Marketing implications of traditional and ICT-mediated leisure activities

This study investigates the role of traditional and information and communication technology (ICT)-mediated leisure activities in consumer behaviour. An online survey of 558 members and 1319 ex-members of an Australian DVD rental company gathered preferences for nine traditional leisure activities and seven ICT-mediated leisure activities. The results of a cluster analysis showed four clusters with significant cluster differences across leisure activities and across demographics and consumer behaviours. For practitioners, the study illustrates how profiling customers on their leisure preferences can increase advertising effectiveness, reflect loyalty and help predict customer lifetime value. For academia, the results reveal how another consumer dimension, leisure activities, relates to demographic and behavioural characteristics

Simplified amino acid alphabets based on deviation of conditional probability from random background

The primitive data for deducing the Miyazawa-Jernigan contact energy or BLOSUM score matrix consists of pair frequency counts. Each amino acid corresponds to a conditional probability distribution. Based on the deviation of such conditional probability from random background, a scheme for reduction of amino acid alphabet is proposed. It is observed that evident discrepancy exists between reduced alphabets obtained from raw data of the Miyazawa-Jernigan's and BLOSUM's residue pair counts. Taking homologous sequence database SCOP40 as a test set, we detect homology with the obtained coarse-grained substitution matrices. It is verified that the reduced alphabets obtained well preserve information contained in the original 20-letter alphabet.Comment: 9 pages,3figure

Meaning in life: investigating protective and risk factors for harmful alcohol consumption

Background Individuals with greater meaning in life tend to consume less alcohol. However, research elucidating pathways through which meaning in life influences consumption is lacking. Behavioral economic theories posit that distortions in valuation processes, whilst negative reinforcement models posit that avoidance or regulation of negative internal states, are central in decisions to consume alcohol. Method Pre-registered, cross-sectional design. Five hundred forty-six regular alcohol consumers (≥18 years old) completed an online questionnaire which asked about alcohol use, meaning in life, alcohol-free reinforcement, alcohol value, depressive symptoms, and drinking to cope motives. Results Presence of meaning had a significant negative association with AUDIT scores (β = −.26, p .53). Subsequent path analyses revealed a significant indirect effect of presence of meaning on AUDIT scores through lower alcohol value (95% CI = −.17 to −.08) and drinking to cope (95% CI = −.07 to −.00), and a serial mediation effect through both lower depressive symptoms and drinking to cope (95% CI = −.09 to −.04). Although search for meaning was not a direct predictor of AUDIT scores, there was a significant indirect effect through greater drinking to cope (95% CI = .01 to .06) and a serial mediation effect through both greater depressive symptoms and drinking to cope (95% CI = .01 to .04). Conclusions Meaning in life subscales predict alcohol consumption indirectly via individual differences in alcohol value, depressive symptoms, and drinking to cope

Paramagnetic species in catalysis research: A unified approach towards (the role of EPR in) heterogeneous, homogeneous and enzyme catalysis

Paramagnetic (open-shell) systems, including transition metal ions, radical intermediates and defect centres, are often involved in catalytic transformations. Despite the prevalence of such species in catalysis, there are relatively few studies devoted to their characterisation, compared to their diamagnetic counterparts. Electron Paramagnetic Resonance (EPR) is an ideal technique perfectly suited to characterise such reaction centres, providing valuable insights into the molecular and supramolecular structure, the electronic structure, the dynamics and even the concentration of the paramagnetic systems under investigation. Furthermore, as EPR is such a versatile technique, samples can be measured as liquids, solids (frozen solutions and powders) and single crystals, making it ideal for studies in heterogeneous, homogeneous and enzyme catalysis. Coupled with the higher resolving power of the pulsed, higher frequency and hyperfine techniques, unsurpassed detail on the structure of these catalytic centres can be obtained. In this Chapter, we provide an overview to demonstrate how advanced EPR methods can be successfully exploited in the study of open-shell paramagnetic reaction centres in heterogeneous, homogeneous and enzymatic catalysts, including heme-based enzymes for use in biocatalysts, polymerisation based catalysts, supported microporous heterogeneous catalytic centres to homogeneous metal complexes for small molecule actions

The JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis

Innate immunity contributes to the pathogenesis of inflammatory bowel disease (IBD). However, the mechanisms of IBD mediated by innate immunity are incompletely understood and there are limited models of spontaneous innate immune colitis to address this question. Here we describe a new robust model of colitis occurring in the absence of adaptive immunity. RAG1-deficient mice expressing TNFAIP3 in intestinal epithelial cells (TRAG mice) spontaneously developed 100% penetrant, early-onset colitis that was limited to the colon and dependent on intestinal microbes but was not transmissible to co-housed littermates. TRAG colitis was associated with increased mucosal numbers of innate lymphoid cells (ILCs) and depletion of ILC prevented colitis in TRAG mice. ILC depletion also therapeutically reversed established colitis in TRAG mice. The colitis in TRAG mice was not prevented by interbreeding to mice lacking group 3 ILC nor by depletion of TNF. Treatment with the JAK inhibitor ruxolitinib ameliorated colitis in TRAG mice. This new model of colitis, with its predictable onset and colon-specific inflammation, will have direct utility in developing a more complete understanding of innate immune mechanisms that can contribute to colitis and in pre-clinical studies for effects of therapeutic agents on innate immune-mediated IBD

Isospin Response of the 4-He Continuum

This research was sponsored by the National Science Foundation Grant NSF PHY-931478

The outer halos of elliptical galaxies

Recent progress is summarized on the determination of the density distributions of stars and dark matter, stellar kinematics, and stellar population properties, in the extended, low surface brightness halo regions of elliptical galaxies. With integral field absorption spectroscopy and with planetary nebulae as tracers, velocity dispersion and rotation profiles have been followed to ~4 and ~5-8 effective radii, respectively, and in M87 to the outer edge at ~150 kpc. The results are generally consistent with the known dichotomy of elliptical galaxy types, but some galaxies show more complex rotation profiles in their halos and there is a higher incidence of misalignments, indicating triaxiality. Dynamical models have shown a range of slopes for the total mass profiles, and that the inner dark matter densities in ellipticals are higher than in spiral galaxies, indicating earlier assembly redshifts. Analysis of the hot X-ray emitting gas in X-ray bright ellipticals and comparison with dynamical mass determinations indicates that non-thermal components to the pressure may be important in the inner ~10 kpc, and that the properties of these systems are closely related to their group environments. First results on the outer halo stellar population properties do not yet give a clear picture. In the halo of one bright galaxy, lower [alpha/Fe] abundances indicate longer star formation histories pointing towards late accretion of the halo. This is consistent with independent evidence for on-going accretion, and suggests a connection to the observed size evolution of elliptical galaxies with redshift.Comment: 8 pages. Invited review to appear in the proceedings of "Galaxies and their Masks" eds. Block, D.L., Freeman, K.C. & Puerari, I., 2010, Springer (New York

The Self Model and the Conception of Biological Identity in Immunology

The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for sixty years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity

An integrated assessment of nitrogen source, transformation and fate within an intensive dairy system to inform management change

From an environmental perspective optimised dairy systems, which follow current regulations, still have low nitrogen (N) use efficiency, high N surplus (kg N ha-1) and enable ad-hoc delivery of direct and indirect reactive N losses to water and the atmosphere. The objective of the present study was to divide an intensive dairy farm into N attenuation capacity areas based on this ad-hoc delivery. Historical and current spatial and temporal multi-level datasets (stable isotope and dissolved gas) were combined and interpreted. Results showed that the farm had four distinct attenuation areas: high N attenuation: characterised by ammonium-N (NH4+-N) below 0.23 mg NH4+-N l-1 and nitrate (NO3--N) below 5.65 mg NO3--N l-1 in surface, drainage and groundwater, located on imperfectly to moderately-well drained soils with high denitrification potential and low nitrous oxide (N2O) emissions (av. 0.0032 mg N2O-N l-1); moderate N attenuation: characterised by low NO3--N concentration in drainage water but high N2O production (0.0317 mg N2O-N l-1) and denitrification potential lower than group 1 (av. δ15N-NO3-: 16.4‰, av. δ18O-NO3-: 9.2‰), on well to moderately drained soils; low N attenuation—area 1: characterised by high NO3--N (av. 6.90 mg NO3--N l-1) in drainage water from well to moderately-well drained soils, with low denitrification potential (av. δ15N-NO3-: 9.5‰, av. δ18O-NO3-: 5.9‰) and high N2O emissions (0.0319 mg N2O l-1); and low N attenuation—area 2: characterised by high NH4+-N (av. 3.93 mg NH4+-N l-1 and high N2O emissions (av. 0.0521 mg N2O l-1) from well to imperfectly drained soil. N loads on site should be moved away from low attenuation areas and emissions to air and water should be assessed

Summary for Policymakers - Marine Ecosystem Assessment for the Southern Ocean

i. The Antarctic Treaty System (beginning in 1959 with the Antarctic Treaty) and its emphasis on conservation and protection, exemplified in the Convention on the Conservation of Antarctic Marine Living Resources (1980) and its Protocol on Environmental Protection to the Antarctic Treaty (1991), provide the most recent articulation of the global interest in Antarctica and the Southern Ocean and the need for their protection. ii. The Southern Ocean and its ecosystems play critical roles in the climate system. Ecosystem functions are at risk because of anthropogenic climate change. iii. Global policies and actions are urgently required to safeguard Southern Ocean ecosystems from the effects of climate change, ocean warming and acidification caused by greenhouse gas emissions. iv. Regional human pressures on Southern Ocean species and ecosystems have been dominated by fisheries, with human presence (science and tourism) and pollution having localised, but increasing, impacts. v. The Marine Ecosystem Assessment for the Southern Ocean (MEASO) has demonstrated the array of existing knowledge, data, tools and approaches available for informing decisions on conserving and sustaining the marine ecosystems in the region and the services they provide, and how implementation of those processes could be improved