Nonlinear capacitance and electrochemical response of ionic liquid-ionic polymers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98712/1/JApplPhys_109_084901.pd

Boundary layer charge dynamics in ionic liquid-ionic polymer transducers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98705/1/JApplPhys_109_014909.pd

HIV protease inhibitors inhibit FACE1/ ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy

Abstract HIV-PIs (HIV protease inhibitors) have proved to be of great benefit for the millions of people suffering from AIDS. However, one of the side effects of this component of combined highly active antiretroviral therapy is lipodystrophy, which affects a large number of the patients taking this class of drug. It has been shown that many of these protease inhibitors inhibit the ZMPSTE24 enzyme responsible for removing the farnesylated tail of prelamin A, which is a nuclear lamina component that has been implicated in some of the nuclear laminopathies. Build up of this protein somehow leads to acquired lipodystrophy, possibly through its interaction with a transcription factor called SREBP-1 (sterol-regulatory-element-binding protein-1). The downstream effect of this is altered fatty acid metabolism and sterol synthesis, which may cause lipodystrophy in patients. The build-up of this protein also appears to have morphological consequences on the nucleus and we reveal, by dual-axis electron tomography, a complex nucleoplasmic reticulum that forms after HIV-PI treatment as a result of acute farnesylated prelamin A accumulation. A greater understanding of the molecular mechanisms leading to lipodystrophy will hopefully facilitate the design of improved HIV-PIs that do not cause this debilitating side effect

Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice.

Mutations in SLURP1 cause mal de Meleda, a rare palmoplantar keratoderma (PPK). SLURP1 is a secreted protein that is expressed highly in keratinocytes but has also been identified elsewhere (e.g., spinal cord neurons). Here, we examined Slurp1-deficient mice (Slurp1(-/-)) created by replacing exon 2 with β-gal and neo cassettes. Slurp1(-/-) mice developed severe PPK characterized by increased keratinocyte proliferation, an accumulation of lipid droplets in the stratum corneum, and a water barrier defect. In addition, Slurp1(-/-) mice exhibited reduced adiposity, protection from obesity on a high-fat diet, low plasma lipid levels, and a neuromuscular abnormality (hind-limb clasping). Initially, it was unclear whether the metabolic and neuromuscular phenotypes were due to Slurp1 deficiency, because we found that the targeted Slurp1 mutation reduced the expression of several neighboring genes (e.g., Slurp2, Lypd2). We therefore created a new line of knockout mice (Slurp1X(-/-) mice) with a simple nonsense mutation in exon 2. The Slurp1X mutation did not reduce the expression of adjacent genes, but Slurp1X(-/-) mice exhibited all of the phenotypes observed in the original line of knockout mice. Thus, Slurp1 deficiency in mice elicits metabolic and neuromuscular abnormalities in addition to PPK

The Student Movement Volume 105 Issue 3: Students Take Appling Break

NEWS Reimagining Chapel through Pulse Groups, Jenae Rogers Pacific Union College Students Evacuated After Glass Fire, Staff Unidos Through Ethnicity, Caralynn Chan PULSE Fresh Air, Fresh Produce, Jessica Rim Pumpkin Spice and Everything Nice, Wambui Karanja Yo Tengo Hambre!: A Sample of Hispanic Cuisine, Interviewed by Alec Bofetiado HUMANS Diversity in the English Classroom, Interviewed by Alyssa Henriquez Kyara Samuels on Panamanian Culture, Interviewed by Ben Lee My Multicultural Experience: Eight Students Discuss The Impact of Hispanic Culture on Their Lives, Interviewed by Celeste Richardson ARTS & ENTERTAINMENT Hispanic & Latinx Show and Movie Recommendations!, Megan Napod TikTok, Time\u27s Running Out, Joshua Deonarine Zoey\u27s Extraordinary Playlist, Hannah Cruse IDEAS Conversations With Me, Evin N. Musgrove Faith in Our Current Moment, Adoniah Simon Remembering RBG Part 1: Legacy of the Supreme Court Justice, American Icon and Feminist Champion, Lyle Goulbourne THE LAST WORD Gaming and \u27The Guys\u27, Daniel Selfhttps://digitalcommons.andrews.edu/sm-105/1003/thumbnail.jp

The Student Movement Volume 105 Issue Issue 5: Artist Spotlight: Jel Tamayo

NEWS Andrews University Transitions to Dynamic Campus, Taylor Uphus ASIS Holds First Vespers of Fall 2020, Joelle Kim Students Participate in Andrews University Vote Week, Caralynn Chan The Andrews University Symphony Orchestra Performs Awakening Concert, Jenae Rogers PULSE How to Stay Eco-Friendly During the Pandemic, Gloria Oh Paralleling the Hispanic and Filipino Cultural Experience, Alec Bofetiado The GetApp Go-To Orders, Wambui Karanja HUMANS AU Athletics for the Year 2020-21, Interviewed by Fitz-Earl McKenzie II Checking in with Honors: 2020-21 Plans, Interviewed by Terika Williams Discussing Mental Health and the CTC with Dr. Judith Bernard-Fisher and Mindy Kissinger, Interviewed by Abigail Lee ARTS & ENTERTAINMENT Filipino Artist Spotlight: Jel Tamayo, Megan Napod Noche Latina: A Night of Music, Poetry, Dance, and Culture, Megan Napod Signal Boost, Monday by Evin-Nazya Musgrove IDEAS That\u27s Just Me , Evin N. Musgrove Superspreader in Chief, Lyle Goulbourne The Vice Presidential Debate, Alannah Tjhatrahttps://digitalcommons.andrews.edu/sm-105/1005/thumbnail.jp

The Student Movement Volume 105 Issue 2: Clubs Fare Well: Clubs Preserve Community During COVID

NEWS Clubs, Clubs, Clubs Galore, Taylor Uphus The Andreasen Center for Wellness Reopening, Amanda Cho Danielle Pilgrim Delivers Inspiring Message, Terika Williams PULSE Planning University Club Events Amidst a Pandemic, Masy Domecillo Research at the Science Complex During COVID-19, Jessica Rim Socializing During a Pandemic: Freshmen Perspectives, Interviewed by Wambui Karanja HUMANS BSCF Club Spotlight, Interviewed by TJ Hunter Distance Learning Student Interview, Sydney Saint-Jean Meet Lamson Hall\u27s Newest Dean, Interviewed by Pearl Parker Spiritual Leadership During COVID-19, Interviewed by Terika Williams ARTS & ENTERTAINMENT More Apples to Byte, Hannah Cruse Playing Out the Pandemic: Our Orchestras Dealing with COVID, Megan Napod Signal Boost: The Domino Effect, Pearl Parker Virtual Game Night: A Virtual Reality, Joshua Deonarine IDEAS How Climate Change is Fueling the West Coast Fires, Lyle Goulbourne Ideas That Heal Us: So You Think You\u27re Self-Aware, Evin N. Musgrove THE LAST WORD What am I Applying for & Who am I?, Daniel Selfhttps://digitalcommons.andrews.edu/sm-105/1002/thumbnail.jp

Political mobilisation by minorities in Britain: negative feedback of ‘race relations'?

This article uses a political opportunity approach to study the relationship of minority groups to the political community in Britain. The main argument is that the British race relations approach established in the 1960s had an important effect that still shapes the patterns of political contention by different minority groups today. Original data on political claims-making by minorities demonstrate that British 'racialised' cultural pluralism has structured an inequality of opportunities for the two main groups, African-Caribbeans and Indian subcontinent minorities. African-Caribbeans mobilise along racial lines, use a strongly assimilative 'black' identity, conventional action forms, and target state institutions with demands for justice that are framed within the recognised framework of race relations. Conversely, a high proportion of the Indian subcontinent minority mobilisation is by Muslim groups, a non-assimilative religious identity. These are autonomously organised, but largely make public demands for extending the principle of racial equality to their non-racial group. Within the Indian subcontinent minorities, the relative absence of mobilisation by Indian, Sikh and Hindu minorities, who have achieved much better levels of socio-economic success than Pakistani and Bangladeshi Muslims, suggests that there is also a strong socioeconomic basis for shared experiences and grievances as Muslims in Britain. This relativises the notion that Muslim mobilisation is Britain is purely an expression of the right for cultural difference per se, and sees it as a product of the paradoxes of British race relations

Transnational and diasporic youth identities: exploring conceptual themes and future research agendas

This special issue brings together multidisciplinary and international perspectives on the importance of diasporic and transnational networks for the formation of ethnic identity by migrant youths. Within the context of this issue migrant youths refer to young people (aged 16–35 years) who are themselves migrants or are children and grandchildren of migrants. Our attention to the transnational and diasporic identities of migrant youths is in direct response to policy debates and migration scholarship in this area, which in recent times have focused on the supposed crisis of minority ethnic youths and their perceived marginalisation and social exclusion from a wider society. The special issue broadens the parameters of this debate by exploring not how transnational migrant youths are but more interestingly, we believe, what it means for them to have grown up in a transnational social field. In the special issue rather than simply addressing identity outcomes, we want to emphasise identity processes. This is because we are more interested in understanding the ways the migrant youths are ‘doing transnationalism’ and also through this process ‘doing identity’ (including intersected racial, ethnic, gender, class and sexual identities)