Formulation and stability of topical water in oil emulsion containing corn silk extract

Purpose: To formulate the water in oil (W/O) emulsion of corn silk (CS) extract and to evaluate its stability at various storage conditions.Methods: Ethanol CS extract was prepared using maceration (cold) technique. A 4 % CS emulsion was prepared using varying concentrations of liquid paraffin, ABIL EM90 and water. The formulations were kept at 25 oC for 28 days and to screen out the less stable formulations. The remaining formulations were further stressed at 40 oC to choose the most stable formulation. The optimized formulation was evaluated for physical characteristics including phase separation, rheology and mean droplet size. The physical stability of the formulation was evaluated by monitoring these parameters over a period of 12 weeks at 8, 25, 40 and 40 oC, and 75 % RH.Results: The chosen formulation showed good resistance to phase separation on centrifugation under all storage conditions. Rheological behavior followed non-Newtonian pseudoplastic pattern at various storage conditions. Mean droplet size of freshly prepared formulation was 2.98 ± 1.32 μm and did not show significant (p < 0.05) changes at normal storage conditions (8 and 25 oC).Conclusion: The findings indicate that the developed CS extract W/O emulsion is stable and therefore may be suitable for topical use on skin as an antioxidant preparation.Keywords: Corn silk, Emulsion, Nonionic surfactant, Rheology, Flow index, Droplet size, Non-Newtonian pseudoplasti

ANTIBACTERIAL AND ANTIOXIDANT POTENTIAL OF STEM BARK EXTRACT OF BOMBAX CEIBA COLLECTED LOCALLY FROM SOUTH PUNJAB AREA OF PAKISTAN

Background: Ethnic medication systems have been used extensively by humans since their origin. Now a day, in the developing countries these systems are being used due to their effectiveness and affordability. Especially inhabitants of rural areas still rely on these systems as first line of treatment against diseased conditions. Till now, majority of medicines is derived from the natural origin particularly plants owing to their little side effects and cost effectiveness. Materials and Methods: In the present work, we evaluated antibacterial and antioxidant activity of methanolic extract of Bombax ceiba stem bark. Total phenolic and flavonoid contents were also assessed in the extract. The antioxidant capacity was determined by DPPH, Nitric Oxide scavenging and reducing power activity. For antibacterial activity, Gram-negative (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi) and Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus) were used. Results: Phenolic content was 133.21±1.56 μg GAE/mg of extract while Flavonoid content was 997.93±2.14 μg QE/mg. Plant extract demonstrated strong antiradical activity with EC50 18.78 ± 0.69 and 23.62 ± 1.99μg/ml for Nitric Oxide and DPPH assay respectively while EC50 in case of reducing power activity was 139.4 ± 0.98μg/ml. Plant extract displayed inhibitory effect against microbial growth with S. typhi as the most resistant strain and Staphylococcus aureus the most sensitive one. Conclusion: This study revealed that Bombax ceiba of local origin has broad spectrum antibacterial activity and it can also provide defense against oxidative stress

Effects of Emblica Officinalis Extract Cream on Human Skin Trans-epidermal Water Loss Measured with Non Invasive Probe

The purpose of this study was to assess hydroalcoholic Emblica officinalis fruit extract cream on human skin trans-epidermal water loss (TEWL). Ten male volunteers were examined in this study. Measurements were made on cheeks. Creams with different concentrations of ABIL® EM 90 and liquid paraffin containing 3% hydroalcoholic Emblica officinalis fruit extract were developed and tested for stability studies for a period of 28 days. Selected cream and its base were further assessed in different conditions at 8 °C (in refrigerator), 25 °C (in incubator), 40 °C (in incubator) and 40 °C (in incubator) with 75% relative humidity (RH) for color, odor, thickness, grittiness liquefaction, phase separation, and pH at different time intervals. Trans-epidermal water loss (TEWL) was monitored every week by non-invasive bio-instrument Tewameter MPA 5. All measurements were made statistically by ANOVA and t-paired test. Significant decrease on skin TEWL was produced. Keywords: Hydroalcoholic Emblica officinalis fruit extract, Facial cream, Biophysical paramete

Hydrophilic polymers based sustained release matrix tablets of Ibuprofen: Optimization of formulation using Box-Behnken statistical design

The current study was aimed to formulate sustained release matrix tablets of Ibuprofen; a Propionic acid derivative, and is non-steroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic properties and optimize by using a 3-factor 3-level Box-Behnken statistical design as an optimization tool. Matrix tablets were prepared by direct compression technique using HPMC(X1), NaCMC(X2) and Xanthan Gum(X3) as independent variables and % release at 2hr (Y1), % release at 12hr (Y2) and hardness (Y3) of tablet were selected as dependent variables. Regression analysis was performed on dissolution data and construct polynomial regression models for these response variables. Polynomial models were further validated using ANOVA and results indicate that all the polymers used have significant effect on selected response (p<0.05). Contour plots were drawn to evaluate the effect of polymer combination on selected responses. The results obtained from kinetic modeling indicate that drug release follows the non-fickian diffusion process. Hence Box-Behnken statistical design facilitates the formulation and optimization of Ibuprofen sustained release matrix tablets to achieve better bioavailability. Keywords: Matrix tablets, Sustained release, Ibuprofen, Ant-inflammatory, Box-Behnken statistical desig

Fostering coastal resilience to climate change vulnerability in Bangladesh, Brazil, Cameroon and Uruguay: a cross-country comparison

© 2017, Springer Science+Business Media B.V. This paper describes a comparative study of four different cases on vulnerability, hazards and adaptive capacity to climate threats in coastal areas and communities in four developing countries: Bangladesh, Brazil, Cameroon and Uruguay. Coastal areas are vulnerable to sea-level rise (SLR), storm surges and flooding due to their (i) exposure, (ii) concentration of settlements, many of which occupied by less advantaged groups and (iii) the concentration of assets and services seen in these areas. The objective of the paper is twofold: (i) to evaluate current evidence of coastal vulnerability and adaptive capacity and (ii) to compare adaptation strategies being implemented in a sample of developing countries, focusing on successful ones. The followed approach for the case evaluation is based on (i) documenting observed threats and damages, (ii) using indicators of physical and socioeconomic vulnerability and adaptive capacity status and (iii) selecting examples of successful responses. Major conclusions based on cross-case comparison are (a) the studied countries show different vulnerability, adaptive capacity and implementation of responses, (b) innovative community-based (CBA) and ecosystem-based adaptation (EbA) and (c) early warning systems are key approaches and tools to foster climate resilience. A recommendation to foster the resilience of coastal communities and services is that efforts in innovative adaptation strategies to sea-level rise should be intensified and integrated with climate risk management within the national adaption plans (NAPAs) in order to reduce the impacts of hazards

Parametric studies on tramcar suspension system

Suspension system plays an important role in the performance of a vehicle, especially the handling and ride comfort. The role of suspension parameter, particularly spring stiffness, in relation to ride quality is being analysed in this paper. This study focused on the suspension system of a non-commercial transport for recreational purposes designed by the Mechanical Engineering Faculty of Universiti Teknologi Malaysia, which is commonly known as ‘tramcar’. For the purpose of the analysis, a full car model for the tramcar suspension system was developed. The simulation on the model was performed using MATLAB Simulink software. The spring stiffness value was varied in the simulation, and the suspension response was observed. From the suspension parameter analysis, it was concluded that the ride comfort of the tramcar can be improved to an optimum level by having the lowest practical spring stiffness value. Lower suspension spring stiffness was shown to provide better ride comfort in term of lower acceleration, pitch rate and roll rate responses. However, the spring stiffness should not produce response frequencies lower than 1Hz in avoiding sensations assimilated to motion sicknes

A Bibliometric Analysis of Coronavirus Research in Gulf Cooperation Council Countries

COVID-19 was declared a pandemic by World Health Organization in March 2020. Since then, it has attracted the enormous attention of researchers from around the world. The world has gone through previous instances of corona-viruses such as Severe Acute Respiratory Syndrome and Middle Eastern Respiratory Syndrome. Nevertheless, none was of these were of this serious nature as COVID-19. In this research, we carry out a bibliometric analysis of coronavirus research using the Scopus database. However, we restricted ourselves to the Gulf Cooperation Council countries, comprising Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates. The analysis was performed using Biblioshiny software. We analyzed 4288 articles written by 24226 researchers from 1994 till 2021, published in 1429 sources. The number of authors per publication is 5.65. A bulk of the research (more than 68%) appeared in the form of articles. More than 43% of the publications appeared in 2020 and more than 44% in 2021. Saudi Arabia appears the most-cited country, followed by Qatar. Journal of Infection and Public Health published the most number of papers, whereas New England Journal of Medicine is the most-cited one. Memish, Z.A. wrote the maximum number of papers. The top source, according to the H-index, is the Journal of Virology. Furthermore, the two most prolific universities are King Saud University and King Abdulaziz University, both from Saudi Arabia. The research uncovered deep learning as a niche theme used in recent publications. The research landscape continues to alter as the pandemic keeps on evolving