Cosmological neutrino bounds for non-cosmologists

I briefly review cosmological bounds on neutrino masses and the underlying gravitational physics at a level appropriate for readers outside the field of cosmology. For the case of three massive neutrinos with standard model freezeout, the current 95% upper limit on the sum of their masses is 0.42 eV. I summarize the basic physical mechanism making matter clustering such a sensitive probe of massive neutrinos. I discuss the prospects of doing still better in coming years using tools such as lensing tomography, approaching a sensitivity around 0.03 eV. Since the lower bound from atmospheric neutrino oscillations is around 0.05 eV, upcoming cosmological measurements should detect neutrino mass if the technical and fiscal challenges can be met.Comment: 4 pages, 2 figs, in "Neutrino Physics", Proceedings of Nobel Symposium 129, eds., L Bergstrom, O. Botner, P. Carlson, P. O. Hulth, and T. Ohlsso

Loop-induced photon spectral lines from neutralino annihilation in the NMSSM

We have computed the loop-induced processes of neutralino annihilation into two photons and, for the first time, into a photon and a Z boson in the framework of the NMSSM. The photons produced from these radiative modes are monochromatic and possess a clear "smoking gun" experimental signature. This numerical analysis has been done with the help of the SloopS code, initially developed for automatic one-loop calculation in the MSSM. We have computed the rates for different benchmark points coming from SUGRA and GMSB soft SUSY breaking scenarios and compared them with the MSSM. We comment on how this signal can be enhanced, with respect to the MSSM, especially in the low mass region of the neutralino. We also discuss the possibility of this observable to constrain the NMSSM parameter space, taking into account the latest limits from the FERMI collaboration on these two modes.Comment: 18 pages, 3 figures. Minor clarifications added in the text. Typing mistakes and references corrected. Matches published versio

International Network for Capacity Building for the Control of Emerging Viral Vector-Borne Zoonotic Diseases: Arbo-Zoonet

Arboviruses are arthropod-borne viruses, which include West Nile fever virus (WNFV), a mosquito-borne virus, Rift Valley fever virus (RVFV), a mosquito-borne virus, and Crimean-Congo haemorrhagic fever virus (CCHFV), a tick-borne virus. These arthropod-borne viruses can cause disease in different domestic and wild animals and in humans, posing a threat to public health because of their epidemic and zoonotic potential. In recent decades, the geographical distribution of these diseases has expanded. Outbreaks of WNF have already occurred in Europe, especially in the Mediterranean basin. Moreover, CCHF is endemic in many European countries and serious outbreaks have occurred, particularly in the Balkans, Turkey and Southern Federal Districts of Russia. In 2000, RVF was reported for the first time outside the African continent, with cases being confirmed in Saudi Arabia and Yemen. This spread was probably caused by ruminant trade and highlights that there is a threat of expansion of the virus into other parts of Asia and Europe. In the light of global warming and globalisation of trade and travel, public interest in emerging zoonotic diseases has increased. This is especially evident regarding the geographical spread of vector-borne diseases. A multi-disciplinary approach is now imperative, and groups need to collaborate in an integrated manner that includes vector control, vaccination programmes, improved therapy strategies, diagnostic tools and surveillance, public awareness, capacity building and improvement of infrastructure in endemic regions

Anodal block permits directional vagus nerve stimulation

© 2020, The Author(s). Vagus nerve stimulation (VNS) is a bioelectronic therapy for disorders of the brain and peripheral organs, and a tool to study the physiology of autonomic circuits. Selective activation of afferent or efferent vagal fibers can maximize efficacy and minimize off-target effects of VNS. Anodal block (ABL) has been used to achieve directional fiber activation in nerve stimulation. However, evidence for directional VNS with ABL has been scarce and inconsistent, and it is unknown whether ABL permits directional fiber activation with respect to functional effects of VNS. Through a series of vagotomies, we established physiological markers for afferent and efferent fiber activation by VNS: stimulus-elicited change in breathing rate (ΔBR) and heart rate (ΔHR), respectively. Bipolar VNS trains of both polarities elicited mixed ΔHR and ΔBR responses. Cathode cephalad polarity caused an afferent pattern of responses (relatively stronger ΔBR) whereas cathode caudad caused an efferent pattern (stronger ΔHR). Additionally, left VNS elicited a greater afferent and right VNS a greater efferent response. By analyzing stimulus-evoked compound nerve potentials, we confirmed that such polarity differences in functional responses to VNS can be explained by ABL of A- and B-fiber activation. We conclude that ABL is a mechanism that can be leveraged for directional VNS

Nonlinear kT factorization for Forward Dijets in DIS off Nuclei in the Saturation Regime

We develop the QCD description of the breakup of photons into forward dijets in small-x deep inelastic scattering off nuclei in the saturation regime. Based on the color dipole approach, we derive a multiple scattering expansion for intranuclear distortions of the jet-jet transverse momentum spectrum. A special attention is paid to the non-Abelian aspects of the propagation of color dipoles in a nuclear medium. We report a nonlinear $k_{\perp}$-factorization formula for the breakup of photons into dijets in terms of the collective Weizs\"acker-Williams (WW) glue of nuclei as defined in ref. \cite{Saturation,NSSdijet}. For hard dijets with the transverse momenta above the saturation scale the azimuthal decorrelation (acoplanarity) momentum is of the order of the nuclear saturation momentum QA. For minijets with the transverse momentum below the saturation scale the nonlinear kT-factorization predicts a complete disappearance of the jet-jet correlation. We comment on a possible relevance of the nuclear decorrelation of jets to the experimental data from the STAR-RHIC Collaboration.Comment: 40 pages, 7 figure

Antibiotic exposure and the risk of colorectal adenoma and carcinoma: a systematic review and meta-analysis of observational studies

The Incidence of colorectal cancer (CRC) is increasing, and evidence suggests that maladaptation of the bowel microbiome may be associated with colorectal carcinogenesis. Consumption of antibiotics may cause imbalance of the bowel microbiome but research assessing an association between antibiotic exposure and CRC is inconsistent. The aim of this systematic review and meta‐analysis was to appraise and synthesize the available evidence

Mode oscillation and harmonic distortions associated with sinusoidal modulation of semiconductor lasers

This paper investigates mode dynamics, operation characteristics and signal distortions associated with sinusoidal modulation of semiconductor lasers. The study is based on intensive integrations of the multimode rate equation model of semiconductor lasers over wide ranges of the modulation frequency and depth. The rate equations take into account both spectral symmetric and asymmetric suppressions of modal gain. The higher harmonic distortions as well as the half harmonic distortion associated with the period doubling effect are investigated. The study is applied to both cases of single-mode and multimode oscillations of the non-modulated laser. The obtained results showed that the modulated signal has six distinct waveforms depending on the modulation conditions; three types have continuous periodic waveforms and the others have periodic pulsing waveforms. The modulated laser is found to oscillate in a single mode under weak modulation where the modulated signal is continuous, whereas the pulsing signals are associated with multimode oscillation. The higher harmonic distortions of single-mode laser are lower than those of two-mode lasers, and become serious at modulation frequencies around the relaxation oscillation frequency. These distortions are highest when the laser output is pulsating and the pulses are superposed by relaxation oscillations. © EDP Sciences, Società Italiana di Fisica, Springer-Verlag 2012

HiTrust: building cross-organizational trust relationship based on a hybrid negotiation tree

Small-world phenomena have been observed in existing peer-to-peer (P2P) networks which has proved useful in the design of P2P file-sharing systems. Most studies of constructing small world behaviours on P2P are based on the concept of clustering peer nodes into groups, communities, or clusters. However, managing additional multilayer topology increases maintenance overhead, especially in highly dynamic environments. In this paper, we present Social-like P2P systems (Social-P2Ps) for object discovery by self-managing P2P topology with human tactics in social networks. In Social-P2Ps, queries are routed intelligently even with limited cached knowledge and node connections. Unlike community-based P2P file-sharing systems, we do not intend to create and maintain peer groups or communities consciously. In contrast, each node connects to other peer nodes with the same interests spontaneously by the result of daily searches

Real-time MRI for dynamic assessment of gastroesophageal reflux disease: comparison to pH-metry and impedance

Purpose To evaluate the diagnostic potential of real-time MRI for dynamic assessment of gastroesophageal reflux in patients with GERD (gastroesophageal reflux disease)-like symptoms compared to pH-metry and impedance. Methods Patients who underwent real-time MRI and pH-metry between 2015–2018 were included in this retrospective study. Real-time MRI at 3 T was achieved by undersampled radial FLASH acquisitions with iterative image reconstruction by NLINV. Real-time MRI visualized transit of pineapple juice through the gastroesophageal junction and during Valsalva maneuver. MRI results were compared to 24 h pH-metry to assess acidic reflux (following Lyon Consensus guidelines) and to impedance to assess non-acidic reflux. A standard 2 × 2 table was chosen to calculate diagnostic performance. Results 91/93 eligible patients fulfilled inclusion criteria (male n = 49; female n = 42; median age 55 y). All MRI studies were successfully completed without adverse events at a mean examination time of 15 min. On real-time MRI, reflux was evident in 60 patients (66 %). pH-metry revealed reflux in 41 patients (45 %), and impedance in 54 patients (59 %). Compared to pH-metry and impedance, real-time MRI sensitivity was 0.78 (95 % CI: 0.66-0.87), specificity 0.67 (95 % CI: 0.45-0.84) and PPV 0.87 (95 % CI: 0.75-0.94). Conclusion Real-time MRI is an imaging method for assessment of gastroesophageal reflux in patients with GERD-like symptoms. Considering its high positive predictive value, real-time MRI can accurately identify patients in which further invasive testing with pH-metry and impedance might be considered

High HIV prevalence in an early cohort of hospital admissions with COVID-19 in Cape Town, South Africa

Background. South Africa (SA) has a high prevalence of HIV and tuberculosis. Cape Town was the SA metropole most affected in the early stages of the COVID-19 pandemic. Early observational data from Africa may provide valuable insight into what can be expected as the pandemic expands across the continent.Objectives. To describe the prevalence, clinical features, comorbidities and outcome of an early cohort of HIV-positive and HIV-negative patients admitted with COVID-19.Methods. This was a descriptive observational study of an early cohort of adults with COVID-19 pneumonia admitted from 25 March to 11 May 2020.Results. Of 116 patients (mean age 48 years, 61% female) admitted, 24 were HIV-positive (21%). The most common symptoms reported were cough (n=88; 73%), shortness of breath (n=78; 69%), fever (n=67; 59%), myalgia (n=29; 25%) and chest pain (n=22; 20%). The most common comorbidities were hypertension (n=46; 41%), diabetes mellitus (n=43; 38%), obesity (n=32; 28%) and HIV (n=24; 21%). Mortality was associated with older age (mean (standard deviation) 55 (12) years v. 46 (14) years; p<0.01); the presence of hypertension or hypertension along with diabetes and/or obesity; lower partial pressure of arterial oxygen to fraction of inspired oxygen ratio; and higher urea level, white cell count, neutrophil count, and C-reactive protein, lactate dehydrogenase and ferritin levels, and high neutrophil to lymphocyte ratio. The overall survival rate for all hospital admissions was 86/116 (73%). In this early cohort, survival was similar in patients with HIV (n=18; 75%) compared with those without HIV (n=67; 75%) (p=1). Of the 74 patients admitted to the wards, 63 (85%) survived, whereas 22 of 42 (52%) admitted to the intensive care unit survived.Conclusions. Patients with HIV infection represented a large proportion of all COVID-19 admissions. The presentation and outcome of patients with HIV did not differ significantly from those of patients without HIV