672 research outputs found
The Sensitivity of the Proportionality between Temperature Change and Cumulative CO2 Emissions to Ocean Mixing
The ratio of global mean surface air temperature change to cumulative CO2 emissions, referred to as transient climate response to cumulative CO2 emissions (TCRE), has been shown to be approximately constant on centennial time scales. The mechanisms behind this constancy are not well understood, but previous studies suggest that compensating effects of ocean heat and carbon fluxes, which are governed by the same ocean mixing processes, could be one cause for this approximate constancy. This hypothesis is investigated by forcing different versions of the University of Victoria Earth System Climate Model, which differ in the ocean mixing parameterization, with an idealized scenario of 1% annually increasing atmospheric CO2 until quadrupling of the preindustrial CO2 concentration and constant concentration thereafter. The relationship between surface air warming and cumulative emissions remains close to linear, but the TCRE varies between model versions, spanning the range of 1.2°–2.1°C EgC−1 at the time of CO2 doubling. For all model versions, the TCRE is not constant over time while atmospheric CO2 concentrations increase. It is constant after atmospheric CO2 stabilizes at 1120 ppm, because of compensating changes in temperature sensitivity (temperature change per unit radiative forcing) and cumulative airborne fraction. The TCRE remains approximately constant over time even if temperature sensitivity, determined by ocean heat flux, and cumulative airborne fraction, determined by ocean carbon flux, are taken from different model versions with different ocean mixing settings. This can partially be explained with temperature sensitivity and cumulative airborne fraction following similar trajectories, which suggests ocean heat and carbon fluxes scale approximately linearly with changes in vertical mixing
X-ray Bright Active Galactic Nuclei in Massive Galaxy Clusters II: The Fraction of Galaxies Hosting Active Nuclei
We present a measurement of the fraction of cluster galaxies hosting X-ray
bright Active Galactic Nuclei (AGN) as a function of clustercentric distance
scaled in units of . Our analysis employs high quality Chandra X-ray
and Subaru optical imaging for 42 massive X-ray selected galaxy cluster fields
spanning the redshift range of . In total, our study involves
176 AGN with bright () optical counterparts above a keV flux
limit of . When excluding
central dominant galaxies from the calculation, we measure a cluster-galaxy AGN
fraction in the central regions of the clusters that is times lower
that the field value. This fraction increases with clustercentric distance
before becoming consistent with the field at . Our data
exhibit similar radial trends to those observed for star formation and
optically selected AGN in cluster member galaxies, both of which are also
suppressed near cluster centers to a comparable extent. These results strongly
support the idea that X-ray AGN activity and strong star formation are linked
through their common dependence on available reservoirs of cold gas.Comment: 9 Pages, 4 Figures, accepted for publication in MNRAS, please contact
Steven Ehlert ([email protected]) with any querie
X-ray bright active galactic nuclei in massive galaxy clusters III: New insights into the triggering mechanisms of cluster AGN
We present the results of a new analysis of the X-ray selected Active
Galactic Nuclei (AGN) population in the vicinity of 135 of the most massive
galaxy clusters in the redshift range of 0.2 < z < 0.9 observed with Chandra.
With a sample of more than 11,000 X-ray point sources, we are able to measure,
for the first time, evidence for evolution in the cluster AGN population beyond
the expected evolution of field AGN. Our analysis shows that overall number
density of cluster AGN scales with the cluster mass as .
There is no evidence for the overall number density of cluster member X-ray AGN
depending on the cluster redshift in a manner different than field AGN, nor
there is any evidence that the spatial distribution of cluster AGN (given in
units of the cluster overdensity radius r_500) strongly depends on the cluster
mass or redshift. The scaling relation we measure is
consistent with theoretical predictions of the galaxy merger rate in clusters,
which is expected to scale with the cluster velocity dispersion, , as or . This consistency suggests that AGN in
clusters may be predominantly triggered by galaxy mergers, a result that is
further corroborated by visual inspection of Hubble images for 23
spectroscopically confirmed cluster member AGN in our sample. A merger-driven
scenario for the triggering of X-ray AGN is not strongly favored by studies of
field galaxies, however, suggesting that different mechanisms may be primarily
responsible for the triggering of cluster and field X-ray AGN.Comment: 21 Pages, 8 figures, 5 tables. Submitted to MNRAS. Comments are
welcome, and please request Steven Ehlert for higher resolution figure
Probing the extreme realm of AGN feedback in the massive galaxy cluster, RX J1532.9+3021
We present a detailed Chandra, XMM-Newton, VLA and HST analysis of one of the
strongest cool core clusters known, RX J1532.9+3021 (z=0.3613). Using new, deep
90 ks Chandra observations, we confirm the presence of a western X-ray cavity
or bubble, and report on a newly discovered eastern X-ray cavity. The total
mechanical power associated with these AGN-driven outflows is (22+/-9)*10^44
erg/s, and is sufficient to offset the cooling, indicating that AGN feedback
still provides a viable solution to the cooling flow problem even in the
strongest cool core clusters. Based on the distribution of the optical
filaments, as well as a jet-like structure seen in the 325 MHz VLA radio map,
we suggest that the cluster harbours older outflows along the north to south
direction. The jet of the central AGN is therefore either precessing or
sloshing-induced motions have caused the outflows to change directions. There
are also hints of an X-ray depression to the north aligned with the 325 MHz
jet-like structure, which might represent the highest redshift ghost cavity
discovered to date. We further find evidence of a cold front (r=65kpc) that
coincides with the outermost edge of the western X-ray cavity and the edge of
the radio mini-halo. The common location of the cold front with the edge of the
radio mini-halo supports the idea that the latter originates from electrons
being reaccelerated due to sloshing induced turbulence. Alternatively, its
coexistence with the edge of the X-ray cavity may be due to cool gas being
dragged out by the outburst. We confirm that the central AGN is highly
sub-Eddington and conclude that a >10^10M_Sun or a rapidly spinning black hole
is favoured to explain both the radiative-inefficiency of the AGN and the
powerful X-ray cavities.Comment: Accepted for publication to ApJ (minor corrections), 16 pages, 16
figures, 5 tables. Full resolution at http://www.stanford.edu/~juliehl/M1532
ixpeobssim: a Simulation and Analysis Framework for the Imaging X-ray Polarimetry Explorer
ixpeobssim is a simulation and analysis framework, based on the Python
programming language and the associated scientific ecosystem, specifically
developed for the Imaging X-ray Polarimetry Explorer (IXPE). Given a source
model and the response functions of the telescopes, it is designed to produce
realistic simulated observations, in the form of event lists in FITS format,
containing a strict super-set of the information provided by standard IXPE
level-2 files. The core ixpeobssim simulation capabilities are complemented by
a full suite of post-processing applications, allowing for the implementation
of complex, polarization-aware analysis pipelines, and facilitating the
inter-operation with the standard visualization and analysis tools
traditionally in use by the X-ray community. We emphasize that, although a
significant part of the framework is specific to IXPE, the modular nature of
the underlying implementation makes it potentially straightforward to adapt it
to different missions with polarization capabilities.Comment: 12 pages, 6 figures. Accepted for publication on SoftwareX; source
code available at https://github.com/lucabaldini/ixpeobssi
Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors
Positive allosteric modulators (PAMs) that target the M1 muscarinic acetylcholine (ACh) receptor (M1 mAChR) are potential treatments for cognitive deficits in conditions such as Alzheimer's disease and schizophrenia. We recently reported novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one M1 mAChR PAMs with the potential to display different modes of positive allosteric modulation and/or agonism (Mistry et al., 2016), but their molecular mechanisms of action remain undetermined. The current study compared the pharmacology of three such novel PAMs with the prototypical first-generation PAM, BQCA, in a recombinant Chinese hamster ovary (CHO) cell line stably expressing the human M1 mAChR. Interactions between the orthosteric agonists and the novel PAMs or BQCA suggested their allosteric effects were solely governed by modulation of agonist affinity. The greatest degree of positive co-operativity was observed with higher efficacy agonists, whereas minimal potentiation was observed when the modulators were tested against the lower efficacy agonist, xanomeline. Each PAM was investigated for its effects on the endogenous agonist, ACh, on three different signalling pathways, (ERK1/2 phosphorylation, IP1 accumulation and β-arrestin-2 recruitment), revealing that the allosteric potentiation generally tracked with the efficiency of stimulus-response coupling and that there was little pathway bias in the allosteric effects. Thus, despite the identification of novel allosteric scaffolds targeting the M1 mAChR, the molecular mechanism of action of these compounds is largely consistent with a model of allostery previously described for BQCA, suggesting that this may be a more generalized mechanism for M1 mAChR PAM effects than previously appreciated
The Lausanne Infant Crying Stress Paradigm: Validation of an Early Postpartum Stress Paradigm with Women at Low vs. High Risk of Childbirth-Related Posttraumatic Stress Disorder.
Stress reactivity is typically investigated in laboratory settings, which is inadequate for mothers in maternity settings. This study aimed at validating the Lausanne Infant Crying Stress Paradigm (LICSP) as a new psychosocial stress paradigm eliciting psychophysiological stress reactivity in early postpartum mothers (n = 52) and to compare stress reactivity in women at low (n = 28) vs. high risk (n = 24) of childbirth-related posttraumatic stress disorder (CB-PTSD). Stress reactivity was assessed at pre-, peri-, and post-stress levels through salivary cortisol, heart rate variability (high-frequency (HF) power, low-frequency (LF) power, and LF/HF ratio), and perceived stress via a visual analog scale. Significant time effects were observed for all stress reactivity outcomes in the total sample (all p < 0.01). When adjusting for perceived life threat for the infant during childbirth, high-risk mothers reported higher perceived stress (p < 0.001, d = 0.91) and had lower salivary cortisol release (p = 0.023, d = 0.53), lower LF/HF ratio (p < 0.001, d = 0.93), and marginally higher HF power (p = 0.07, d = 0.53) than low-risk women. In conclusion, the LICSP induces subjective stress and autonomic nervous system (ANS) reactivity in maternity settings. High-risk mothers showed higher perceived stress and altered ANS and hypothalamic-pituitary-adrenal reactivity when adjusting for infant life threat. Ultimately, the LICSP could stimulate (CB-)PTSD research
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