The availability and characteristics of patient-focused YouTube videos related to oral hygiene instruction

Introduction: YouTube is a popular social media platform that is being increasingly used for the distribution of healthcare-related information. To date, there appear to be no published studies assessing the quality of oral hygiene instruction provided by YouTube videos. Objective: To assess the availability, quality and accuracy of patient-focused YouTube videos aiming to provide oral hygiene instruction. Method: YouTube videos meeting the inclusion criteria were evaluated for quality and information accuracy using an eight-item, evidence-based checklist relating to important aspects in the prevention of caries and periodontal disease. Results: Fifty-two relevant videos were included; 20 videos (38.5%) were produced by lay people (social media influencers and bloggers) who had no professional qualifications. None of the included videos contained accurate information relating to all eight items of the evidence-based checklist. Seven videos contained none of the information from the checklist. Numerous videos contained health advice which was not scientifically sound. Conclusion: The results of this study highlight that currently available YouTube videos may not contain evidence-based information relating to oral hygiene instruction. There are also concerns regarding the lack of regulation and quality assurance processes in the development of healthcare-related YouTube videos. Currently, clinicians should be cautious when advising patients to utilise YouTube as a source of information regarding oral health

Repeated delivery of chlorhexidine chips for the treatment of peri‐implantitis: A multicenter, randomized, comparative clinical trial

BackgroundPeri‐implantitis is a challenging condition to manage and is frequently treated using non‐surgical debridement. The local delivery of antimicrobial agents has demonstrated benefit in mild to moderate cases of peri‐implantitis. This study compared the safety and efficacy of chlorhexidine gluconate 2.5 mg chip (CHX chips) as an adjunctive treatment to subgingival debridement in patients afflicted with peri‐implantitis.MethodsA multicenter, randomized, single‐blind, two‐arm, parallel Phase‐3 study was conducted. Peri‐implantitis patients with implant pocket depths (IPD) of 5‐8 mm underwent subgingival implant surface debridement followed by repeated bi‐weekly supragingival plaque removal and chlorhexidine chips application (ChxC group) for 12 weeks, or similar therapy but without application of ChxC (control group). All patients were followed for 24 weeks. Plaque and gingival indices were measured at every visit whereas IPD, recession, and bleeding on probing were assessed at 8, 12, 16, 24 week.ResultsA total of 290 patients were included: 146 in the ChxC group and 144 in the control. At 24 weeks, a significant reduction in IPD (P = 0.01) was measured in the ChxC group (1.76 ± 1.13 mm) compared with the control group (1.54 ± 1.13 mm). IPD reduction of ≥2 mm was found in 59% and 47.2% of the implants in the ChxC and control groups, respectively (P = 0.03). Changes in gingival recession (0.29 ± 0.68 mm versus 0.15 ± 0.55 mm, P = 0.015) and relative attachment gain (1.47 ± 1.32 mm and 1.39 ± 1.27 mm, P = 0.0017) were significantly larger in the ChxC group. Patients in the ChxC group that were < 65 years exhibited significantly better responses (P < 0.02); likewise, non‐smokers had similarly better response (P < 0.02). Both protocols were well tolerated, and no severe treatment‐related adverse events were recorded throughout the study.ConclusionsPatients with peri‐implantitis that were treated with an intensive treatment protocol of bi‐weekly supragingival plaque removal and local application of chlorhexidine chips had greater mean IPD reduction and greater percentile of sites with IPD reduction of ≥2 mm as compared with bi‐weekly supra‐gingival plaque removal.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/166183/1/jper10672.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/166183/2/jper10672_am.pd

C3-targeted therapy in periodontal disease: moving closer to the clinic

Complement plays a key role in immunosurveillance and homeostasis. When dysregulated or overactivated, complement can become a pathological effector, as seen in several inflammatory disorders, including periodontal disease. Recently, clinical correlative studies and preclinical mechanistic investigations have collectively demonstrated that complement is hyperactivated during periodontitis and that targeting its central component (C3) provides therapeutic benefit in nonhuman primates (NHPs). The preclinical efficacy of a C3-targeted drug candidate combined with excellent safety and pharmacokinetic profiles supported its use in a recent Phase IIa clinical study in which C3 inhibition resolved gingival inflammation in patients with periodontal disease. We posit that C3-targeted intervention might represent a novel and transformative host-modulation therapy meriting further investigation in Phase III clinical trials for the treatment of periodontitis

Urbanization and its effects on water resources: Scenario of a tropical river basin in South India

Karamana River Basin (KRB), set in the tropical monsoon climate (i.e., Koppen\u27s Am), hosts the drinking water supply to the capital city of Thiruvanathapuram, one of the highly urbanized cities in the southwestern seaboard of India. Primary focus of the study is a scrutiny of future water security status of KRB, amidst the rising population and subsequent urban sprawl. The study was done through a combination of analysis of remotely sensed data, and collation of data on population growth, surface water distribution and decadal-level groundwater monitoring. An uptrend of the decadal-level population and unscientific constructions across KRB led to the decline of per capita water entitlement and causing conflicts around water service delivery. So this study has an imperative focus on the effects of rapidly growing urban life and its impact on water resources in KRB. This was accomplished by studying the land use, land surface temperature (LST), annual precipitation, and groundwater trend for two decades, followed by land use modeling and quantifying total water deposit. The estimated LST values in KRB, robustly substantiate an upward shift in surface temperature between 2001 (47.55%) to 2020 (64.01%), a testimony of urban sprawl and it may be the major cause to reduce the rate of rainwater infiltration and increase in runoff. The Normalized Difference Vegetation Index (NDVI), used to generate land use map, and LST of the basin have been assessed for the years 2001, 2011, and 2020 to model whether or not land use has been modulated by urbanization. Based on this, future trends of land use changes for 2030 and 2050 have been predicted using CA-Markov model - a model combining Cellular Automata and Markov chain. We also carried out a quantification of annual water deposit, potential evapo-transpiration, infiltration, surface runoff, and storage. Decadal trends of population change, degree of urbanization and consequent rise in domestic water demand and shrinkage of area of open space/soil cover have also been factored in assessing water security in KRB. The results show that, as of today, the city is facing an acute annual shortage of surface water by 321.51 MCM. Furthermore, we propose potential sources for future water security of the state\u27s capital region

ILC Reference Design Report Volume 4 - Detectors

This report, Volume IV of the International Linear Collider Reference Design Report, describes the detectors which will record and measure the charged and neutral particles produced in the ILC's high energy e+e- collisions. The physics of the ILC, and the environment of the machine-detector interface, pose new challenges for detector design. Several conceptual designs for the detector promise the needed performance, and ongoing detector R&D is addressing the outstanding technological issues. Two such detectors, operating in push-pull mode, perfectly instrument the ILC interaction region, and access the full potential of ILC physics.This report, Volume IV of the International Linear Collider Reference Design Report, describes the detectors which will record and measure the charged and neutral particles produced in the ILC's high energy e+e- collisions. The physics of the ILC, and the environment of the machine-detector interface, pose new challenges for detector design. Several conceptual designs for the detector promise the needed performance, and ongoing detector R&D is addressing the outstanding technological issues. Two such detectors, operating in push-pull mode, perfectly instrument the ILC interaction region, and access the full potential of ILC physics

ILC Reference Design Report Volume 3 - Accelerator

The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2 s^-1. The complex includes a polarized electron source, an undulator-based positron source, two 6.7 km circumference damping rings, two-stage bunch compressors, two 11 km long main linacs and a 4.5 km long beam delivery system. This report is Volume III (Accelerator) of the four volume Reference Design Report, which describes the design and cost of the ILC.The International Linear Collider (ILC) is a 200-500 GeV center-of-mass high-luminosity linear electron-positron collider, based on 1.3 GHz superconducting radio-frequency (SCRF) accelerating cavities. The ILC has a total footprint of about 31 km and is designed for a peak luminosity of 2x10^34 cm^-2 s^-1. The complex includes a polarized electron source, an undulator-based positron source, two 6.7 km circumference damping rings, two-stage bunch compressors, two 11 km long main linacs and a 4.5 km long beam delivery system. This report is Volume III (Accelerator) of the four volume Reference Design Report, which describes the design and cost of the ILC