'But I thought we were friends?' Life cycles and research relationships

This chapter is concerned with a relatively under-explored aspect of ‘engaged research’ – the nature of friendship relations between researchers and practitioners, and the ethical dilemmas that arise in such relationships. Attention has been paid to the relational aspects of research in the methodology literature, but this chapter focuses more closely on friendship in particular. The chapter is framed around two guiding concerns: how do friendships, formed in and around research, change over time; and in view of friendship conceived in this dynamic fashion, what ethical questions and dilemmas arise for the ‘friends’

Photoionization of Co+^{+} and electron-impact excitation of Co2+^{2+} using the Dirac R-matrix method

Modelling of massive stars and supernovae (SNe) plays a crucial role in understanding galaxies. From this modelling we can derive fundamental constraints on stellar evolution, mass-loss processes, mixing, and the products of nucleosynthesis. Proper account must be taken of all important processes that populate and depopulate the levels (collisional excitation, de-excitation, ionization, recombination, photoionization, bound-bound processes). For the analysis of Type Ia SNe and core collapse SNe (Types Ib, Ic and II) Fe group elements are particularly important. Unfortunately little data is currently available and most noticeably absent are the photoionization cross-sections for the Fe-peaks which have high abundances in SNe. Important interactions for both photoionization and electron-impact excitation are calculated using the relativistic Dirac Atomic $R$-matrix Codes (DARC) for low ionization stages of cobalt. All results are calculated up to photon energies of 45 eV and electron energies up to 20 eV. The wavefunction representation of Co III has been generated using GRASP0 by including the dominant 3d$^7$, 3d$^6$[4s, 4p], 3p$^4$3d$^9$ and 3p$^6$3d$^9$ configurations, resulting in 292 fine structure levels. Electron-impact collision strengths and Maxwellian averaged effective collision strengths across a wide range of astrophysically relevant temperatures are computed for Co III. In addition, statistically weighted level-resolved ground and metastable photoionization cross-sections are presented for Co II and compared directly with existing work.Comment: 11 pages, 8 figures and 4 table

Estimating probability density functions using a combined maximum entropy moments and Bayesian method. Theory and numerical examples

© 2019 BIPM & IOP Publishing Ltd. Estimating the probability density function (pdf) from a limited sample of data is a challenging data analysis problem. Furthermore, determining which pdf best describes the available data involves an extra layer of complexity to the analysis, which if ignored, can have considerable consequences. We propose a combined maximum entropy (MaxEnt) moments and Bayesian model selection method to address this problem. The MaxEnt moments component is used to formulate a set of possible pdf models, each constrained by a different set of moments and parameterised by a set of Lagrangian multipliers. The Bayesian model selection component makes an inference about the most probable model, from the set of MaxEnt moment models. The structure of the prior pdf for the Lagrangian multipliers is determined from an expansion of the free energy functional for each MaxEnt model, and corresponding hyperparameters are calculated empirically. Numerical experiments were used to test the proposed method on samples taken from Gaussian and (more complex) non-Gaussian distributions, over a range of sample sizes. The results clearly demonstrate that the method can discriminate between simple and complex MaxEnt models for sample sizes approximately greater than 60. Our results demonstrate that MaxEnt and Bayesian methods are complementary. More critically, Bayesian inference is necessary when a set of competing MaxEnt models can be derived for a single dataset from a range of assumptions

The influence of electron collisions on non-LTE Li line formation in stellar atmospheres

The influence of the uncertainties in the rate coefficient data for electron-impact excitation and ionization on non-LTE Li line formation in cool stellar atmospheres is investigated. We examine the electron collision data used in previous non-LTE calculations and compare them to recent calculations that use convergent close-coupling (CCC) techniques and to our own calculations using the R-matrix with pseudostates (RMPS) method. We find excellent agreement between rate coefficients from the CCC and RMPS calculations, and reasonable agreement between these data and the semi-empirical data used in non-LTE calculations up to now. The results of non-LTE calculations using the old and new data sets are compared and only small differences found: about 0.01 dex (~ 2%) or less in the abundance corrections. We therefore conclude that the influence on non-LTE calculations of uncertainties in the electron collision data is negligible. Indeed, together with the collision data for the charge exchange process Li(3s) + H Li^+ + H^- now available, and barring the existence of an unknown important collisional process, the collisional data in general is not a source of significant uncertainty in non-LTE Li line formation calculations.Comment: 8 pages, accepted by Astronomy and Astrophysics; Replaced with minor corrections following proof

BIMODAL WHOLE-1 MOUNT IMAGING OF TENDON USING CONFOCAL MICROSCOPY AND X-RAY MICRO-COMPUTED TOMOGRAPHY

BACKGROUND:3-dimensional imaging modalities for optically dense connective tissues such as tendons are limited and typically have a single imaging methodological endpoint. Here, we have developed a bimodal procedure utilising fluorescence-based confocal microscopy and x-ray micro-computed tomography for the imaging of adult tendons to visualise and analyse extracellular sub-structure and cellular composition in small and large animal species. RESULTS: Using fluorescent immunolabelling and optical clearing, we visualised the expression of the novel cross-species marker of tendon basement membrane, laminin-α4 in 3D throughout whole rat Achilles tendons and equine superficial digital flexor tendon 5 mm segments. This revealed a complex network of laminin-α4 within the tendon core that predominantly localises to the interfascicular matrix compartment. Furthermore, we implemented a chemical drying process capable of creating contrast densities enabling visualisation and quantification of both fascicular and interfascicular matrix volume and thickness by x-ray micro-computed tomography. We also demonstrated that both modalities can be combined using reverse clarification of fluorescently labelled tissues prior to chemical drying to enable bimodal imaging of a single sample. CONCLUSIONS: Whole-mount imaging of tendon allowed us to identify the presence of an extensive network of laminin-α4 within tendon, the complexity of which cannot be appreciated using traditional 2D imaging techniques. Creating contrast for x-ray micro-computed tomography imaging of tendon using chemical drying is not only simple and rapid, but also markedly improves on previously published methods. Combining these methods provides the ability to gain spatio-temporal information and quantify tendon substructures to elucidate the relationship between morphology and function

Vitamin D toxicity of dietary origin in cats fed a natural complementary kitten food

Case series summary This case series describes two young sibling cats and an additional unrelated cat, from two separate households, that developed hypercalcaemia associated with hypervitaminosis D. Excessive vitamin D concentrations were identified in a natural complementary tinned kitten food that was fed to all three cats as part of their diet. In one of the cases, there was clinical evidence of soft tissue mineralisation. The hypercalcaemia and soft tissue mineralisation resolved following withdrawal of the affected food and medical management of the hypercalcaemia. Relevance and novel information This case series demonstrates the importance of obtaining a thorough dietary history in patients presenting with hypercalcaemia and the measurement of vitamin D metabolites when investigating such cases. Complementary foods may have the potential to induce nutritional toxicity even when fed with complete, nutritionally balanced diets

The role of insulin glulisine to improve glycemic control in children with diabetes mellitus

Glulisine (Apidra®) is a rapid-acting human insulin analog approved for use in children with diabetes mellitus ≥4 years of age. Management of children with type 1 diabetes has seen a shift in favor of mimicking normal physiological insulin responses with multiple daily injections or continuous subcutaneous insulin infusions (CSII). Few studies have compared the rapid-acting insulin analogs in this population but limited data indicate that glulisine is as effective as lispro when used in a basal–bolus regimen. This review appraises the current available studies and reviews on insulin glulisine in children. An extensive keyword search of ‘insulin glulisine’, ‘insulin analogs’, and ‘Apidra’ in the pediatric population was performed. These studies have suggested that glulisine is safe, well tolerated, and is an effective option in the diabetes armamentarium. Further studies are needed to determine its safety for use in CSII pumps in the pediatric population

Magnetic record of deglaciation using FORC-PCA, sortable-silt grain size, and magnetic excursion at 26 ka, from the Rockall Trough (NE Atlantic)

Core MD04-2822 from the Rockall Trough has apparent sedimentation rates of ∼ 1 m/kyr during the last deglaciation (Termination I). Component magnetization directions indicate a magnetic excursion at 16.3 m depth in the core, corresponding to an age of 26.5 ka, implying an excursion duration of ∼350 years. Across Termination I, the mean grain size of sortable silt implies reduced bottom-current velocity in the Younger Dryas and Heinrich Stadial (HS)−1A, and increased velocities during the Bølling-Allerød warm period. Standard bulk magnetic parameters imply fining of magnetic grain size from the mid-Younger Dryas (∼12 ka) until ∼ 8 ka. First-order reversal curves (FORCs) were analyzed using ridge extraction to differentiate single domain (SD) from background (detrital) components. Principal component analysis (FORC-PCA) was then used to discriminate three end members corresponding to SD, pseudo-single domain (PSD), and multidomain (MD) magnetite. The fining of bulk magnetic grain size from 12 to 8 ka is due to reduction in concentration of detrital (PSD + MD) magnetite, superimposed on a relatively uniform concentration of SD magnetite produced by magnetotactic bacteria. The decrease in PSD+MD magnetite concentration from 12 to 8 ka is synchronized with increase in benthic δ13C, and with major (∼70 m) regional sea-level rise, and may therefore be related to detrital sources on the shelf that had reduced influence as sea level rose, and to bottom-water reorganization as Northern Source Water (NSW) replaced Southern Source Water (SSW)