Readability of Instructional Materials and Usability of Online Learning Environment: Their Relations to the Development of Authentic and Contingent Knowledge

This research project correlates authentic knowledge with the readability of instructional materials and contingent knowledge with usability of the online learning environment. Based on thematic analyses in above two areas, we propose a model that governs how adult learners develop authentic and contingent knowledge in an intertwined manner

Children\u27s Books

Alain Leonard (1992). Barnaby and the Big Gorilla; Holly Keller (1991). Island Baby; Anthony Browne (1992). Through the Magic Mirror; John Greenleaf Whittier (1992). Barbara Frietchie; Lydia Dabcovich (1992). The Keys to My Kingdon: A Poem in Three Languages; Charlotte Zolotow (1992). This Quiet Lad

Children\u27s Books

(Childrens books) The Dragons are Singing Tonight (1993) Jack Prelutsky; Komodo (1993) Peter Sis; Timothy Twinge. (1993) Florence Parry and Roxanne Heide Pierce; Time To Get Out (1993) Fulvio Testa; I Love You As Much.(1993) Laura Krauss Melmed; Bard of Avon: The Story of William Shakespeare. (1992) Diane Stanley and Peter Vennema; Alamo Across Texas. (1993) Jill Stover; J Spy Two Eyes. (1993

REVIEWS: Professional Materials

Science Learning: Processes and Applications. Carol Minnick Santa and Donna E. Alvermann (Eds.) 1991. Books for Children and Young Adults: The Day Patch Stood Guard; The Day Veronica Was Nosy; The Day Sidney Ran Off; The Day the Ducks Went Skating; The Pumpkin Man and the Craft Creeper; Monster Goes to School; Monster\u27s Birthday Hiccups; Fast Forward; Reynard the Fox; Androcles and the Lion and Other Aesop\u27s Fables; Tales of Edgar Allen Poe; Oscar Wilde: The Happy Prince and Other Storie

REVIEWS: Professional Materials

Jerry L. Johns (1991). Basic Reading Inventory; Children\u27s Books: Merry Christmas, Amanda and April; Chicken Man; All the Lights in the Night; Jack and the Beanstalk; The Swineherd; The Worst Person\u27s Christmas; That\u27s Exactly the Way it Wasn’t; An Auto Mechanic, A Carpenter, A Potter; Meredith\u27s Mother Takes the Trai

Enacting The Spirit Of The United Nations Convention On The Rights Of Persons With Disabilities: The Role Of Postsecondary Faculty In Ensuring Access

Nations throughout the world have signed the United Nations (UN) Convention on the Rights of Persons With Disabilities.  Many postsecondary educators support the ideals of access and equity for students with disabilities, but have received no training in how to ensure that these goals are achieved.  This paper introduces the concepts of universal design and universal instructional design and provides specific guidelines for general communication and for creating accessible classrooms, lectures or presentations, documents, media, websites, and distance education courses

Human Case of Swine Influenza A (H1N1) Triple Reassortant Virus Infection, Wisconsin

Zoonotic infections with swine influenza A viruses are reported sporadically. Triple reassortant swine influenza viruses have been isolated from pigs in the United States since 1998. We report a human case of upper respiratory illness associated with swine influenza A (H1N1) triple reassortant virus infection that occurred during 2005 following exposure to freshly killed pigs

Risk of Parkinson's disease after tamoxifen treatment

<p>Abstract</p> <p>Background</p> <p>Women have a reduced risk of developing Parkinson's disease (PD) compared with age-matched men. Neuro-protective effects of estrogen potentially explain this difference. Tamoxifen, commonly used in breast cancer treatment, may interfere with the protective effects of estrogen and increase risk of PD. We compared the rate of PD in Danish breast cancer patients treated with tamoxifen to the rate among those not treated with tamoxifen.</p> <p>Methods</p> <p>A cohort of 15,419 breast cancer patients identified from the Danish Breast Cancer Collaborative Group database was linked to the National Registry of Patients to identify PD diagnoses. Overall risk and rate of PD following identification into the study was compared between patients treated with tamoxifen as adjuvant hormonal therapy and patients not receiving tamoxifen. Time-dependent effects of tamoxifen treatment on PD rate were examined to estimate the likely induction period for tamoxifen.</p> <p>Results</p> <p>In total, 35 cases of PD were identified among the 15,419 breast cancer patients. No overall effect of tamoxifen on rate of PD was observed (HR = 1.3, 95% CI: 0.64-2.5), but a PD hazard ratio of 5.1 (95% CI: 1.0-25) was seen four to six years following initiation of tamoxifen treatment.</p> <p>Conclusions</p> <p>These results provide evidence that the neuro-protective properties of estrogen against PD occurrence may be disrupted by tamoxifen therapy. Tamoxifen treatments may be associated with an increased rate of PD; however these effects act after four years, are of limited duration, and the adverse effect is overwhelmed by the protection against breast recurrence conferred by tamoxifen therapy.</p

Copy Number Variation in Familial Parkinson Disease

Copy number variants (CNVs) are known to cause Mendelian forms of Parkinson disease (PD), most notably in SNCA and PARK2. PARK2 has a recessive mode of inheritance; however, recent evidence demonstrates that a single CNV in PARK2 (but not a single missense mutation) may increase risk for PD. We recently performed a genome-wide association study for PD that excluded individuals known to have either a LRRK2 mutation or two PARK2 mutations. Data from the Illumina370Duo arrays were re-clustered using only white individuals with high quality intensity data, and CNV calls were made using two algorithms, PennCNV and QuantiSNP. After quality assessment, the final sample included 816 cases and 856 controls. Results varied between the two CNV calling algorithms for many regions, including the PARK2 locus (genome-wide p = 0.04 for PennCNV and p = 0.13 for QuantiSNP). However, there was consistent evidence with both algorithms for two novel genes, USP32 and DOCK5 (empirical, genome-wide p-values<0.001). PARK2 CNVs tended to be larger, and all instances that were molecularly tested were validated. In contrast, the CNVs in both novel loci were smaller and failed to replicate using real-time PCR, MLPA, and gel electrophoresis. The DOCK5 variation is more akin to a VNTR than a typical CNV and the association is likely caused by artifact due to DNA source. DNA for all the cases was derived from whole blood, while the DNA for all controls was derived from lymphoblast cell lines. The USP32 locus contains many SNPs with low minor allele frequency leading to a loss of heterozygosity that may have been spuriously interpreted by the CNV calling algorithms as support for a deletion. Thus, only the CNVs within the PARK2 locus could be molecularly validated and associated with PD susceptibility