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Opportunities for system level improvement in antibiotic use across the surgical pathway
Optimizing antibiotic prescribing across the surgical pathway (before, during, and after surgery) is a key aspect of tackling important drivers of antimicrobial resistance and simultaneously decreasing the burden of infection at the global level. In the UK alone, 10 million patients undergo surgery every year, which is equivalent to 60% of the annual hospital admissions having a surgical intervention. The overwhelming majority of surgical procedures require effectively limited delivery of antibiotic prophylaxis to prevent infections. Evidence from around the world indicates that antibiotics for surgical prophylaxis are administered ineffectively, or are extended for an inappropriate duration of time postoperatively. Ineffective antibiotic prophylaxis can contribute to the development of surgical site infections (SSIs), which represent a significant global burden of disease. The World Health Organization estimates SSI rates of up to 50% in postoperative surgical patients (depending on the type of surgery), with a particular problem in low- and middle-income countries, where SSIs are the most frequently reported healthcare-associated infections. Across European hospitals, SSIs alone comprise 19.6% of all healthcare-acquired infections. Much of the scientific research in infection management in surgery is related to infection prevention and control in the operating room, surgical prophylaxis, and the management of SSIs, with many studies focusing on infection within the 30-day postoperative period. However it is important to note that SSIs represent only one of the many types of infection that can occur postoperatively. This article provides an overview of the surgical pathway and considers infection management and antibiotic prescribing at each step of the pathway. The aim was to identify the implications for research and opportunities for system improvement
Spontaneous periodic travelling waves in oscillatory systems with cross-diffusion
We identify a new type of pattern formation in spatially distributed active
systems. We simulate one-dimensional two-component systems with predator-prey
local interaction and pursuit-evasion taxis between the components. In a
sufficiently large domain, spatially uniform oscillations in such systems are
unstable with respect to small perturbations. This instability, through a
transient regime appearing as spontanous focal sources, leads to establishment
of periodic traveling waves. The traveling waves regime is established even if
boundary conditions do not favor such solutions. The stable wavelength are
within a range bounded both from above and from below, and this range does not
coincide with instability bands of the spatially uniform oscillations.Comment: 7 pages, 4 figures, as accepted to Phys Rev E 2009/10/2
The Clostridium difficile problem: A South African tertiary institution's prospective perspective
BACKGROUND AND OBJECTIVES: The aim of this study is to report the incidence of Clostridium difficile-associated disease (CDAD) in a tertiary-care hospital in South Africa and to identify risk factors, assess patient outcomes and determine the impact of the hypervirulent strain of the organism referred to as North American pulsed-field type 1 (NAP1). METHODS: Adults who presented with diarrhoea over a period of 15 months were prospectively evaluated for CDAD using stool toxin enzyme immunoassay (EIA). Positive specimens were evaluated by PCR. Patient demographics, laboratory parameters and outcomes were analysed. RESULTS: CDAD was diagnosed in 59 (9.2%) of 643 patients (median age 39 years, IQR 30 - 55). Thirty-four (58%) were female. Recent antibiotic exposure was reported in 39 (66%), 27 (46%) had been hospitalised within 3 months, and 14 (24%) had concomitant inflammatory bowel disease (IBD). Nineteen (32%) had community-acquired CDAD (CA-CDAD). The annual incidence of hospital-acquired CDAD (HA-CDAD) was 8.7 cases/10 000 hospitalisations. Two cases of the hypervirulent strain NAP1 were identified. Seven (12%) patients underwent colectomy (OR 6.83; 95% CI 2.41 - 19.3). On logistic regression, only antibiotic exposure independently predicted for CDAD (OR 2.9; 95% CI 1.6 - 5.1). Three (16%) cases of CA-CDAD reported antibiotic exposure (v. 90% of HA-CDAD, p<0.0001). Twelve (86%) patients had concomitant IBD (p<0.0001 v. HA-CDAD). CA-CDAD was significantly associated with antibiotic exposure (OR 0.04, 95% CI 0.01 - 0.24) and IBD (OR 9.6, 95% CI 1.15 - 79.8). CONCLUSION: The incidence of HA-CDAD in the South African setting is far lower than that reported in the West. While antibiotic use was a major risk factor for HA-CDAD, CA-CDAD was not associated with antibiotic therapy. Concurrent IBD was a predictor of CA-CDAD
Labels for non-individuals
Quasi-set theory is a first order theory without identity, which allows us to
cope with non-individuals in a sense. A weaker equivalence relation called
``indistinguishability'' is an extension of identity in the sense that if
is identical to then and are indistinguishable, although the
reciprocal is not always valid. The interesting point is that quasi-set theory
provides us a useful mathematical background for dealing with collections of
indistinguishable elementary quantum particles. In the present paper, however,
we show that even in quasi-set theory it is possible to label objects that are
considered as non-individuals. We intend to prove that individuality has
nothing to do with any labelling process at all, as suggested by some authors.
We discuss the physical interpretation of our results.Comment: 11 pages, no figure
Twirling Elastica: Kinks, Viscous Drag, and Torsional Stress
Biological filaments such as DNA or bacterial flagella are typically curved
in their natural states. To elucidate the interplay of viscous drag, twisting,
and bending in the overdamped dynamics of such filaments, we compute the
steady-state torsional stress and shape of a rotating rod with a kink. Drag
deforms the rod, ultimately extending or folding it depending on the kink
angle. For certain kink angles and kink locations, both states are possible at
high rotation rates. The agreement between our macroscopic experiments and the
theory is good, with no adjustable parameters.Comment: 4 pages, 4 figure
The Viscous Nonlinear Dynamics of Twist and Writhe
Exploiting the "natural" frame of space curves, we formulate an intrinsic
dynamics of twisted elastic filaments in viscous fluids. A pair of coupled
nonlinear equations describing the temporal evolution of the filament's complex
curvature and twist density embodies the dynamic interplay of twist and writhe.
These are used to illustrate a novel nonlinear phenomenon: ``geometric
untwisting" of open filaments, whereby twisting strains relax through a
transient writhing instability without performing axial rotation. This may
explain certain experimentally observed motions of fibers of the bacterium B.
subtilis [N.H. Mendelson, et al., J. Bacteriol. 177, 7060 (1995)].Comment: 9 pages, 4 figure
Effective Viscosity of Dilute Bacterial Suspensions: A Two-Dimensional Model
Suspensions of self-propelled particles are studied in the framework of
two-dimensional (2D) Stokesean hydrodynamics. A formula is obtained for the
effective viscosity of such suspensions in the limit of small concentrations.
This formula includes the two terms that are found in the 2D version of
Einstein's classical result for passive suspensions. To this, the main result
of the paper is added, an additional term due to self-propulsion which depends
on the physical and geometric properties of the active suspension. This term
explains the experimental observation of a decrease in effective viscosity in
active suspensions.Comment: 15 pages, 3 figures, submitted to Physical Biolog
Signs of low frequency dispersions in disordered binary dielectric mixtures (50-50)
Dielectric relaxation in disordered dielectric mixtures are presented by
emphasizing the interfacial polarization. The obtained results coincide with
and cause confusion with those of the low frequency dispersion behavior. The
considered systems are composed of two phases on two-dimensional square and
triangular topological networks. We use the finite element method to calculate
the effective dielectric permittivities of randomly generated structures. The
dielectric relaxation phenomena together with the dielectric permittivity
values at constant frequencies are investigated, and significant differences of
the square and triangular topologies are observed. The frequency dependent
properties of some of the generated structures are examined. We conclude that
the topological disorder may lead to the normal or anomalous low frequency
dispersion if the electrical properties of the phases are chosen properly, such
that for ``slightly'' {\em reciprocal mixture}--when , and
--normal, and while for ``extreme'' {\em reciprocal
mixture}--when , and --anomalous
low frequency dispersions are obtained. Finally, comparison with experimental
data indicates that one can obtain valuable information from simulations when
the material properties of the constituents are not available and of
importance.Comment: 13 pages, 7 figure
Molecular elasticity and the geometric phase
We present a method for solving the Worm Like Chain (WLC) model for twisting
semiflexible polymers to any desired accuracy. We show that the WLC free energy
is a periodic function of the applied twist with period 4 pi. We develop an
analogy between WLC elasticity and the geometric phase of a spin half system.
These analogies are used to predict elastic properties of twist-storing
polymers. We graphically display the elastic response of a single molecule to
an applied torque. This study is relevant to mechanical properties of
biopolymers like DNA.Comment: five pages, one figure, revtex, revised in the light of referee's
comments, to appear in PR
Swift/XRT monitoring of five orbital cycles of LSI +61 303
LSI +61 303 is one of the most interesting high-mass X-ray binaries owing to
its spatially resolved radio emission and its TeV emission, generally
attributed to non-thermal particles in an accretion-powered relativistic jet or
in the termination shock of the relativistic wind of a young pulsar. Also, the
nature of the compact object is still debated. Only LS 5039 and PSR B1259-63
(which hosts a non-accreting millisecond pulsar) have similar characteristics.
We study the X-ray emission from LSI +61 303 covering both short-term and
orbital variability. We also investigate the source spectral properties in the
soft X-ray (0.3-10 keV) energy range. 25 snapshot observations of LSI +61 303
have been collected in 2006 with the XRT instrument on-board the Swift
satellite over a period of four months, corresponding to about five orbital
cycles. Since individual data sets have too few counts for a meaningful
spectral analysis, we extracted a cumulative spectrum. The count rate folded at
the orbital phase shows a clear modulation pattern at the 26.5 days period and
suggests that the X-ray peak occurs around phase 0.65. Moreover, the X-ray
emission appears to be variable on a timescale of ~1 ks. The cumulative
spectrum is well described by an absorbed power-law model, with hydrogen column
density Nh=(5.7+/-0.3)E+21 cm^-2 and photon index 1.78+/-0.05. No accretion
disk signatures, such as an iron line, are found in the spectrum.Comment: Revised to match the A&A versio
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