Polars of Artin-Schreier curves

Submitted by Vitor Silverio Rodrigues ([email protected]) on 2014-05-27T11:18:09Z No. of bitstreams: 0Made available in DSpace on 2014-05-27T11:18:09Z (GMT). No. of bitstreams: 0 Previous issue date: 1996-12-01Universidade Federal Fluminense Depto. de Matemática Aplicada Campus do Valonguinho, R. São Paulo s/n, 24020-005 Niterói, RJDepartamento de Matemática IBILCE, R. Cristovão Colombo 2265, 15054-000 S. Jose do Rio Preto, SPDepartamento de Matemática IBILCE, R. Cristovão Colombo 2265, 15054-000 S. Jose do Rio Preto, S

Effects and feasibility of a multi-disciplinary orientation program for newly registered cancer patients: design of a randomised controlled trial

Background Diagnosis and treatment of cancer can contribute to psychological distress and anxiety amongst patients. Evidence indicates that information giving can be beneficial in reducing patient anxiety, so oncology specific information may have a major impact on this patient group. This study investigates the effects of an orientation program on levels of anxiety and self-efficacy amongst newly registered cancer patients who are about to undergo chemotherapy and/or radiation therapy in the cancer care centre of a large tertiary Australian hospital. Methods The concept of interventions for orienting new cancer patients needs revisiting due to the dynamic health care system. Historically, most orientation programs at this cancer centre were conducted by one nurse. A randomised controlled trial has been designed to test the effectiveness of an orientation program with bundled interventions; a face-to-face program which includes introduction to the hospital facilities, introduction to the multi-disciplinary team and an overview of treatment side effects and self care strategies. The aim is to orientate patients to the cancer centre and to meet the health care team. We hypothesize that patients who receive this orientation will experience lower levels of anxiety and distress, and a higher level of self-efficacy. Discussion An orientation program is a common health care service provided by cancer care centres for new cancer patients. Such programs aim to give information to patients at the beginning of their encounter at a cancer care centre. It is clear in the literature that interventions that aim to improve self-efficacy in patients may demonstrate potential improvement in health outcomes. Yet, evidence on the effects of orientation programs for cancer patients on self-efficacy remains scarce, particularly with respect to the use of multidisciplinary team members. This paper presents the design of a randomised controlled trial that will evaluate the effects and feasibility of a multidisciplinary orientation program for new cancer patients

Post‐traumatic stress disorder in Stevens–Johnson syndrome and toxic epidermal necrolysis: prevalence and risk factors. A prospective study of 31 patients

International audienceBackground: Epidermal necrolysis is a rare and severe cutaneous adverse reaction to drugs with long-term somatic consequences and potentially underrecognized psychological complications.Objectives: To assess the prevalence and risk factors of post-traumatic stress disorder (PTSD) in Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in a population of adults undergoing psychiatric evaluation.Methods: In this prospective study, we included adult patients admitted at the acute phase of SJS/TEN to our dermatology department from June 2009 to February 2013. The main objective was to assess the prevalence of PTSD at 6 months after the acute disease phase, defined by a PTSD Checklist score > 44. Secondary objectives were to investigate risk factors of PTSD in the medical history of patients and characteristics of the disease at the acute phase by the Peritraumatic Dissociative Experience Questionnaire (PDEQ) and Peritraumatic Distress Inventory (PDI) and the degree of impairment on the Sheehan Disability Scale.Results: We initially included 32 of 80 patients admitted during the study period. At 6 months, seven of 30 still followed up had a PTSD Checklist score > 44, suggesting a PTSD prevalence of 23%; 23 (77%) patients had a hydroxyzine prescription at the acute phase. The main risk factors associated with PTSD at 6 months were psychological results at the acute phase.Conclusions: Despite frequent prescription of hydroxyzine at the acute phase, almost one-quarter of patients with SJS/TEN had PTSD at 6 months. A systematic psychiatric evaluation should be offered regularly for at least 1 year after the acute disease phase

Isotrétinoïne : quelles actualités en dermatologie ? Conclusions du séminaire Centre de preuves en dermatologie et groupe DEFI de la SFD

National audienceContextIn November 2021, the French National Medicines Agency (ANSM – Agence nationale de sécurité des médicaments) asked the French Society of Dermatology (SFD) to examine current isotretinoin use in France.MethodsTo answer the questions raised by the ANSM, a seminar was organized by the Centre of Evidence (CDP) of the SFD in June 2022 involving a multidisciplinary panel of French experts (including members of the CDP, health professionals and patient association leader). After a short presentation of each question by one or more experts, a number of proposed solutions and clinical and translational research projects were discussed.ResultsThe main points concerned the use of the Adolescent Depression Rating Scale score before and during isotretinoin treatment for acne to evaluate the risk of depression and the need to reinforce information to patients concerning prevention of pregnancy. Reducing the frequency of laboratory monitoring was also proposed. Off-label uses for other indications (first-line therapy for certain types of acne on pigmented skin, adult acne, rosacea, seborrheic dermatitis, hidradenitis suppurativa, etc.) were specified with proposals for research projects. Finally, the need for improving both communication tools (health professionals and patients/parents) and the care pathway was highlighted. The development of continuing medical education for health professionals and updating recommendations were proposed and will be supported by the French DErmatoses FacIales group of the SFD.ContexteEn novembre 2021, l’Agence nationale de sécurité des médicaments (ANSM) a sollicité la Société française de dermatologie (SFD) sur les modalités actuelles d’utilisation de l’isotrétinoïne en France.MéthodesPour répondre aux interrogations soulevées par l’ANSM, un séminaire a été organisé par le Centre de preuves (CDP) de la SFD en juin 2022, réunissant les membres du CDP et des experts (professionnels de santé, représentant de patient). Après un état des lieux pour chaque question par un ou plusieurs experts, un temps de discussion était dédié à la formulation de solutions et de projets de recherche clinique et translationnelle.RésultatsLes principales propositions concernaient l’utilisation du score ADRS (Adolescent Depression Rating Scale) lors de l’introduction et du renouvellement de l’isotrétinoïne dans l’acné pour identifier les patients à risque psychiatrique et la nécessité d’un renforcement de l’information sur la prévention des grossesses. Un allègement de la surveillance biologique est également proposé. Les modalités d’utilisation hors AMM pour d’autres indications (1re ligne dans certaines acnés sur peaux noires et pigmentées, acné du bas du visage de la femme adulte, rosacée, dermatite séborrhéique, hidradénite suppurée, etc.) ont été précisées avec des propositions de projets de recherche. Enfin, une amélioration des outils de communication (professionnels de santé et patients/parents) et du parcours de soins est nécessaire. Le développement de la formation continue pour les professionnels de santé et l’actualisation des recommandations ont été proposés et seront portés par le nouveau groupe thématique DEFI (DErmatoses FacIales) de la SFD