Analysis of rolling bearing power loss models for twin screw oil injected compressor

The mechanical losses inside a screw compressor limit the performance of the compressor in terms of efficiency. These losses arise due to relative motion between elements inside the screw compressor. The estimation of mechanical losses predicted in the literature is around 10-15% of the total shaft power. One of the elements which contribute significantly to these losses is rolling element bearings. There are numerous mathematical models available which predict power losses in the rolling bearings. The objective of this paper is to study different models to predict power loss for rolling bearings and to predict the power losses for the bearings used for oil injected, twin screw compressor. A comparison between different power loss models for different operating conditions of compressor is also presented in this paper and results of analysis are compared with available experimental observations. The analysis helps to determine suitable power loss model for different operating conditions and more realistic predictions of the power losses. This allows designers for more accurate estimation of the performance of screw compressors

Development and Design of Energy Efficient Oil-Flooded Screw Compressors

It is estimated that about 17% of the world's generated power is used for compression. Thus all, even minor improvement of the efficiency of compressors will substantially reduce CO2 emission. This paper presents development of family of energy efficient oil-flooded screw compressors for Kirloskar Pneumatic Company Ltd. The developmental techniques adopted to improve efficiency such as introduction of superior 'N' rotor profile, rotor clearance management, performance calculation using 3D CCM (Computational Continuum Mechanics), direct parametric interface to CAD (Computer Aided Design), which contains bearing selection for complete 3D solid modelling. Also, contemporary prototyping and experimental investigation is supported by the fully computerised data acquisition and processing. The cumulative improvement of all these elements of the design process resulted in a very efficient machine which guarantees the competitive position of Kirloskar Pneumatic Company Limited in the screw compressor market

Oil drag loss in oil-flooded, twin-screw compressors

Rotary twin screw compressors are widely used because of their high efficiency and reliability. Their most common mode of operation is as oil-flooded machines when delivering air and gases at moderate pressures and flow rates. In order to achieve the best performance, it is essential to be able to predict the optimum amount of oil, required for the oil injection process, accurately. Analytical procedures for the design and performance estimation of twin screw compressors are well developed and widely available, but the determination of oil drag losses, in oil-flooded machines is only guesstimated. This paper describes a more detailed and accurate procedure for estimating oil drag loss, using a combined Couette-Poiseuille flow model and gives the results of studies on three sizes of machines operating over a range of pressure ratios and speeds. To this end, a parametric analysis has been developed based on a combined Couette-Poiseuille flow model and has been used to estimate the individual effects of pressure ratio, the various clearances and the oil viscosity on the total drag loss, for different sizes of the compressor. It can be seen from the results that at pressure ratios of up to 8.5, the drag loss due to the discharge axial clearance gap is nearly 2/3rd of the total, while nearly 1/3rd is due to the radial clearance. At normal operating speeds, the loss due to the interlobe clearance is insignificant, but as the pressure ratio increases, this rises more rapidly than that due to the axial and radial losses. The gain in the drag loss due to greater oil viscosity becomes more significant as the compressor size is increased. In larger machines, when clearance values are increased, the radial and axial elements of the drag loss are reduced more rapidly than that due to the interlobe loss

Attaching DNA to Nanoceria: Regulating Oxidase Activity and Fluorescence Quenching

This document is the Accepted Manuscript version of a Published Work that appeared in final form in Applied Materials and Interfaces copyright © American Chemical Society after peer review and technical editing by publisher. To access the final edited and published work see Pautler, R., Kelly, E. Y., Huang, P.-J. J., Cao, J., Liu, B., & Liu, J. (2013). Attaching DNA to Nanoceria: Regulating Oxidase Activity and Fluorescence Quenching. ACS Applied Materials & Interfaces, 5(15), 6820–6825. https://doi.org/10.1021/am4018863Cerium oxide nanoparticles (nanoceria) have recently emerged as a nanozyme with oxidase activity. In this work, we present a few important interfacial properties of nanoceria. First, the surface charge of nanoceria can be controlled not only by adjusting pH but also by adsorption of simple inorganic anions. Adsorption of phosphate and citrate gives negatively charged surface over a broad pH range. Second, nanoceria adsorbs DNA via the DNA phosphate backbone in a sequence-independent manner; DNA adsorption inhibits its oxidase activity. Other anionic polymers display much weaker inhibition effects. Adsorption of simple inorganic phosphate does not have the inhibition effect. Third, nanoceria is a quencher for many fluorophores. These discoveries provide an important understanding for further use of nanoceria in biosensor development, materials science, and nanotechnology.University of Waterloo || Canadian Foundation for Innovation || Natural Sciences and Engineering Research Council || Ontario Ministry of Research and Innovation |

PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer

Combined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy in oncology. Since PTEN lies at the intersection of these two pathways, we investigated whether PTEN status determines the functional response to combined pathway inhibition. PTEN (gene, mRNA, and protein) status was extensively characterized in a panel of cancer cell lines and combined MEK/mTOR inhibition displayed highly synergistic pharmacologic interactions almost exclusively in PTEN-loss models. Genetic manipulation of PTEN status confirmed a mechanistic role for PTEN in determining the functional outcome of combined pathway blockade. Proteomic analysis showed greater phosphoproteomic profile modification(s) in response to combined MEK/mTOR inhibition in PTEN- loss contexts and identified JAK1/STAT3 activation as a potential mediator of synergistic interactions. Overall, our results show that PTEN-loss is a crucial determinant of synergistic interactions between MAPK and PI3K pathway inhibitors, potentially exploitable for the selection of cancer patients at the highest chance of benefit from combined therapeutic strategies

Study of liver Disorders during pregnancy and fetomaternal outcome in a tertiary care hospital

Background: Liver disease in pregnancy encompasses a spectrum of diseases which causes abnormal liver function tests. The liver disorders are associated with significant maternal and foetal morbidity and mortality. The present study was done with objective to study incidence, clinicopathological correlation of liver disorder during pregnancy and its impact on maternal and foetal outcome.Methods: This prospective observational study was conducted in Department of Obstetrics and Gynaecology, NSCB Medical College Jabalpur. Eighty-five antenatal cases, on the basis of inclusion criteria were studied prospectively. Those subjected to detailed history and examination, clinical symptoms suggestive of liver disorders followed by all available LFTs including LDH along with some more definitive tests to aid identification of underlying cause and followed up till delivery in terms of maternal and foetal outcome. Results: The incidence of the liver disorders in pregnancy was 0.86%. In study group, 76.5% cases were between 20-30 years of age,72.9% cases were primigravida and 90.59% cases presented in third trimester of pregnancy. In this study, 76.4% presented with pregnancy specific liver disorder, of these 32.9% had pre-eclampsia, 11.7% had eclampsia, 11.7% had HELLP syndrome. 16.4% with ICP, AFLP 2.3%and Hyperemesis gravidarum in 1.1% cases. Maternal mortality was 10.58% and morbidity was 34.12%. Live birth 61%, still birth 38.82%, preterm 21.1% and IUGR 24.7%. NICU admission required in 28.57% cases. Conclusions: Regular antenatal check-up, screening and diagnosing liver disorder at an earliest, proper treatment and timely referral to higher centres can save the lives of many mothers and foetuses

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