Stable configurations of hybrid stars with colour-flavour-locked core

We construct static and mass-shedding limit sequences of hybrid stars, composed of colour flavour locked (CFL) quark matter core, for a set of equations of state (EOSs). The EOS for the hadronic matter is obtained using appropriately calibrated extended field theoretical based relativistic mean-field model. The MIT bag model is employed to compute the EOSs of the CFL quark matter for different values of the CFL gap parameter in the range of $50 - 150\text{MeV}$ with the deconfinement phase transition density ranging from $4\rho_0 - 6\rho_0$ ($\rho_0 = 0.16\text{fm}^{-3}$). We find, depending on the values of the CFL gap parameter and the deconfinement phase transition density, the sequences of stable configurations of hybrid stars either form third families of the compact stars or bifurcate from the hadronic sequence. The hybrid stars have masses $1.0 - 2.1 M_\odot$ with radii $9 - 13.5$ km. The maximum values of mass shedding limit frequency for such hybrid stars are $1 -2$ kHz. For the smaller values of the CFL gap parameter and the deconfinement phase transition density, mass-radius relationships are in harmony with those deduced by applying improved hydrogen atmosphere model to fit the high quality spectra from compact star X7 in the globular cluster 47 Tucanae. We observed for some cases that the third family of compact stars exist in the static sequence, but, disappear from the mass-shedding limit sequence. Our investigation suggests that the third family of compact stars in the mass-shedding limit sequence is more likely to appear, provided they have maximum mass in the static limit higher than their second family counterpart composed of pure hadronic matter.Comment: 27 pages including 10 figures. Accepted in Phys. Rev.

Superior vena cava obstruction as manifestation of synovial cell sarcoma: a case report and review of literature

Synovial cell sarcomas are one of the most common soft tissue tumors affecting adolescents and young adults. The common location of these tumors is often extremities. Primary involvement of mediastinum is a very rare presentation of this tumor, only few cases have been reported so far. We are reporting the case of a 27-year-old male patient who presented to us with a history of dyspnoea and chest discomfort of one week duration along with features of SVC obstruction. Chest is a frequently involved site of metastasis and lymphomas but rarely involved in synovial sarcoma. The learning point from this case is that rare causes like synovial sarcoma of mediastinum should always be included in differential diagnosis of mediastinal mass and SVC obstruction. We are reporting this case in view of its rarity.  Though uncommon this case report emphasizes that synovial cell sarcoma should also be considered in differential diagnosis of mediastinal mass and early recognition with HPE, IHC and prompt institution of treatment can be lifesaving

DOCUMENTED VETERINARY AYURVEDIC TREATMENT CLAIMS FROM ANDHRA PRADESH REGION ON CERTAIN IMPORTANT GASTROINTESTINAL DISEASES OF CATTLE

Gastro intestinal (GI) diseases are common to cattle. These diseases give lots of pain and discomfort to the cattle and loss to the cattle keepers. Ayurvedic medicines have high potentiality in treating many non infectious GI disorders. In infectious GI diseases irrational use of antibiotics has increased the risk of resistance as well as side effects. There is a surge of search for alternative therapies and Ayurveda is believed to be the promised answer. In Andhra Pradesh many scholars and traditional physicians practiced Ayurvedic methods; medicines for the cattle treatment and few of them had dedicated their lives completely to Ayurvedic veterinary practice. They magnificently combined traditional wisdom of classical Ayurvedic texts with newly acquired knowledge from modern veterinary medicine. They used to diagnose the diseases on modern methods and treatment was given through Ayurvedic drugs. They recorded their treatment and research findings, documented and presented them in a systematic way for their publications. These publications are not available in public domains and they are protected by AP states archives, Hyderabad. These Telugu publications are unique to veterinary medicine. With lots of efforts and literary research the data is compiled and translated. Many GI diseases and there remedies are dealt in these publications and present paper deals the treatments of indigestion, painful condition due to indigestion, tympanites (abdominal distension), grain sickness (grain poisoning or acidosis), fardel-bound and colic., This article explores treatments in a scientific manner with suitable Botanical or English names of the plants along with dose in metric equivalents.

Dynamic Response and Static Analysis of RCC Space Frames Supporting High Speed Centrifugal Machines with Coupled Soil-Structure Interaction

The paper reviews the current state of the art on the dynamic and static analyses of RCC space frames supporting high speed centrifugal machines e.g. large turbogenerators and compressors. The need to include the effects of soil-structure interaction formulations on overall behaviour of various analytical models are highlighted, At the same time, the uncertainties involved in evaluating essential geotechnical parameters and paucity of reliable and elaborate information from the machine manufacturers are discussed. The analysis and design aspects of this inter-disciplinary problem are illustrated with two typical design case studies selected from authors’ own experience in this specialised field. The paper also discusses the usefulness, if any, of such rigorous analysis and identifies various shortcomings which still persist in finalising realistic design data and adopting suitable models to represent machine foundation-soil system

Pressure effects on the magnetic structure in La0.5Ca0.5-xSrxMnO3 (0.1 -< x -< 0.4) manganites

The effect of high pressure (0 - 8 GPa) on the magnetic structure of polycrystalline samples of La0.5Ca0.5-xSrxMnO3 (0.1 -< x -< 0.4) manganites at 5 K is investigated using neutron diffraction technique. Application of pressure is found to modify the previously reported magnetic structure, observed under ambient conditions, in these compounds [I. Dhiman et al., Phys. Rev. B 77, 094440 (2008)]. In x = 0.1 composition, at 4.6(2) GPa and beyond, A-type antiferromagnetic structure is found to coexist with CE-type antiferromagnetic phase, observed at ambient pressure, with TN ~ 150 K. For x = 0.3 sample, as a function of pressure the CE-type phase is fully suppressed at 2.3(1) GPa and A-type antiferromagnetic phase is favored. Further Sr doping at x = 0.4, the A-type antiferromagnetic phase is observed at ambient pressure and for T < TN (~ 250K). This phase is retained in the studied pressure range. However, the magnetic moment progressively reduces with increasing pressure, indicating the suppression of A-type antiferromagnetic phase. The present study brings out the fragile nature of the CE-type antiferromagnetic state in half doped manganites as a function of pressure and disorder \sigma 2. We observe that pressure required for destabilizing the CE-type antiferromagnetic state is reduced with increasing disorder \sigma 2. External pressure and changing A-site ionic radii have analogous effect on the magnetic structure.Comment: 9 pages, 6 figures, 1 table, To appear in Physical Review

Diffuse Neutron Scattering Study of Magnetic Correlations in half-doped La0.5Ca0.5-xSrxMnO3 (x = 0.1, 0.3 and 0.4) Manganites

The short range ordered magnetic correlations have been studied in half doped La0.5Ca0.5-xSrxMnO3 (x = 0.1, 0.3 and 0.4) compounds by polarized neutron scattering technique. On doping Sr2+ for Ca2+ ion, these compounds with x = 0.1, 0.3, and 0.4 exhibit CE-type, mixture of CE-type and A-type, and A-type antiferromagnetic ordering, respectively. Magnetic diffuse scattering is observed in all the compounds above and below their respective magnetic ordering temperatures and is attributed to magnetic polarons. The correlations are primarily ferromagnetic in nature above T\_N, although a small antiferromagnetic contribution is also evident. Additionally, in samples x = 0.1 and 0.3 with CE-type antiferromagnetic ordering, superlattice diffuse reflections are observed indicating correlations between magnetic polarons. On lowering temperature below T\_N the diffuse scattering corresponding to ferromagnetic correlations is suppressed and the long range ordered antiferromagnetic state is established. However, the short range ordered correlations indicated by enhanced spin flip scattering at low Q coexist with long range ordered state down to 3K. In x = 0.4 sample with A-type antiferromagnetic ordering, superlattice diffuse reflections are absent. Additionally, in comparison to x = 0.1 and 0.3 sample, the enhanced spin flip scattering at low Q is reduced at 310K, and as temperature is reduced below 200K, it becomes negligibly low. The variation of radial correlation function, g(r) with temperature indicates rapid suppression of ferromagnetic correlations at the first nearest neighbor on approaching TN. Sample x = 0.4 exhibits growth of ferromagnetic phase at intermediate temperatures (~ 200K). This has been further explored using SANS and neutron depolarization techniques.Comment: 13 pages, 12 figures, To appear in Physical Review

INTEGRATION OF AYURVEDA WITH BIOMEDICINE: A RESPONSE IDENTIFICATION CROSS SECTIONAL SURVEY

Background: There is re-emergence of the integrative approach to facilitate affordable, safe and equitable health to all. Due to the active initiatives taken up by the Government of India and other stake holders the reach of Ayurveda has expanded along with wide spread consumer acceptance. The efforts to co-locate Ayurveda centers along with bio-medical facilities across India through programs like National Rural Health Mission (NRHM are limited to the extent of only physical proximity between biomedicine and Ayurveda and far away from the possibility of functional integration granulated to the level of clinical service delivery together. Objective: To document the perceptions of biomedical practitioners about Ayurveda and possible integration with the biomedicine.Methods: Survey through self administered questionnaire carried out at Safdarjung Hospital, New Delhi involving 300 doctors from various biomedical medical specialties. Out of them, 98 doctors did not respond where as 202 responses were received in the stipulated format, which were analyzed, and interpreted based on standard statistical methods.Results: From the analysis of 202 responses, it is evident that all the respondents were aware of basic principles and strengths of Ayurveda. They also opined that, integration is useful to strengthen the overall health care delivery in India. Further, they expressed that the communication barrier between practitioners of Ayurveda and Biomedicine, meagre research work with respect to safety and efficacy of Ayurvedic medicines and therapies, inadequate policy initiatives are the important obstacles in realizing functional integration between Ayurveda and Biomedicine.Conclusion: The survey reported good level of awareness of biomedical practitioners and their supportive attitude about the integration. Need for upgrading the skills of Ayurveda practitioners, safety and efficacy of the medicines, interdisciplinary research, information sharing and coordination between practitioners of Ayurveda and Biomedicine are identified as essential elements for successful integration

SNPPicker: High quality tag SNP selection across multiple populations

<p>Abstract</p> <p>Background</p> <p>Linkage Disequilibrium (LD) bin-tagging algorithms identify a reduced set of tag SNPs that can capture the genetic variation in a population without genotyping every single SNP. However, existing tag SNP selection algorithms for designing custom genotyping panels do not take into account all platform dependent factors affecting the likelihood of a tag SNP to be successfully genotyped and many of the constraints that can be imposed by the user.</p> <p>Results</p> <p>SNPPicker optimizes the selection of tag SNPs from common bin-tagging programs to design custom genotyping panels. The application uses a multi-step search strategy in combination with a statistical model to maximize the genotyping success of the selected tag SNPs. User preference toward functional SNPs can also be taken into account as secondary criteria. SNPPicker can also optimize tag SNP selection for a panel tagging multiple populations. SNPPicker can optimize custom genotyping panels including all the assay-specific constraints of Illumina's GoldenGate and Infinium assays.</p> <p>Conclusions</p> <p>A new application has been developed to maximize the success of custom multi-population genotyping panels. SNPPicker also takes into account user constraints including options for controlling runtime. Perl Scripts, Java source code and executables are available under an open source license for download at <url>http://mayoresearch.mayo.edu/mayo/research/biostat/software.cfm</url></p

Liver cirrhosis, hydroureter and splenomegaly in a cadaver : a case study

Background: Liver cirrhosis is among the most common causes of death in the United States. Cirrhosis can result from alcoholic liver disease, hepatitis, or non-alcoholic fatty liver disease. Advanced cases of liver cirrhosis may result in complications such as portal hypertension, hepatosplenomegaly, varices, and many others. Case Presentation: This report describes a case of extensive liver cirrhosis found during the cadaveric dissection of a 71-year-old male. Observation revealed a slightly enlarged, cirrhotic liver with recanalization of the umbilical vein (of the round ligament). The patient also had significant splenomegaly, indicative of portal hypertension, and dilation of the left ureter. In developing countries, the leading cause of liver cirrhosis is schistosomiasis. Schistosomiasis has been shown to cause both liver cirrhosis and hydroureter (Genitourinary schistosomiasis, 2012). While this infection cannot be completely ruled out, the likelihood that this was the case in this cadaver is unlikely. Discussion: Non-invasive and cost-effective options such as serum and imaging tests can prove useful in detecting liver pathology. Detection of early liver disease and intervention can decrease the incidence of advanced complications and prolong life (Smith et al. 2019). In the case of hydroureter, a parasitic infection can be ruled out by laboratory analysis of stool or urine samples by detecting the presence of parasitic eggs. Histological specimens of the liver, ureter, and urinary bladder can be taken to determine if parasitic eggs were present in either of these areas. Conclusion: This cadaver reveals a classic presentation of portal hypertension that can lead to various secondary pathologies. This case study can be used as additional supporting evidence linking portal hypertension to splenomegaly, hydroureter, and liver cirrhosis