Trust and social customer relationship management consequences on donor’s intention to donate via social media

Fundraising trough social media platforms started to emerge as an easy, fast and practical instrument for non-profit organizations to collect donations. Users can both directly donate to a non-profit organisation social media page, or organize fundraisers inviting their friends to participate. This article proposes a model to investigate the effect of different factors on the intention to donate via social media. Based on data collected from 130 responses, this study uses the multiple linear regression and mediation analysis to test the research model. The result showed that different factors directly influenced the intention to donate, mainly Social Customer Relationship Management and trust in social media. Furthermore, we proved the mediator effect of trust in the non-profit organisation on the relationship between Social Customer Relationship Management and the intention to donate. This findings contribute both to the context of online donations and Social Customer Relationship Management.Angariação de fundos através das plataformas de redes sociais, tem-se desenvolvido como uma forma fácil, rápida e um instrumento prático para a recolha de doações pelas organizações sem fins lucrativos. Os utilizadores das redes sociais podem facilmente doar diretamente para uma organização sem fins lucrativos via a plataforma e sem sair desta. A presente dissertação sugere um modelo de análise do impacto na intenção em doar através da rede social, da gestão do relacionamento social com o cliente (SCRM), da confiança na rede social (trust in SM) e da confiança na organização sem finslucrativos. Suportado por dados recolhidos através de um inquérito online de 130 respondentes de diferentes nacionalidades, este estudo utiliza os métodos de análise de regressão múltipla e de mediação para testar as hipóteses do modelo conceptual proposto. Os resultados mostram que diferentes fatores influenciam diretamente a intenção em doar através das redes sociais, nomeadamente gestão do relacionamento social com o cliente (SCRM) e a confiança na rede social (trust in SM). Ainda, verificou-se um efeito de mediação da confiança na rede social com a relação entre o SCRM e a intenção de doar através da rede social. Estes resultados contribuem para aprofundar o estudo destes conceitos num contexto quer das doações online, quer da gestão do relacionamento social com o cliente

The role of taxanes in triple-negative breast cancer: literature review

Breast cancer (BC) is the most frequent tumor worldwide. Triple-negative BCs are characterized by the negative estrogen and progesterone receptors and negative HER2, and represent 15% of all BCs. In this review, data on the use of taxanes in triple-negative BCs are analyzed, concluding they are effective in any clinical setting (neoadjuvant, adjuvant, and metastatic). Further, the role of nab-paclitaxel (formulation of albumin-bound paclitaxel) in these tumors is also evaluated. The available data show the clinical potential of nab-paclitaxel based combinations in terms of long-duration response, increased survival, and better quality of life of patients with triple-negative metastatic BC. The ongoing trials will give further information on the better management of this type of tumor

Ancient myths with perennial question

Even though myths have an imaginative component that frequently clashes with logical thinking, their symbolism often resonates with our collective unconscious. The divine inspiration that propels mythological heroes towards the noblest and highest ideals also carries the risk of taunting the jealousy of the gods. This may culminate in fatal results as has happened to Remus when he overstepped the newly defined boundaries set by his twin Romulus when outlining the future city of Rome. Fortunately, mythological heroes often enjoyed the benefit of having wise advisors. These were generally able to counsel their charges against yielding to the sin of pride so as to avoid triggering the anger of the gods. But when deprived of such advisors - as we are - how are we to place legitimate boundaries to our citadel of growing medical knowledge lest we scoff at limits and pay the penalty exacted from Remus

Surgery versus primary endocrine therapy for operable primary breast cancer in elderly women (70 years plus).

While younger women with early-stage, oestrogen-sensitive breast cancer are almost invariably treated with surgery plus endocrine therapy, (which deprives the cancer of the hormonal stimulus that induces its growth), women over the age of 70 years are frequently offered endocrine therapy alone. This is known as primary endocrine therapy. Primary endocrine therapy using tamoxifen (a drug which blocks oestrogen receptors on the cancer cell, inhibiting its growth) was first suggested as a treatment for older women in the 1980s. Tamoxifen was given without surgery, radiotherapy or chemotherapy on the basis that older women are more likely to have cancers with oestrogen receptors and will therefore respond well to treatment. In addition they were thought less suitable for major surgery because of other existing health issues. However, a tumour will often only respond to this treatment for between 18 and 24 months, and those women who relapse will have to consider additional hormone treatment or opt for surgery or radiotherapy at a greater age. The long-term data suggest that, at 12 years of follow-up, more elderly women treated by primary tamoxifen alone will suffer a progression of their cancer than those who have had surgery. We undertook this review to assess the evidence for the clinical effectiveness of surgery (with or without endocrine therapy) compared with primary endocrine therapy in the treatment of operable breast cancer in women aged 70 years and over. Based on seven trials and an estimated 1081 deaths in 1571 women, the results of this review showed no benefit in respect to survival for either surgery or primary endocrine therapy. However, women who had surgery were less likely to relapse than women on primary endocrine therapy. The authors conclude that surgery controls breast cancer better than tamoxifen alone in older women but does not extend survival. Both interventions were associated with adverse events. Tamoxifen-related adverse effects included hot flushes, skin rash, vaginal discharge, indigestion, breast pain, sleepiness, headache, vertigo, itching, hair loss, cystitis, acute thrombophlebitis, nausea, and indigestion. Surgery-related adverse effects included tingling or numbness on the arm on the side of the surgery, and psychosocial problems. On this basis, primary endocrine therapy should only be offered to women with oestrogen receptor (ER)-positive tumours who are unfit for, or who refuse surgery. We need further trials to evaluate the clinical effectiveness of other agents such as aromatase inhibitors for use as primary endocrine therapy for an infirm older population with ER-positive tumours. - See more at: http://summaries.cochrane.org/CD004272/surgery-versus-primary-endocrine-therapy-for-elderly-women-with-operable-primary-breast-cancer#sthash.RRAt9B6f.dpu