Mothers’ self-focused reflective functioning interacts with childhood experiences of rejection to predict romantic relationship quality and insensitive parenting

Parents exposed to rejection in their childhood could experience bonding disturbances in their current relationships. Reflective functioning (RF), the capacity to understand one’s own and others’ behavior through the lens of underlying mental states (cognitions, emotions), has been identified as a potential protective process. The aim of this longitudinal study was to examine whether RF moderates the effect of parents’ experiences of rejection in childhood on later relationship functioning with partners and infants. Pregnant women with experiences of abuse and neglect were recruited and completed the Adult Attachment Interview, which was coded for RF and experiences of childhood rejection. During two follow‐up assessments, when their infants were 5 and 17 months old, the mothers in our sample who had partners reported on dyadic cohesion with these partners. Further, at 5 months postnatal, mothers completed interaction tasks with their infants, which were later assessed using observational measures (i.e., CARE‐Index). Results of mothers with partners (N = 93) indicated that RF moderated the relationship between dyadic cohesion with partners at 17 months only. Additionally, results with all mothers in the sample (N = 108) indicated that RF moderated the relationship between retrospectively reported experiences of rejection and controlling and unresponsive behaviors with infants. Adequate‐to‐high RF was associated with lower unresponsiveness and higher relationship satisfaction in the context of rejection, while being associated with higher levels of control. These findings have important clinical implications, as RF is amenable to change and can therefore be more prominently implemented within various interventions

Metodologias para avaliação da integridade estrutural de cúpulas e abóbadas históricas em alvenaria

Modern non-destructive investigation techniques and computational tools for nonlinear analysis allow understanding the structural behavior and damage of existing buildings, aiming at the least possible extent of intervention. Careful and minimal intervention is essential to preserve the authenticity of the built cultural heritage. An investigation with a historical, experimental, and numerical approach was carried out in the Theatro Municipal do Rio de Janeiro, in Brazil, a building with an eclectic architecture from the beginning of the twentieth century. Its masonry domes and vault have paintings by renowned artists on their intrados and were strengthened in the 1970s. The adopted methodology was based on anamnesis, characterization and observation of the structure employing non-destructive tests, and on the assessment of its vulnerability by nonlinear analyses of calibrated numerical models. Several hypotheses of differential settlement under gravitational actions were investigated, seeking to reproduce the cracking pattern and to identify the causes of damage to the masonry domes and vault before the strengthening. The nonlinear analysis of the structure allowed to evaluate the causes of the observed damage, assess the level of safety, identify the most vulnerable parts, and characterize the collapse mechanisms, in addition to demonstrating the efficiency of the intervention measures adopted in the past.Técnicas modernas de investigação não destrutiva e ferramentas computacionais para análise não linear permitem compreender o comportamento estrutural e danos em edifícios existentes, visando a menor intervenção possível. A intervenção cuidadosa e mínima é essencial para preservar a autenticidade do patrimônio cultural construído. Uma investigação de abordagem histórica, experimental e numérica foi realizada no Theatro Municipal do Rio de Janeiro, no Brasil, edifício de arquitetura eclética do início do século XX. Suas cúpulas e abóbada em alvenaria possuem pinturas de renomados artistas no intradorso e foram reforçadas na década de 1970. A metodologia adotada baseou-se na anamnese, caracterização e observação da estrutura por meio de ensaios não destrutivos e na avaliação de sua vulnerabilidade por análises não lineares de modelos numéricos calibrados. Diversas hipóteses de recalque diferencial sob ações gravitacionais foram investigadas, buscando reproduzir o padrão de fissuração e identificar as causas dos danos nas alvenarias antes do reforço. A análise não linear da estrutura permitiu avaliar as causas dos danos observados, estimar o nível de segurança, identificar as partes mais vulneráveis e caracterizar os mecanismos de colapso, além de demonstrar a eficácia das medidas de intervenção adotadas no passado.This research was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES) – Finance Code 001 and Faperj, grant number E-26/201.812/2017

Enhancing the utility of antroduodenal manometry in pediatric intestinal pseudo-obstruction

BACKGROUND: Antroduodenal manometry (ADM) and histopathology are currently employed to aid the diagnosis of pediatric intestinal pseudo-obstruction (PIPO). Limited data are available on the reliability of ADM analysis and its correlation with histopathology. We aimed to develop a protocol for enhanced analysis of ADM contractile patterns, including a scoring system, and explore whether this provided better correlation with histopathology. METHODS: Children referred with suspected PIPO between April 2012-December 2019 who underwent both ADM and full-thickness biopsies were included. ADM tracings were analyzed using both standard (conventional ADM) and novel (enhanced ADM) motility parameters. A novel ADM score (GLASS score) was generated based on the enhanced ADM analysis. Conventional and enhanced ADM analyses were then correlated with histopathology. RESULTS: Forty patients were included. Using conventional clinical criteria, 29 of these were diagnosed with PIPO and the other 11 with non-PIPO diagnoses. Twenty-three of the PIPO patients had abnormal histopathology: 6 myopathy, 4 neuropathy, 3 neuro-myopathy, and 10 non-specific changes. No agreement in diagnosis was found between conventional ADM analysis and histopathology (ϰ = 0.068; p = 0.197), whereas the latter significantly correlated with enhanced ADM analysis (ϰ = 0.191; p = 0.003). The enhanced ADM score was significantly higher in PIPO versus non-PIPO (16.0 vs. 8.0; p < 0.001). CONCLUSIONS: As opposed to conventional analysis protocols, the newly developed enhanced ADM analysis and associated score is not only able to discriminate between PIPO and non-PIPO patients, but also between distinct histopathological pathologies. Further studies are required to assess the utility of enhanced ADM analysis in larger populations

Chiral Fermions on the Lattice through Gauge Fixing -- Perturbation Theory

We study the gauge-fixing approach to the construction of lattice chiral gauge theories in one-loop weak-coupling perturbation theory. We show how infrared properties of the gauge degrees of freedom determine the nature of the continuous phase transition at which we take the continuum limit. The fermion self-energy and the vacuum polarization are calculated, and confirm that, in the abelian case, this approach can be used to put chiral gauge theories on the lattice in four dimensions. We comment on the generalization to the nonabelian case.Comment: 31 pages, 5 figures, two refs. adde

Evolução do Sistema AIDA Centralizado para um Ambiente Concorrente usando OMT e SDL-92

Este trabalho propõe o uso combinado da metodologia OMT com a linguagem de especificação formal SDL para a evolução do AIDA, um software para o gerenciamento e análise de dados experimentais, em desenvolvimento na EMBRAPA, partindo de uma versão centralizada para um ambiente concorrente. Esta abordagem apresenta facilidades que produzem ganhos no processo de desenvolvimento de software, como a possibilidade de validação e de simulação do sistema, e também a geração de código para sua prototipação. São apresentados os modelos de objetos e as especificações em SDL das duas versões, o resultado da validação do ambiente AIDA centralizado e também um exemplo de simulação deste sistema.Ingeniería de SoftwareRed de Universidades con Carreras en Informática (RedUNCI

Evolução do Sistema AIDA Centralizado para um Ambiente Concorrente usando OMT e SDL-92

Este trabalho propõe o uso combinado da metodologia OMT com a linguagem de especificação formal SDL para a evolução do AIDA, um software para o gerenciamento e análise de dados experimentais, em desenvolvimento na EMBRAPA, partindo de uma versão centralizada para um ambiente concorrente. Esta abordagem apresenta facilidades que produzem ganhos no processo de desenvolvimento de software, como a possibilidade de validação e de simulação do sistema, e também a geração de código para sua prototipação. São apresentados os modelos de objetos e as especificações em SDL das duas versões, o resultado da validação do ambiente AIDA centralizado e também um exemplo de simulação deste sistema.Ingeniería de SoftwareRed de Universidades con Carreras en Informática (RedUNCI

Outcomes in Hybrid Breast Reconstruction: A Systematic Review

Background and Objectives: Lipofilling is a commonly performed procedure worldwide for breast augmentation and correction of breast contour deformities. In breast reconstruction, fat grafting has been used as a single reconstructive technique, as well as in combination with other procedures. The aim of the present study is to systematically review available studies in the literature describing the combination of implant-based breast reconstruction and fat grafting, focusing on safety, complications rate, surgical sessions needed to reach a satisfying reconstruction, and patient-reported outcomes. Materials and Methods: We adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) throughout the whole review protocol. A systematic review of the literature up to April 2022 was performed using Medline, Embase, and Cochrane Library databases. Only studies dealing with implant-based breast reconstruction combined with fat grafting were included. Results: We screened 292 articles by title and abstract. Only 48 articles were assessed for full-text eligibility, and among those, 12 studies were eventually selected. We included a total of 753 breast reconstructions in 585 patients undergoing mastectomy or demolitive breast surgeries other than mastectomy (quadrantectomy, segmentectomy, or lumpectomy) due to breast cancer or genetic predisposition to breast cancer. Overall, the number of complications was 60 (7.9%). The mean volume of fat grafting per breast per session ranged from 59 to 313 mL. The mean number of lipofilling sessions per breast ranged from 1.3 to 3.2. Conclusions: Hybrid breast reconstruction shows similar short-term complications to standard implant-based reconstruction but with the potential to significantly decrease the risk of long-term complications. Moreover, patient satisfaction was achieved with a reasonably low number of lipofilling sessions (1.7 on average)

Non-syndromic cleft palate: Association analysis on three gene polymorphisms of the folate pathway in Asian and Italian populations

Periconceptional folic acid supplementation can reduce the risk of inborn malformations, including orofacial clefts. Polymorphisms of MTHFR, TCN2, and CBS folate-related genes seem to modulate the risk of cleft lip with or without cleft palate (CL/P) in some populations. CL/P and cleft palate only (CPO) are different malformations that share several features and possibly etiological causes. In the present investigation, we conducted a family-based, candidate gene association study of non-syndromic CPO. Three single nucleotide polymorphisms, namely, rs1801133 of MTHFR, rs1801198 of TCN2, and rs4920037 of CBS, were investigated in a sample that included 129 Italian and 65 Asian families. No evidence of association between the three genotyped polymorphisms and CPO was found in the Italian and Asian cases, indeed the transmission disequilibrium test did not detect any asymmetry of transmission of alleles. This investigation, although with some limitation, further supports that CL/P and CPO diverge in their genetic background

The Standard Model from a New Phase Transition on the Lattice

Several years ago it was conjectured in the so-called Roma Approach, that gauge fixing is an essential ingredient in the lattice formulation of chiral gauge theories. In this paper we discuss in detail how the gauge-fixing approach may be realized. As in the usual (gauge invariant) lattice formulation, the continuum limit corresponds to a gaussian fixed point, that now controls both the transversal and the longitudinal modes of the gauge field. A key role is played by a new phase transition separating a conventional Higgs or Higgs-confinement phase, from a phase with broken rotational invariance. In the continuum limit we expect to find a scaling region, where the lattice correlators reproduce the euclidean correlation functions of the target (chiral) gauge theory, in the corresponding continuum gauge.Comment: 16 pages, revtex, one figure. Clarifications made, mainly in sections 3 and 6 that deal with the fermion action, to appear in Phys Rev