867 research outputs found
Charge density functional plus calculation of lacunar spinel GaMSe (M = Nb, Mo, Ta, and W)
Charge density functional plus calculations are carried out to examine
the validity of molecular =1/2 and 3/2 state in lacunar spinel
GaMX (M = Nb, Mo, Ta, and W). With LDA (spin-unpolarized local density
approximation), which has recently been suggested as the more desirable
choice than LSDA (local spin density approximation), we examine the band
structure in comparison with the previous prediction based on the
spin-polarized version of functional and with the prototypical
=1/2 material SrIrO. It is found that the previously
suggested =1/2 and 3/2 band characters remain valid still in
LDA calculations while the use of charge-only density causes some minor
differences. Our result provides the further support for the novel molecular
state in this series of materials, which can hopefully motivate
the future exploration toward its verification and the further search for new
functionalities
Comparison of implant stability after different implant surface treatments in dog bone
OBJECTIVES: The purpose of this investigation was to evaluate the effects of different implant surface treatments on implant stability in dog mandibles. MATERIAL AND METHODS: A total of 30 implants (Dentium Co, Seoul, Korea) were placed in 5 dog mandibles. Bone quality was assessed at each site. Implant stability was evaluated using 2 different methods. An OsstellTM resonance frequency analyzer (RFA) was used to determine the stability at baseline (day 1), and 3, 6 and 10 weeks after surgery. Animals were euthanized 10 weeks after implant installation. Specimens were obtained and submitted to the laboratory processing. Sections were stained with hematoxylin and eosin for histologic and histomorphometric analyses. All implantation sites in dog mandibles demonstrated bone types II and III. RESULTS AND CONCLUSIONS: All implants showed good primary stability at baseline in terms of insertion torque. The results of this study suggest that surface treatment may have significant effects on biological stability 3 weeks after implant placement. Further studies are needed to confirm these initial observations in poor quality bone
Genome-Based Construction of the Metabolic Pathways of Orientia tsutsugamushi and Comparative Analysis within the Rickettsiales Order
Orientia tsutsugamushi, the causative agent of
scrub typhus, is an obligate intracellular
bacterium that belongs to the order of
Rickettsiales. Recently, we have reported that
O. tsutsugamushi has a unique
genomic structure, consisting of highly
repetitive sequences, and suggested that it may
provide valuable insight into the evolution of
intracellular bacteria. Here, we have used
genomic information to construct the major
metabolic pathways of
O. tsutsugamushi and performed a
comparative analysis of the metabolic genes and
pathways of O. tsutsugamushi
with other members of the Rickettsiales order.
While O. tsutsugamushi has the
largest genome among the members of this order,
mainly due to the presence of repeated
sequences, its metabolic pathways have been
highly streamlined. Overall, the metabolic
pathways of O. tsutsugamushi
were similar to Rickettsia but
there were notable differences in several
pathways including carbohydrate metabolism, the
TCA cycle, and the synthesis of cell wall
components as well as in the transport systems.
Our results will provide a useful guide to the
postgenomic analysis of
O. tsutsugamushi and lead
to a better understanding of the virulence and
physiology of this intracellular pathogen
Caroli's Syndrome with Autosomal Recessive Polycystic Kidney Disease in a Two Month Old Infant
Caroli's syndrome is a rare congenital disorder that involves intrahepatic bile duct ectasia and congenital hepatic fibrosis, frequently seen with concomitant autosomal recessive polycystic kidney disease (ARPKD). Literature on infants with ARPKD is rare. Here, we present a case of a two month old boy who was diagnosed with Caroli's syndrome and ARPKD
The current capacity and quality of colonoscopy in Korea
Background/Aims Little is known for the capacity and quality of colonoscopy, and adherence to colonoscopy surveillance guidelines in Korea. This study aimed to investigate the present and potential colonoscopic capacity, colonoscopic quality, and adherence to colonoscopy surveillance guidelines in Korea. Methods We surveyed representative endoscopists of 72 endoscopy units from June to August 2015, using a 36-item questionnaire regarding colonoscopic capacity, quality, and adherence to colonoscopy surveillance guidelines of each hospitals. Results Among the 62 respondents who answered the questionnaire, 51 respondents were analyzed after exclusion of 11 incomplete answers. Only 1 of 3 of endoscopy units can afford to perform additional colonoscopies in addition to current practice, and the potential maximum number of colonoscopies per week was only 42. The quality of colonoscopy was variable as reporting of quality indicators of colonoscopy were considerably variable (29.4%–94.1%) between endoscopy units. Furthermore, there are substantial gaps in the adherence to colonoscopy surveillance guidelines, as concordance rate for guideline recommendation was less than 50% in most scenarios. Conclusions The potential capacity and quality of colonoscopy in Korea was suboptimal. Considering suboptimal reporting of colonoscopic quality indicators and low adherence rate for colonoscopy surveillance guidelines, quality improvement of colonoscopy should be underlined in Korea
A multicenter, prospective, randomized, controlled trial evaluating the safety and efficacy of intracoronary cell infusion mobilized with granulocyte colony-stimulating factor and darbepoetin after acute myocardial infarction: study design and rationale of the 'MAGIC cell-5-combination cytokine trial'
<p>Abstract</p> <p>Background</p> <p>Bone marrow derived stem/progenitor cell transplantation after acute myocardial infarction is safe and effective for improving left ventricular systolic function. However, the improvement of left ventricular systolic function is limited. This study will evaluate novel stem/progenitor cell therapy with combination cytokine treatment of the long-acting erythropoietin analogue, darbepoetin, and granulocyte colony-stimulating factor (G-CSF) in patients with acute myocardial infarction.</p> <p>Methods</p> <p>The 'MAGIC Cell-5-Combination Cytokine Trial' is a multicenter, prospective, randomized, 3-arm, controlled trial with blind evaluation of the endpoints. A total of 116 patients will randomly receive one of the following three treatments: an intravenous darbepoetin infusion and intracoronary infusion of peripheral blood stem cells mobilized with G-CSF (n = 58), an intracoronary infusion of peripheral blood stem cells mobilized with G-CSF alone (n = 29), or conventional therapy (n = 29) at phase I. Patients with left ventricular ejection fraction < 45% at 6 months, in the patients who received stem cell therapy at phase I, will receive repeated cell therapy at phase II. The objectives of this study are to evaluate the safety and efficacy of combination cytokine therapy with erythropoietin and G-CSF (phase I) and repeated progenitor/stem cell treatment (phase II).</p> <p>Discussion</p> <p>This is the first study to evaluate the safety and efficacy of combination cytokine based progenitor/stem cell treatment.</p> <p>Trial registration</p> <p><url>http://www.ClinicalTrials.gov</url> identifier: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00501917">NCT00501917</a>.</p
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