Ergonomic Chair Design For Thermal Comfort Using Phase Change Materials

The metabolism process of humanoids is well designed for emitting the heat constantly. But no heat transfer phenomena occur from the spinal side of the body in sitting posture. The proper heat transfer is arrested in the sitting posture; this makes the human to feel discomfort. The bus drivers are the main victims who face this problem every day and cause of the disease called “hemorrhoid”. This project mainly focused to modify and construct a convenient chilled cushion chair with jam-backed Phase Change Material (PCM) to overcome such problems. This chair absorbs body heat when occupied and discharges while vacant. The stages when liquid change to solid and solid change to liquid occurs nearly by a constant temperature. The chair provides a cooling effect and also a cushioning effect to the occupier. The PCMs are having large latent heat and provide a cooling effect by maintaining nearly by constant temperature to the human body.  The jam-backed chilled cushion chair is invented for improved thermal comfort for the driver for some extended time by the proper temperature that acceptable level of the human. The performance tests are carried out to evaluate the working of the pad

Prevalence of asymptomatic cardiac and renal damage in treatment naïve adult patients with Systemic Hypertension and its co-relation with hsCRP and Uric acid levels: A Cross Sectional Study

OBJECTIVES: To look at the prevalence of asymptomatic cardiac and renal damage in newly diagnosed treatment naive adult patients with systemic hypertension and to study the co-relation between inflammatory markers, hsCRP and uric acid, with the asymptomatic organ damage in hypertensives. METHODS: The study recruited 98 hypertensives who presented to the medicine OPD and were willing to participate in the study. The patient data was collected with a questionnaire and the blood pressure, height, weight and abdominal circumference were measured in these patients. The blood investigations including fasting glucose, creatinine, electrolytes and lipid profile were done in these patients. The patients also underwent electrocardiography and echocardiography with the documentation of M-Mode values. The albumin creatinine ratio, eGFR and the LV Mass index were also subsequently calculated in these patients. RESULTS: The prevalence of microalbuminuria was 31.9% and the prevalence of Left ventricular Hypertrophy was 29.59% of the study population. The uric and hsCRP were not related to asymptomatic organ damage when analysed. The hsCRP was however very significantly related to body mass index (p=0.000) and abdominal circumference (p=0.003) on bivariate analysis. This association of hsCRP to elevated body mass index and abdominal circumference might be due to its association with the metabolic syndrome. CONCLUSION: Almost one third of the newly detected hypertensives in the study population had evidence of asymptomatic cardiac and renal damage. However, the asymptomatic cardiac and renal damage was not related to elevated inflammatory markers in these patients. The elevated hsCRP in the study population might berelated to an underlying metabolic syndrome

Evaluating iron deficiency anaemia in the third trimester of pregnancy with haematological parameters and serum ferritin concentration

Background: Iron deficiency is the commonest cause of anaemia and at least half of anaemia cases will have causes other than iron deficiency. The objective of this study was to determine the prevalence of iron deficiency anaemia among antenatal mothers based on haematological parameters and serum ferritin levels.Methods: This was a hospital based cross sectional study, conducted at Meenakshi Medical College and Research Institute, Kancheepuram from January 2017 to June 2018. Two hundred antenatal mothers who were diagnosed with anaemia in the third trimester of pregnancy were evaluated by haematological parameters and serum ferritin assay.Results: 38% of women had mild anaemia, 50% had moderate anaemia and 12% had severe anaemia. On peripheral smear, 60% had microcytic hypochromic anaemia indicating iron deficiency, and 12% had megaloblastic anaemia. In 41% of cases, the mean corpuscular volume was 160µg/lit in 19% of cases.Conclusions: Based on the haematological parameters and serum ferritin estimation, in 60% of cases, anaemia was due to iron deficiency. Before initiating treatment, it is important to differentiate various types of anaemia, so that appropriate treatment can be given

4-[4-(Diethyl­amino)­phen­yl]-N-methyl-3-nitro-4H-chromen-2-amine

In the title compound, C20H23N3O3, the dihydro­pyran ring adopts half-chair conformation. The chromene system makes a dihedral angle of 87.35 (5)° with the adjacent benzene ring. An intra­molecular N—H⋯O hydrogen bond generates an S(6) motif, which stabilizes the mol­ecular conformation. In the crystal, weak inter­molecular C—H⋯O hydrogen bonds contribute to the stabilization of the packing

1-(2-Naphth­yl)-3-phenyl-3-(4,5,6,7-tetra­hydro-1,2,3-benzoselenadiazol-4-yl)propan-1-one

In the title compound, C25H22N2OSe, the fused six-membered cyclo­hexene ring of the 4,5,6,7-tetra­hydro-1,2,3-benzoselenadiazole group adopts a near half-chair conformation and the five-membered 1,2,3-selenadiazole ring is essentially planar (r.m.s. deviation = 0.004 Å). There are weak inter­molecular C—H⋯O and C—H⋯π inter­actions in the crystal structure. Inter­molecular π–π stacking is also observed between the naphthyl units, with a centroid–centroid distance of 3.529 (15) Å

TaLoS: secure and transparent TLS termination inside SGX enclaves

We introduce TaLoS1, a drop-in replacement for existing transport layer security (TLS) libraries that protects itself from a malicious environment by running inside an Intel SGX trusted execution environment. By minimising the amount of enclave transitions and reducing the overhead of the remaining enclave transitions, TaLoS imposes an overhead of no more than 31% in our evaluation with the Apache web server and the Squid proxy

Glamdring: automatic application partitioning for Intel SGX

Trusted execution support in modern CPUs, as offered by Intel SGX enclaves , can protect applications in untrusted environments. While prior work has shown that legacy applications can run in their entirety inside enclaves, this results in a large trusted computing base (TCB). Instead, we explore an approach in which we partition an applica- tion and use an enclave to protect only security-sensitive data and functions, thus obtaining a smaller TCB. We describe Glamdring , the first source-level parti- tioning framework that secures applications written in C using Intel SGX. A developer first annotates security- sensitive application data. Glamdring then automatically partitions the application into untrusted and enclave parts: (i) to preserve data confidentiality, Glamdring uses dataflow analysis to identify functions that may be ex- posed to sensitive data; (ii) for data integrity, it uses back- ward slicing to identify functions that may affect sensitive data. Glamdring then places security-sensitive functions inside the enclave, and adds runtime checks and crypto- graphic operations at the enclave boundary to protect it from attack. Our evaluation of Glamdring with the Mem- cached store, the LibreSSL library, and the Digital Bitbox bitcoin wallet shows that it achieves small TCB sizes and has acceptable performance overheads

Extraction process optimization of flavonoid and in vitro amylase inhibitory effect of purified quercetin derivative from Amorphophallus paeoniifolius tubers

544-556Amorphophallus paeoniifolius (Elephant foot yam) is a prominent tuberous plant utilized across several parts of India to treat various ailments such as a tumour, haemorrhage, microbial infections, cough, bronchitis, diabetes, anaemia, and hepato-gastro and cardiovascular diseases. In this context, the present study aims to optimize the extraction process of the flavonoid and to study the in vitro amylase inhibitory effect of purified flavonoid moiety. The Shake flask method with different extraction solvents was adopted to quantify the flavonoid content. Central composite design (CCD) based response surface methodology (RSM) was formulated to optimize the extraction process. Three-dimensional preparative chromatography (3D PTLC) was executed to purify the flavonoid content and high-resolution liquid chromatography-mass spectrometry (HRLC-MS) was adopted to predict the structure. 3,5-dinitrosalicylic acid (DNS) based spectrophotometry method was used to determine the amylase inhibitory property. All the analyses were subjected to standard statistical tests. The developed model for the extraction optimization process was found to be near significant (P = 0.242) with temperature as a significant variable (P = 0.029), and a 107-fold increase (71.11±0.5 mg/g tissue) of flavonoid content was recorded. A strong yellow colour spot (flavonoid fraction) was eluted using 3D PTLC technique and the molecule was identified as quercetin derivative (m/z 447) by the direct MS method. Significant amylase inhibition (36.1±2.1%) recorded by purified quercetin derivative has documented the utilization of A. paeoniifolius tubers as classical traditional medicine

6-Meth­oxy-N-methyl-3-nitro-4-nitro­methyl-4H-chromen-2-amine

In the title compound, C12H13N3O6, the dihydro­pyran ring adopts a near screw-boat conformation. The dihedral angle between the mean planes of the benzene and dihydro­pyran rings is 6.35 (5)°. An intra­molecular N—H⋯O hydrogen bond generates an S(6) motif, which stabilizes the mol­ecular conformation. In the crystal, weak inter­molecular C—H⋯O, N—H⋯O and C—H⋯π hydrogen bonds contribute to the stabilization of the packing

4-{(4-Chloro­phen­yl)[4-(4-methyl­phen­yl)-1,2,3-selenadiazol-5-yl]meth­yl}-4,5,6,7-tetra­hydro-1,2,3-benzoselenadiazole

In the title compound, C22H19ClN4Se2, the mean plane of the non-fused selenadiazole ring forms dihedral angles of 54.20 (16)° and 70.48 (11)°, respectively, with the essentially planar [maximum deviations of 0.025 (5) and 0.009 (2) Å, respectively] methyl­phenyl and chloro­phenyl substituents. The tetra­hydro-1,2,3-benzoselenadiazole group is disordered over two sets of sites with a refined occupancy ratio of 0.802 (5):0.198 (5). In the crystal, weak inter­molecular C—H⋯N inter­actions are observed