602 research outputs found
A Sidetrack-Based Algorithm for Finding the k Shortest Simple Paths in a Directed Graph
We present an algorithm for the k shortest simple path problem on weighted
directed graphs (kSSP) that is based on Eppstein's algorithm for a similar
problem in which paths are allowed to contain cycles. In contrast to most other
algorithms for kSSP, ours is not based on Yen's algorithm and does not solve
replacement path problems. Its worst-case running time is on par with
state-of-the-art algorithms for kSSP. Using our algorithm, one may find O(m)
simple paths with a single shortest path tree computation and O(n + m)
additional time per path in well-behaved cases, where n is the number of nodes
and m is the number of edges. Our computational results show that on random
graphs and large road networks, these well-behaved cases are quite common and
our algorithm is faster than existing algorithms by an order of magnitude.
Further, the running time is far better predictable due to very small
dispersion
Subgraph Matching Kernels for Attributed Graphs
We propose graph kernels based on subgraph matchings, i.e.
structure-preserving bijections between subgraphs. While recently proposed
kernels based on common subgraphs (Wale et al., 2008; Shervashidze et al.,
2009) in general can not be applied to attributed graphs, our approach allows
to rate mappings of subgraphs by a flexible scoring scheme comparing vertex and
edge attributes by kernels. We show that subgraph matching kernels generalize
several known kernels. To compute the kernel we propose a graph-theoretical
algorithm inspired by a classical relation between common subgraphs of two
graphs and cliques in their product graph observed by Levi (1973). Encouraging
experimental results on a classification task of real-world graphs are
presented.Comment: Appears in Proceedings of the 29th International Conference on
Machine Learning (ICML 2012
Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation. This process imposes a plethora of questions: How do cells count their X chromosome number and ensure that exactly one stays active? How do they randomly choose one of two identical X chromosomes for inactivation? And how do they stably maintain this state of monoallelic expression? Here, different regulatory concepts and their plausibility are evaluated in the context of theoretical studies that have investigated threshold behavior, ultrasensitivity, and bistability through mathematical modeling. It is discussed how a twofold difference between a single and a double dose of X‐linked genes might be converted to an all‐or‐nothing response and how mutually exclusive expression can be initiated and maintained. Finally, candidate factors that might mediate the proposed regulatory principles are reviewed
Faster Algorithms for the Maximum Common Subtree Isomorphism Problem
The maximum common subtree isomorphism problem asks for the largest possible
isomorphism between subtrees of two given input trees. This problem is a
natural restriction of the maximum common subgraph problem, which is -hard in general graphs. Confining to trees renders polynomial time
algorithms possible and is of fundamental importance for approaches on more
general graph classes. Various variants of this problem in trees have been
intensively studied. We consider the general case, where trees are neither
rooted nor ordered and the isomorphism is maximum w.r.t. a weight function on
the mapped vertices and edges. For trees of order and maximum degree
our algorithm achieves a running time of by
exploiting the structure of the matching instances arising as subproblems. Thus
our algorithm outperforms the best previously known approaches. No faster
algorithm is possible for trees of bounded degree and for trees of unbounded
degree we show that a further reduction of the running time would directly
improve the best known approach to the assignment problem. Combining a
polynomial-delay algorithm for the enumeration of all maximum common subtree
isomorphisms with central ideas of our new algorithm leads to an improvement of
its running time from to ,
where is the order of the larger tree, is the number of different
solutions, and is the minimum of the maximum degrees of the input
trees. Our theoretical results are supplemented by an experimental evaluation
on synthetic and real-world instances
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