22 research outputs found
Skeletal Diversification via Heteroatom Linkage Control: Preparation of Bicyclic and Spirocyclic Scaffolds from NSubstituted Homopropargyl Alcohols
The discovery and application of a new branching pathway synthesis strategy that rapidly produces skeletally diverse scaffolds is described. Two different scaffold types, one a bicyclic iodo-vinylidene tertiary amine/tertiary alcohol and the other, a spirocyclic 3-furanone, are each obtained using a two-step sequence featuring a common first step. Both scaffold types lead to intermediates that can be orthogonally diversified using the same final components. One of the scaffold types was obtained in sufficiently high yield that it was immediately used to produce a 97-compound library
Intracranial tumors of the central nervous system and air pollution - A nationwide case-control study from Denmark
Background: Inconclusive evidence has suggested a possible link between air pollution and central nervous
system (CNS) tumors. We investigated a range of air pollutants in relation to types of CNS tumors.
Methods: We identified all (n = 21,057) intracranial tumors in brain, meninges and cranial nerves diagnosed in
Denmark between 1989 and 2014 and matched controls on age, sex and year of birth. We established personal 10-
year mean residential outdoor exposure to particulate matter < 2.5 μm (PM2.5), nitrous oxides (NOX), primary emitted
black carbon (BC) and ozone. We used conditional logistic regression to calculate odds ratios (OR) linearly (per
interquartile range (IQR)) and categorically. We accounted for personal income, employment, marital status, use of
medication as well as socio-demographic conditions at area level.
Results: Malignant tumors of the intracranial CNS was associated with BC (OR: 1.034, 95%CI: 1.005–1.065 per IQR.
For NOx the OR per IQR was 1.026 (95%CI: 0.998–1.056). For malignant non-glioma tumors of the brain we found
associations with PM2.5 (OR: 1.267, 95%CI: 1.053–1.524 per IQR), BC (OR: 1.049, 95%CI: 0.996–1.106) and NOx (OR:
1.051, 95% CI: 0.996–1.110).
Conclusion: Our results suggest that air pollution is associated with malignant intracranial CNS tumors and
malignant non-glioma of the brain. However, additional studies are needed
Electroencephalographic study of divers with histories of neurological decompression illness.
Use of Rapid, Point-of-Care Assays by Private Practitioners in Chennai, India: Priorities for Tuberculosis Diagnostic Testing
Aryl-Csp<sup>3</sup> bond rotation barriers of 2-aryl perhydropyrrolo[3,4- c]pyrrole-1,3-diones
(Chemical Equation Presented) The static and dynamic features of 2-aryl perhydropyrrolo[3,4-c]pyrrole-1,3-diones bearing N-acyl substituents have been assessed with the aid of crystal structures and VT NMR spectra. Rotation barriers for the aryl-Csp3 bonds in these molecules show surprising variation. Amide-substituted derivatives and fused piperazinediones (six-membered fusion) exhibit very substantial barriers of 14-15 kcal/mol. Fused benzodiazepinediones (seven-membered fusion) have lower but still significant barriers (10 kcal/mol), while fused hydantoins (five-membered fusion) have barriers that are too low to measure by VT NMR (≤10 kcal/mol). A rationale for the origin of the barriers is presented. © 2009 American Chemical Society
cDNA cloning and characterization of A3i, an alternatively spliced rat A3 adenosine receptor variant
Immunogenicity and safety of an accelerated hepatitis E vaccination schedule in healthy adults: a randomized, controlled, open-label, phase IV trial
Synthesis and evaluation of N6-substituted apioadenosines as potential adenosine A3 receptor modulators
From Cationic to Anionic Helicenes: New Reactivity through Umpolung
Using a two-step reduction/metalation procedure, highly stable chiral carbenium ions are transformed into reactive carbanion intermediates. Interesting polar ketone and thioamide products are the results of this umpolung that occurs with complete retention of configuration of the helical backbone