Microsomal superoxide anion production and NADPH-oxidation in a series of 22 aziridinylbenzoquinones

Several 2,5-bis(1-aziridinyl)-1,4-benzoquinones (BABQs) can be activated to alkylating species by reduction of the quinone moiety. On the other hand, cytotoxicity of these compounds can be induced by redox cycling. A series of BABQs and their methylated analogues (BMABQs) with different substituents at the 3- and 6-position was synthesized in order to investigate the influence of the substituents on the reduction of the quinone moiety and on the generation of superoxide anion radicals with rat liver microsomes. Superoxide anion production (SAP) ranged from 3.7±0.1 to 742±74 nmoles/min/mg protein with quinone concentrations of 10 nmoles/ml. NADPH-oxidation was measured under the same conditions and it correlated well (r = 0.88, P < 0.001) with SAP. It ranged from 1.4±0.2 to 494±60 nmoles/min/mg protein. SAP for 22 B(M)ABQs showed a good correlation with the summated electronic substituent constant θpara,total (r = 0.86, P < 0.001). It can be concluded that superoxide anion production by 22 B(M)ABQs in rat liver microsomes can be predicted from structural features of the compounds

A Model of Global Positioning System (GPS) Master Control Station (MCS) Operations

The United States Air Force\u27s Navstar Global Positioning System (GPS) provides high-accuracy space-based navigation and time distribution to suitably- equipped military and civilian users. The system consists of earth-orbiting satellites and a world-wide network of ground stations. A single operational control center, the GPS Master Control Station (MCS) monitors, maintains, and commands the GPS satellite constellation. The on-going deployment of the complete satellite constellation and recent changes in the operational crew structure may invalidate previously used planning and management paradigms. There is currently no analytical method for predicting the impact of these and other environmental changes on system parameters and performance. Extensive testing cannot be performed at the MCS itself due to the criticality of the GPS mission and lack of operational redundancy. This research provides and validates a discrete event simulation model of the MCS operations center task flow, focusing on the creation and testing of a sliding-window MCS activity scheduler. The simulation was validated using MCS historical data. Experiments were conducted by varying the number of ground stations and satellite constellation size available to the simulation. The results, while not quantitatively trustworthy, were used to draw general conclusions about the GPS operational environment

Worrying and rumination are both associated with reduced cognitive control

Persistent negative thought is a hallmark feature of both major depressive disorder and generalized anxiety disorder. Despite its clinical significance, little is known about the underlying mechanisms of persistent negative thought. Recent studies suggest that reduced cognitive control might be an explanatory factor. We investigated the association between persistent negative thought and switching between internal representations in working memory, using the internal shift task (IST). The IST was administered to a group of undergraduates, classified as high-ruminators versus low-ruminators, or high-worriers versus low-worriers. Results showed that high-ruminators and high-worriers have more difficulties to switch between internal representations in working memory as opposed to low-ruminators and low-worriers. Importantly, results were only significant when the negative stimuli used in the IST reflected personally relevant worry themes for the participants. The results of this study indicate that rumination and worrying are both associated with reduced cognitive control for verbal information that is personally relevant

A Backtracking-Based Algorithm for Computing Hypertree-Decompositions

Hypertree decompositions of hypergraphs are a generalization of tree decompositions of graphs. The corresponding hypertree-width is a measure for the cyclicity and therefore tractability of the encoded computation problem. Many NP-hard decision and computation problems are known to be tractable on instances whose structure corresponds to hypergraphs of bounded hypertree-width. Intuitively, the smaller the hypertree-width, the faster the computation problem can be solved. In this paper, we present the new backtracking-based algorithm det-k-decomp for computing hypertree decompositions of small width. Our benchmark evaluations have shown that det-k-decomp significantly outperforms opt-k-decomp, the only exact hypertree decomposition algorithm so far. Even compared to the best heuristic algorithm, we obtained competitive results as long as the hypergraphs are not too large.Comment: 19 pages, 6 figures, 3 table

Editorial: Role of protein palmitoylation in synaptic plasticity and neuronal differentiation, volume II

No abstrac

Authentication and authorisation in entrusted unions

This paper reports on the status of a project whose aim is to implement and demonstrate in a real-life environment an integrated eAuthentication and eAuthorisation framework to enable trusted collaborations and delivery of services across different organisational/governmental jurisdictions. This aim will be achieved by designing a framework with assurance of claims, trust indicators, policy enforcement mechanisms and processing under encryption to address the security and confidentiality requirements of large distributed infrastructures. The framework supports collaborative secure distributed storage, secure data processing and management in both the cloud and offline scenarios and is intended to be deployed and tested in two pilot studies in two different domains, viz, Bio-security incident management and Ambient Assisted Living (eHealth). Interim results in terms of security requirements, privacy preserving authentication, and authorisation are reported

Is the sky the limit? an analysis of high-rise office buildings

Modern central business districts are characterised by high-rise office buildings. Helsley and Strange (2008) argue that skyscrapers are caused by agglomeration economies and a prize for being the tallest, so a reputation effect. We aim to test the relevance of this model by investigating the impact of building height on commercial office rents. The results show that firms are willing to pay about 4 percent more for a building that is 10 meters taller, which we interpret as the sum of a within-building agglomeration effect and a reputation effect. Using semiparametric techniques, we disentangle reputation effects from agglomeration effects and demonstrate that the reputation effect is substantial for tall buildings. For example, it is at least 17.5 percent of the rent for a building that is 6 times the average height

Direct patterning of functional interfaces in oxide heterostructures

We report on the direct patterning of high-quality structures incorporating the LaAlO3-SrTiO3 interface by an epitaxial-liftoff technique avoiding any reactive ion beam etching. Detailed studies of temperature dependent magnetotransport properties were performed on the patterned heterostructures with variable thickness of the LaAlO3 layer and compared to their unstructured thin film analogues. The results demonstrate the conservation of the high-quality interface properties in the patterned structures enabling future studies of low-dimensional confinement on high mobility interface conductivity as well as interface magnetism

Response time analysis of a live-cube compact storage system with two storage classes

We study a next generation of storage systems: live-cube compact storage systems. These systems are becoming increasingly popular, due to their small physical and environmental footprint paired with a large storage space. At each level of a live-cube system, multiple shuttles take care of themovement of unit loads in the x and y directions. When multiple empty locations are available, the shuttles can cooperate to create a virtual aisle for the retrieval of a desired unit load. A lift takes care of the movement across different levels in the z-direction. Two-class-based storage, in which high turnover unit loads are stored at storage locations closer to the Input/Output point, can result in a short response time. We study two-class-based storage for a live-cube system and derive closed-form formulas for the expected retrieval time. Although the system needs to be decomposed into several cases and sub-cases, we eventually obtain simple-to-use closed-form formulas to evaluate the performance of systems with any configuration and first zone boundary. Continuous-space closed-form formulas are shown to be very close to the results obtained for discretespace live-cube systems. The numerical results show that two-class-based storage can reduce the average response time of a live-cube system by up to 55% compared with random storage for the instances tested

Reconsidering the Impact of Informational Provision on Opinions of Suspended Sentences in the Netherlands: The Importance of Cultural Frames

A recent study scrutinized the effects of providing people with information about suspended sentences on their opinions of these sentences, and concluded that the impact is modest or even absent. Re-analyzing the original data, we demonstrate that this conclusion greatly underestimates the relevance of informational provision. Recognizing that information is framed differently by people with different cultural predispositions, we show that the effects of informational provision are much stronger among groups with specific penal attitudes than analyses of mere “direct” effects suggest. Even more importantly, the direction of these effects also depends on people’s penal attitudes; among specific groups, more information leads to less, instead of more, favorable opinions on suspended sentences