Synthesis of Some New 3-Pyrrolidinylquinoline Derivatives via 1,3-Dipolar Cycloaddition of Stabilized Azomethine Ylides to Quinolinyl α,β- Unsaturated Ketones

International audienceN-Metallated azomethine ylide generated from methyl (E)-N-benzylideneglycinate, LiBr and triethylamine underwent cycloaddition to quinolyl α,β- unsaturated ketones with excellent diastereoselectivity to afford new functionalised 3-pyrrolidinylquinoline derivatives

Retrospective study of epidemiological, clinicopathological and biological profils of 62 colorectal cancers cases in Jijel provence (Algeria)

In Algeria, the CRC wing and become the first digestive cancer in both sexes,  outperforming stomach cancer. To enrich the Algerian cancer registries, we analyzed the profiles of patients with these cancers in Jijel Willaya. This was a retrospective and descriptive analysis of epidemiological, clinicopathological and biological profiles of 62 CRC cases. We found that the CRC represented the first type of digestive cancers in which the three quarters were colon cancers. The most affected age group was 60-70 years with a male predominance and an average age of 56.20 years. The bleeding and abdominal pain were the majority telltale signs. The combined chemotherapy has been standardized with all patients and the Lieberkühnien adenocarcinoma was the major histological form. The disease issue and the choice of therapy depended on the K-RAS gene mutations. Our results were often compatible with the available literature and may provide reliable and relevant data on this disease.Key words: Colorectal cancer; Epidemiology; Therapy; Adenocarcinoma; K-RAS gen

Light Behaviors around Black Holes in M-theory

We study the deflection angle and the trajectory of the light rays around black holes in M-theory scenarios. Using the Gauss-Bonnet theorem, we first compute and examine the deflection angle of the light rays near four and seven-dimensional AdS black holes obtained from the M-theory compactifications on the real spheres on $S^7$ and $S^4$, respectively. We discuss the effect of the M-theory brane number and the rotating parameter on such an optical quantity. We then investigate the trajectories of the light rays using the equation of motion associated with $M2$ and $M5$ branes.Comment: Latex, 22 pages, 8 figure

Drivers of extreme burnt area in Portugal: fire weather and vegetation

Fire weather indices are used to assess the effect of weather on wildfire behaviour and to support fire management. Previous studies identified the high daily severity rating percentile (DSRp) as being strongly related to the total burnt area (BA) in Portugal, but it is still poorly understood how this knowledge can support fire management at a smaller spatial scale. The aims of this study were to (1) assess whether the 90th DSRp (DSR90p) threshold is adequate for estimating most of the BA in mainland Portugal; (2) analyse the spatial variability of the DSRp threshold that explains a large part of BA, at higher resolution; and, (3) analyse whether vegetation cover can justify the DSRp spatial variability. We used weather reanalysis data from ERA5-Land, wildfire and land use data from Portuguese land management departments for an extended summer period (15 May to 31 October) from 2001 to 2019. We computed and related DSRp to large wildfires (BA > 100 ha) and land use to clarify the effectiveness of the DSRp for estimating BA in Portugal and assess how vegetation influences it. Results revealed that the DSR90p is an adequate indicator of extreme fire weather days and BA in Portugal. In addition, the spatial pattern of the DSRp associated with most of the total BA shows variability at the municipality scale. Municipalities where large wildfires occur with more extreme weather conditions have most of the BAs in forests and are in coastal areas. By contrast, municipalities where large wild fires occur with less extreme weather conditions are predominantly covered by shrublands and are situated in eastern and inland regions. These findings are a novelty for fire science in Portugal and should be considered by fire managers and fire risk assessors.info:eu-repo/semantics/publishedVersio

Nonlinear optical properties of selected natural pigments extracted from spinach: Carotenoids

They are report here, for the first time in authors knowledge, results on third order nonlinear optical susceptibilities from a series of natural pigments extracted from spinach. The measurements were performed in-situ at 532 nm wavelength using degenerate four wave mixing technique (DFWM). For comparison third order nonlinear optical susceptibilities of the same pigments were also evaluated using third harmonic generation (THG) set up at 1064 nm. The electronic contribution to the observed properties was also deduced. The measurements were performed on thin films deposited on a thick glass substrate. These pigments were also identified by UV–VIS spectral analysis. All these results were in good agreement with the literature data

Menopause and metabolic syndrome in Tunisian women

Objectives. This study aimed to evaluate the effect of menopausal status on the risk of metabolic syndrome (MetS) in Tunisian women. Methods. We analyzed a total of 2680 women aged between 35 and 70 years. Blood pressure, anthropometric indices, fasting glucose, and lipid profile were measured. The MetS was assessed by the modified NCEP-ATPIII definition. Results. The mean values of waist circumference, blood pressure, plasma lipids, and fasting glucose were significantly higher in postmenopausal than in premenopausal women, a difference that was no longer present when adjusting for age. Except for hypertriglyceridaemia, the frequency of central obesity, hyperglycemia, high blood pressure, and high total cholesterol was significantly higher in postmenopausal than in premenopausal women. After adjusting for age, the significance persisted only for hyperglycemia. The overall prevalence of MetS was 35.9%, higher in postmenopausal (45.7% versus 25.6%) than in premenopausal women. A binary logistic regression analysis showed that menopause was independently associated with MetS (OR = 1.41, 95% CI 1.10-1.82) after adjusting for age, residence area, marital status, family history of cardiovascular disease, education level, and occupation. Conclusions. The present study provides evidence that the MetS is highly prevalent in this group of women. Menopause can be a predictor of MetS independent of age in Tunisian women

THE USE OF NEW TECHNOLOGIES IN THE RESTORATION AND CONSERVATION OF BUILT CULTURAL HERITAGE/ THE CASE OF THE STATUE OF FOUARA, SETIF, ALGERIA

The present paper deals with the techniques using the laser scanner survey in the restoration of the statue of Fouara in Setif, Algeria. This statue which is made of marble was realized by Francis de St Vidal in 1899 that represents a nymph which is a part of the fountain, publicly displayed in the center of the city's main plaza. On 18 December 2018, a man defaced the statue, removing the facial features and breasts with a hammer and chisel.As a matter of fact, the build cultural heritage in Algeria is in danger from attacks and reaction time deterioration with age. Following the day of the incident, our team has been called to use a previous scanner laser survey of the nymph that was stored in our cultural heritage monument database in order to help the restoration of the missing part of the nymph (the face and the breast. as matter of fact, the original laser scanning survey provided a helpful and accurate details to support the restoration of the nymph.</p