?n)

El presente estudio tiene por objetivo proponer un modelo de negocio para la empresa Peruvian Harvest en Joint Venture con la Cooperativa Agraria Cafetalera Fe y Esperanza Valle del Alto Mayo Ltda., incrementando la calidad mediante la producci?n de caf?s especiales con proceso Honey, que permita a la empresa diversificar la oferta del productor frente al tostador, para ser m?s competitivos y tener la capacidad de negociar con mejores precios. Este plan de negocios est? enfocado en innovaci?n de proceso mediante la producci?n de caf?s especiales con procesos honey, contribuyendo al cuidado del medio ambiente, puesto que en este proceso el grano de caf? se separa del cerezo sin el uso de agua, sin procesos de fermentaci?n y lavado, y se convierte en un caf? ecol?gico; mediante este tipo de proceso el caf? sufre cambios en su composici?n, que permiten incrementar la calidad de taza del producto final que saldr? al mercado. El an?lisis econ?mico nos confirma que el plan de negocio es viable y rentable lo que permitir? el crecimiento de la empresa y la cooperativa, teniendo un VNA financiero positivo de S/1, 170,955 y una TIR de 45.27% y con una Tasa de descuento (CPPC) del 13.88%

ZNF577 Methylation Levels in Leukocytes From Women With Breast Cancer Is Modulated by Adiposity, Menopausal State, and the Mediterranean Diet

The methylation levels of ZNF577 in breast tumors has been previously identified as a possible epigenetic mark of breast cancer associated with obesity. The aim of the current study was to investigate differences in methylation levels of ZNF577 depending on obesity, menopausal state and dietary pattern in blood leukocytes, a non-invasive sample. The methylation levels of ZNF577 of two CpG sites (CpGs) located in promoter and island previously identified as differentially methylated according to adiposity and menopausal state by 450 k array (cg10635122, cg03562414) were evaluated by pyrosequencing in DNA from the blood leukocytes of breast cancer patients [n = 90; n = 64 (71.1%) overweight/obesity and n = 26 (28.9%) normal-weight] and paired tumor tissue biopsies (n = 8 breast cancer patients with obesity; n = 3/5 premenopausal/postmenopausal women). Differences in methylation levels were evaluated at each CpGs individually and at the mean of the two evaluated CpGs. Adherence to the Mediterranean diet was evaluated using the MEDAS-validated questionnaire, and the consumption of food groups of interest was also evaluated using the recommended intakes of the Sociedad Espanola de Nutricion Comunitaria. The methylation levels of ZNF577 were correlated between paired leukocytes and breast tumor biopsies (r = 0.62; p = 0.001). Moreover, higher methylation was found in leukocytes from patients with obesity (p = 0.002) and postmenopausal patients (p = 0.022) than patients with normal-weight or premenopausal, respectively. After adjusting for the body mass index and age, higher levels of ZNF577 methylation were also found in women with greater adherence to the Mediterranean diet (p = 0.017) or specific foods. Relevantly, the methylation levels of ZNF577 showed a good ability for fish consumption detection [area under the ROC curve (AUC) = 0.72; p = 0.016]. In conclusion, the association between methylation of ZNF577 and adiposity, menopausal state, and adherence to the Mediterranean diet can be detected in the blood leukocytes. The results guarantee the need of performing further studies in longer longitudinal cohorts in order to elucidate the role of ZNF577 methylation in the association between breast cancer, adiposity and dietary patterns

Increased RPA1 gene dosage affects genomic stability potentially contributing to 17p13.3 duplication syndrome

A novel microduplication syndrome involving various-sized contiguous duplications in 17p13.3 has recently been described, suggesting that increased copy number of genes in 17p13.3, particularly PAFAH1B1, is associated with clinical features including facial dysmorphism, developmental delay, and autism spectrum disorder. We have previously shown that patient-derived cell lines from individuals with haploinsufficiency of RPA1, a gene within 17p13.3, exhibit an impaired ATR-dependent DNA damage response (DDR). Here, we show that cell lines from patients with duplications specifically incorporating RPA1 exhibit a different although characteristic spectrum of DDR defects including abnormal S phase distribution, attenuated DNA double strand break (DSB)-induced RAD51 chromatin retention, elevated genomic instability, and increased sensitivity to DNA damaging agents. Using controlled conditional over-expression of RPA1 in a human model cell system, we also see attenuated DSB-induced RAD51 chromatin retention. Furthermore, we find that transient over-expression of RPA1 can impact on homologous recombination (HR) pathways following DSB formation, favouring engagement in aberrant forms of recombination and repair. Our data identifies unanticipated defects in the DDR associated with duplications in 17p13.3 in humans involving modest RPA1 over-expression

Recent developments of the Hierarchical Reference Theory of Fluids and its relation to the Renormalization Group

The Hierarchical Reference Theory (HRT) of fluids is a general framework for the description of phase transitions in microscopic models of classical and quantum statistical physics. The foundations of HRT are briefly reviewed in a self-consistent formulation which includes both the original sharp cut-off procedure and the smooth cut-off implementation, which has been recently investigated. The critical properties of HRT are summarized, together with the behavior of the theory at first order phase transitions. However, the emphasis of this presentation is on the close relationship between HRT and non perturbative renormalization group methods, as well as on recent generalizations of HRT to microscopic models of interest in soft matter and quantum many body physics.Comment: 17 pages, 5 figures. Review paper to appear in Molecular Physic