Habilidades informacionales integradas en los grados de edificación y geomática (EPSEB-UPC): caso práctico de cooperación entre docentes y bibliotecarios

Se expone el caso práctico de la colaboración entre PDI y PAS de biblioteca para la impartición del itinerario competencial en Habilidades Informacionales en los grados de la Escola Politècnica Superior d'Edificació de Barcelona (EPSEB). Docentes y bibliotecarios diseñan conjuntamente actividades que contemplan sesiones taller especializadas, cursos “ad-hoc” y cursos de contenidos transversales de complejidad progresiva integrados en asignaturas obligatorias. Los contenidos se adaptan a cada asignatura implicada en el itinerario y se da una orientación práctica para captar el interés de los alumnos. Coordinados por el Servei General de Biblioteques de la UPC, los bibliotecarios desarrollan material didáctico de apoyo y valoran los resultados conjuntamente de forma periódica para proponer mejoras. Las actividades se imparten en modalidad presencial y semipresencial. Así mismo, la biblioteca imparte formación al profesorado conducente tanto a desarrollar su faceta investigadora como a dinamizar la docencia en el aula. La experiencia en sesiones formativas desde el año 2000 y la buena acogida por parte de del profesorado y el estudiantado, avalan la puesta en marcha del itinerario a partir de septiembre 2009.Postprint (author's final draft

Alternativa metodológica para el aprendizaje del contenido de vacunación e inmunización en la asignatura Prevención en Salud. (Original)

Challenges of the Higher Education to 21st century require a new educational process based on the principles of excellence, quality and pertinence. The educational systems challenges are the generation of conditions and resources for its members to have a quality educational experience. A methodological alternative is developed based on a teaching tasks system for learning the Vaccination and Immunization content in Medicine Major students.Los desafíos de la Educación Superior para el siglo XXI requieren de un nuevo proceso educativo, fundamentado en los principios de excelencia, calidad y pertinencia. Los retos de los sistemas educativos son la generación de condiciones y recursos para que sus miembros tengan una experiencia educativa de calidad, por lo que se elabora una alternativa metodológica basada en un sistema de tareas docentes para el aprendizaje del contenido de Vacunación e Inmunización en estudiantes de la carrera de Medicina

Generation and characterization of the human iPSC line IDISi001-A isolated from blood cells of a CADASIL patient carrying a NOTCH3 mutation

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary stroke disorder. It is caused by mutations in NOTCH3 that lead to progressive degeneration of the smooth muscle cells in blood vessels. There is currently no treatment for this disorder. We reprogrammed to pluripotency blood mononuclear cells isolated from a patient carrying a NOTCH3 mutation by using a commercially available non-integrating system. The success in the generation of this iPSC line (IDISi001-A) suggests that the NOTCH3 mutation did not limit cell reprogramming and offers an unprecedented opportunity for studying and modeling CADASIL pathology

Aplicación de una alternativa metodológica en la asignatura Prevención en Salud (Original)

The challenges of Higher Education for the 21st century require a new educational process, based on the principles of excellence, quality and relevance. The challenges of educational systems is the generation of conditions and resources so that their members have a quality educational experience. In the direction of the teaching-learning process of the subject Prevention in health, methodological insufficiencies are verified that limit the assimilation in an integrated way of the contents of vaccination and immunization in students of the Medicine career, constituting this the starting point to carry out a investigative process that favors the learning of this content. In this sense, a development research was carried out at the University of Medical Sciences of Granma, in the period between September 2019 and July 2020 with the aim of developing a methodological alternative based on the design of teaching tasks in the subject Prevention in health that strengthens the learning of the content of Vaccination and Immunization in second year students of the Medicine career. The population was considered to be 51 students from two brigades of the second year of the career and 25 teachers from the Department of Comprehensive General Medicine. For data collection, theoretical, empirical and statistical methods were used. As a result of this research, a methodological alternative based on questions, learning situations and an exercise system is provided to enhance the learning of the content, it was submitted to the criteria of experts for its evaluation.Los desafíos de la Educación Superior para el siglo XXI requieren de un nuevo proceso educativo, fundamentado en los principios de excelencia, calidad y pertinencia. Los retos de los sistemas educativos es la generación de condiciones y recursos para que sus miembros tengan una experiencia educativa de calidad. En la dirección del proceso de enseñanza-aprendizaje de la asignatura Prevención en salud se constatan insuficiencias metodológicas que limitan la asimilación de forma integrada de los contenidos de vacunación e inmunización en estudiantes de la carrera de Medicina, constituyendo esto el punto de partida para realizar un proceso investigativo que favorezca el aprendizaje de este contenido. En tal sentido, se realizó una investigación de desarrollo en la Universidad de Ciencias Médicas de Granma, en el período comprendido entre septiembre de 2019 a julio de 2020 con el objetivo de elaborar una alternativa metodológica basada en el diseño de tareas docentes en la asignatura Prevención en salud que fortalezca el aprendizaje del contenido de Vacunación e Inmunización en estudiantes de segundo año de la carrera de Medicina. Se consideró como población los 51 estudiantes de dos brigadas del segundo año de la carrera y 25 docentes del departamento de Medicina General Integral. Para la recolección de los datos se emplearon métodos teóricos, empíricos y estadísticos. Como resultado de esta investigación se aporta una alternativa metodológica basada en preguntas, situaciones de aprendizaje y sistema de ejercicios para potenciar el aprendizaje del contenido, se sometió al criterio de expertos para su evaluación

Implantación de la competencia genérica: uso solvente de recursos de información en los grados de la EPSEB

Peer ReviewedPostprint (published version

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition.

The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor 1 (IF1), which is highly abundant in neurons. Herein, we ablated or overexpressed IF1 in mouse neurons to show that IF1 dose defines the fraction of active/inactive enzyme in vivo, thereby controlling mitochondrial function and the production of mitochondrial reactive oxygen species (mtROS). Transcriptomic, proteomic, and metabolomic analyses indicate that IF1 dose regulates mitochondrial metabolism, synaptic function, and cognition. Ablation of IF1 impairs memory, whereas synaptic transmission and learning are enhanced by IF1 overexpression. Mechanistically, quenching the IF1-mediated increase in mtROS production in mice overexpressing IF1 reduces the increased synaptic transmission and obliterates the learning advantage afforded by the higher IF1 content. Overall, IF1 plays a key role in neuronal function by regulating the fraction of ATP synthase responsible for mitohormetic mtROS signaling

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition.

The mitochondrial ATP synthase emerges as key hub of cellular functions controlling the production of ATP, cellular signaling, and fate. It is regulated by the ATPase inhibitory factor 1 (IF1), which is highly abundant in neurons. Herein, we ablated or overexpressed IF1 in mouse neurons to show that IF1 dose defines the fraction of active/inactive enzyme in vivo, thereby controlling mitochondrial function and the production of mitochondrial reactive oxygen species (mtROS). Transcriptomic, proteomic, and metabolomic analyses indicate that IF1 dose regulates mitochondrial metabolism, synaptic function, and cognition. Ablation of IF1 impairs memory, whereas synaptic transmission and learning are enhanced by IF1 overexpression. Mechanistically, quenching the IF1-mediated increase in mtROS production in mice overexpressing IF1 reduces the increased synaptic transmission and obliterates the learning advantage afforded by the higher IF1 content. Overall, IF1 plays a key role in neuronal function by regulating the fraction of ATP synthase responsible for mitohormetic mtROS signaling

Highly deformable and strongly magnetic semi-interpenetrating hydrogels based on alginate or cellulose

The effective implementation of many of the applications of magnetic hydrogels requires the development of innovative systems capable of withstanding a substantial load of magnetic particles to ensure exceptional responsiveness, without compromising their reliability and stability. To address this challenge, double-network hydrogels have emerged as a promising foundation, thanks to their extraordinary mechanical deformability and toughness. Here, we report a semi-interpenetrating polymer networks (SIPNs) approach to create diverse magnetic SIPNs hydrogels based on alginate or cellulose, exhibiting remarkable deformability under certain stresses. Achieving strong responsiveness to magnetic fields is a key objective, and this characteristic is realized by the incorporation of highly magnetic iron microparticles at moderately large concentrations into the polymer network. Remarkably, the SIPNs hydrogels developed in this research accommodate high loadings of magnetic particles without significantly compromising their physical properties. This feature is essential for their use in applications that demand robust responsiveness to applied magnetic fields and overall stability, such as a hydrogel luminescent oxygen sensor controlled by magnetic fields that we designed and tested as proof-of-concept. These findings underscore the potential and versatility of magnetic SIPNs hydrogels based on carbohydrate biopolymers as fundamental components in driving the progress of advanced hydrogels for diverse practical implementations.This study was supported by grant PID2020-118498GB-I00 funded by MCIN/AEI/10.13039/501100011033, Spain. A.L.-C. acknowledges grant FPU19/01801 funded by MCIN/AEI/10.13039/501100011033 and “ESF Investing in your future”, Spain. V.M. acknowledges VIRTUOUS project, funded by the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie-RISE Grant Agreement No. 872181 (https://www.virtuoush2020.com/) and the Project European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie-RISE Grant Agreement “SUSTAINABLE” No. 101007702 (https://www.projectsustainable.eu/). A.L.M.-C. acknowledges funding by Plan Propio-Investigación y Transferencia de la Universidad de Granada: “Programa 9. Proyectos de Investigación para la Incorporación de Jóvenes Doctores a Nuevas Líneas de Investigación en Grupos de la UGR”. Profs. Manuel Toledano and Raquel Osorio are acknowledged for providing access to the universal testing machine Instron 3345. Funding for open access charge: Universidad de Granada/CBUA

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group