Mindfulness and Creative Process Engagement: The Mediating Role of Workplace Relational Systems

Purpose Despite widespread recognition of the importance of mindfulness in organizational science literature, little is known about how mindfulness motivates individuals to configure information processing and team member exchange relationships to increase creative process engagement. Drawing on motivated information processing theory, this study conceptualizes and empirically examines whether and how mindfulness motivates individuals toward creative process engagement. Design/methodology/approach The authors collected data through an online survey from 311 respondents working in the Research and Development (R&D) departments of organizations in multiple industries in Pakistan. For analytical purposes, the authors have applied the structural equation modeling technique. Findings This study advances a different view of individual mindfulness on the creative process engagement in the following ways. First, mindfulness enables individuals to self-regulate in specific situations and become effective in fostering creative process engagement. Second, this study extends research on relational information processing by linking it to mindfulness and creative process engagement. Relational information processing partially mediates the relationship between mindfulness and creative process engagement. Third, this study highlights that mindfulness motivates individuals to focus more on developing quality working relationships, but they seem less willing to participate in idea generation and problem-solving solutions. Originality/value The study findings provide implications for research on mindfulness, creativity and motivated information processing to enhance individuals’ creative process engagements. The authors also discuss the implications for executives on the relational and creative benefits of mindfulness

Correction: Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil

Following publication of the original article [1], the authors identified an error to the last name of Mumina Akthar. The incorrect author name is: Mumina Akhtar The correct author name is: Mumina Akthar The author group has been updated above and the original article [1] has been corrected

Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil.

BackgroundSystemic lupus erythematosus (SLE) is a clinically and biologically heterogeneous autoimmune disease. We explored whether the deconvolution of whole blood transcriptomic data could identify differences in predicted immune cell frequency between active SLE patients, and whether these differences are associated with clinical features and/or medication use.MethodsPatients with active SLE (BILAG-2004 Index) enrolled in the BILAG-Biologics Registry (BILAG-BR), prior to change in therapy, were studied as part of the MASTERPLANS Stratified Medicine consortium. Whole blood RNA-sequencing (RNA-seq) was conducted at enrolment into the registry. Data were deconvoluted using CIBERSORTx. Predicted immune cell frequencies were compared between active and inactive disease in the nine BILAG-2004 domains and according to immunosuppressant use (current and past).ResultsPredicted cell frequency varied between 109 patients. Patients currently, or previously, exposed to mycophenolate mofetil (MMF) had fewer inactivated macrophages (0.435% vs 1.391%, p = 0.001), naïve CD4 T cells (0.961% vs 2.251%, p = 0.002), and regulatory T cells (1.858% vs 3.574%, p = 0.007), as well as a higher proportion of memory activated CD4 T cells (1.826% vs 1.113%, p = 0.015), compared to patients never exposed to MMF. These differences remained statistically significant after adjusting for age, gender, ethnicity, disease duration, renal disease, and corticosteroid use. There were 2607 differentially expressed genes (DEGs) in patients exposed to MMF with over-representation of pathways relating to eosinophil function and erythrocyte development and function. Within CD4 + T cells, there were fewer predicted DEGs related to MMF exposure. No significant differences were observed for the other conventional immunosuppressants nor between patients according disease activity in any of the nine organ domains.ConclusionMMF has a significant and persisting effect on the whole blood transcriptomic signature in patients with SLE. This highlights the need to adequately adjust for background medication use in future studies using whole blood transcriptomics

Non-technical skills amongst multidisciplinary surgeons (notss) in a tertiary hospital in India

Non-technical skills for surgeons are a set of skills that are non-surgical in nature but make the surgical procedure safer for the patient. In this context, this is a study in a tertiary hospital where the non-technical skills of multi-disciplinary surgeons were observed and assessed when they were performing live surgeries. We found that none of our participant surgeons were rated poor for any skills, which endangered performance or potentially endangered patient safety and for which serious remediation would have been required. "Acceptable" standards of "Situational Awareness" and "Leadership" and "Good" standards of "Decision Making" and "Communication &amp; Teamwork", which were the four skills observed.</jats:p

Non-technical skills amongst multidisciplinary surgeons (notss) in a tertiary hospital in India

Non-technical skills for surgeons are a set of skills that are non-surgical in nature but make the surgical procedure safer for the patient. In this context, this is a study in a tertiary hospital where the non-technical skills of multi-disciplinary surgeons were observed and assessed when they were performing live surgeries. We found that none of our participant surgeons were rated poor for any skills, which endangered performance or potentially endangered patient safety and for which serious remediation would have been required. "Acceptable" standards of "Situational Awareness" and "Leadership" and "Good" standards of "Decision Making" and "Communication &amp; Teamwork", which were the four skills observed

Non-technical Skills Amongst Multidisciplinary Surgeons (Notss) in A Tertiary Hospital in India

Non-technical skills for surgeons are a set of skills that are non-surgical in nature but make the surgical procedure safer for the patient. In this context, this is a study in a tertiary hospital where the non-technical skills of multi-disciplinary surgeons were observed and assessed when they were performing live surgeries. We found that none of our participant surgeons were rated poor for any skills, which endangered performance or potentially endangered patient safety and for which serious remediation would have been required. "Acceptable" standards of "Situational Awareness" and "Leadership" and "Good" standards of "Decision Making" and "Communication &amp; Teamwork", which were the four skills observed

Carcinoma of uterine cervix: Top ranking in our country

e16580 Background: Carcinoma of cervix is worldwide, the most frequent gynecological cancer particularly in developing countries like ours. Carcinoma of the cervix uterine is the second commonest gynecological cancer in the developed countries and top ranking in the developing countries like ours. Methods: One hundred and fifty women having carcinoma of the cervix uteri were prospectively studied in the department of Gynaecology and Obstetrics and Radiotherapy department of Rajshahi Medical College Hospital from January 2004 to December 2007. The cases were diagnosed clinically and confirmed by histopathological examination. Results: In all 150 patients of carcinoma of the cervix were selected for this study. There mean age was 50.12 yrs. Most of the patients (78%) had marriage between the age of 10–15 years; 8% married below 10 years and 14% between 16–20 years of age.In this study the all were multipara; 30% patients had 6 pregnancies throughout life. 10% had more than 10 pregnancies, 8% had 8 pregnancies, 4% had 9 pregnancies, 14% had 5 pregnancies and 16% had 4 pregnancies.The study shows that the distribution of patients according to the staging of the carcinoma. 54 (36%) were of III A stage. 39 (26%) in II B stage, 21 (14%) in III B stage, 9 (6%) in IV A stage, 6 (4%) in I B stage, and 3 (2%) in IV B stage. No patient presented with O or IA stage. Conclusions: The study showed that the majority of the patients were between the ages of 40–50. HPV types 16/18 has a significant role for the development of the disease. Religious practices are of important role for its causation. It is less frequent in Jew and most frequent in Hindu. Histopathologically 90%-95% are squamous cell carcinoma and 1–5% are adnocarcinoma.From the findings it is observed that early marriage, creation of awareness about sex hygiene, discourage to have multiple sexual partners and marriages, discourage to have multiple pregnancies and providing adequate health care and health education to the women could reduce the development of carcinoma of cervix. No significant financial relationships to disclose. </jats:p