MASTER Optical Polarization Variability Detection in the Microquasar V404 Cyg/GS 2023+33

On 2015 June 15, the Swift space observatory discovered that the Galactic black hole candidate V404 Cyg was undergoing another active X-ray phase, after 25 years of inactivity. The 12 telescopes of the MASTER Global Robotic Net located at six sites across four continents were the first ground-based observatories to start optical monitoring of the microquasar after its gamma-ray wake up at 18h 34m 09s U.T. on 2015 June 15. In this paper, we report, for the first time, the discovery of variable optical linear polarization, changing by 4%-6% over a timescale of ∼1 hr, on two different epochs. We can conclude that the additional variable polarization arises from the relativistic jet generated by the black hole in V404 Cyg. The polarization variability correlates with optical brightness changes, increasing when the flux decreases.Fil: Lipunov, V.. M.V.Lomonosov Moscow State University. Physics Department; RusiaFil: Gorbovskoy, E.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Krushinskiy, V.. Kourovka Astronomical Observatory, Ural Federal University; RusiaFil: Vlasenko, D.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Tiurina, N.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Balanutsa, P.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Kuznetsov, A.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Budnev, N.. Applied Physics Institute. Irkutsk State University; RusiaFil: Gress, O.. Applied Physics Institute, Irkutsk State University; RusiaFil: Tlatov, A.. Kislovodsk Solar Station of the Main (Pulkovo) Observatory RAS; RusiaFil: Rebolo Lopez, L.. Instituto de Astrofsica de Canarias; EspañaFil: Serra-Ricart, M.. Instituto de Astrofsica de Canarias; EspañaFil: Buckley, D. A. H.. South African Astronomical Observatory; SudáfricaFil: Israelyan, G.. Instituto de Astrofsica de Canarias; EspañaFil: Lodieu, N.. Instituto de Astrofisica de Canarias; EspañaFil: Ivanov, K.. Applied Physics Institute. Irkutsk State University; RusiaFil: Yazev, S.. Applied Physics Institute, Irkutsk State University; RusiaFil: Sergienko, Y.. Blagoveschensk State Pedagogical University; RusiaFil: Gabovich, A.. Blagoveschensk State Pedagogical University; RusiaFil: Yurkov, V.. Blagoveschensk State Pedagogical University; RusiaFil: Levato, Orlando Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Saffe, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Podesta, R.. Observatorio "Felix Aguiklar". Universidad Nacional de San Juan; ArgentinaFil: Lopez, C.. Observatorio "Felix Aguilar". Universidad nacional de San juan; Argentin

Olaparib maintenance therapy after frontline chemotherapy in patients with BRCA-mutated ovarian cancer: real-world results in expanded access program

Introduction. Olaparib is the only PARP inhibitor approved in Russia for the maintenance therapy for BRCA-positive ovarian cancer after frontline chemotherapy. We conducted a real-world analysis of olaparib efficacy and safety for this indication.Aim. To assess the efficacy of PARP inhibitors in real-world clinical practice.Materials and methods. Patients with stage III-IV BRCA-mutated ovarian cancer who received olaparib maintenance therapy in expanded access program in 03.2019-12.2020 timeframe. Briefly, key inclusion criteria were: serous or endometrioid highgrade ovarian cancer; pathogenic BRCA1/2 mutation; primary or interval debulking; complete or partial response to frontline platinum-based therapy. Olaparib was administered as tablets (300 mg BID) up to 2-years, disease progression or unacceptable toxicity, whichever occurred first. The primary endpoint of the study was progression-free survival (PFS), overall survival (OS) and safety were key secondary endpoints. Statistical analysis was done with R and RStudio software.Results and discussion. 23 patients were enrolled. Median age was 49 years, all patients had high-grade serous adenocarcinoma histology. Complete debulking at primary or interval surgery was achieved in 30% of patients. With median follow-up time equal to 22 months, median PFS and OS were not reached. The 2-year PFS and OS were 65 and 84%, respectively. Grade 3-4 adverse events was detected in 7 (30.4%) patients.Conclusion. Our results supports high efficacy of olaparib in real clinical practice setting reported in the SOLO1 trial

Режим паклитаксел, гемцитабин, оксалиплатин в индукционной терапии пациентов с рецидивирующими и рефрактерными герминогенными опухолями перед высокодозной химиотерапией: результаты пилотного исследования

Purpose: to evaluate the efficacy of TGO (paclitaxel, gemcitabine, oxaliplatin) regimen as induction therapy for hematopoietic stem cells mobilization (HSC) before high-dose chemotherapy (HDCT) in patients with recurrent nonseminomatous germ cell tumors (NSGCT).Patients and methods: the study enrolled patients with relapsed and/or refractory NSGCT after frontline chemotherapy. Modified TGO regimen (paclitaxel 100 mg/m2 on day 1 + gemcitabine 1000 mg/m2 on day 1 + oxaliplatin 130 mg/m2 on day 1, once every 14 days) was administered with filgrastim support 10 mcg/kg subcutaneous from day 8 and until the completion of leukapheresis. Maximum 3 cycles of TGO regimen was administered. After harvesting the required volume of CD34+ cells, HDCT was initiated which consisted of 3 cycles of the CE regimen (carboplatin AUC8 on day 1–3 + etoposide 400 mg/m2 on day 1–3) with further HSC autologous stem cell transplantation (ASCT).Results: Five patients with NSGCT with poor IGCCCG prognosis according were enrolled. All of them received ifosfamide-containing chemotherapy as initial treatment. The required HSC were collected for three cycles of HDCT in all patients (100 %); in four (80 %) patients the required number of cells was collected after the 1st cycle of TGO. Four (80 %) patients started the HDCT phase, one patient prematurely terminated treatment due to the rapid progression. One patient who received full planned therapy demonstrated complete and durable tumor regression at the time of data analysis (with 37 months follow-up).Conclusions: the TGO regimen can be used to collect PBSC from patients with relapsed and/or refractory NSGCT before HDCT, further study of this approach is required.Цель исследования: оценка эффективности применения схемы TGO (паклитаксел, гемцитабин, оксалиплатин) в качестве режима индукционной терапии для мобилизации гемопоэтических стволовых клеток (ГСК) с последующим проведением 3 курсов высокодозной химиотерапии (ВДХТ) с трансплантацией аутологичными ГСК (аутоТГСК) у пациентов с редицивом несеминомной герминогенной опухоли (НГО).Материалы и методы: включались пациенты с рецидивирующими и / или рефрактерными НГО с прогрессированием опухолевого процесса после химиотерапии 1 линии. Проводилось до 3 курсов индукционной терапии в модифицированном режиме TGO (паклитаксел 100 мг / м2 в день 1 + гемцитабин 1000 мг / м2 в день 1 + оксалиплатин 130 мг / м2 в день 1, 1 раз в 14 дней). С целью химиомобилизации ГСК с 8 дня каждого курса вводился филграстим в дозе 10 мкг / кг в день п / к. После заготовки необходимого количества ГСК было запланировано проведение 3 курсов ВДХТ в режиме СЕ (карбоплатин AUC8 в день 1–3 + этопозид 400 мг / м2 в день 1–3) с последующей реинфузией аутологичных ГСК после каждого курса.Результаты исследования: включено 5 пациентов с НГО с неблагоприятным прогнозом по IGCCCG. Во всех случаях в качестве первоначального лечения была проведена ифосфамид-содержащая химиотерапия. У всех пациентов (100 %) было собрано необходимое для проведения 3 курсов ВДХТ количество ГСК. У 4 (80 %) пациентов удалось собрать необходимое количество ГСК уже после 1 курса TGO. Этап ВДХТ был начат у 4 пациентов. В одном случае лечение было досрочно прекращено вследствие бурного прогрессирования опухолевого процесса. У 1 пациента, завершившего весь объем противоопухолевой терапии, была достигнута полная регрессия опухолевого процесса, сохраняющаяся на момент сбора данных (длительность наблюдения 37 мес. от начала лечения).Заключение: режим TGO может быть использован для сбора аутологичных ГСК у пациентов с рецидивом и / или рефрактерным течением НГО. Требуется дальнейшее изучение данного подхода

Integrated stratigraphy of the Priabonian (upper Eocene) Urtsadzor section, Armenia

The transition from the Bartonian to the Priabonian, as traditionally understood, has long been associated with a series of extinctions and originations in several microfossil groups. The planktonic forami- nifer genus Morozovelloides and large species of Acarinina suffered a rapid global extinction, as did many radiolarians. Calcareous nannofossils show several assemblage changes including the acme beginning of Cri- brocentrum erbae and the lowest and highest occurrences of Chiasmolithus oamaruensis and C. grandis re- spectively. In shallow water environments, larger foraminifera also show an extinction among large species of Nummulites, as well as the first occurrences of the stratigraphically important genus Spiroclypeus. Howe- ver, the correlation between shallow and deep water records remains uncertain, as do the mechanisms driving these biotic events. Here we present the results of a new integrated stratigraphical study (calcareous nanno- fossils, planktonic foraminifera, larger benthic foraminifera, and low-resolution magnetostratigraphy) of the Urtsadzor section in south-western Armenia which appears to be continuous through this interval. The Urt- sadzor section consists of calcareous siltstones rich in micro- and nannofossils, with interbedded limestones containing abundant larger benthic foraminifera. Our new data enable us to correlate larger foraminiferal events with global plankton biostratigraphy, in a section outside of southwest Europe where most previous correlations have been based. At Urtsadzor, the large Nummulites species of N. millecaput-group are present throughout the whole section but decrease in abundance toward the top. The first occurrence of Spiroclypeus, also occurs in the upper part of the section, marking the SBZ 18/19 boundary. These events are associated with the phylogenetic development of the Nummulites fabianii and Heterostegina reticulata lineages. Howe- ver, the calcareous plankton biostratigraphy indicates the section is well within the Priabonian; within plank-tonic foraminiferal Zones E14 and E15 and calcareous nannoplankton Zones CNE 18 and CNE 19. These re- sults indicate larger foraminiferal events occur well above the planktonic foraminiferal extinction level and nannofossil assemblage changes indicating the events are not synchronous across groups, with implications for biostratigraphy and recognition of the basal Priabonian in different depositional settings and regions

Dissonant Voices: Soviet Youth Mobilization and the Cuban Missile Crisis

International audienc

Evaluation of the efficiency and safety of magnet therapy for osteoarthritis. Results of the multicenter blind placebo-controlled study COSMO (Clinical Evaluation of Current Magnet Therapy for Osteoarthritis)

Magnet therapy (Mt) is a well-known physiotherapy technique that is widely used to treat knee osteoarthritis (OA). Objective: to determine the efficiency and safety of Mt for knee OA.Subjects and methods. A study group consisted of 231 patients with knee OA (77.9% were women; mean age,61.9+12.2 years; body mass index, 30.6+5.8 kg/m2; median disease duration, 5.0 [2, 0; 10.0] years). The patients were randomly assigned to two groups. Group 1 patients received Mt with an ALMAG+ device for 14 days; Group 2 had false Mt with a completely imitating ALMAG+ device that failed to create a magnetic field. The investigators evaluated the changes of the WOMAC index, pain intensity at rest and during movement on a 100 mm visual analogue scale (VAS), the need for nonsteroidal anti-inflammatory drugs (NSAIDs), and the degree of improvement, as assessed by patients (on a 5-point scale).Results and discussion. During the therapy, there was a statistically significant pain and stiffness reduction and functional improvement. Thus, there were decreases in the median WOMAC pain scores from 231 [180; 290] to 110 [60; 166.3] (p<0.001) in Group 1, from 212.4 [145; 260] to 143 [76.5; 200] (p<0.001) in Group 2, in pain intensity at rest from 47 [27.8; 60] to 20 [10; 30] mm (p<0.001) in Group 1; from 40 [20; 57.5] to 20 [7.5; 40] mm (p<0.001) in Group 2. During the therapy, there was also a reduction in the need for NSAIDs: the drug was discontinued or its dose reduced in 33.1% and 16.8% of the patients in Groups 1 and 2, respectively (p=0.006). The changes of all parameters were statistically more significant in Group 1 than in Group 2. Treatment results were assessed as good and excellent by 58.5% and 39.8% patients in Groups 1 and 2, respectively (p<0.001). No serious adverse events to true and false Mt were observed. Therapy was discontinued due to increase of joint pain in two patients who received false Mt.Conclusion. Short-term Mt provides a significant improvement in patients with knee OA. Mt is well tolerated and causes no serious complications

MASTER Optical Detection of the First LIGO/Virgo Neutron Star Binary Merger GW170817

Following the discovery of the gravitational-wave source GW170817 by three Laser Interferometer Gravitational-wave Observatory (LIGO)/Virgo antennae (Abbott et al., 2017a), the MASTER Global Robotic Net telescopes obtained the first image of the NGC 4993 host galaxy. An optical transient, MASTER OTJ130948.10-232253.3/SSS17a was later found, which appears to be a kilonova resulting from the merger of two neutron stars (NSs). Here we describe this independent detection and photometry of the kilonova made in white light, and in B, V, and R filters. We note that the luminosity of this kilonova in NGC 4993 is very close to those measured for other kilonovae possibly associated with gamma-ray burst (GRB) 130603 and GRB 080503.Fil: Lipunov, V. M.. Lomonosov Moscow State University; RusiaFil: Gorbovskoy, E.. Lomonosov Moscow State University; RusiaFil: Kornilov, V. G.. Lomonosov Moscow State University; RusiaFil: Tyurina, N.. Lomonosov Moscow State University; RusiaFil: Balanutsa, P.. Lomonosov Moscow State University; RusiaFil: Kuznetsov, A.. Lomonosov Moscow State University; RusiaFil: Vlasenko, D.. Lomonosov Moscow State University; RusiaFil: Kuvshinov, D.. Lomonosov Moscow State University; RusiaFil: Gorbunov, I.. Lomonosov Moscow State University; RusiaFil: Buckley, D. A. H.. South African Astrophysical Observatory; SudáfricaFil: Krylov, A. V.. Lomonosov Moscow State University; RusiaFil: Podesta, R.. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Informática. Observatorio Astronómico Félix Aguilar; ArgentinaFil: Lopez, C.. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Informática. Observatorio Astronómico Félix Aguilar; ArgentinaFil: Podesta, F.. Universidad Nacional de San Juan. Facultad de Ciencias Exactas Físicas y Naturales. Departamento de Informática. Observatorio Astronómico Félix Aguilar; ArgentinaFil: Levato, Orlando Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Saffe, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Mallamachi, C.. Universidad Nacional de San Juan; ArgentinaFil: Potter, S.. South African Astrophysical Observatory; SudáfricaFil: Budnev, N. M.. Irkutsk State University; RusiaFil: Gress, O.. Lomonosov Moscow State University; Rusia. Irkutsk State University; RusiaFil: Ishmuhametova, Yu.. Irkutsk State University; RusiaFil: Vladimirov, V.. Lomonosov Moscow State University; RusiaFil: Zimnukhov, D.. Lomonosov Moscow State University; RusiaFil: Yurkov, V.. Blagoveschensk State Pedagogical University; RusiaFil: Sergienko, Yu.. Blagoveschensk State Pedagogical University; RusiaFil: Gabovich, A.. Blagoveschensk State Pedagogical University; RusiaFil: Rebolo, R.. Instituto de Astrofísica de Canarias; EspañaFil: Serra Ricart, M.. Instituto de Astrofísica de Canarias; EspañaFil: Israelyan, G.. Instituto de Astrofísica de Canarias; EspañaFil: Chazov, V.. Lomonosov Moscow State University; RusiaFil: Wang, Xiaofeng. Tsinghua University; ChinaFil: Tlatov, A.. Kislovodsk Solar Observing Station of Pulkovo Observatory; RusiaFil: Panchenko, M. I.. Lomonosov Moscow State University; Rusi