Back to normal? The future of global production networks.

It is neither likely nor desirable for central banks to exit from unconventional monetary policies in the near future. However, it is important that central banks develop an exit strategy, evaluate the merits of new and old monetary policy tools and communicate with the public so as to maintain financial stability, support economic growth and minimize future inflationary risks. Central bank communication policy will turn out to be crucial and more challenging than it was before the crisis.Wertschöpfung; Outsourcing; Business Network; Offshoring; Globalisierung; Wirtschaftskrise;

Creating topological interfaces and detecting chiral edge modes in a 2D optical lattice

We propose and analyze a general scheme to create chiral topological edge modes within the bulk of two-dimensional engineered quantum systems. Our method is based on the implementation of topological interfaces, designed within the bulk of the system, where topologically-protected edge modes localize and freely propagate in a unidirectional manner. This scheme is illustrated through an optical-lattice realization of the Haldane model for cold atoms, where an additional spatially-varying lattice potential induces distinct topological phases in separated regions of space. We present two realistic experimental configurations, which lead to linear and radial-symmetric topological interfaces, which both allows one to significantly reduce the effects of external confinement on topological edge properties. Furthermore, the versatility of our method opens the possibility of tuning the position, the localization length and the chirality of the edge modes, through simple adjustments of the lattice potentials. In order to demonstrate the unique detectability offered by engineered interfaces, we numerically investigate the time-evolution of wave packets, indicating how topological transport unambiguously manifests itself within the lattice. Finally, we analyze the effects of disorder on the dynamics of chiral and non-chiral states present in the system. Interestingly, engineered disorder is shown to provide a powerful tool for the detection of topological edge modes in cold-atom setups.Comment: 18 pages, 21 figure

A Web application for creating and sharing visual bibliographies

The amount of information provided by peer-reviewed scientific literature citation indexes such as Scopus, Web of Science (WOS), CrossRef and OpenCitations is huge: it offers to the users a lot of metadata about publications, such as the list of papers written by a specific author, the editorial and content details of a paper, the list of references and citations. But, for a researcher could be interesting also to: extract in real-time these data in order to create bibliographies, for example, starting with a small set of significant papers or a restricted number of authors, and progressively enriching them by exploring cited/citing references; dispose of a graphical and aggregate representation for them; be able to easily share them with other interested researchers. With these main intents, we modelled and realized VisualBib, a Web application prototype, which enables the user to select sets of papers and/or authors in order to create customized bibliographies, and in real-time visualize them, aggregating data from different sources, in a comprehensive, holistic graphical view. The bibliographies are displayed using time-based visualizations, called narrative views, which contain explicit representations of the authorship and citing relations. These views may help users to: describe a research area; disseminate the research on a specific topic through the sharing of personal points of view; show in a fresh look the entire production of a researcher, or research groups, in order present or evaluate it

Do Multinational enterprises push up wages of domestic firms in the Italian Manufacturing sector?

This paper analyzes the effects of foreign direct investment on wages paid by domestic firms in the Italian manufacturing sector over the period 2002–2007. In particular, the authors investigate the im-pact of multinational enterprises on wages paid by local firms which operate in the same industry, known and horizontal wage spillovers, or have linkages with multinational enterprises in both downstream and upstream industries, known as vertical wage spillovers. By using a large panel dataset, consisting of 551,000 observations, the authors find evidence of wage spillovers only at inter-industry level and, more specifically, for those firms who supply their goods to multinational enterprises, described as backward wage spillovers. Moreover, findings suggest that the wage spillover effect is strongly affected by the technological gap between local and foreign firms: only workers employed in domestic firms with a low-medium technological absorptive capacity seem to benefit from the presence of multinational enterprises in terms of higher wages

Challenging the production function approach to assess the developmental effects of FDI

From a theoretical point of view, it is traditionally assumed that foreign firms possess a centrally accumulated firm-specific technological advantage over domestic firms (see, for example, Findlay, 1978; Dunning, 1979). Given a sufficient level of absorptive capacity and human capital, domestic firms in host economies are able to benefit from various externalities stimulated by the presence of foreign firms

Handling a messy world: lessons learned when trying to make the ecosystem services concept operational

The concept of ecosystem services is widely used in the scientific literature and increasingly also in policy and practice. Nevertheless, operationalising the concept, i.e. putting it into practice, is still a challenge. We describe the approach of the EU-project OpenNESS (Operationalisation of Ecosystem Services and Natural Capital), which was created in response to this challenge to critically evaluate the concept when applied to real world problems at different scales and in different policy sectors. General requirements for operationalization, the relevance of conceptual frameworks and lessons learnt from 27 case study applications are synthesized in a set of guiding principles. We also briefly describe some integrative tools as developed in OpenNESS which support the implementation of the principles. The guiding principles are grouped under three major headlines: “Defining the problem and opening up the problem space”, “Considering ethical issues” and “Assessing alternative methods, tools and actions”. Real world problems are often “wicked” problems, which at first are seldom clear-cut and well-defined, but often rather complex and subject to differing interpretations and interests. We take account of that complexity and emphasise that there is not one simple and straightforward way to approach real world problems involving ecosystem services. The principles and tools presented are meant to provide some guidance for tackling this complexity by means of a transdisciplinary methodology that facilitates the operationalisation of the ecosystem services concept

Kapitel 28. Theorien des Wandels und der Gestaltung von Strukturen: Gesellschaftsperspektive

Die Gesellschaftsperspektive beschäftigt sich mit historisch entstandenen, tiefenwirksamen Treibern der Klimakrise. Ihr Fokus liegt auf klimaschädlichen Merkmalen von Natur-Mensch-Beziehungen, die für die westliche Moderne typisch und auch in Österreich wirksam sind. Dazu zählen Wachstumszwang, Kapitalakkumulation, dualistische Verständnisse von Natur und Mensch, Vorstellungen und Praktiken der Naturbeherrschung, sozial-ökologische Ungleichheit und disziplinäre Wissensproduktion

Semantic text mining support for lignocellulose research

Biofuels produced from biomass are considered to be promising sustainable alternatives to fossil fuels. The conversion of lignocellulose into fermentable sugars for biofuels production requires the use of enzyme cocktails that can efficiently and economically hydrolyze lignocellulosic biomass. As many fungi naturally break down lignocellulose, the identification and characterization of the enzymes involved is a key challenge in the research and development of biomass-derived products and fuels. One approach to meeting this challenge is to mine the rapidly-expanding repertoire of microbial genomes for enzymes with the appropriate catalytic properties. Semantic technologies, including natural language processing, ontologies, semantic Web services and Web-based collaboration tools, promise to support users in handling complex data, thereby facilitating knowledge-intensive tasks. An ongoing challenge is to select the appropriate technologies and combine them in a coherent system that brings measurable improvements to the users. We present our ongoing development of a semantic infrastructure in support of genomics-based lignocellulose research. Part of this effort is the automated curation of knowledge from information on fungal enzymes that is available in the literature and genome resources. Working closely with fungal biology researchers who manually curate the existing literature, we developed ontological natural language processing pipelines integrated in a Web-based interface to assist them in two main tasks: mining the literature for relevant knowledge, and at the same time providing rich and semantically linked information

Kapitel 24. Theorien des Wandels und der Gestaltung von Strukturen

Abschnitt 5 nimmt eine Bestandsaufnahme von Theorien vor, die in einem weiten Sinne Wandel untersuchen. „Theorien des Wandels“ ist ein Überbegriff für all diejenigen Theorien, die helfen, aktuelle Dynamiken der Klimakrise zu verstehen und sowohl die stattfindenden als auch die notwendigen Transformationen zu fassen

Identification of O-Linked Glycoproteins Binding to the Lectin Helix pomatia Agglutinin as Markers of Metastatic Colorectal Cancer

Background Protein glycosylation is an important post-translational modification shown to be altered in all tumour types studied to date. Mucin glycoproteins have been established as important carriers of O-linked glycans but other glycoproteins exhibiting altered glycosylation repertoires have yet to be identified but offer potential as biomarkers for metastatic cancer. Methodology In this study a glycoproteomic approach was used to identify glycoproteins exhibiting alterations in glycosylation in colorectal cancer and to evaluate the changes in O-linked glycosylation in the context of the p53 and KRAS (codon 12/13) mutation status. Affinity purification with the carbohydrate binding protein from Helix pomatia agglutinin (HPA) was coupled to 2-dimensional gel electrophoresis with mass spectrometry to enable the identification of low abundance O-linked glycoproteins from human colorectal cancer specimens. Results Aberrant O-linked glycosylation was observed to be an early event that occurred irrespective of the p53 and KRAS status and correlating with metastatic colorectal cancer. Affinity purification using the lectin HPA followed by proteomic analysis revealed annexin 4, annexin 5 and CLCA1 to be increased in the metastatic colorectal cancer specimens. The results were validated using a further independent set of specimens and this showed a significant association between the staining score for annexin 4 and HPA and the time to metastasis; independently (annexin A4: Chi square 11.45, P = 0.0007; HPA: Chi square 9.065, P = 0.0026) and in combination (annexin 4 and HPA combined: Chi square 13.47; P = 0.0002). Conclusion Glycoproteins showing changes in O-linked glycosylation in metastatic colorectal cancer have been identified. The glycosylation changes were independent of p53 and KRAS status. These proteins offer potential for further exploration as biomarkers and potential targets for metastatic colorectal cancer