Can raisins ameliorate the hypercholesterolaemia-induced cardiac affection?

Raisins were investigated for their protective role on cardiac muscle both biochemically and histopathologically in high cholesterol diet (HCD)-fed rats. Wister male rats were randomly divided into four groups (n = 10): control, raisin-fed, HCD-fed and HCD-raisin fed group. Animals were anaesthetized after 13 weeks. Hearts were dissected and processed for histopathological examination. Raisins administration with HCD significantly decreased the animals’ blood glucose, insulin, cholesterol, triglycerides, and low density lipoprotein levels; while increased their high density lipoprotein levels compared with rats fed HCD alone. They also decreased cardiomyocytes’ degeneration, cellular infiltration, haemorrhages and blood vessels affection. Raisins reduced fibrosis by decreasing the immuno-expression of alpha smooth muscle actin marker, whereas they significantly increased the immuno-expression of endothelial nitric oxide synthase. Raisins showed a cardioprotective effect and were able to alleviate the biochemical and the histopathological changes induced by the HCD. Consumption of raisins or their pharmaceutical product should be recommended specially for those eating a high-fat diet

Hepatocyte Lysosomal Membrane Stabilization by Olive Leaves against Chemically Induced Hepatocellular Neoplasia in Rats

Extensive efforts are exerted looking for safe and effective chemotherapy for hepatocellular carcinoma (HCC). Specific and sensitive early biomarkers for HCC still in query. Present work to study proteolytic activity and lysosomal membrane integrity by hepatocarcinogen, trichloroacetic acid (TCA), in Wistar rats against aqueous olive leaf extract (AOLE).TCA showed neoplastic changes as oval- or irregular-shaped hepatocytes and transformed, vesiculated, and binucleated liver cells. The nuclei were pleomorphic and hyperchromatic. These changes were considerably reduced by AOLE. The results added, probably for the first time, that TCA-induced HCC through disruption of hepatocellular proteolytic enzymes as upregulation of papain, free cathepsin-D and nonsignificant destabilization of lysosomal membrane integrity, a prerequisite for cancer invasion and metastasis. AOLE introduced a promising therapeutic value in liver cancer, mostly through elevating lysosomal membrane integrity. The study substantiated four main points: (1) the usefulness of proteolysis and lysosomalmembrane integrity in early prediction of HCC. (2) TCA carcinogenesis is possibly mediated by lysosomal membrane destabilization, through cathepsin-D disruption, which could be reversed by AOLE administration. (3) A new strategy for management of HCC, using dietary olive leaf system may be a helpful phytotherapeutic trend. (4) A prospective study on serum proteolytic enzyme activity may introduce novel diagnostic tools

Existence and multiplicity for elliptic problems with quadratic growth in the gradient

We show that a class of divergence-form elliptic problems with quadratic growth in the gradient and non-coercive zero order terms are solvable, under essentially optimal hypotheses on the coefficients in the equation. In addition, we prove that the solutions are in general not unique. The case where the zero order term has the opposite sign was already intensively studied and the uniqueness is the rule.Comment: To appear in Comm. PD

Synthesis of some quinoline thiosemicarbazone derivatives of potential antimicrobial activity

5-Acetyl (or 5-benzoyl)-8-hydroxyquinoline-4-substituted thiosemi-carbazones (IIa-m, IIIa-m respectively) have been prepared via the condensation of . The thiosemicarbazones (IIa-l, IIIa-f) were subjected to cyclization into the corresponding thiazolidinones (IVa-l, Va-f) by the reaction with ethyl bromoacetate in the presence of anhydrous sodium acetate. The structures of the thiosemicarbazones as well as the corresponding thiazolidinones were assigned based on both elemental and spectroscopic evidences. The prepared compounds were also evaluated for antibacterial and antifungal activities

EFFECT OF FOLIAR APPLICATION OF ANTIOXIDANTS ON VEGETATIVE GROWTH AND LEAF MINERAL CONTENT OF CHINESE TANGERINE YOUNG TREES BUDDED ON SOME CITRUS ROOTSTOCKS GROWN UNDER SALINE CONDITIONS

Wady El Natroun high way (Beer Hooker Area) in a private orchard in a sandy soil under drip irrigation system with saline water.  in 2015 and 2016 seasons. Chinese tangerine (Citrus tangerine) transplant were budded on three rootstocks namely sour orange (Citrus aurantum, mion), volkamer lemon (Citrus volkameriana, Tem) and X639 hybrid between (Cleopatra mandarin × Ponicurus trifoliata) grown under saline conditions to study the effect of foliar  application of antioxidants namely ascorbic and salicylic acid on vegetative growth and leaf mineral contents. Results showed that, Volkamer lemon rootstock surpassed sour orange and x639 rootstocks under saline conditions, the highest incremental percentage young tree height, stem diameter, number of leaves per shoot and leaf area were registered by Chinese tangarine scion budded on Volkamer lemon rootstock. Among selected antioxidants ascorbic acid at the concentrations of 800 ppm recorded the highest significant values for vegetative growth parameters and surpassed salicylic acid. Also Chinese mandarin scion budded on volkamer lemon accumulated the highest concentrations of nitrogen (N), phosphorus(P), magnesium(Mg), and chloride (Cl-) and the lowest concentration of sodium (Na+). Chinese mandarin scion budded on sour orange rootstock accumulated the highest concentrations of potassium (K) while Chinese tangerine scion budded on x639 accumulated the highest concentrations of sodium (Na)

Cellular Transplantation-Based Therapeutic Strategies for Spinal Cord Injuries: Preclinical and Clinical Updates

Spinal cord injury (SCI) is a distressing neurological condition that causes loss of neural tissue, with subsequent damages to neural circuitry, and loss of sensorimotor function. The SCIs have an estimated incidence rate of ~80 cases per million populations. Till date, no ratified effective therapeutic strategy for SCIs exist; however, recent advancements in regenerative medicines to protect and regenerate damaged/lost neural tissues following SCIs have shown promising results in preclinical and clinical trials. Moreover, there is a greater need to fully understand underlying mechanisms following cellular transplantation that can be achieved through proper differentiation of desired cell type, and their in-vivo tracking of migration, proliferation and integration into the host system. Furthermore, techniques that can prevent teratomas formation following cellular transplantation have been reported. In addition to the ongoing comprehensive neuroregenerative and neuroprotective therapeutic strategies for SCIs, novel technologies are emerging including neuroscience-based computational and robotic rehabilitational therapies. These improved strategies in combination with cell-based therapeutic approaches are opening new avenues for future research to completely cure SCIs. Herein, we intended to review pathophysiological mechanisms following SCI, preclinical and clinical updates of cellular transplantation, the extent of success from these transplantations, associated controversies and other emerging technologies

Numerical Study for a Marine Current Turbine Blade Performance under Varying Angle of Attack

Energy generation from marine currents is a promising technology for sustainable development. The success of using marine current turbines to tap the ocean hydrodynamic energy depends on predicting the hydrodynamic characteristics and performance of such turbines. This paper presents an analysis of the two-dimensional flow using commercial CFD software over a marine current turbine blade. The 2D flow is simulated for HF-SX NACA foil modified from S1210 NACA foil at various angles of attack with Reynolds number of 19×104, which represents the marine current flow. The hydrofoil is designed with considerations for lift and drag coefficients. The flow is simulated by solving the steady-state Navier-Stokes equations coupled with the k-ω shear stress transport (SST) turbulence model. The aim of this work is to study the effect of the angle of attack on the lift and drag coefficients. The computational domain is composed of non-homogenous structured meshing, with sufficient refinement of the domain near the foil blade in order to capture the boundary layer effects. Hence, all calculations are done at constant flow velocity while varying the angle attack for every model tested. The results have shown that the drag and lift coefficient, Cd and Cl coefficient increases with increasing the value of the angle of attack, ratio Cl/Cd curve related on performance at the peak 7o angle of attack

IMPROVING FRUIT SET, YIELD AND FRUIT QUALITY OF KHADRAWI DATE PALM CULTIVAR

This experiment was carried out during 2015 and 2016 experimental seasons to investigate the effect of spraying with moringa extract at 3%, garlic extract at 3% or ascorbic acid at 300 ppm on fruit set, yield and fruit quality of Khadrawi date palm cultivar. Anyhow, bunches were sprayed at three times (3 hours before pollination then 4 and 8 weeks after pollination). The present results indicated that spraying date palm bunches with moringa extract or garlic extract recorded the highest initial fruit set in the first and second seasons, respectively. As well as, moringa extract gave the highest fruit retention and yield in both seasons. In addition, all treatments improved some fruit physical characteristics i.e. fruit weight, flesh weight, fruit volume and fruit length compared to the control treatment in the two studied seasons. Also, results showed that moringa extract or ascorbic acid increased TSS%, total sugars % and reducing sugars % in both seasons compared to the control. Meanwhile, the lowest fibers % was obtained by garlic extract in the two seasons. Also, all treatments had no significant effect on total acidity % and tannins content in both seasons

Bio-Inspired Multi-Layer Spiking Neural Network Extracts Discriminative Features from Speech Signals

Spiking neural networks (SNNs) enable power-efficient implementations due to their sparse, spike-based coding scheme. This paper develops a bio-inspired SNN that uses unsupervised learning to extract discriminative features from speech signals, which can subsequently be used in a classifier. The architecture consists of a spiking convolutional/pooling layer followed by a fully connected spiking layer for feature discovery. The convolutional layer of leaky, integrate-and-fire (LIF) neurons represents primary acoustic features. The fully connected layer is equipped with a probabilistic spike-timing-dependent plasticity learning rule. This layer represents the discriminative features through probabilistic, LIF neurons. To assess the discriminative power of the learned features, they are used in a hidden Markov model (HMM) for spoken digit recognition. The experimental results show performance above 96% that compares favorably with popular statistical feature extraction methods. Our results provide a novel demonstration of unsupervised feature acquisition in an SNN

Antimicrobial resistance preparedness in sub-Saharan African countries

Background: Antimicrobial resistance (AMR) is of growing concern globally and AMR status in sub-Saharan Africa (SSA) is undefined due to a lack of real-time data recording, surveillance and regulation. World Health Organization (WHO) Joint External Evaluation (JEE) reports are voluntary, collaborative processes to assess country capacities and preparedness to prevent, detect and rapidly respond to public health risks, including AMR. The data from SSA JEE reports were analysed to gain an overview of how SSA is working towards AMR preparedness and where strengths and weaknesses lie. Methods: SSA country JEE AMR preparedness scores were analysed. A cumulative mean of all the SSA country AMR preparedness scores was calculated and compared to the overall mean SSA JEE score. AMR preparedness indicators were analysed, and data were weighted by region. Findings: The mean SSA AMR preparedness score was 53% less than the overall mean SSA JEE score. East Africa had the highest percentage of countries reporting having AMR National Action Plans in place, as well as human and animal pathogen AMR surveillance programmes. Southern Africa reported the highest percentage of countries with training programmes and antimicrobial stewardship. Conclusions: The low mean AMR preparedness score compared to overall JEE score, along with the majority of countries lacking implemented National Action Plans, suggests that until now AMR has not been a priority for most SSA countries. By identifying regional and One Health strengths, AMR preparedness can be fortified across SSA with a multisectoral approach