1,719 research outputs found
Towards a Reconceptualization of Striatal Interactions Between Glutamatergic and Dopaminergic Neurotransmission and Their Contribution to the Production of Movements
According to the current model of the basal ganglia organization, simultaneous activation of the striato-nigral direct pathway by glutamatergic and dopaminergic neurotransmission should lead to a synergistic facilitatory action on locomotor activity, while in contrast activation of the indirect pathway by these two neurotransmittions should lead to antagonistic effects on locomotor activity. Based on published data, as a break with the current thinking, we propose a reconceptualization of functional interactions between dopaminergic and glutamatergic neurotransmission. In this model, dopaminergic neurotransmission is seen as a motor pacemaker responsible for the basal and primary activation of striatal output neurons and glutamate as a driver providing a multiple combination of tonic, phasic, facilitatory and inhibitory influxes resulting from the processing of environmental, emotional and mnesic stimuli. Thus, in the model, glutamate-coded inputs would allow tuning the intrinsic motor-activating properties of dopamine to adjust the production of locomotor activity into goal-oriented movements
An Example of Quantum Anomaly in the Physics of Ultra-Cold Gases
In this article, we propose an experimental scheme for observation of a
quantum anomaly---quantum-mechanical symmetry breaking---in a two-dimensional
harmonically trapped Bose gas. The anomaly manifests itself in a shift of the
monopole excitation frequency away from the value dictated by the
Pitaevskii-Rosch dynamical symmetry [L. P. Pitaevskii and A. Rosch, Phys. Rev.
A, 55, R853 (1997)]. While the corresponding classical Gross-Pitaevskii
equation and the derived from it hydrodynamic equations do exhibit this
symmetry, it is---as we show in our paper---violated under quantization. The
resulting frequency shift is of the order of 1% of the carrier, well in reach
for modern experimental techniques. We propose using the dipole oscillations as
a frequency gauge.Comment: Misprints corrected, a discussion on damping added, text is polished
and shortened. 5 pages, 1 figur
On the uniqueness for the spatially homogeneous Boltzmann equation with a strong angular singularity
We prove an inequality on the Wasserstein distance with quadratic cost
between two solutions of the spatially homogeneous Boltzmann equation without
angular cutoff, from which we deduce some uniqueness results. In particular, we
obtain a local (in time) well-posedness result in the case of (possibly very)
soft potentials. A global well-posedeness result is shown for all regularized
hard and soft potentials without angular cutoff. Our uniqueness result seems to
be the first one applying to a strong angular singularity, except in the
special case of Maxwell molecules.
Our proof relies on the ideas of Tanaka: we give a probabilistic
interpretation of the Boltzmann equation in terms of a stochastic process. Then
we show how to couple two such processes started with two different initial
conditions, in such a way that they almost surely remain close to each other
A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure.
Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to date only 11 IOP loci have been reported, accounting for 1.5% of IOP variability. Here, we conduct a genome-wide association study of IOP in 69,756 untreated individuals of European, Latino, Asian, and African ancestry. Multiple longitudinal IOP measurements were collected through electronic health records and, in total, 356,987 measurements were included. We identify 47 genome-wide significant IOP-associated loci (P < 5 × 10-8); of the 40 novel loci, 14 replicate at Bonferroni significance in an external genome-wide association study analysis of 37,930 individuals of European and Asian descent. We further examine their effect on the risk of glaucoma within our discovery sample. Using longitudinal IOP measurements from electronic health records improves our power to identify new variants, which together explain 3.7% of IOP variation
Bi-layer Kinetic Inductance Detectors for space observations between 80-120 GHz
We have developed Lumped Element Kinetic Inductance Detectors (LEKID)
sensitive in the frequency band from 80 to 120~GHz. In this work, we take
advantage of the so-called proximity effect to reduce the superconducting gap
of Aluminium, otherwise strongly suppressing the LEKID response for frequencies
smaller than 100~GHz. We have designed, produced and optically tested various
fully multiplexed arrays based on multi-layers combinations of Aluminium (Al)
and Titanium (Ti). Their sensitivities have been measured using a dedicated
closed-circle 100 mK dilution cryostat and a sky simulator allowing to
reproduce realistic observation conditions. The spectral response has been
characterised with a Martin-Puplett interferometer up to THz frequencies, and
with a resolution of 3~GHz. We demonstrate that Ti-Al LEKID can reach an
optical sensitivity of about ~ (best pixel), or
~ when averaged over the whole array. The optical
background was set to roughly 0.4~pW per pixel, typical for future space
observatories in this particular band. The performance is close to a
sensitivity of twice the CMB photon noise limit at 100~GHz which drove the
design of the Planck HFI instrument. This figure remains the baseline for the
next generation of millimetre-wave space satellites.Comment: 7 pages, 9 figures, submitted to A&
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