Deep model simulation of polar vortices in gas giant atmospheres

The Cassini and Juno probes have revealed large coherent cyclonic vortices in the polar regions of Saturn and Jupiter, a dramatic contrast from the east-west banded jet structure seen at lower latitudes. Debate has centered on whether the jets are shallow, or extend to greater depths in the planetary envelope. Recent experiments and observations have demonstrated the relevance of deep convection models to a successful explanation of jet structure and cyclonic coherent vortices away from the polar regions have been simulated recently including an additional stratified shallow layer. Here we present new convective models able to produce long-lived polar vortices. Using simulation parameters relevant for giant planet atmospheres we find flow regimes that are in agreement with geostrophic turbulence (GT) theory in rotating convection for the formation of large scale coherent structures via an upscale energy transfer fully three-dimensional. Our simulations generate polar characteristics qualitatively similar to those seen by Juno and Cassini: they match the structure of cyclonic vortices seen on Jupiter; or can account for the existence of a strong polar vortex extending downwards to lower latitudes with a marked spiral morphology and the hexagonal pattern seen on Saturn. Our findings indicate that these vortices can be generated deep in the planetary interior. A transition differentiating these two polar flows regimes is described, interpreted in terms of different force balances and compared with previous shallow atmospheric models which characterised polar vortex dynamics in giant planets. In addition, the heat transport properties are investigated confirming recent scaling laws obtained in the context of reduced models of GT.Comment: 18 pages, 13 figures and 3 table

Reduction of the model noise in non-linear reconstruction via an efficient calculation of the incident field: application to a 434 MHz Scanner

Microwave tomography has been drastically boosted by the development of efficient reconstruction algorithms based on an iterative solution of the corresponding non-linear inverse problem. The accuracy of the electric field radiated by the antennas of a microwave scanner, inside the target area, has been shown to play a significant role on the overall image quality. Taking into account the antenna environment is of prime importance, especially when operating at low frequency. For instance, the wall of a 60 cm diameter whole-body microwave scanner cannot be neglected at 434 MHz, even when using the immersion technique consisting of putting the target in water. Indeed, at such a frequency, the attenuation introduced by water is not sufficient to avoid multiple reflections on the scanner boundary walls. Consequently, the method of calculating the incident field constitutes a key factor in iteratively solving non-linear inverse problems. The selected technique must accommodate high accuracy while maintaining acceptable calculation complexity. In this paper, three distinct techniques are analysed. They are based on the use of i) free-space and ii) non free-space Green's function, and iii) a FDTD approach. All these techniques have been firstly investigated for their 2D version, being used in 2D reconstruction algorithms. However, the scattered field data are collected in a 3D scanner. For assessing the validity of the previous 2D techniques, their results have been compared to both experimentally and 3D-FDTD results.Peer ReviewedPostprint (published version

Microwave imaging techniques for biomedical applications

Microwaves have been considered for medical applications involving the detection of organ movements and changes in tissue water content. More particularly cardiopulmonary interrogation via microwaves has resulted in various sensors monitoring ventricular volume change or movement, arterial wall motion, respiratory movements, pulmonary oedema, etc. In all these applications, microwave sensors perform local measurements and need to be displaced for obtaining an image reproducing the spatial variations of a given quantity. Recently, advances in the area of inverse scattering theory and microwave technology have made possible the development of microwave imaging and tomographic instruments. This paper provides a review of such equipment developed at Suplec and UPC Barcelona, within the frame of successive French-Spanish PICASSO cooperation programs. It reports the most significant results and gives some perspectives for future developments. Firstly, a brief historical survey is given. Then, both technological and numerical aspects are considered. The results of preliminary pre-clinical assessments and in-lab experiments allow to illustrate the capabilities of the existing equipment, as well as its difficulty in dealing with clinical situations. Finally, some remarks on the expected development of microwave imaging techniques for biomedical applications are given.Peer ReviewedPostprint (published version

O olhar cultural: conquistas e desafios

NUSSBAUMER, Gisele Marchiori (Org.). Teorias & Políticas da Cultura: visões multidisciplinares. Salvador: UDUFBA, 2007

The evolution of hematopoietic cells under cancer therapy

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Asociación Española Contra el Cáncer (AECC) (GC16173697BIGA); Severo Ochoa Centre of Excellence Award from the Spanish Ministry of Economy and Competitiveness (MINECO; Government of Spain); CERCA (Generalitat de Catalunya); Secretariat for Universities and Research of the Ministry of Business and Knowledge of the Government of Catalonia; Barcelona Institute of Science and Technology (BIST); Hartwig Medical Foundation; Center for Personalized Cancer Treatment (CPCT).Chemotherapies may increase mutagenesis of healthy cells and change the selective pressures in tissues, thus influencing their evolution. However, their contributions to the mutation burden and clonal expansions of healthy somatic tissues are not clear. Here, exploiting the mutational footprint of some chemotherapies, we explore their influence on the evolution of hematopoietic cells. Cells of Acute Myeloid Leukemia (AML) secondary to treatment with platinum-based drugs show the mutational footprint of these drugs, indicating that non-malignant blood cells receive chemotherapy mutations. No trace of the 5-fluorouracil (5FU) mutational signature is found in AMLs secondary to exposure to 5FU, suggesting that cells establishing the leukemia could be quiescent during treatment. Using the platinum-based mutational signature as a barcode, we determine that the clonal expansion originating the secondary AMLs begins after the start of the cytotoxic treatment. Its absence in clonal hematopoiesis cases is consistent with the start of the clonal expansion predating the exposure to platinum-based drugs

Standardised proformas improve patient handover: Audit of trauma handover practice

<p>Abstract</p> <p>Background</p> <p>The implementation of the European Working Time Directive has meant the introduction of shift patterns of working for junior doctors. Patient handover between shifts has become a necessary part of practice in order to reduce the risk of medical errors. Data handed over between shifts are used to prioritise clinical jobs outstanding, and to create theatre lists. We present a closed-loop audit of handover practice to assess whether standardised proformas improve clinical data transfer between shifts during handover in our Orthopaedic Unit.</p> <p>Methods</p> <p>We collected data handed over between shifts for a period of one week at our department. The data were in the form of hand written data on plain paper used to assist verbal handover. Data were analysed and a standardised handover sheet was trialled. After feedback from juniors the sheet was revised and implemented. A re-audit, of handover data, was then undertaken using the revised standardised proforma during a period of 1 week.</p> <p>Results</p> <p>Forty-eight patients were handed over in week 1 while 55 patients were handed over during re-audit. The standardised proformas encouraged use of pre-printed patient labels which contained legible patient identifiers, use of labels increased from 72.9% to 93.4%. Handover of outstanding jobs increased from 31.25% to 100%. Overall data handed over increased from 72.6% to 93.2%. Handover of relevant blood results showed little improvement from 18.8% to 20.7%</p> <p>Conclusion</p> <p>This audit highlights the issue of data transfer between shifts. Standardised proformas encourage filling of relevant fields and increases the data transferred between shifts thereby reducing the potential for clinical error cause by shift patterns.</p

Protein dynamics at slow timescales in engineered ß-lactamases does not limit evolvability

Understanding the underlying mechanisms in the evolution of new protein functions is key to better directing enzyme engineering efforts. Intragenic epistasis (the non-additive interaction of mutations affecting function) is a key feature of protein evolution. For example, in TEM-1 ß-lactamase, the mutations E104K and G238S show positive epistasis in that their combination show a greater than expected increase in antibiotic resistance1. Here, we aim to understand the impact of protein dynamics at slow timescales on epistasis. Large conformational rearrangements associated with ligand-binding, turnover of substrate or allostery occur at this timescale2. The readily evolvable antibiotic-resistant TEM-1 ß-lactamase and two of its variants that are more dynamic at slow timescales serve as models for this study. Our models show similar catalytic activity and substrate recognition, thermal stability, as well as conserved motions in fast (ps-ns) and intermediate (ns-ms) timescales but different motions at slow timescales (ms-ms)123. Please click Additional Files below to see the full abstract